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Depolarization field in relaxor-based ferroelectric single crystals under one-cycle bipolar pulse drive

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Chinese Physics B 2019年第12期28卷 326-330页

作者： Chuan-Wen Chen Yang xiang Li-Guo Tang Lian cui Bao-Qing Lin Wei-Dong Du Wen-Wu Cao Fujian Provincial Key Laboratory of Light Propagation and Transformation College of Information Science and EngineeringHuaqiao UniversityXiamen 361021China Department of Mathematics and Materials Research Institute The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA Department of Applied Marine Physics&Engineering Xiamen UniversityXiamen 361010China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Electronic and Information Engineering Yangtze Normal UniversityChongqing 408003China Acoustic Science and Technology Laboratory Harbin Engineering UniversityHarbin 150001China

The [001]c-polarized(1-x)Pb(Mg1/3Nb2/3)O3–xPbTiO3(PMN-PT) single crystals are widely used in ultrasonic detection transducers and underwater acoustic sensors. However, the relatively small coercive field( 2 kV/cm) of such crystals restricts their application at high frequencies because the driving field will exceed the coercive field. The depolarization field can be considerably larger in an antiparallel direction than in a parallel direction with respect to polarization when the bipolar driving cycle starts. Thus, if the direction of the sine wave signal in the first half cycle is opposite to the polarization direction, then the depolarized domains can be repolarized in the second half of the sine cycle. However, if the direction of the sine wave signal in the first half of the cycle is along the polarization direction, then the change is negligible,and the domains switched in the second half of the sine cycle cannot be recovered. The design of electric driving method needs to allow the use of a large applied field to emit strong enough signals and produce good images. This phenomenon combined with the coercive field increases with the driving frequency, thereby making the PMN-PT single crystals usable for high-frequency applications. As such, the applied field can be considerably larger than the conventionally defined coercive field.

关键词： piezoelectric crystal coercive field depolarization field bipolar pulse

基于“MLT”原则采用扩张皮瓣整复面颈部瘢痕的方法及其临床效果

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中华烧伤与创面修复杂志 2024年第7期40卷 657-664页

作者：陶明秋黄覛韬梁鹏飞张明华张丕红何志友曾纪章周捷崔旭郭乐周思拓杨燕谢庭鸿黄晓元中南大学湘雅医院烧伤整形科长沙410008

目的探讨基于“MLT”原则采用扩张皮瓣整复面颈部瘢痕的方法及其临床效果。方法该研究为回顾性观察性研究。2019年1月-2022年5月,中南大学湘雅医院收治74例符合入选标准的烧创伤后面颈部瘢痕患者,其中男38例、女36例,年龄5~58岁,单纯面... 详细信息

目的探讨基于“MLT”原则采用扩张皮瓣整复面颈部瘢痕的方法及其临床效果。方法该研究为回顾性观察性研究。2019年1月-2022年5月,中南大学湘雅医院收治74例符合入选标准的烧创伤后面颈部瘢痕患者,其中男38例、女36例,年龄5~58岁,单纯面部受累者24例、单纯颈部受累者24例、面部和颈部均受累者26例,瘢痕面积12~145 cm^(2)。遵循色泽、质地与面部相似;皮瓣面积足够大以修复整个缺损;皮肤组织足够薄,能传递表情,以利于面部形态和五官的塑形的“MLT”原则,Ⅰ期行皮肤软组织扩张器(以下简称扩张器)置入术,Ⅱ期行扩张器取出+瘢痕切除+皮瓣移植术修复继发创面,将皮瓣供区创面直接缝合。术后采用硅凝胶制剂、激光治疗等抗瘢痕增生。观察并记录扩张器扩张倍数、扩张周期,皮肤软组织扩张术并发症发生情况,以及采用的皮瓣类型、Ⅱ期术后皮瓣成活情况。术后随访,评估患者面颈部远期整复效果和皮瓣供、受区恢复情况。结果135个扩张器扩张倍数为1.36~3.00倍,扩张周期为6~14个月。行皮肤软组织扩张术期间,8例患者出现扩张器置入后切口愈合不良、7例患者出现扩张器破裂、5例患者出现扩张器置入后切口感染、3例患者出现扩张器外露、2例患者出现注射壶注水困难、1例患者出现注射壶漏水。8例患者采用颈横动脉与旋肩胛动脉双血供肩背部扩张皮瓣,11例患者采用颈横动脉前穿支扩张皮瓣,12例患者采用胸廓内动脉穿支扩张皮瓣,16例患者采用上胸部及颈部串联扩张皮瓣,5例患者采用胸背动脉穿支扩张皮瓣,22例患者采用邻近旋转推进扩张皮瓣。Ⅱ期术后,71例患者皮瓣完全成活;1例患者皮瓣出现血运障碍,经高压氧治疗后成活;2例患者皮瓣末端出现坏死,经换药后愈合。术后对42例患者随访3~24个月,皮瓣颜色、质地、厚度均佳,与受区周围正常皮肤组织相近,面颈部外形及功能明显改善,皮瓣供、受区创面位置隐蔽且瘢痕形成较轻。结论整复面颈部瘢痕时,遵循“MLT”原则,在术前精心设计扩张皮瓣,Ⅱ期手术时重建亚单位内局部美学特征,术后积极采取规范的抗瘢痕治疗措施,整复后可使皮瓣颜色、质地、厚度与面颈部正常皮肤接近,面颈部外形及功能改善明显,遗留线性瘢痕较轻,有利于提升治疗效果。

