检索结果-南通市图书馆

Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2021年第6期13卷 190-230页

作者： Pooyan Makvandi Melissa Kirkby Aaron RJHutton Majid Shabani cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly Istituto Italiano Di Tecnologia Centre for Materials InterfaceViale Rinaldo Piaggio 3456025 PontederaPisaItaly School of Pharmacy Queen’s University Belfast97 Lisburn RoadBelfast BT97BLUK The BioRobotics Institute Scuola Superiore Sant’AnnaViale Rinaldo Piaggio 3456025 PontederaPisaItaly Paediatric Dentistry and Orthodontics Faculty of DentistryThe University of Hong KongPrince Philip Dental HospitalHong Kong SARChina Department of Chemical Materials and Industrial Production EngineeringUniversity of Naples FedericoⅡ80125 NaplesItaly Center for Advanced Biomaterials for Health Care(iit@CRIB) Italian Institute of Technology80125 NaplesItaly

Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the *** serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during *** ensures that the cargo is released at the predetermined place and ***,the ability of MN patches to sufficiently pierce the skin is a crucial *** the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and *** is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical *** that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research.

关键词： Insertion responsive Implantable microneedles Skin indentation Transdermal microneedles Pain management

Chemicals of Emerging Arctic Concern:Preface

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging Contaminants 2019年第1期5卷 1-3页

作者： cynthia A.de Wit Jennifer Balmer Derek C.G.Muir Katrin Vorkamp Simon Wilson Department of Environmental Science and Analytical Chemistry(ACES) Stockholm UniversitySE-10691StockholmSweden Arctic Monitoring and Assessment Programme The Fram CentreN-9296TromsøNorway Department of Biology The CitadelCharlestonSCUSA Canada Centre for Inland Waters Environment and Climate Change CanadaBurlingtonONL7S 1A1Canada Department of Environmental Science Arctic Research CentreAarhus UniversityFrederiksborgvej 399PO Box 358DK-4000RoskildeDenmark

*** The Arctic Monitoring and Assessment Programme(AMAP)was established as an international program for monitoring and assessing Arctic pollution in 1991,under the Arctic Environmental Protection Strategy[1].AMAP is now aWorking Group of the Arctic Council(http://***)responsible for monitoring and assessing a range of pollution-and climate change-related issues in the Arctic in order to“provide reliable and sufficient information on the status of,and threats to,the Arctic environment,and scientific advice on actions to be taken in order to support Arctic governments in their efforts to take remedial and preventive actions relating to contaminants and adverse effects of climate change”(see Ref.[2]).

关键词： Chemicals of emerging concern Arctic Persistent organic pollutants Arctic monitoring and assessment programme

Defining 'science-based targets'

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2021年第7期8卷 17-20页

作者： Inger Andersen Naoko Ishii Thomas Brooks cynthia Cummis Gustavo Fonseca Astrid Hillers Nicholas Macfarlane Nebojsa Nakicenovic Kevin Moss Johan Rockstr?m rew Steer Dominic Waughray Caroline Zimm United Nations Environment Programme Global Environment Facility International Union for Conservation of Nature World Resources Institute International Institute for Applied Systems Analysis Potsdam Institute for Climate Impact Research Conservation International Stockholm Resilience Centre World Economic Forum Centre for Global Public Goods

The 2015 Paris Agreement to keep global warming well below 2?C above pre-industrial levels and aim towards limiting warming to 1.5?C marked a watershed in planetary governance, for two reasons. First, of course, it se...

关键词：

Nocturnal foragers exploit tree exudates from holes gouged by diurnal common marmoset monkeys(Callithrix jacchus)

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2020年第6期15卷 617-623页

作者： cynthia L.THOMPSON Lauren M.GAPP Leonardo C.O.MELO Christopher J.VINYARD Maria A.B.DE OLIVEIRA Department of Biomedical Sciences Grand Valley State UniversityAllendaleMichiganUSA Departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de PernambucoRecife-PEBrazil Department of Anatomy&Neurobiology Northeast Ohio Medical UniversityRootstownOhioUSA

INTRODUCTION Plant exudates are a common,yet often overlooked food source eaten by 94 mammalian species spread across 6 orders(Nash&Burrows 2010;Cabana et al.2018).However,exudates(including gums,resins,and latex,defined following Cabana et al.2018)contain large amounts of non-digestible carbohydrates and plant secondary metabolites,posing challenges for mammals exploiting this resource(Power 2010).Due to the difficulty of gaining nutrition from exudates,they are not considered a high-quality food source,despite the number of species that consume them(Power 2010;Cabana et al.2018).

