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Biochemical dissection of StAt3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： StAt3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

the Bloomsbury Short Story

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Fudan Journal of the Humanities and Social Sciences 2017年第1期10卷 5-19页

作者： ira Nadel department of English University of British Columbia 397 1873 East Mall VancouverBC V6T 1Z1 Canada

this article examines the importance of the short story form for the Bloomsbury writers and how their aesthetic theories influenced its composition, structure and content. Often overlooked in the history of the genre, the Bloomsbury short story has a claim to be an important aspect of the twentieth-century accounts of the short story form. Attention to Virginia and Leonard Woolf, Katherine Mansfield, Vita Sackville- West, E.M. Forster and others, such as Arnold Bennett and d.H. Lawrence, indicates their widespread engagement with the genre and the ways in which they treated it from fragmented conversation, as in Woolf s ＂the String Quartet,＂ to Foster＇s employment of linear narrative detail in ＂the Road from Colonus.＂ Formal experiments with syntax, imagery, and vocabulary and prose rhythm exhibit the seriousness of the short story for Bloomsbury authors. the influence of the Russians is particularly important with Che- kov dominating the reading and writing of Woolf, Mansfield, Lawrence and others. the very form of publication--mostly journals and magazines--is also crucial in shaping the length and structure of the short story. Attention to experimentation, as well as renewal, of the genre balances the impact of the short story on writers today and the question of a successor to the efforts and achievements of Bloomsbury＇s authors. A reading of the short stories of Julian Barnes explores this possibility.

关键词： Short story Bloomsbury Virginias Woolf. Katherine Mansfield d.H.Lawrence

design of Slant-Form tool in Precision Reuse of digital paper display

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Journal of Materials Science & technology 2011年第9期27卷 846-850页

作者： pai-Shan pa department of digital Content design Graduate School of Toy and Game Design National Taipei University of Education Taipei 10667 Taiwan China

A reuse fabrication module using micro electroetching as a precision machining process with a new design of a slant-form tool to remove the defective indium-tin-oxide （ItO） nanostructure from the optical polyethyleneterephthalate （PEt） surfaces of digital paper display is presented in current studies. the low yield of ItO thin film deposition is an important factor in optoelectronic semiconductor production. the adopted precision reuse process requires only a short period of time to remove the ItO nanostructure easily and cleanly, which is based on technical and economical considerations and is highly efficient. In the current experiment, a large inclined angle of the cathode and a small end radius of the anode take less time for the same amount of ItO removal. A higher feed rate of the optical PEt diaphragm combines with enough electric power to drive fast micro electroetching. A small rotational diameter of the anode accompanied by a small width of the cathode corresponds to a higher removal rate for the ItO nanostructure. A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the workpiece. this improvement is associated with an increase in current rating. High rotational speed of the slant-form tool can improve the effect of dregs discharge and is advantageous to associate with the fast feed rate of the workpiece （optical PEt diaphragm）.

关键词： Reuse fabrication Slant-Form digital paper display Optical polyethyleneterephthalate (PEt) diaphragm Indium-tin-oxide (ItO) nanostructure Micro electroetching

dactyls and Pterodactyls： New Convergences of Poetics and Science

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2013年第2期7卷 287-304页

作者： ira Livingston Humanities & Media Studies Pratt Institute Main Brooklyn Campus New York NY 11205 USA

If poetics refers broadly to the principles by which things are made, how is the kind of process that yields poetry （in the narrow sense） related to other kinds of making？ this essay explores promising resonances between traditional poetics and new paradigms coming out of complexity and systems theory. Of particular interest is terrence deacon＇s Incomplete Nature, an account of the relationships among layers of emergent order in the universe, under the heading of a general theory of dynamics. In particular, this essay understands poetry in relation to other kinds of making through three principles deacon identifies as crucial： constraint, emergence, and absence. these principles tend to validate rather than to undermine traditional accounts of poetic making as inspiration, often involving entification in the form of attribution of creative agency to entities such as muses or to the text itself.

