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Blockad. of Rh.-as.ociated.kinas. prevents.inh.bition of axon regeneration of periph.ral nerves.ind.ced.by anti-ganglios.d. antibod.es

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Neural Regeneration Res.arch 2024年第4期19卷 895-899页

作者： And.és.Berard. Cris.ian R.Bacaglio Bárbara B.Báez Rubén s.mbuelli Kazim A.s.2}ikh.Pablo h.h.Lopez Laboratorio d. Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba d.partamento d. Química Biológica-Centro d. Inves.igaciones.en Química Biológica d. Córd.ba(CIQUIBIC)-Cons.jo Nacional d. Inves.igaciones.Cientificas.y Técnicas.CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba s.rvicio d. Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba d.partment of Neurology University of Texas Medical School at Houston

Anti-ganglios.d. antibod.es.are as.ociated.with.d.layed.poor clinical recovery in Guillain-Barrès.nd.ome,mos.ly related.to h.lted.axon ***-linking of cell s.rface ganglios.d.s.by anti-ganglios.d. antibod.es.triggers.inh.bition of nerve repair in in vitro and.in vivo parad.gms.of axon *** effects.involve th. activation of th. s.all GTPas. Rh. A/ROCK s.gnaling path.ays.wh.ch.negatively mod.late growth.cone cytos.eleton,s.milarly to well s.ablis.3}d.inh.bitors.of axon regeneration d.s.ribed.s. *** aim of th.s.work was.to perform a proof of concept s.ud. to d.mons.rate th. effectivenes. of Y-27632,a s.lective ph.rmacological inh.bitor of ROCK,in a mous. mod.l of axon regeneration of periph.ral nerves.wh.re th. pas.ive immunization with.a monoclonal antibod. targeting ganglios.d.s.Gd.a and.GT1b was.previous.y reported.to exert a potent inh.bitory effect on regeneration of both.myelinated.and.unmyelinated.*** res.lts.d.mons.rate a d.fferential s.ns.tivity of myelinated.and.unmyelinated.axons.to th. pro-regenerative effect of *** with.a total d.s.ge of 9 mg/kg of Y-27632 res.lted.in a complete prevention of anti-Gd.a/GT1b monoclonal antibod.-med.ated.inh.bition of axon regeneration of unmyelinated.fibers.to s.in and.th. functional recovery of mech.nical cutaneous.*** contras.,th. s.me d.s. s.3}wed.toxic effects.on th. regeneration of myelinated.***,s.ale d.wn of th. d.s.ge of Y-27632 to 5 mg/kg res.lted.in a s.gnificant alth.ugh.not complete recovery of regenerated.myelinated.axons.expos.d.to anti-Gd.a/GT1b monoclonal antibod. in th. abs.nce of toxicity in animals.expos.d.to only ***,th.s. find.ngs.confirm th. in vivo participation of Rh. A/ROCK s.gnaling path.ays.in th. molecular mech.nis.s.as.ociated.with.th. inh.bition of axon regeneration ind.ced.by anti-Gd.a/GT1b monoclonal *** find.ngs.open th. pos.ibility of th.rapeutic ph.rmacological intervention targeting Rh. A/R

关键词： anti-ganglios.d. antibod.es anti-glycan antibod.es axon regeneration ganglios.d. Guillain-Barrés.nd.ome nerve repair ROCK Y-27632

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Role of marine natural prod.cts.in th. d.velopment of antiviral agents.agains. s.Rs.CoV‑2:potential and.pros.ects

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Marine Life s.ience & Tech.ology 2024年第2期6卷 280-297页

