检索结果-南通市图书馆

recent advances in endovascular techniques for management of acute nonvariceal upper gastrointestinal bleeding

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal surgery 2011年第7期3卷 89-100页

作者： romaric f Loffroy Basem A Abualsaud Ming d Lin pramod p rao LE2I Laboratory CNRS UMR 5158Department of Vascular and Interventional RadiologyUniversity of Dijon School of MedicineBocage Teaching Hospital2 Bd Maréchal de Lattre de TassignyBP 7790821079 DijonFrance department of vascular and Interventional radiology University of Dijon School of MedicineBocage Teaching Hospital2 Bd Maréchal de Lattre de TassignyBP 7790821079 DijonFrance clinical Informatics Interventionaland Translational SolutionsPhilips Research North America345 Scarborough RoadBriarcliff ManorNY 10510United States russell H.Morgan department of radiology and radiological Science Division of Vascular and Interventional RadiologyJohns Hopkins Hospital600 North Wolfe Street Blalock 545BaltimoreMD 21287United States

Over the past two decades,transcatheter arterial embolization has become the first-line therapy for the management of upper gastrointestinal bleeding that is refractory to endoscopic *** in catheter-based techniques and newer embolic agents, as well as recognition of the effectiveness of minimally invasive treatment options,have expanded the role of interventional radiology in the management of hemorrhage for a variety of indications,such as peptic ulcerbleeding,malignant disease,hemorrhagic dieulafoy lesions and iatrogenic or trauma *** interventions include the following:selective embolization of the feeding artery,sandwich coil occlusion of the gastroduodenal artery,blind or empiric embolization of the supposed bleeding vessel based on endoscopic findings and coil pseudoaneurysm or aneurysm embolization by three-dimensional sac packing with preservation of the parent *** embolization is a fast,safe and effective,minimally invasive alternative to surgery when endoscopic treatment fails to control bleeding from the upper gastrointestinal *** article reviews the various transcatheter endovascular techniques and devices that are used in a variety of clinical scenarios for the management of hemorrhagic gastrointestinal emergencies.

关键词： Upper gastrointestinal bleeding Endoscopy Angiography Embolization surgery

Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & vascular Neurology 2022年第2期7卷 124-131页

作者： deepthi rajashekar Matthias Wilms M Ethan Macdonald Serena Schimert Michael d Hill Andrew demchuk Mayank Goyal Sean p dukelow Nils daniel forkert Biomedical Engineering Graduate program Hotchkiss Brain InstituteUniversity of CalgaryCalgaryAlbertaCanada department of radiology Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Hotchkiss Brain Institute University of CalgaryCalgaryAlbertaCanada department of clinical Neurosciences University of CalgaryCalgaryAlbertaCanada department of Electrical and computer Engineering University of CalgaryCalgaryAlbertaCanada department of community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada department of Medicine Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Alberta children's Hospital research Institute University of CalgaryCalgaryABCanada

Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical *** clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to *** far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS ***,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not *** Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the EScApE *** NIHSS domains were grouped into six categories using two *** was conducted for each category of the two groupings and the total NIHSS *** Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised *** These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging.

关键词： patients score category

Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of clinical Oncology 2018年第1期9卷 20-25页

作者： Mina S Makary Lawrence S Krishner Evan J Wuthrick Mark p Bloomston Joshua d dowell division of vascular and Interventional radiology Department of Radiology the Ohio State University Comprehensive Cancer Center division of Medical Oncology Department of Internal Medicine the Ohio State University Comprehensive Cancer Center department of radiation Oncology the Ohio State University Comprehensive Cancer Center division of Surgical Oncology Department of Surgery and James Cancer Hospital and Richard Solove Research Institute the Ohio State University Comprehensive Cancer Center

Adrenocortical carcinoma(Acc)is a rare malignancy with generally poor outcomes and limited treatment *** surgical resection can be curative for early local disease,most patients present with advanced Acc owing to nonspecific *** those patients,treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial *** present the first reported case of utilizing yttrium-90 microsphere selective internal radiation therapy(SIrT)in combination with first line Edp-M(Etoposide,doxorubicin,cisplatin,Mitotane)chemotherapy and debulking surgical primary tumor resection for treatment of metastatic *** complete radiologic response has been maintained after twelve months with resolution of clinical *** findings prompt the need for further consideration and studies to elucidate the role of SIrT in combination with systemic and surgical treatment for metastatic Acc.

