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Search for two-neutrino double-beta decay of^(136)Xe to the 0^(+)_(1)excited state of 136Ba with the complete EXO-200 dataset

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chinese Physics c 2023年第10期47卷 1-9页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau d.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.cao W.R.cen c.chambers B.cleveland M.coon A.craycraft T.daniels L.darroch S.J.daugherty J.davis S.delaquis A.der Mesrobian-Kabakian R.deVoe J.dilling A.dolgolenko M.J.dolinski J.Echevers W.Fairbank Jr. d.Fairbank J.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu d.Fudenberg P.Gautam R.Gornea G.Gratta c.Hall E.V.Hansen J.Hoessl P.Hufschmidt M.Hughes A.Iverson A.Jamil c.Jessiman M.J.Jewell A.Johnson A.Karelin L.J.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo d.S.Leonard G.S.Li S.Li Z.Li c.Licciardi Y.H.Lin R.MacLellan T.McElroy T.Michel B.Mong d.c.moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.c.Rowson J.Runge S.Schmidt d.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado J.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel J.-L.Vuilleumier M.Wagenpfeil J.Watkins M.Weber L.J.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia d.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler 无 Physics department McGill UniversityMontrealQuebec H3A 2T8Canada Erlangen centre for Astroparticle Physics(EcAP) Friedrich-Alexander-University Erlangen-NürnbergErlangen 91058Germany Physics department Carleton UniversityOttawaOntario K1S 5B6Canada department of Physics Duke Universityand Triangle Universities Nuclear Laboratory(TUNL)DurhamNorth Carolina 27708USA Physics department University of IllinoisUrbana-ChampaignIllinois 61801USA Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research centre“Kurchatov Institute” Moscow 117218Russia department of Physics University of South DakotaVermillionSouth Dakota 57069USA SLAc National Accelerator Laboratory Menlo ParkCalifornia 94025USA TRIUMF VancouverBritish Columbia V6T 2A3Canada Institute of High Energy Physics Beijing 100049China department of Physics Laurentian UniversitySudburyOntario P3E 2C6Canada Physics department Colorado State UniversityFort CollinsColorado 80523USA department of Physics and Physical Oceanography University of North Carolina at WilmingtonWilmingtonNC 28403USA Physics department and cEEM Indiana UniversityBloomingtonIndiana 47405USA Physics department Stanford UniversityStanfordCalifornia 94305USA department of Physics Drexel UniversityPhiladelphiaPennsylvania 19104USA Amherst center for Fundamental Interactions and Physics department University of MassachusettsAmherstMA 01003USA Technische Universität München Physikdepartment and Excellence Cluster UniverseGarching 80805Germany Physics department University of MarylandCollege ParkMaryland 20742USA department of Physics and Astronomy University of AlabamaTuscaloosaAlabama 35487USA Wright Laboratory Department of PhysicsYale UniversityNew HavenConnecticut 06511USA IBS center for Underground Physics Daejeon 34126Korea department of Physics and Astronomy Stony Brook UniversitySUNYStony BrookNew York 11794USA Kellogg Lab CaltechPasadenaCalifornia 91125USA LHEP Albert Einstein CenterUniversi

A new search for two-neutrino double-beta(2νββ)decay of^(136)Xe to the 0+1 excited state of 136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase II dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2νββdecay to the 0+1 state of 136Ba is 2.9×10^(24)yr using a total^(136)Xe exposure of 234.1 kg *** statistically significant evidence for 2νββdecay to the 0^(+)_(1)state is observed,leading to a lower limit of T2ν1/2(0^(+)→0^(+)_(1))>1.4×10^(24)yr at 90%confidence level,improved by 70%relative to the current world's best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram d.dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling cui Jo Anne Stratton G.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Evaluation of effects of 1,3-dinitrobenzene on sperm motility of hamster using computer assisted semen analysis (cASA)

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Asian Journal of Andrology 2001年第2期3卷 109-114页

