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Advancing engineered approaches for sustainable wound regeneration and repair:Harnessing the potential of green synthesized silver nanoparticles

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Engineered Regeneration 2024年第3期5卷 306-325页

作者： J.Nandhini E.Karthikeyan E.Elizabeth Rani V.S.Karthikha d.sakthi sanjana H.Jeevitha S.Rajeshkumar Vijayan Venugopal A.Priyadharshan department of Pharmaceutics Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India department of Pharmaceutical Chemistry Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India department of Pharmacology Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesChennaiIndia department of Pharmaceutics School of PharmacySri Balaji Vidyapeeth(Deemed to be university)PuducherryIndia department of conservative dentistry and Endodontics Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia

Wound healing is a crucial biological process for tissue repair and regeneration,preventing infections and ***’s been a growing interest in exploring sustainable wound healing strategies in recent *** review examines the use of green-synthesized silver nanoparticles(AgNPs)in sustainable wound healing *** highlights the need for innovative approaches and the challenges posed by *** current wound therapies and treatments,highlighting gaps in existing methodologies,are *** review provides a com-prehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of *** properties and characterization of AgNPs are elucidated,providing insights into their *** biocompati-bility of AgNPs in wound healing is also explored,emphasizing safety in medical *** synthesized AgNPs incorporated wound dressings are detailed,showcasing their potential in clinical *** and future perspectives are discussed,addressing hurdles to widespread *** conclusion consolidates key findings,offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices.

关键词： Green synthesis Wound healing AgNPs Wound healing mechanism Eco-friendly synthesis

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BioPerine Encapsulated Nanoformulation for Overcoming drug-Resistant Breast Cancers

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Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 701-712页

作者： Sindhu C Pillai Ankita Borah Amandeep Jindal Eden Mariam Jacob Yohei Yamamoto d.sakthi Kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New ScienceToyo UniversitySaitama 350-8585Japan department of Materials Science Faculty of Pure and Applied SciencesUniversity of TsukubaTsukubaIbaraki 305-8573Japan

The evolving dynamics of drug resistance due to tumor heterogeneity often creates impediments to traditional therapies making it a challenging issue for cancer *** cancer often faces challenges of current therapeutic interventions owing to its multiple complexities and high drug resistivity,for example against drugs like trastuzumab and *** resistance in the majority of breast cancer is often aided by the overtly expressed P-glycoprotein(P-gp)that guides in the rapid drug efflux of chemotherapy *** continuous endeavors and ground-breaking achievements in the pursuit of finding better cancer therapeutic avenues,drug resistance is still a menace to hold *** newer therapeutic approaches,the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer *** this work,we would like to present a black pepper alkaloid derivative known as Bio Perine-loaded chitosan(CS)-polyethylene glycol(PEG)coated polylactic acid(PLA)hybrid polymeric nanoparticle to improve the bioavailability of Bio Perine and its therapeutic efficacy in suppressing P-gp expression in MdA-MB 453 breast cancer cell *** findings revealed that the CS-PEG-Bio PerinePLA nanoparticles demonstrated a smooth spherical morphology with an average size of316 nm,with improved aqueous solubility,and provided sustained Bio Perine *** nanoparticles also enhanced in vitro cytotoxicity and downregulation of P-gp expression in MdA-MB 453 cells compared to the commercial inhibitor verapamil hydrochloride,thus promising a piece of exciting evidence for the development of Bio Perine based nano-drug delivery system in combination with traditional therapies as a crucial approach to tackling multi-drug resistance in cancers.

关键词： drug Resistant cancer P-glycoprotein BioPerine Chitosan PLA nanoparticle

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Ultra-fast microwave aided synthesis of gold nanocages and structural maneuver studies

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Nano Research 2017年第3期10卷 1078-1091页

作者： Sreejith Raveendran Anindito Sen Toru Maekawa d. sakthi Kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New Science Toyo University 2100 Kujirai Kawagoe Saitama 350-8585 Japan JEOL Ltd. 13F Ohtemachi Nomura Building 2-1-10htemachi Chiyoda-Ku. Tokyo 100-0004 Japan