关键词： Adrenocortical carcinoma Hepatic metastases radioembolization Yttrium-90

disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem cells 2021年第5期13卷 452-469页

作者： Vladimir p Baklaushev Oleg V durov Vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A revkova Ekaterina M Samoilova pavel A Melnikov dzhina d Karal-Ogly Sergey V Orlov Alexander V Troitskiy Vladimir p chekhonin Alexander V Averyanov Jan-Eric Ahlfors Biomedical research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia radiology and clinical physiology Scientific research center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia department of primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia department of vascular surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia department of Medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BAcKGrOUNd The development of regenerative therapy for human spinal cord injury(ScI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in ScI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNpcs).METHOdS Seven non-human primates with verified complete thoracic ScI were divided into two groups:drNpc group(n=4)was subjected to intraspinal transplantation of 5 million drNpcs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** follow-up for 12 wk revealed that animals in the drNpc group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNpcs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNpcs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNpc transplantation was safe and contributed to improvement of spinal cord function after acute ScI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： direct cell reprogramming Neural precursor cells directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates regenerative therapy,Evoked potentials

Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & vascular Neurology 2023年第5期8卷 358-367页

作者： Julián N Acosta Stefan p Haider cyprien rivier Audrey c Leasure Kevin N Sheth Guido J falcone Seyedmehdi payabvash department of Neurology Yale School of MedicineNew HavenConnecticutUSA department of radiology and Biomedical Imaging Yale School of MedicineNew HavenConnecticutUSA department of Otorhinolaryngology Ludwig Maximilians University MunichMunchenGermany

Background and objectives We aimed to investigate the white matter(WM)microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure(SBp),and whether they mediate SBp effects on cognitive performance in middle-aged *** Using the uk Biobank study of community-dwelling volunteers aged 40-69 years,we included participants without a history of stroke,dementia,demyelinating disease or traumatic brain *** investigated the association of SBp with MrI diffusion metrics:fractional anisotropy(fA),mean diffusivity(Md),intracellular volume fraction(a measure of neurite density),isotropic(free)water volume fraction(ISOVf)and orientation dispersion across WM ***,we determined whether WM diffusion metrics mediated the effects of SBp on cognitive *** We analysed 31363 participants-mean age of 63.8 years(Sd:7.7),and 16523(53%)*** SBp was associated with lower fA and neurite density,but higher Md and *** different WM tracts,diffusion metrics of the internal capsule anterior limb,external capsule,superior and posterior corona radiata were most affected by higher *** seven cognitive metrics,SBp levels were only associated with‘fluid intelligence’(adjusted pdiation analysis,the averaged fA of external capsule,internal capsule anterior limb and superior cerebellar peduncle mediated 13%,9%and 13%of SBp effects on fluid intelligence,while the averaged Md of external capsule,internal capsule anterior and posterior limbs,and superior corona radiata mediated 5%,7%,7%and 6%of SBp effects on fluid intelligence,*** Among asymptomatic adults,higher SBp is associated with pervasive WM microstructure disintegrity,partially due to reduced neuronal count,which appears to mediate SBp adverse effects on fluid *** metrics of select WM tracts,which are most reflective of SBp-related parenchymal damage and cognitive impairment,may serve as imaging biomarkers to

关键词： capsule Blood impairment

Two-stage liver transplant for ruptured hepatic adenoma:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2019年第2期11卷 242-249页

作者： Marc Salhanick Malcolm p Macconmara Mark r pedersen Lafaine Grant christine S Hwang Justin r parekh division of vascular surgery Department of Surgerythe University of Texas Southwestern Medical Center division of Surgical Transplantation Department of Surgerythe University of Texas Southwestern Medical Center division of digestive and Liver diseases Department of Internal Medicinethe University of Texas Southwestern Medical Center

BAcKGrOUNd Only one case of liver transplantation for hepatic adenoma has previously been reported for patients with rupture and uncontrolled *** present the case of a massive ruptured hepatic adenoma with persistent hemorrhagic shock and toxic liver syndrome which resulted in a two-stage liver *** is the first case of a two-stage liver transplantation performed for a ruptured hepatic *** SUMMArY A 23 years old African American female with a history of pre-diabetes and oral contraceptive presented to an outside facility complaining of right-sided chest pain and emesis for one *** was found to be in hemorrhagic shock due to a massive ruptured hepatic hepatic *** underwent repeated embolizations with interventional radiology with ongoing hemorrhage and the development of renal failure,hepatic failure,and hemodynamic instability,known as toxic liver *** the setting of uncontrolled hemorrhage and toxic liver syndrome,a hepatectomy with porto-caval anastomosis was performed with liver transplantation 15 h *** tolerated the anhepatic stage well,and has done well over one year *** When toxic liver syndrome is recognized,liver transplantation with or withouthepatectomy should be considered before the patient becomes unstable.