关键词： absentiality constraint terrence deacon emergence entification,incomplete nature poetics.

Selective removal technology using chemical etching and excimer assistance in precision recycle of color filter

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transactions of Nonferrous Metals Society of China 2011年第A01期21卷 210-214页

作者： pai-shan pa digital Content design Graduate School of Toy and Game Design National Taipei University of Education Taipei City 10671 China

Color filters are produced using semiconductor production techniques although problems with low yield remain to be addressed. this study presents a new means of selective removal using excimer irradiation, chemical etching, or electrochemical machining on the fifth generation tFt LCds. the selective removal of microstructure layers from the color filter surface of an optoelectronic flat panel display, as well as complete removal of the ItO thin-films, RGB layer, or resin black matrix (BM) layer from the substrate is possible. Individual defective film layers can be removed, or all films down to the Cr layer or bare glass can be completely eliminated. Experimental results demonstrate that defective ItO thin-films, RGB layers, or the resin BM layer can now be recycled with a great precision. When the ItO or RGB layer proves difficult to remove, excimer light can be used to help with removal. during this recycling process, the use of 225 nm excimer irradiation before chemical etching, or electrochemical machining, makes removal of stubborn film residues easy, effectively improving the quality of recycled color filters and reducing fabrication cost.

关键词： chemical etching excimer light selective removal technology display color filter

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American Roth

Fudan Journal of the Humanities and Social Sciences 2019年第3期12卷 493-510页

作者： ira Nadel department of English University of British Columbia 397-1873 East Mall Vancouver BC V6T 1Z1 Canada

An analysis of the Philip Roth's sustained pursuit of his American identity mixed with his engagement with the trope of the American Adam is the center of this paper. From the outset of his career, Roth has sought to be understood as an American, not Jewish, writer. But as his career unfolded, the challenges of sustaining his American identity grew, whether in Portnoy's Complaint, Sabbath's theatre or the American trilogy. the confrontation between American and Judaic identities increasingly became his subject as his Jewish roots threatened his American identity stemming from a Protestant, if not Puritan, literary heritage. Coleman Silk and Swede Levov from the Human Stain and American pastoral represent the challenge best summarized by Abe Ravelstein in Bellow's eponymous novel when he remarks that “as a Jew you are also an American, but somehow you are not.” the paradox of Roth’s entanglement with the trope of the American Adam is that he both pursues and denies this identity, accepting its heroism but acknowledging its impossibility. One moment he publically declares “if I’m not an American, I am nothing,” but on the other, to be Roth he knows he must violate the Adamic ideal, prepared to renounce neither his American nor Jewish identities.

关键词： American Adam Philip Roth Identity Heroism Captain America

An effective round ball tool in electrochemistry process as novel reuse fabrication technology

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中国有色金属学会会刊：英文版 2012年第S3期22卷 825-830页

作者： P.S.pa department of digital Content design Graduate School of Toy and Game DesignNational Taipei University of Education

A reuse fabrication module using micro electrochemistry (MECM) with a round-ball tool to remove the defective In2O3 SnO2 thin film from the surfaces of digital paper display was *** etching effect improves that the number of the round-balls decreases for promoting the concentration of electric power and increasing discharge *** a small size of the round-ball tool takes less time for the same amount of In2O3 SnO 2 layer removal since the effect of MECM is easily developed for supplying of sufficient electrochemical power.A higher feed rate of the poly ethylene terephthalate (PEt) diaphragm combines with enough electric power to drive fast etching rate.A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the *** the ultra-precise etching of In2O 3 SnO2,the optoelectronic semiconductor industry can effectively reuse the defective products,reducing production *** precision etching process is of high efficiency and requires only a short period of time to remove the In2O3 SnO2 nanostructures.

关键词： thin film round-ball tool In2O3SnO2 micro electrochemistry digital paper display