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Metabolic signatures of Arabidopsis thaliana abiotic stress responses elucidate patterns in stress priming,acclimation,and recovery

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Stress Biology 2022年第1期2卷 550-565页

作者： Yuan Xu dana M.Freund Adrian d.Hegeman Jerry d.cohen department of Horticultural Science and the Microbial and Plant Genomics Institute University of MinnesotaMNSaint PaulUSA department of Plant and Microbial Biology University of MinnesotaMNSaint PaulUSA

Temperature,water,and light are three abiotic stress factors that have major influences on plant growth,development,and *** can be primed by a prior mild stress to enhance their resistance to future *** used an untargeted metabolomics approach to examine Arabidopsis thaliana 11-day-old seedling’s abiotic stress responses including heat(with and without priming),cold(with and without priming),water-deficit and high-light before and after a 2-day-recovery *** of the physiological phenotypes showed that seedlings with stress treatment resulted in a reduction in fresh weight,hypocotyl and root length but remained *** stress responsive metabolites were identified,confirmed with reference standards,quantified,and *** identified shared and specific stress signatures for cold,heat,water-deficit,and high-light *** metabolism including amino acid metabolism,sugar metabolism,glycolysis,TCA cycle,GABA shunt,glutathione metabolism,purine metabolism,and urea cycle were found to undergo changes that are fundamentally different,although some shared commonalities in response to different *** increases in cysteine abundance and decreases in reduced glutathione were observed following multiple stress treatments highlighting the importance of oxidative stress as a general phenomenon in abiotic *** fold increases in low-turnover amino acids and maltose demonstrate the critical role of protein and starch autolysis in early abiotic stress responses.

关键词： Abiotic stress Arabidopsis thaliana LC-HRMS Metabolomics Plant stress acclimation Priming Recovery

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Learning Mandarin in Later Life:Can Old dogs Learn New Tricks?

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当代外语研究 2013年第12期 5-14页

作者： ANdREW d.cohen PING LI University of Minnesota Beijing University of Posts and Telecommunications

This case study reports on a native English speaker's learning of Mandarin as a 13th language starting at the age *** learner,after completing a 150-hour,3-dVd course called Fluenz Mandarin,had 70online sessions with a Chinese-language instructor from a Beijing-based *** learning content focused mainly on pinyin,a Romanization system for the pronunciation of Standard *** sessions contained real-life communication in Chinese based on Chinese sentences produced beforehand by the learner consistent with his life experiences and professional interests as an applied *** the sessions,the instructor developed the sentences into formulated language and kept a detailed log with the learner's feedback as ***,the learner created electronic flashcards for words and phrases to *** paper considers the impact of advanced age,hyperpolyglot status,and the use of a sophisticated language strategy repertoire on Mandarin *** paper reports on the learner's results as viewed from the vantage point of the learner and from that of his instructor as well,paying particular attention to vocabulary(e.g.,the use of measure words and the overabundance of homonyms and near homonyms),grammar(e.g.,word order),and pronunciation(e.g.,the perception and production of the four tones).

关键词：英语学习学习方法阅读知识阅读材料

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人工描绘CT影像中结构轮廓的观察者间变异性

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国际医学放射学杂志 2019年第3期 371-371页

作者：于子川 L.Joskowicz d.cohen N.Caplan J.Sosna The Rachel and Selim Benin School of Computer Science and Engineering The Hebrew University of Jerusalem

摘要目的量化CT影像中人工描绘病变和器官轮廓时不同观察者间的差异,为临床决策和自动分割算法的评价提供体积测量的参考标准。方法 11名放射科医生在490层CT

关键词：变异性 CT

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Pioneering the direct large-scale laser printing of flexible“graphenic silicon”self-standing thin films as ultrahigh-performance lithium-ion battery anodes

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Carbon Energy 2024年第7期6卷 26-40页

作者： Avinash Kothuru Adam cohen Gil daffan Yonatan Juhl Fernando Patolsky School of Chemistry Faculty of Exact SciencesTel Aviv UniversityTel AvivIsrael department of Materials Science and Engineering The Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael

Recent technological advancements,such as portable electronics and electric vehicles,have created a pressing need for more efficient energy storage ***-ion batteries(LIBs)have been the preferred choice for these applications,with graphite being the standard anode material due to its ***,graphite falls short of meeting the growing demand for higher energy density,possessing a theoretical capacity that lags *** address this,researchers are actively seeking alternative materials to replace graphite in commercial *** promising avenue involves lithiumalloying materials like silicon and phosphorus,which offer high theoretical ***-silicon composites have emerged as a viable option,showing improved capacity and performance over traditional graphite or pure silicon ***,the existing methods for synthesizing these composites remain complex,energy-intensive,and costly,preventing widespread adoption.A groundbreaking approach is presented here:the use of a laser writing strategy to rapidly transform common organic carbon precursors and silicon blends into efficient“graphenic silicon”composite thin *** films exhibit exceptional structural and energy storage *** resulting three-dimensional porous composite anodes showcase impressive attributes,including ultrahigh silicon content,remarkable cyclic stability(over 4500 cycles with∼40%retention),rapid charging rates(up to 10 A g^(-1)),substantial areal capacity(>5.1 mAh cm^(-2)),and excellent gravimetric capacity(>2400 mAh g^(-1) at 0.2 A g^(-1)).This strategy marks a significant step toward the scalable production of high-performance LIB *** widely available,cost-effective precursors,the laser-printed“graphenic silicon”composites demonstrate unparalleled performance,potentially streamlining anode production while maintaining exceptional *** innovation not only paves the way for advanced LIBs but also sets a precedent for