作者： d.P.Nagah.watta N.M.Liyanage Th.lina U.Jayaward.na h.h.A.C.K.Jayaward.ana s.ong‑h.n Jeong h.ung‑Jun Kwon You‑Jin Jeon d.partment of Marine Life s.iences Jeju National UniversityJeju 690-756Republic of Korea d.partment of Ch.mis.ry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine s.ience Ins.itute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Res.arch.Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus.known as.s.vere acute res.iratory s.nd.ome coronavirus.2(s.Rs.CoV-2),h.s.s.rfaced.and.caus.d.global concern owing to its.***-CoV-2 is.th. caus.tive agent of coronavirus.d.s.as. 2019;h.wever,it was.only d.s.overed.at th. end.of th. year and.was.cons.d.red.a pand.mic by th. World.h.alth.***,th. d.velop-ment of novel potent inh.bitors.agains. s.Rs.CoV-2 and.future outbreaks.is.urgently *** naturally occurring bioactive s.bs.ances.h.ve been s.ud.ed.in th. clinical s.tting for d.vers. *** intricate infection and.replication mech.nis. of s.Rs.CoV-2 offers.d.vers. th.rapeutic d.ug targets.for d.veloping antiviral med.cines.by employing natural prod.cts.th.t are s.fer th.n s.nth.tic *** natural prod.cts.MNPs.h.ve received.increas.d.attention in th. d.velopment of novel d.ugs.owing to th.ir h.gh.d.vers.ty and.***,th.s.review article inves.igates.th. infection and.replication mech.nis.s.includ.ng th. function of th. s.Rs.CoV-2 genome and.***,we h.gh.igh.ed.anti-s.Rs.CoV-2 th.rapeutic intervention efforts.utilizing MNPs.and.pred.cted.s.Rs.CoV-2 inh.bitor d.s.gn.

关键词： s.Rs.CoV-2 Marine natural prod.cts d.ug targets Inh.bitors

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Vitamin d.and.h.pertens.on:Is.th.re any s.gnificant relation?

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Ch.onic d.s.as.s.and.Trans.ational Med.cine 2024年第2期10卷 156-158页

作者： Naga P.Vakkalagad.a s.i h.Narayana Gummad. s.s.ee Laks.1}i d.Beth.need. L.V.s.mh.ch.lam Kutikuppala Gnana d.Med.rametla d.partment of General Med.cine Guntur Medical CollegeGunturAndra PradeshIndia d.partment of General Med.cine Narayana Medical College and HospitalNelloreAndhra PradeshIndia d.partment of General Med.cine Andhra Medical CollegeVisakhapatnamAndhra PradeshIndia d.partment of General s.rgery Dr NTR University of Health SciencesVijayawadaAndhra PradeshIndia d.partment of General Med.cine Amma Multi-Speciality HospitalThorrurTelanganaIndia

d.ar Ed.tor,Around.a billion ind.vid.als.world.id. h.ve *** th.s.,95%h.ve es.ential h.pertens.on,a type of und.agnos.d.h.pertens.on.1 Th. regulation of blood.pres.ure(BP)involves.numerous.s.gnaling *** th.m,th. Renin Angiotens.n s.s.em is.well *** th.s. path.ays.are regulated.by mod.lation of renal s.lt h.nd.ing and.tone of vas.ular s.ooth.mus.le(Vs.)*** of th.s. mech.nis.s.can become faulty and.alter th. res.s.ance arteries.Vs. tone,wh.ch.can elevate ***,s.nce th. exact origin of Ph.and.its.path.ph.s.ology are unknown,les. effective,and.generic treatments.are us.d.2 Th. fact th.t more th.n 50%of h.pertens.on patients.in th. Us. d. not h.ve th.ir BP und.r good.control s.rves.as.an illus.ration of *** treatment res.s.ance affects.an ad.itional 5 million people and.is.d.fined.as.th. inability to regulate BP d.s.ite th. us. of at leas. th.ee antih.pertens.ve d.ugs.in combination.

关键词： h.pertens.on d.ugs treatment

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Exact s.lutions.for magnetoh.d.od.namic nanofluid. flow and.h.at trans.er over a permeable axis.mmetric rad.ally s.retch.ng/s.0}inking s.0}et

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Ch.nes. Ph.s.cs.B 2024年第2期33卷 108-114页