作者： L.d.c.Peiris H.d.M.moore dept. of Zoology University of Colombo Colombo 03 Sri LankaDept. of Molecular Biology and Biotechnology University of Sheffield Sheffield S 10 2TN UK

Aim: To evaluate the effects of 1,3-dinitrobenznene (mdNB) on sperm motility of hamster and to correlate the re-sults with the fertility. Methods: Adult male hamsters were gavaged with one of the 3 dose regimes of mdNB(1.5 mg daily for 4 weeks ,1.5 mg one day a week for 4 weeks and 1.0 mg 3 days a week for 4 weeks). computerassisted semen analysis (cASA) was used to analyse the sperm motility parameters, curvilinear velocity (VcL) andstraight line velocity (VSL) of sperm in distal corpus epididymides and distal cauda epididymides. In vitro fertilisationwas carried out only for 1.5 mg mdNB daily group to determine the sperm fertilising capacity. Results: There wasa significant reduction in sperm velocity parameters at weeks 3 and 4 after treatment, which was correlated with a de-cline in sperm fertility. conclusion; Sperm velocity parameters may be used to determine the effect of a toxic insulton the sperm function.

关键词： mdNB sperm motility cASA sperm fertility

Effects of acut and chronic doses of methoxy acetic acid on hamster sperm fertilising ability

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Asian Journal of Andrology 2001年第3期3卷 209-216页

作者： L.d.c.Peiris H.d.M.moore dept. of Zoology University of Colombo Colombo 03 Sri LankaDept. of Molecular Biology and Biotechnology University of Sheffield Sheffield S10 2TN UK

Aim: To evaluate the effects of acute and chronic doses of methoxy acetic acid (MAA) on in vitro fertilisation byhamster sperm and to correlate the data with the testicular damage. Methods: Adult male hamsters were gavagedwith 3 single doses (0, 80, 160 and 650 mg/kg) and 3 chronic doses (0, 8, 32 and 64 mg/kg daily for 5 weeks) ofMAA in distilled water. After treatment hamsters were killed at weekly intervals and spermatozoa recovered from thedistal cauda epididymides were used to assess the fertilising capacity in vitro. The testes were processed for histologicalexamination. Results; Acute doses showed a significant reduction in sperm fertilising ability from week 3 and 4 af-ter treatment and with the chronic doses, the effects were more extensive and persistent. The results were in correpon-dence with the testicular damages observed. conclusion: It is evident that both acute and chronic doses of MAAcan impair the sperm function by damaging one or more cell populations in the testis.(Asian J Androl 2001 Sep; 3: 209- 216)

关键词： methoxy acetic acid fertilisation in vitro testis spermatozoa fertility

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： desmond A.Nunez Ru c.Guo division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEdLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Pressure vessel priming analysis for a regulated liquid propulsion system

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Propulsion and Power Research 2020年第2期9卷 101-115页

作者： Jeffrey d.moore The Pennsylvania State University Altoona CollegeAltoonaPA16601USA

An investigation was performed to determine the pressure transient levels and time required to reach pressure equilibrium in a regulated liquid propulsion system due to the priming of a propellant tank during system *** experimental fluid flow test setup was designed and fabricated using a pressure vessel to house distilled water as a propellant simulant for liquid hydrazine and high-pressure gaseous nitrogen as the pressurant.A snubber orifice was installed downstream of the high-pressure gaseous nitrogen bottles to protect a regulator from high-pressure transients,prior to the regulation of incoming gas to beginning of life propulsion system propellant tank *** were conducted to measure pressure transients and time to pressure equilibrium by varying initial system pressures,snubber orifice diameter,and system ullage volume.A mathematical model was developed and compared against the experimental regulated system priming results to predict the system pressures and time to reach system pressure equilibrium during the pressurization period for regulated propulsion systems given initial conditions.

关键词： Priming event Regulated liquid propulsion system Pressure vessel Pressure transients Snubber orifice