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Semantic Segmentation of Lumbar Vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S V V Shiloah Elizabeth Darmanayagam Sunil Retmin Raj cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

Restricted Boltzmann machine: Recent advances and mean-field theory

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Chinese Physics B 2021年第4期30卷 1-24页

作者： Aurélien Decelle cyril Furtlehner Departamento de Fìsica Téorica I Universidad Complutense28040 MadridSpain TAU team INRIA Saclay&LISN UniversitéParis Saclay Orsay 91405France

This review deals with restricted Boltzmann machine(RBM) under the light of statistical *** RBM is a classical family of machine learning(ML) models which played a central role in the development of deep *** it as a spin glass model and exhibiting various links with other models of statistical physics,we gather recent results dealing with mean-field theory in this *** the functioning of the RBM can be analyzed via the phase diagrams obtained for various statistical ensembles of RBM,leading in particular to identify a compositional phase where a small number of features or modes are combined to form complex *** we discuss recent works either able to devise mean-field based learning algorithms;either able to reproduce generic aspects of the learning process from some ensemble dynamics equations or/and from linear stability arguments.

关键词： restricted Boltzmann machine(RBM) machine learning statistical physics

Consistency features and fuzzy-based segmentation for shadow and reflection detection in digital image forgery

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Science China(Information Sciences) 2017年第8期60卷 83-100页

作者： Rajan CRISTIN Velankanni cyril RAJ St.Peter’s Institute of Higher Education and Research Dr.M.G.R Educational and Research Institute University

Advances in photo editing software have made it possible to generate visually convincing photographic forgeries which have been increased tremendously in recent years. In order to alleviate the problem of image forgery, a handful of techniques have been presented in the literature to detect forgery either in shadow or reflection. This paper aims to develop a technique to detect the image forgery either in shadow or reflection using features enabled neural network. The proposed technique of image forgery detection contains three important steps, like segmentation, feature extraction and detection. In segmentation, shadow points and reflection points are identified using map-based segmentation and FCM clustering. Then, feature points from the shadow points and reflective parts are extracted by considering texture consistency and strength consistency using LVP operator. The final step of forgery detection is performed using the feed forward neural network, where a new algorithm called ABCLM is developed for training of neural network weights. The performance is analyzed with four existing algorithms using measures such as accuracy and MSE. From the analysis, we understand that the proposed technique obtained the maximum accuracy of 80.49%.

关键词： image forensics forgery detection shadow reflection texture neural network

Sensing of physiological regulators by innate lymphoid cells

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Cellular & Molecular Immunology 2019年第5期16卷 442-451页

作者： cyril Seillet Nicolas Jacquelot Molecular Immunology Division Walter and Eliza Hall Institute of Medical ResearchMelbourneVIC 3052Australia Department of Medical Biology University of MelbourneMelbourneVIC 3010Australia

Maintenance of homeostasis and immune protection rely on the coordinated action of different physiological *** communication between the immune system and physiological systems is required to sense and restore any disruption of *** transcriptomic analyses of innate lymphoid cells(ILCs)from different tissues have revealed that ILCs express a large array of receptors involved in the recognition of neuropeptides,hormones and metabolic *** rapidly secrete effector cytokines that are central in the development and activation of early immune responses,but they also constitutively secrete mediators that are important for tissue *** achieve these functions effectively,ILCs integrate intrinsic and extrinsic signals that modulate their constitutive and induced *** of the regulation of ILCs by physiological regulators leads to altered immune responses with harmful consequences for the *** understanding of these complex interactions between the immune system and physiological mediators is crucial to decipher the events leading to the protective versus pathological effects of these cells.

关键词： innate lymphoid cells immunity immune protection homeostasis

Energy balance model to assess the resistance of ballistic protection materials

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Defence Technology（防务技术） 2023年第12期30卷 141-153页

作者： Bogdan Stirbu Irene Ndindabahizi Tom Vancaeyzeele cyril Robbe Department of Weapon Systems and Ballistics Royal Military AcademyBrussels 1000Belgium

NATO standards"AEP-2920 Procedures for the Evaluation and Classification of Personal Armor"and NIJ Standard-0101.06,indicate the method to statistically assess the resistance of personal ballistic protection *** be validated and accepted through these procedures,a personal ballistic protection material should withstand an impact of a specific projectile with a probability of a partial penetration confidence level higher than 90%.The present study introduces an energy equilibrium method to assess the confidence level for the probability of partial penetration of ductile and brittle *** experiments performed in the Ballistics laboratory of the Royal Military Academy in Belgium,use a modified pendulum method that allowed the quantification of the energy balance before and after the ballistic *** results were then compared with the ones obtained using the method specified by the NATO standard and NIJ 0101.06,mentioned *** outcome of this comparison shows the tendency of the values obtained by the pendulum method to faithfully follow the values obtained according to NATO and NIJ *** presented method is not based on statistical estimations,but instead,an exact method,of computing the energy absorbed by the tested *** is an advantage for the cases when the material to be evaluated is expensive or it is in the development phase and mass production is not possible.