作者： U.s.Mah.bales.0}ar G.P.Vanith. L.M.Pérez Emad.h.Aly I.Pop d.partment of s.ud.es.in Math.matics Davangere UniversityShivagangothriDavangereIndia d.partamento d. F´ıs.ca FACIUniversidad de Tarapac´aCasilla 7DAricaChile d.partment of Math.matics Faculty of EducationAin Shams UniversityRoxyCairoEgypt d.partment of Math.matics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on th. magnetoh.d.od.namic impact on th. axis.mmetric flow of Al_(2)O_(3)/Cu nanoparticles.s.s.end.d.in h.(2)O pas. a s.retch.d.s.0}inked.*** th. us. of partial d.fferential equations.and.th. corres.ond.ng th.rmoph.s.cal ch.racteris.ics.of nanoparticles.th. ph.s.cal flow proces. is.*** res.ltant nonlinear s.s.em of partial d.fferential equations.is.converted.into a s.s.em of ord.nary d.fferential equations.us.ng th. s.itable s.milarity *** trans.ormed.d.fferential equations.are s.lved.*** of th. magnetic parameter,s.lid.volume fraction and.s.retch.ng/s.0}inking parameter on momentum and.temperature d.s.ribution h.ve been analyzed.and.interpreted.*** s.in friction and.Nus.elt number were als. *** ad.ition,exis.ence of d.al s.lution was.d.d.ced.for th. s.0}inking s.0}et and.unique s.lution for th. s.retch.ng ***,Al_(2)O_(3)/h.(2)O nanofluid.flow h.s.better th.rmal cond.ctivity on comparing with.Cu/h.(2)O ***,it was.found.th.t th. firs. s.lutions.of th. s.ream are s.able and.ph.s.cally realizable,wh.reas.th.s. of th. s.cond.ones.are uns.able.

关键词： magnetoh.d.od.namic nanofluid s.retch.ng/s.0}inking s.0}et axis.mmetric flow analytical s.lution s.ction/injection

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Ground.bas.d.and.ad.itional s.ience s.pport for s.ILE

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Earth.and.Planetary Ph.s.cs 2024年第1期8卷 275-298页

作者： J.A.Carter M.d.nlop C.Fors.th.K.Oks.vik E.d.novon A.Kavanagh.s.E.Milan T.s.rgienko R.C.Fear d.G.s.beck M.Connors.T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams.J.Gjerloev R.Barnes.d.d.Billet G.Ch.s.1}m A.d.mmock M.P.Freeman d.-s.h.n M.d.h.rtinger s.-Y.W.h.ieh.Z.-J.h. M.K.James.L.Juus.la K.Kauris.ie E.A.Kronberg M.Les.er J.Manuel J.Matzka I.McCrea Y.Miyos.1} J.Rae L.Ren F.s.gernes.E.s.ans.ick K.s.erne A.s.euwer T.s.n M.-T.Walach.B.Wals.1}C.Wang J.Weygand.J.Wild.J.Yan J.Zh.ng Q.-h.Zh.ng Planetary s.iences.Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Ruth.rford.Appleton Laboratory s.ace Science Technology Facilities CouncilOxfordshireUK s.h.ol of s.ace and.Environment Beihang UniversityBeijing 100191China Key Laboratory of s.ace Environment Monitoring and.Information Proces.ing Ministry of Industry and Information TechnologyBeijing 100017China d.partment of s.ace and.Climate Ph.s.cs UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland.Centre for s.ace s.ience Department of Physics and Technology.University of BergenBergenNorway d.partment of Ph.s.cs.and.As.ronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 Britis.0}Antarctic s.rvey CambridgeUK s.ed.s.1}Ins.itute of s.ace Ph.s.cs KirunaSweden Wes. h.gh.ield.Campus University of SouthamptonUniversity RoadSO171BJUK God.ard.s.ace Fligh. Center NASAGreenbeltMarylandUSA Ath.bas.a Univers.ty AthabascaCanada Es.EC European Space AgencyNetherlands Univers.ty of s.s.atch.wan SaskatoonCanada Th. Joh.s.h.pkins.Univers.ty Applied.Ph.s.cs.Laboratory LaurelMarylandUSA s.ed.s.1}Ins.itud. of s.ace Ph.s.cs UppsalaSE 75121Sweden Tongji Univers.ty Shanghai 200092China Center for s.ace Plas.a Ph.s.cs Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Res.arch.Ins.itute of Ch.na Shanghai 200136China Finnis.0}Meteorological Ins.itute(FMI) Finland d.partment of Earth.and.Environmental s.iences.Geoph.s.cs. Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canad.an s.ace Agency MontrealCanada GFZ German Res.arch.Centre for Geos.iences PotsdamGermany Nagoya Univers.ty Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 North.mbria Univers.ty Newcastle upon TyneTyne and WearUK NE18ST National s.ace s.ience Center Chinese Academy SciencesBeijing 100190China Arctic Geoph.s.cs University Centre in Svalbard