Gold nanocages （AuNcgs） are well-studied, hollow, metallic nanostructures that have fascinated researchers in the fields of nanotechnology, materials science, photoelectronics, biotechnology, and medical science for the last decade. However, the time-consuming synthesis of AuNcgs has limited their widespread use in materials science and nano-biotechnology. A novel, ultra-fast, simple, and highly convenient method for the production of AuNcgs using microwave heating is demonstrated herein. This quick method of AuNcg synthesis requires mild laboratory conditions for large-scale production of AuNcgs. The microwave heating technique offers the advantage of precise mechanical control over the temperature and heating power, even for the shortest reaction period （i.e., seconds）. Microwave-synthesized AuNcgs were compared with conventionally synthesized AuNcgs. Structural maneuver studies employing the conventionally produced AuNcgs revealed the formation of screw dislocations and a shift in the lattice plane. detailed characterization of the microwave-generated AuNcgs was performed using high resolution transmission electron microscopy （HRTEM）, scanning electron microscopy （SEM）, X-ray powder diffraction （XRd）, and spectroscopic techniques.

关键词： gold nanocages nanocages nanoboxes microwave technology ultra-fast screw dislocation

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Size tuning and oxygen plasma induced pore formation on silica nanoparticles

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Progress in Natural Science:Materials International 2012年第3期22卷 193-200页

作者： Remya Nair Y. Yoshida T. Maekawa d. sakthi Kumarn BioNano Electronics Research Center Graduate School of Interdisciplinary New Science Toyo University

Silica nanoparticles have been prepared from tetraethylorthosilicate dissolved in ethanol followed by base-catalyzed condensation. Earlier works reported that at least four parameters, namely concentration of tetraethylorthosilicate, ethanol, water and ammonia solution are needed to be optimized for the size tuning of silica nanoparticles. In this work size tuning of 5 nm-250 nm has been achieved by varying a single synthesis parameter i.e., the concentration of ammonia solution. Oxygen plasma was found to be successful for generating pores on silica nanoparticles without using any structure directing agents. The properties and morphology of nanoparticles were investigated by transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and Fourier transformed infrared spectroscopy.

关键词： Silica nanoparticles Size tuning Plasma treatment Pore induction

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Using Crop Management Scenario Simulations to Evaluate the Sensitivity of the Ohio Phosphorus Risk Index

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Journal of Environmental Protection 2017年第2期8卷 141-158页

作者： Elizabeth A. dayton Christopher H. Holloman sakthi Subburayalu Mark d. Risser School of Environment and Natural Resources The Ohio State University Columbus OH USA Statistical Consulting Services Department of Statistics The Ohio State University Columbus OH USA

Phosphorus (P) risk indices are commonly used in the USA to estimate the field-scale risk of agricultural P runoff. Because the Ohio P Risk Index is increasingly being used to judge farmer performance, it is important to evaluate weighting/scoring of all P Index parameters to ensure Ohio farmers are credited for practices that reduce P runoff risk and not unduly penalized for things not demonstrably related to runoff risk. A sensitivity analysis provides information as to how sensitive the P Index score is to changes in inputs. The objectives were to determine 1) which inputs are most highly associated with P Index scores and 2) the relative impact of each input variable on resultant P Index scores. The current approach uses simulations across 6134 Ohio point locations and five crop management scenarios (CMSs), representing increasing soil disturbance. The CMSs range from all no-till, which is being promoted in Ohio, rotational tillage, which is a common practice in Ohio to full tillage to represent an extreme practice. Results showed that P Index scores were best explained by soil test P (31.9%) followed by connectivity to water (29.7%), soil erosion (13.4%), fertilizer application amount (11.3%), runoff class (9.5%), fertilizer application method (2.2%), and finally filter strip (2.0%). Ohio P Index simulations across CMSs one through five showed that >40% scored d >45 points (very high). Given Ohio water quality problems, the Ohio P Index needs to be stricter. The current approach is useful for Ohio P Index evaluations and revision decisions by spatially illustrating the impact of potential changes regionally and state-wide.

关键词： Ohio P Index Sensitivity Analysis P Index Simulations RUSLE2 Simulations Crop Management Simulations

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