关键词： Energy NATO Ballistic Protection materials Statistics NIJ Bootstrapping

Otitis media with effusion in children: Pathophysiology, diagnosis, and treatment.A review

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Journal of Otology 2019年第2期14卷 33-39页

作者： Pauline Vanneste cyril Page Department of Otorhinolaryngology and Head & Neck Surgery Amiens University Hospital

Otitis media with effusion(OME)is a frequent paediatric *** condition is often asymptomatic,and so can easily be ***,OME can lead to hearing loss that impairs the child's language and behavioural *** diagnosis is essentially clinical,and is based on otoscopy and(in some cases)*** endoscopy is only indicated in cases of unilateral OME or when obstructive adenoid hypertrophy is *** media with effusion is defined as the observation of middle-ear effusion at consultations three months *** must be evaluated(using an age-appropriate audiometry technique)before and after treatment,so as not to miss another underlying cause of deafness(*** deafness).Craniofacial dysmorphism,respiratory allergy and gastro-oesophageal reflux all favour the development of *** a certain number of medications(antibiotics,corticoids,antihistamines,mucokinetic agents,and nasal decongestants)can be used to treat OME,they are not reliably effective and rarely provide long-term *** benchmark treatment for OME is placement of tympanostomy tubes(TTs)and(in some cases)adjunct *** TTs rapidly normalize hearing and effectively prevent the development of cholesteatoma in the middle *** contrast,TTs do not prevent progression towards tympanic atrophy or a retraction *** enhances the effectiveness of *** children with adenoid hypertrophy,adenoidectomy is indicated before the age of 4 but can be performed later when OME is identified by nasal *** must be followed up until OME has disappeared completely,so that any complications are not missed.

关键词： Otitis media with effusion Tympanostomy tube Ventilation tube Grommet Child

Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications

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World Journal of Gastroenterology 2020年第35期26卷 5223-5247页

作者： Noémie Legrand Dan A Dixon cyril Sobolewski Department of Medicine Faculty of MedicineUniversity of GenevaGeneva CH-1211Switzerland Department of Molecular Biosciences University of KansasLawrenceKansasand University of Kansas Cancer CenterLawrenceKS 66045United States Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGeneva CH-1211Switzerland

Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful *** the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in *** CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of *** SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer *** this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them.

关键词： Stress-Granules Colorectal cancer Adenylate-Uridylate-rich element-binding proteins Post-transcriptional regulation Oncogenes Tumor suppressors

AU-rich element-binding proteins in colorectal cancer

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World Journal of Gastrointestinal Oncology 2019年第2期11卷 71-90页

作者： Noémie Legrand Dan A Dixon cyril Sobolewski Department of Microbiology Faculty of Medicine University of Geneva Department of Molecular Biosciences University of Kansas Lawrence Kansasand University of Kansas Cancer Center Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of Geneva

Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called "Adenylate-Uridylate-rich elements binding proteins"(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC ***, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy.

关键词： Colorectal cancer Adenylate-Uridylate-rich element-binding proteins Oncogenes Tumor suppressors Post-transcriptional regulation

Concentrations of disinfection by-products in swimming pool following modifications of the water treatment process:An exploratory study

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Journal of Environmental Sciences 2017年第8期29卷 163-172页

作者： Robert Tardif Manuel Rodriguez cyril Catto Ginette Charest-Tardif Sabrina Simard Department of Environmental and Occupational Health School of Public HealthUniversité de Montréal NSERC Industrial Research Chair on Drinking Water Université Laval

The formation and concentration of disinfection by-products（DBPs） in pool water and the ambient air vary according to the type of water treatment process used. This exploratory study was aimed at investigating the short-term impact of modifications of the water treatment process on traditional DBP levels（e.g., trihalomethanes（THMs）, chloramines） and emerging DBPs（e.g., Halonitromethanes, Haloketones, NDMA） in swimming pool water and/or air. A sampling program was carried to understand the impact of the following changes made successively to the standard water treatment process： activation of ultraviolet（UV）photoreactor, halt of air stripping with continuation of air extraction from the buffer tank,halt of air stripping and suppression of air extraction from the buffer tank, suppression of the polyaluminium silicate sulfate（PASS） coagulant. UV caused a high increase of Halonitromethanes（8.4 fold）, Haloketones（2.1 fold）, and THMs in the water（1.7 fold） and, of THMs in the air（1.6 fold） and contributed to reducing the level of chloramines in the air（1.6fold） and NDMA in the water（2.1 fold）. The results highlight the positive impact of air stripping in reducing volatile contaminants. The PASS did not change the presence of DBPs, except for the THMs, which decrease slightly with the use of this coagulant. This study shows that modifications affecting the water treatment process can rapidly produce important and variable impacts on DBP levels in water and air and suggests that implementation of any water treatment process to reduce DBP levels should take into account the specific context of each swimming pool.

关键词： Disinfection by-products Swimming pool UV rays Air stripping Chloramines Emerging DBPs NDMA