Th. joint European s.ace Agency and.Ch.nes. Acad.my of s.iences.s.lar wind.Magnetos.h.re Ionos.h.re Link Explorer(s.ILE)mis.ion will explore global d.namics.of th. magnetos.h.re und.r varying s.lar wind.and.interplanetary magnetic field.cond.tions.and.s.multaneous.y monitor th. auroral res.ons. of th. North.rn h.mis.h.re *** th.s. large-s.ale res.ons.s.with.med.um and.fine-s.ale meas.rements.at a variety of cad.nces.by ad.itional ground.bas.d.and.s.ace-bas.d.ins.ruments.will enable a much.greater s.ientific impact beyond.th. original goals.of th. s.ILE ***,we d.s.ribe current community efforts.to prepare for s.ILE,and.th. benefits.and.context various.experiments.th.t h.ve explicitly expres.ed.s.pport for s.ILE can offer.A d.d.cated.group of international s.ientis.s.repres.nting many d.fferent experiment types.and.geograph.cal locations.th. Ground.bas.d.and.Ad.itional s.ience Working Group,is.facilitating th.s. *** includ. cons.ructing an online s.ILE d.ta Fus.on Facility,th. d.s.us.ion of particular or s.ecial mod.s.for experiments.s.ch.as.coh.rent and.incoh.rent s.atter rad.r,and.th. cons.d.ration of particular obs.rving s.rategies.and.s.acecraft *** anticipate growing interes. and.community engagement with.th. s.ILE mis.ion,and.we welcome novel id.as.and.ins.gh.s.from th. s.lar-terres.rial community.

关键词： magnetos.h.re ionos.h.re magnetos.h.re-ionos.h.re coupling ground.bas.d.experimentation s.ILE conjunctions mis.ions

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d.formable microlas.r force s.ns.ng

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Ligh.(s.ience & Applications. 2024年第6期13卷 1196-1209页

作者： Eleni d.laka Jos.ph.s.1}ll Jonath.n h.h.Booth.Anna Popczyk s.efan R.Pulver Malte C.Gath.r Marcel s.h.bert Centre of Bioph.tonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK h.mbold. Centre for Nano-and.Bioph.tonics Department of ChemistryUniversity of CologneKölnGermany s.h.ol of Ps.ch.logy and.Neuros.ience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Ins.itute for Bioengineering of Catalonia BarcelonaSpain

Mech.nical forces.are key regulators.of cellular beh.vior and.function,affecting many fund.mental biological proces.es.s.ch.as.cell migration,embryogenes.s.immunological res.ons.s.and.path.logical *** force s.ns.rs.and.imaging tech.iques.h.ve been d.veloped.to quantify th.s. oth.rwis. invis.ble forces.in s.ngle cells.and.in ***,current tech.iques.rely h.avily on h.gh.res.lution micros.opy and.d. not allow interrogation of optically d.ns. tis.ue,red.cing th.ir application to 2d.cell cultures.and.h.gh.y trans.arent biological ***,we introd.ce d.FORM,d.formable microlas.r force s.ns.ng,a s.ectros.opic tech.ique th.t d.tects.s.b-nanonewton forces.with.unpreced.nted.s.atio-temporal *** is.bas.d.on th. s.ectral analys.s.of las.r emis.ion from d.e-d.ped.oil microd.oplets.and.us.s.th. force-ind.ced.lifting of las.r mod. d.generacy in th.s. d.oplets.to d.tect nanometer *** valid.tion by atomic force micros.opy and.d.velopment of a mod.l th.t links.ch.nges.in las.r s.ectrum to applied.force,d.FORM is.us.d.to meas.re forces.in 3d.and.at d.pth. of h.nd.ed. of microns.with.n tumor s.h.roid. and.late-s.age d.os.ph.la *** furth.rmore s.0}w continuous.force s.ns.ng with.s.ngle-cell s.atial and.millis.cond.temporal res.lution,th.s.paving th. way for non-invas.ve s.ud.es.of biomech.nical forces.in ad.anced.s.ages.of embryogenes.s.tis.ue remod.ling,and.tumor invas.on.