关键词： 4d printing energy storage fast-charging laser-induced graphene lithium-ion silicon carbon composite anodes

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卫星和地基遥感观测资料约束下的核-壳态气溶胶光学特性模拟研究

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光学学报 2024年第6期44卷 329-340页

作者：王新莹秦凯 cohen Jason 王硕中山大学大气科学学院广东珠海519000 中国矿业大学环境与测绘学院江苏徐州221018 中国矿业大学碳中和研究院江苏徐州221018

针对结合星地观测与模型定量模拟消光性气溶胶光学特性及黑碳质量空间分布这一热点问题,利用TROPOMI卫星紫外波段观测数据与AERONET地基观测数据,基于“核-壳”假设下的米散射模型提出了一种准确量化黑碳气溶胶质量空间分布的模拟方法,... 详细信息

针对结合星地观测与模型定量模拟消光性气溶胶光学特性及黑碳质量空间分布这一热点问题,利用TROPOMI卫星紫外波段观测数据与AERONET地基观测数据,基于“核-壳”假设下的米散射模型提出了一种准确量化黑碳气溶胶质量空间分布的模拟方法,并对北京、中国香港、首尔三个站点的模拟结果进行分析与验证。多源数据约束后米散射模型模拟得到的结果显示:北京的吸收系数在0.04~0.13之间,中国香港的吸收系数整体小于0.08,首尔的吸收系数介于0.02~0.06之间。计算得到的黑碳气溶胶柱内质量空间分布结果显示:北京站黑碳气溶胶柱内质量在200~600 kg/grid之间,中国香港站黑碳气溶胶柱内质量在180~650 kg/grid之间,首尔站黑碳气溶胶柱内质量在300 kg/grid以下。结合卡尔曼滤波排放清单与一阶箱模型对黑碳气溶胶柱内质量结果进行间接验证,计算得到的黑碳气溶胶生命周期为1~4 d不等,符合其在大气中的真实状态,说明结果具有一定可靠性。通过对比加入TROPOMI紫外波段卫星观测数据前后对模型进行约束得到的粒径分布及吸收系数结果的差异发现:加入紫外波段观测数据对模拟结果具有一定增强作用。所提方法模拟结果良好,方案具有一定应用潜力。

关键词： TROPOMI卫星数据 AERONET 黑碳气溶胶米散射模型

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Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders

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Insect Science 2016年第1期23卷 59-67页

作者： Marina Katzman Ya'kobovitz Terry d. Butters Ephraim cohen department of Entomology Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem RehovotIsrael department of Biochemistry University of Oxford Oxford OX1 3QU UK

Secondary metabolites and synthetic iminosugars that structurally resemble monosaccharides are potent inhibitors of a-glucosidase activity. The enzyme is core in cleaving sucrose in phloem feeding insects and it also plays a crucial role of reducing osmotic stress via the formation of oligosaccharides. Inhibition of hydrolysis by iminosug- ars should result in nutritional deficiencies and/or disruption of normal osmoregulation. deoxynojirimycin （dNJ） and 2 N-alkylated analogs [N-butyl dNJ （NB-dNJ） and N-nonyl dNJ （NN-dNJ）] were the major iminosugars used throughout the study. The extensive experiments conducted with a-glucosidase of the whitefly Bemisia tabaci indicated the competitive nature of inhibition and that the hydrophilic dNJ is a potent inhibitor in com- parison to the more hydrophobic NB-dNJ and NN-dNJ compounds. The same inhibitory pattern was observed with the psyllid Cacopsylla bidens a-glucosidase. In contrast to the above pattern, enzymes of the aphids, Myzus persicae and Aphis gossypii were more sen- sitive to the hydrophobic iminosugars as compared to dNJ. In vivo experiments in which adult B. tabaci were fed dietary iminosugars, show that the hydrophilic dNJ was far less toxic than the lipophilic NB-dNJ and NN-dNJ. It is proposed that this pattern is attributed to the better accessibility of the hydrophobic NN-dNJ to the a-glucosidase membrane- bound compartment in the midgut. Based on the inhibitory effects of certain polyhydroxy N-alkylated iminosugars, a-glucosidase of phloem feeding hemipterans could serve as an attractive target site for developing novel pest control agents.