关键词： exploit resins latex

先发制人对词汇学习的影响 ——尼日利亚高中英语学习的证据

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

先发制人对词汇学习的影响 ——尼日利...

作者： Chilaka cynthia Ijeoma 西南大学

学位级别：硕士

尼日利亚学生的词汇建设在很大程度上受到社会学和学术因素的影响。学习构建标准句子大多发生在教室里,但年轻的学习者只会从直系亲属那里构建他们熟悉的句子。这种结构可能是标准的,也可能不是标准的。无论哪种方式,都会影响年轻学习... 详细信息

尼日利亚学生的词汇建设在很大程度上受到社会学和学术因素的影响。学习构建标准句子大多发生在教室里,但年轻的学习者只会从直系亲属那里构建他们熟悉的句子。这种结构可能是标准的,也可能不是标准的。无论哪种方式,都会影响年轻学习者的词汇量发展。这些影响可能并不总是积极的,因为为了在学术环境中学习适当的结构,家庭的错误结构可能更难避免。这篇论文,标题为"先发制人对词汇学习的影响:尼日利亚高中英语学习的证据,"回答了两个重要问题:高中英语学习者在学习词汇方面面临的抢占问题是什么,以及这项研究对尼日利亚高中英语学习者的词汇学习有什么影响?该论文还试图了解先发制人在多大程度上影响了尼日利亚年轻学习者的语言习得创造力。该研究使用结构化问卷从在研究时被认证为尼日利亚人的初中生收集数据。与100多名年轻学习者和教师分享了调查问卷。为简单起见,结果以饼图形式显示。研究结果表明,先发制人是政府日中学生发展词汇的主要问题,学生用他们的母语取代标准的词汇形成,环境因素和同龄人群体影响是影响学生先发制人的两个主要因素。没有研究同时解决词汇学习和抢占问题。本文的结果可以为抢占的使用提供见解,特别是基于词汇学习。抢占式的主题一直是学习英语过程中的一个语言问题。

关键词：先发制人英语词汇学习初中尼日利亚

Temporal trends and practice variation of paediatric diagnostic tests in primary care:retrospective analysis of 14 million tests

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2024年第4期12卷 1-8页

作者： Elizabeth T Thomas Diana R Withrow cynthia Wright Drakesmith Peter J Gill Rafael Perera-Salazar Carl Heneghan Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health SciencesUniversity of OxfordOxfordUK Nuffield Department of Primary Care Health Sciences University of OxfordOxfordUK Department of Pediatrics University of TorontoTorontoOntarioCanada Hospital for Sick Children TorontoOntarioCanada

Objective The primary objective was to investigate temporal trends and between-practice variability of paediatric test use in primary *** and analysis This was a descriptive study of population-based data from Clinical Practice Research Datalink Aurum primary care consultation records from 1 January 2007 to 31 December *** aged 0–15 who were registered to one of the eligible 1464 general practices and had a diagnostic test code in their clinical record were *** primary outcome measures were(1)temporal changes in test rates measured by the average annual percent change,stratified by test type,gender,age group and deprivation level and(2)practice variability in test use,measured by the coefficient of *** 14299598 diagnostic tests were requested over 27.8 million child-years of observation for 2542101 *** test use increased by 3.6%/year(95%CI 3.4 to 3.8%)from 399/1000 child-years to 608/1000 child-years,driven by increases in blood tests(8.0%/year,95%CI 7.7 to 8.4),females aged 11–15(4.0%/year,95%CI 3.7 to 4.3),and children from the most socioeconomically deprived group(4.4%/year,95%CI 4.1 to 4.8).Tests subject to the greatest temporal increases were faecal calprotectin,fractional exhaled nitric oxide and vitamin *** classified as high-use and high-practice variability were iron studies,coeliac testing,vitamin B12,folate,and vitamin *** In this first nationwide study of paediatric test use in primary care,we observed significant temporal increases and practice variability in *** reflects inconsistency in practice and diagnosis rates and a scarcity of evidence-based *** test use generates more clinical activity with significant resource implications but conversely may improve clinical *** research should evaluate whether increased test use and variability are warranted by exploring test indications and test results and directly examine how increased test use impacts