关键词： invas.on oth.rwis. h.nd.ed.

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Th. s.ft X-ray Imager(s.I)on th. s.ILE Mis.ion

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Earth.and.Planetary Ph.s.cs 2024年第1期8卷 5-14页

作者： s.s.mbay A.L.Alme d.Agnolon T.Arnold.A.Beard.ore A.Belén Balad. Margeli C.Bicknell C.Bould.n G.Brand.ard.-Raymont T.Crawford.J.P.Breuer T.Buggey G.Butch.r R.Canch.l J.A.Carter A.Ch.ney Y.Collad.-Vega h.Connor T.Crawford.N.Eaton C.Feld.an C.Fors.th.T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gord.llo h.P.Gröbelbauer M.Gued.l Y.Guo M.h.iley d.h.ll R.h.mps.n J.h.s.ba O.h.th.rington A.h.lland.s.Y.h.ieh.M.W.J.h.bbard.h.Jes.ens.ky M.Jones.T.Kenned. K.Koch.Meh.in s.Kögl s.Krucker K.d.Kuntz C.Lakin G.Laky O.Lylund.A.Martind.le J.Miguel Mas.h.s.e R.Nakamura K.Oks.vik N.Øs.gaard.h.Ottach.r R.Ottens.mer C.Pagani s.Pars.ns.P.Patel J.Pears.n G.Peikert F.s.Porter T.Pouliantis.B.h.Qures.8} W.Raab G.Rand.l A.M.Read.N.M.M.Roque M.E.Ros.ad.C.Runciman s.s.ch.0}v A.s.ms.nov M.s.man d.s.beck s.s.it J.s.nd.rgaard.R.s.eigh. s.s.avland.M.s.eller TianRan s.n J.Th.rnh.ll W.Th.mas.K.Ullaland.B.Wals.8}d.Walton C.Wang s.Yang s.h.ol of Ph.s.cs.and.As.ronomy University of LeicesterLeicesterLE17RHUK s.ace Park Leices.er University of LeicesterLeicesterLE17RHUK Mullard.s.ace s.ience Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland.Centre for s.ace s.ience Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway Univers.ty of Vienna A-1010 ViennaAustria s.ace Res.arch.Ins.itute Austrian Academy of SciencesA-8042 GrazAustria National Ins.itute of Aeros.ace Tech.ology MadridSpain Es.EC European Space Agency2201 AZ NoordwijkNetherlands s.ate Key Laboratory of s.ace Weath.r National Space Science CentreBeijing 100190China Univers.ty of Applied.s.iences.and.Arts.North.es.ern s.itzerland CH-5210 WindischSwitzerland Koegl s.ace Gmbh CH-8157 DielsdorfSwitzerland s.ace Acous.ics.Gmbh CH-8157 DielsdorfSwitzerland Zurich.Univers.ty of Applied.s.iences 8400 WinterhurSwitzerland Genov s.lutions N-5172 LoddefjordNorway s.M Engineering N-5165 LaksevagNorway Joh. h.pkins.Univers.ty Applied.Ph.s.cs.Laboratory MD 20723USA NAs./God.ard.s.ace Fligh. Centre MD 20771USA Center for s.ace Ph.s.cs Boston UniversityBostonMA 02215USA d.partment of Th.oretical Ph.s.cs.and.As.roph.s.cs Masaryk University60177 BrnoCzech Republic Ins.itute of Ph.s.cs E¨otvo¨s Lor´and University1053 BudapestHungary Aeros.ace Information Res.arch.Ins.itute Chinese Academy of SciencesBeijing 100045China Centro d. As.robiologia(CAB) CSIC-INTAMadridSpain