关键词： Hepatic adenoma Toxic liver syndrome Two-stage liver transplantation Hepatectomy ruptured adenoma case report

radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta pharmaceutica Sinica B 2018年第3期8卷 360-370页

作者： Li Tian Linfeng Lu James feng Marites p.Melancon department of Interventional radiology The University of Texas MD Anderson Cancer Center duke university Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston

A review of radiopaque nano and polymeric materials for atherosclerosis imaging and catheterization procedures is presented in this paper. cardiovascular diseases(cVds) are the leading cause of death in the US with atherosclerosis as a significant contributor for mortality and morbidity. In this review paper, we discussed the physics of radiopacity and X-ray/cT, clinically used contrast agents,and the recent progress in the development of radiopaque imaging agents and devices for the diagnosis and treatment of cVds. We focused on radiopaque imaging agents for atherosclerosis, radiopaque embolic agents and drug eluting beads, and other radiopaque medical devices related to catheterization procedures to treat cVds. common strategies of introducing radiopacity in the polymers, together with examples of their applications in imaging and medical devices, are also presented.

关键词： radiopaque contrast nanoparticles and materials X-ray cT vascular diseases Atherosclerosis plaque Stenosis Embolization Inferior vena cava filters

多层cT Willis环成像:Willis环变异与颈动脉病变及脑缺血的相关性

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2019年第2期42卷 242-243页

作者： A.Varga G.d.Leo p.V.Banga c.c.Novák M.Kolossváry p.M.Horvat 郑育聪(译) 陈秀玉(校) department of diagnostic radiology Heart and Vascular CenterSemmelweis University18 Határor streetBudapest 1122Hungary 不详

目的评估颈动脉内膜剥脱术病人Willis环(coW)的变异率,并探讨变异与对照组及cT诊断的脑缺血的相关性。方法本研究经机构伦理委员会批准,回顾性分析544例颈动脉内膜剥离术病人[男331例,平均年龄(69±8)岁]和196例对照组[男117例。

关键词：脑缺血变异率 Willis cT Willis 相关性

Influence of transarterial chemoembolization on angiogenesis and expression of vascular endothelial growth factor and basic fibroblast growth factor in rat with Walker-256 transplanted hepatoma:An experimental study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第11期9卷 2445-2449页

作者： Xin Li Gan-Sheng feng chuan-Sheng Zheng chen-Kai Zhuo Xi Liu, department of Interventional radiology, Union Hospital, Tongji Medical college, Huazhong university of Science and Technology, Wuhan 430022, Hubei province, china department of Interventional radiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China. wxyao2001@***

AIM: After transarterial chemoembolization (TAcE), the residual cancer cells are under extensive hypoxic or even anoxic environment. Hypoxia can lead to adaptive *** example, angiogenesis will help these cells survive. In this study, we examined the effect of TAcE on angiogenesis and expression of vascular endothelial growth factor (VEGf)and basic fibroblast growth factor (b-fGf) and to assess their relevance to Walker-256 transplanted ***: Male Wistar rats were inoculated with Walker256 tumor in the left lobe of liver. Angiography and transarterial chemoembolization were performed at d14 after transplantation. Sixty rats bearing walker-256 transplanted hepatoma were randomly divided into control group, arterial infusion group and TAcE group. Each group consisted of twenty rats. Normal saline, 5-fu, 5-fu and lipiodol were infused through hepatic artery respectively. Two weeks after the infusion, staining of factor Ⅷ, VEGf and b-fGf was performed by immunohistochemistry method in routine paraffin-embeded sections. Microvessel density(MVd) was counted in endothelial cells with positive factor Ⅷ. Their expression levels were analyzed in conjunction with the pathologic ***: While a smaller tumor volume was found in TAcE group (f=37.818, pcal differences between MVd and expression of VEGf and b-fGf were found among the 3 groups. MVd of the control group, chemotherapy group and chemoemoblization group was 80.84±24.24,83.05±20.29 and 85.20±23.91 (f=0.193, p=0.873),respectively. The positive expression of VEGf and b-fGf was 75 %, 75 % , 85 % (X2=0.449, p=0.799) and 30 %,25 %, 30 % (X2=0.141, p=0.922), respectively. Statistical analysis revealed a positive correlation between the expression of VEGf and MVd (r=0.552, pcONcLUSION: There has been little influence of lipiodol chemoembolization on the formation of tumor angiogenesis,but the development of neovascularization and expressionof VEGf play important roles

关键词：肝细胞瘤血管内皮生长因子血管生成基质纤维原生长因子发病机制动物实验