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Neural Regeneration Research 2025年第9期20卷 2589-2590页

作者： Mikio shimizu Tatsusada Okuno department of Neurology Osaka University Graduate School of MedicineSuitaJapan department of Neurology Osaka General Medical CenterOsakaJapan

Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal *** with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).

关键词： paralysis sclerosis

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利用有限元分析法预测楔横轧件心部缺陷

金属加工（热加工） 2008年第19期 48-50页

作者： Yoshida d．shimizu N．Yukawa T．Ishiwa N．Hayashi N．Ogihara Y．Nonaka 张剑桥（译）徐沛（译）夏源（译）曾超（译）胡亚民（校）日本名古屋大学工程学院材料科学与工程系日本春日井市三明制作所重庆工学院材料科学与工程学院 400050

利用有限元分析预测楔横轧件的心部缺陷,预测时使用了两种积分塑性断裂准则。通过分析圆柱试样在拉伸试验时环形缺口的变化形状得到临界破坏值。试验研究了楔横轧模具的初始压缩量和模具轧制工件成形质量的关系。比较了理论分析与试验... 详细信息

利用有限元分析预测楔横轧件的心部缺陷,预测时使用了两种积分塑性断裂准则。通过分析圆柱试样在拉伸试验时环形缺口的变化形状得到临界破坏值。试验研究了楔横轧模具的初始压缩量和模具轧制工件成形质量的关系。比较了理论分析与试验结果验证了破坏准则的有效性。最后,叙述了最佳成形工艺条件。

关键词：有限元分析法缺陷轧件楔横轧模具拉伸试验成形质量断裂准则破坏准则

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

FE FORMULATION FOR THE VISCOELASTIC BOdY MOdELEd BY FRACTIONAL CONSTITUTIVE LAW

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Acta Mechanica Sinica 2001年第4期17卷 354-365页

作者：张卫 Nobuyuki shimizu Institute of Applied Mechanics Jinan UniversityGuangzhou 510632China department of Mechanical Engineering Iwaki Meisei UniversityJapan

This paper presents finite element (FE) formulation of the viscoelastic materials described by fractional constitutive law. The time-domain three-dimensional constitutive equation is constructed. The FE equations are set up by treating the fractional operator as a special case of the hereditary integration. The equations are solved by numerical integration method. The numerical algorithm developed by the authors for Liouville-Riemann's fractional derivative was adopted to formulate FE procedures and extended to solve the more general case of the hereditary integration. The numerical examples were given to show the correctness and effectiveness of the integration algorithm.

关键词： viscoelasticity fractional calculus FEM polymer materials

Progress in numerical simulation of cavitating water jets

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Journal of Hydrodynamics 2013年第4期25卷 502-509页

作者： PENG Guoyi shimizu Seiji College of Engineering Nihon University

This paper reviews recent progress made toward modeling of cavitation and numerical simulation of cavitating water jets. Properties of existing cavitation models are discussed and a compressible mixture flow method for the numerical simulation of high- speed water jets accompanied by intensive cavitation is introduced. Two-phase fluids media of cavitating flow are treated as a homo- geneous bubbly mixture and the mean flow is computed by solving Reynolds-Averaged Navier-Stokes （RANS） equations for com- pressible fluid. The intensity of cavitation is evaluated by the gas volume fraction, which is governed by the compressibility of bubble-liquid mixture corresponding to the status of mean flow field. Numerical results of cavitating water jet issuing from an orifice nozzle are presented and its applicability to intensively cavitating jets is demonstrated. However, the effect of impact pressure caused by collapsing of bubbles is neglected, and effectively coupling of the present compressible mixture flow method with the dynamics of bubbles remains to be a challenge.

关键词： cavitation water jet multi-phase flow numerical simulation

Image of Ne Trap by a Microwave Cavity

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Chinese Physics Letters 1997年第2期14卷 93-95页

作者： XU Lei Satoshi Oishi Kazuko shimizu Hiroshi Takuma Fujio shimizu department of Physics Fudan UniversityShanghai 200433 Institute for Laser Science The University of Electro-communicationsChofugaokaChofushiTokyo 182Japan department of Applied Physics University of TokyoBunkyo-kuTokyo 113Japan

The focusing of Ne metastable atoms trapped in magnetic-optical trap by a microwave cavity was *** cavity was operated at TM010 *** a microwave power of 14W,the Ne trap was imaged to a spot of about 0.25mm(full width ... 详细信息

关键词： microwave Microwave cavity