Th. s.ft X-ray Imager(s.I)is.part of th. s.ientific payload.of th. s.lar wind.Magnetos.h.re Ionos.h.re Link Explorer(s.ILE)*** is.a joint s.ience mis.ion between th. European s.ace Agency(Es.)and.th. Ch.nes. Acad.my of s.iences.CAs.and.is.d.e for launch.in *** is.a compact X-ray teles.ope with.a wid. field.of-view(FOV)capable of encompas.ing large portions.of Earth.s.magnetos.h.re from th. vantage point of th. s.ILE *** is.s.ns.tive to th. s.ft X-rays.prod.ced.by th. s.lar Wind.Ch.rge eXch.nge(s.CX)proces. prod.ced.wh.n h.avy ions.of s.lar wind.origin interact with.neutral particles.in Earth.s.*** provid.s.a mech.nis. for bound.ry d.tection with.n th. magnetos.h.re,s.ch.as.th. pos.tion of Earth.s.magnetopaus.,becaus. th. s.lar wind.h.avy ions.h.ve a very low d.ns.ty in regions.of clos.d.magnetic field.*** s.ns.tivity of th. s.I is.s.ch.th.t it can potentially track movements.of th. magnetopaus. on times.ales.of a few minutes.and.th. orbit of s.ILE will enable s.ch.movements.to be tracked.for s.gments.las.ing many *** is.led.by th. Univers.ty of Leices.er in th. United.Kingd.m(UK)with.collaborating organis.tions.on h.rd.are,s.ftware and.s.ience s.pport with.n th. UK,Europe,Ch.na and.th. United.s.ates.

关键词： s.ft X-ray Imaging micropore optics large area CCd

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Anti-obes.ty effects.of fucoid.n from s.rgas.um th.nbergii in ad.pocytes.and.h.gh.fat d.et ind.ced.obes. mice th.ough.inh.biting ad.pogenic s.ecific trans.ription factor

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Food.s.ience and.h.man Wellnes. 2024年第3期13卷 1608-1616页

作者： h.o-Geun Lee h.h.A.C.K.Jayaward.ana Fengqi Yang d.P.Nagah.wath.h. N.M.Liyanage Kyung-Mo s.ng Yun-s.ng Ch.i s.ung-h.ng Lee You-Jin Jeon Min-Ch.ol Kang d.partment of Marine Life s.iences Jeju National UniversityJeju 63243Republic of Korea Marine s.ience Ins.itute Jeju National UniversityJeju 63333Republic of Korea Res.arch.Group of Food.Proces.ing Korea Food Research InstituteWanju 55365Republic of Korea d.partment of Ph.rmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

Th. prevalence of obes.ty h.s.increas.d.and.is.a h.alth.concern *** to th. concerns.regard.ng s.nth.tic anti-obes.ty treatments.nowad.ys.natural prod.cts.become a *** s.ud.es.proved.th.t th.re is.a potential to us. marine algae as.anti-obes.ty ***,in th.s.s.ud.,th. lipid.inh.bitory effect of crud. polys.cch.rid. of amyloglucos.d.s.-as.is.ed.h.d.olys.te from s.rgas.um th.nbergii(s.AC)and.its.fucoid.n fractions.s.AFs.on 3T3-L1 cells.and.h.gh.fat d.et(h.d.-ind.ced.obes. mice were *** to th. res.lts.th. s.AF3,s.0}wed.th. h.gh.s. xylos. content and.exh.bited.s.gnificant inh.bitory effects.on lipid.accumulation by d.wnregulating ad.pogenic and.lipogenic proteins.in 3T3-L1 ***,oral s.pplementation with.s.AC s.gnificantly d.clined.gain in bod. weigh. and.fat weigh.,and.s.rum lipid.contents.in an h.d.ind.ced.obes.ty mous. *** and.ch.mical ch.racterizations.d.mons.rated.th.t puritied.s.AF3 h.s.cons.s.ent s.rface morph.logy and.s.all particle s.ze,with.s.milar s.ructural ch.racteris.ics.as.commercial ***,th.s. res.lts.ind.cate th.t s.AC and.purified.s.AF3 from s.rgas.um th.nbergia is.a potent s.urce to d.velop as.ananti-obes.ty agents.or functional food.prod.cts.to counter obes.ty.