关键词： a-glucosidase inhibition Bemisia tabaci Cacopsylla bidens iminosugars Myzuspersicae osmoregulation phloem sap feeders

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Is it time for elective left main percutaneous coronary intervention to become 'main stream'?

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Journal of Geriatric Cardiology 2006年第1期3卷 57-58页

作者： Joshua cohen Andrew d.Michaels division of Cardiology University of California San Francisco San Francisco CA 94143-0124 USA

　　Left main (LM) stenting is considered by many to be one of the last frontiers of interventional cardiology. Beginning with the VA cooperative study published in 1976 demonstrating a mortality benefit for patients undergoing coronary artery bypass grafting (CABG), i the standard of care for treatment of left main coronary artery disease has been *** most recent 2005 update of the ACC/AHA/SCAI Practice Guidelines on PCI 2 again notes that "CABG using IMA grafting is the 'gold standard' for treatment of unprotected left main disease and has proven benefit on long-term outcomes."……

关键词： left IVUS Is it time for elective left main percutaneous coronary intervention to become main stream time

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ExquiMo： An Exquisite Corpse Tool for Collaborative 3d Shape design

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Journal of Computer Science & Technology 2017年第6期32卷 1138-1149页

作者： Warunika Ranaweera Parmit Chilana daniel cohen-Or Hao Zhang School of Computer Science Simon Fraser University Burnaby V5A 1S6 Canada department of Computer Science Tel-Aviv University Tel Aviv 69978 Israel

We introduce ExquiMo, a collaborative modeling tool which enables novice users to work together to generate interesting, and even creative, 3d shapes. Inspired by an Exquisite Corpse gameplay, our tool allocates distinct parts of a shape to multiple players who model the assigned parts in a sequence. Our approach is motivated by the understanding that effective surprise leads to creative outcomes. Hence, to maintain the surprise factor of the output, we conceal the previously modeled parts from the most recent player. Part designs from individual players are fused together to produce an often unexpected and novel end result. We investigate the effectiveness of collaboration on the output designs by conducting a sequence of user studies to validate the hypotheses formed based on our research questions. Results of the user studies are supportive of our hypotheses that multi-user collaborative 3d modeling via ExquiMo tends to lead to more creative novice designs according to the commonly used criteria for creativity： novelty and surprise.

关键词： 3d shape design human computer interaction collaborative creativity

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Temporal scatterplots

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Computational Visual Media 2020年第4期6卷 385-400页

作者： Or Patashnik Min Lu Amit H.Bermano daniel cohen-Or Tel-Aviv University Tel-AvivIsrael Shenzhen University ShenzhenChina

Visualizing high-dimensional data on a 2d canvas is generally *** becomes significantly more difficult when multiple time-steps are to be presented,as the visual clutter quickly ***,the challenge to perceive the significant temporal evolution is even *** this paper,we present a method to plot temporal high-dimensional data in a static scatterplot;it uses the established PCA technique to project data from multiple *** key idea is to extend each individual displacement prior to applying PCA,so as to skew the projection process,and to set a projection plane that balances the directions of temporal change and spatial *** present numerous examples and various visual cues to highlight the data trajectories,and demonstrate the effectiveness of the method for visualizing temporal data.

关键词： scatterplot temporal data visual clutter principle component analysis(PCA)

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Herbaceous peony in warm climate:Modelling stem elongation and growers profit responses to dormancy conditions

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Information Processing in Agriculture 2016年第3期3卷 175-182页

作者： Menashe cohen Rina Kamenetsky Gregory Yom din Northern R&d MigalP.O.Box 831Kiryat Shmona 11016Israel Institute of Plant Science Agricultural Research OrganizationVolcani CenterBet Dagan 50250Israel Open University of Israel RaananaIsrael Faculty of Exact Sciences Tel Aviv UniversityTel AvivIsrael

We analysed the data collected for herbaceous peony cultivated in a warm climate region and stored in winter under three constant chilling *** used the quadratic regression model to describe the stem elongation responses to winter dormancy conditions,and the logistic function to describe the weekly stems *** predicted maximal stem length from the first model was used as the input parameter for the second *** than 4000 data for various(a)chilling constant temperatures during dormancy,(b)dormancy duration,and(c)germination duration,were *** models were applied to determine the optimal number of chill *** this purpose,two criteria were used in different versions of the model:the maximal stem length and the maximal profit of *** the two chilling temperatures of 2℃ and 6℃,the optimal values of chill units(in the models of a maximal stem length and maximal profit of farmers)are close to one another,and the values of a maximal stem length and maximal profit are significantly *** the case of the third chilling temperature of 10℃,the model failed to determine the optimal number of chill *** method of inverse confidence intervals for testing the significance of the optimal number of chill units was used.

关键词： Peony dormancy Regression Logistic function Inverse confidence intervals Profit

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