关键词： vitamin nationwide stratified

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际贸易对贫困的影响：尼日利亚的案例研究

国际贸易对贫困的影响：尼日利亚的案例研究

作者： Udeogu Chidinma cynthia 江西财经大学

学位级别：硕士

Trade has often been presented as a panacea for economic growth and poverty *** the volume of international soars,successive Nigerian governments continue to seek and implement policies to increase trade and ***,despite decades of stable and increasing trade volumes,continues to experience growing rates in poverty and *** thesis examines the impact of international trade in Nigeria over the past two *** analysis done using panel data from 1996 to *** inferential statistic technique was used to analyse the data by testing three *** thesis finds that that there is no cointegration between trade openness and economic growth on the one hand,and with poverty reduction,on the other *** will therefore be helpful to pursue macroeconomic stability through reduction of budgetary imbalances by reducing the size and role of government and pursue a greater reliance on the private sector development financing.

关键词：贫困现象国际贸易基础设施产业结构尼日利亚

Effects of plants and plant products on the testis

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第4期12卷 468-479页

作者： Shereen cynthia D＇Cruz Selvaraju Vaithinathan Rajamanickam Jubendradass Premendu Prakash Mathur Department of Biochemistry ＆ Molecular Biology School of Life Sciences Pondicherry University Pondicherry 605014 India

For centuries, plants and plant-based products have been used as a valuable and safe natural source of medicines for treating various ailments. The therapeutic potential of most of these plants could be ascribed to their anticancer, antidiabetic, hepatoprotective, cardioprotective, antispasmodic, analgesic and various other pharmacological properties. However, several commonly used plants have been reported to adversely affect male reproductive functions in wildlife and humans. The effects observed with most of the plant and plant-based products have been attributed to the antispermatogenic and/or antisteroidogenic properties of one or more active ingredients. This review discusses the detrimental effects of some of the commonly used plants on various target cells in the testis. A deeper insight into the molecular mechanisms of action of these natural compounds could pave the way for developing therapeutic strategies against their toxicity.

关键词： male reproduction natural products plants spermatogenesis steroidogenesis testis

Experiences of Low Gestational Weight Gain: A Phenomenological Study with Pregnant Women

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2014年第19期6卷 2611-2623页

作者： cynthia L. Murray Sherrill A. Conroy School of Nursing Memorial University of Newfoundland St. John’s Canada Faculty of Nursing University of Alberta Edmonton Canada

Low maternal, gestational weight gain is associated with preterm birth, intrauterine growth restriction, low birthweight, small-for-gestational-age infants, neural tube defects, infant death, failure to initiate breastfeeding, and childhood asthma. The advantage of qualitative research is it can provide valuable insights for health care professionals into the experience and perceptions of low gestational weight gain from the vantage point of women with first-hand lived experience. In this Heideggarian interpretive phenomenological study, the meaning and experiences of weight gain for pregnant women with low gestational weight gain were explored. Data were collected through interviews with 10 pregnant women from Atlantic Canada. Conroy’s pathway for interpretive phenomenology was utilized. A hermeneutical spiral of interpretation identified six patterns or major themes: confronting one’s mortality;defending oneself against a permanent metamorphosis into a stranger;playing with fire and brimstone;slipping under the radar;trying to find peace;and riding an emotional roller coaster. The findings point to a war that is being waged over pregnant bodies with respect to weight that leaves pregnant women fending for themselves, apparently with little help from their health care providers. Implications of the findings for health practice, education, and research are discussed.

关键词： Embodiment/Bodily Experiences Heideggarian Interpretive Phenomenology Lived Experience Pregnancy Weight Gain