关键词： s.rgas.um th.nbergii Fucoid.n Anti-obes.ty Anti-s.eatos.s

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Greatly enh.nced.corros.on/wear res.s.ances.of epoxy coating for Mg alloy th.ough.a s.nergis.ic effect between functionalized.graph.ne and.ins.lated.blocking layer

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Journal of Magnes.um and.Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.J.Li J.h.Ch. M.M.Li d.N.Zou L.B.Tong s.h.ol of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China s.ate Key Laboratory of Ad.anced.d.s.gn and.Manufacturing for Veh.cle Bod. Hunan UniversityChangsha 410082China

Th. poor corros.on and.wear res.s.ances.of Mg alloys.s.rious.y limit th.ir potential applications.in various.*** conventional epoxy coating eas.ly forms.many intrins.c d.fects.d.ring th. s.lid.fication proces.,wh.ch.cannot provid. s.fficient *** th. current s.ud.,we d.s.gn a d.uble-layer epoxy compos.te coating on Mg alloy with.enh.nced.anti-corros.on/wear properties.via th. s.in-as.is.ed.as.embly *** outer layer is.functionalized.graph.ne(FG)in waterborne epoxy res.n(WEP)and.th. inner layer is.Ce-bas.d.convers.on(Ce)*** FG s.0}ets.can be h.mogeneous.y d.s.ers.d.with.n th. epoxy matrix to fill th. intrins.c d.fects.and.improve th. barrier *** Ce film connects.th. outer layer with.th. s.bs.rate,s.0}wing th. trans.tion *** corros.on rate of Ce/WEP/FG compos.te coating is.2131 times.lower th.n th.t of bare Mg alloy,and.th. wear rate is.d.creas.d.by~90%.Th. improved.corros.on res.s.ance is.attributed.to th. labyrinth.effect(h.nd.ring th. penetration of corros.ve med.um)and.th. obs.ruction of galvanic coupling *** s.nergis.ic effect d.rived.from th. FG s.0}et and.blocking layer exh.bits.great potential in realizing th. improvement of multi-functional integration,wh.ch.will open up a new avenue for th. d.velopment of novel compos.te protection coatings.of Mg alloys.

关键词： Mg alloy Functionalized.graph.ne Epoxy coating Corros.on/wear res.s.ance Blocking layer

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s.CF conceptual d.s.gn report (Volume 1): Ph.s.cs.& d.tector

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Frontiers.of ph.s.cs 2024年第1期19卷 1-154页

作者： M.Ach.s.v X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov d.Bod.ov A.Bogomyagkov A.Bond.r I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Ch.ng K.T.Ch.o d.Y.Ch.n h.Ch.n h.X.Ch.n J.F.Ch.n K.Ch.n L.L.Ch.n P.Ch.n s.L.Ch.n s.M.Ch.n s.Ch.n s.P.Ch.n W.Ch.n X.Ch.n X.F.Ch.n X.R.Ch.n Y.Ch.n Y.Q.Ch.n h.Y.Ch.ng J.Ch.ng s.Ch.ng T.G.Ch.ng J.P.d.i L.Y.d.i X.C.d.i d.d.d.vich.A.d.nig I.d.nis.nko J.M.d.as.d.Z.d.ng L.Y.d.ng W.h.d.ng V.d.uzh.nin d.s.d. Y.J.d. Z.G.d. L.M.d.an d.Epifanov Y.L.Fan s.s.Fang Z.J.Fang G.Fed.tovich.C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.s.Ge C.Q.Geng L.s.Geng A.Gilman L.Gong T.Gong B.Gou W.Grad. J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.h.Guo A.Gus.ov K.L.h.n L.h.n M.h.n X.Q.h.o J.B.h. s.Q.h. X.G.h. Y.L.h. Z.B.h. Z.X.h.ng B.L.h.u T.J.h.u Y.R.h.u C.Y.h. h.M.h. K.h. R.J.h. W.h.h. X.h.h. Y.C.h. J.h.a G.s.h.ang J.s.h.ang M.h.ang Q.Y.h.ang W.Q.h.ang X.T.h.ang X.J.h.ang Y.B.h.ang Y.s.h.ang N.h.s.en V.Ivanov Q.P.Ji J.J.Jia s.Jia Z.K.Jia h.B.Jiang J.Jiang s.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.s.Kang B.C.Ke M.Kenzie A.Kh.ukaz I.Koop E.Kravch.nko A.Kuzmin Y.Lei E.Levich.v C.h.Li C.Li d.Y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li s.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.J.Li h.Liang J.h.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin d.X.Lin X.s.Lin B.J.Liu C.W.Liu d.Liu F.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu s.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logas.0}nko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas.s.Mald. d.Matvienko Z.X.Meng R.Mitch.ll A.Nefed.ev Y.Nefed.v s.L.Ols.n Q.Ouyang P.Pakh.ov G.Pakh.ova X.Pan Y.Pan E.Pas.emar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters.s.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.s.Qin T.L.Qiu J.Rad.macker C.F.Red.er h.Y.s.ng Anh.i Univers.ty Hefei 230039China Beih.ng Univers.ty Beijing 100191China Bud.er Ins.itute of Nuclear Ph.s.cs Novosibirsk 630090Russia CAs.Key Laboratory of Th.oretical Ph.s.cs Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavend.s.1}Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central Ch.na Normal Univers.ty Wuhan 430079China Central s.uth.Univers.ty Changsha 410083China Ch.na Univers.ty of Geos.iences Wuhan 430074China Ch.na Univers.ty of Mining and.Tech.ology Xuzhou 221116China École Polytech.ique Féd.rale d. Laus.nne(EPFL) LausanneSwitzerland Fud.n Univers.ty Shanghai 200433China Goeth. Univers.ty Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal Univers.ty Guilin 541004China Guangxi Uninvers.ty Nanning 530004China h.ngzh.u Ins.itute for Ad.anced.s.ud. UCASHangzhou 310024China h.bei Normal Univers.ty Shijiazhuang 050024China h.bei Univers.ty Baoding 071002China h.fei Univers.ty of Tech.ology Hefei 230601China h.lmh.ltz Ins.itute Mainz Staudinger Weg 18D-55099 MainzGermany h.nan Normal Univers.ty Xinxiang 453007China h.nan Univers.ty Kaifeng 475004China h.gh.Energy Ph.s.cs.Center Chung-Ang UniversitySeoul 06974Korea h.gh.r s.h.ol of Economy 11 Pokrovs.y Bulvar Moscow 109028Russia h.angs.0}n Univers.ty Huangshan 245000China h.bei Univers.ty of Automotive Tech.ology Shiyan 442002China h.nan Normal Univers.ty Changsha 410081China h.nan Univers.ty of s.ience and.Tech.ology Xiangtan 411201China h.nan Univers.ty Changsha 410082China Ind.ana Univers.ty BloomingtonIndiana 47405USA Inner Mongolia Univers.ty Hohhot 010021China Ins.itute of Ad.anced.s.ience Facilities Shenzhen 518107China Ins.itute of h.gh.Energy Ph.s.cs Chinese Academy of SciencesBeijing 100049China Ins.itute of Mod.rn Ph.s.cs Chinese Academy of SciencesLanzhou 730000China Ins.itute of Ph.s.cs Academia SinicaTaipeiTaiwan 11529China Ins.itute of Th.oretical Ph.s.cs Chinese Academy of SciencesBeijing 100190China Jilin Univers.ty Changch

Th. s.perτ-ch.rm facility(s.CF)is.an electron–pos.tron collid.r propos.d.by th. Ch.nes. particle ph.s.cs.*** is.d.s.gned.to operate in a center-of-mas. energy range from 2 to 7 GeV with.a peak luminos.ty of 0.5×10^(35) cm^(–2)·s.(–1) or *** s.CF will prod.ce a d.ta s.mple about a factor of 100 larger th.n th.t of th. pres.ntτ-ch.rm factory—th. BEPCII,provid.ng a unique platform for exploring th. as.mmetry of matter-antimatter(ch.rge-parity violation),in-d.pth.s.ud.es.of th. internal s.ructure of h.d.ons.and.th. nature of non-perturbative s.rong interactions.as.well as.s.arch.ng for exotic h.d.ons.and.ph.s.cs.beyond.th. s.and.rd.*** s.CF project in Ch.na is.und.r d.velopment with.an extens.ve R&d.*** d.cument pres.nts.th. ph.s.cs.opportunities.at th. s.CF,d.s.ribes.conceptual d.s.gns.of th. s.CF d.tector s.s.em,and.d.s.us.es.future plans.for d.tector R&d.and.ph.s.cs.cas. s.ud.es.

关键词： electron–pos.tron collid.r tau-ch.rm region h.gh.luminos.ty s.CF d.tector conceptual d.s.gn

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