关键词：瘢痕外科皮瓣烧伤面部颈扩张术创面修复

Yinlai Decoction Protects Microstructure of Colon and Regulates Serum Level of D-Lactic Acid in Pneumonia Mice Fed with High-Calorie and High-Protein Diet

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Chinese Journal of Integrative Medicine 2023年第8期29卷 714-720页

作者： WANG Yun-hui YU He LIU Tie-gang Teck Chuan Kong ZHENG Zi-an WAN Yu-xiang BAI Chen HAO Yu MAO Ying-qiu WU Jun xu Jing-nan cui Li-jun WANG Yu-han SHAN Yan-ran SHAO Ying-jun GU Xiao-hong College of Chinese Medicine Beijing University of Chinese MedicineBeijing(100029)China Nanyang Technological University Singapore

Objective To investigate the effect of Yinlai Decoction(YD)on the microstructure of colon,and activity of D-lactic acid(DLA)and diamine oxidase(DAO)in serum of pneumonia mice model fed with high-calorie and high-protein diet(HCD).Methods Sixty male Kunming mice were randomly divided into 6 groups by the random number table method:normal control,pneumonia,HCD,HCD with pneumonia(HCD-P),YD(229.2 mg/mL),and dexamethasone(15.63 mg/mL)groups,with 10 in each *** mice were fed with 52%milk solution by *** mice was modeled with lipopolysaccharide inhalation and was fed by gavage with either the corresponding therapeutic drugs or saline water,twice daily,for 3 *** hematoxylin-eosin staining,the changes in the colon structure were observed under light microscopy and transmission electron microscope,***-linked immunosorbent assay was used to detect the protein levels of DLA and DAO in the serum of *** The colonic mucosal structure and ultrastructure of mice in the normal control group were clear and *** colonic mucosal goblet cells in the pneumonia group tended to increase,and the size of the microvilli *** the HCD-P group,the mucosal goblet cells showed a marked increase in size with increased secretory *** mucosal epithelial connections were also observed,as shown by widened intercellular gaps with short sparse *** pathological changes of intestinal mucosa were significantly reduced in mouse models with YD treatment,while there was no significant improvement after dexamethasone *** serum DLA level was significantly higher in the pneumonia,HCD,and HCD-P groups as compared with the normal control group(P0.05).Co

关键词： Yinlai Decoction Chinese medicine pneumonia microstructure D-lactic acid diamine oxidase

Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China

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Neuroscience Bulletin 2017年第6期33卷 703-710页

作者： Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping cui Qing-Song Wang xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqingChina Department of Preventive Medicine Daping HospitalThird Military Medical UniversityChongqingChina Department of Neurology Chengdu General Hospital of the PLAChengduChina Department of Neurology Lanzhou General Hospital of the PLALanzhouChina Department of Neurology Guangzhou General Hospital of the PLAGuangzhouChina Department of Neurology Wuhan General Hospital of the PLAWuhanChina Department of Neurology Shenyang General Hospital of the PLAShenyangChina Department of Neurology Fuzhou General HospitalFujian Medical UniversityFuzhouChina Department of Prevention Medicine Guangzhou General Hospital of the PLAGuangzhouChina

Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer＇s disease（AD）, vascular dementia（Va D）, or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index（CCI） was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients.

关键词： Alzheimer’s disease Vascular dementia Prevalence Comorbidity Charlson comorbidity index

Review of compact computational spectral information acquisition systems

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Frontiers of Information Technology & Electronic Engineering 2020年第8期21卷 1119-1133页

作者： Hongya SONG Wenyi ZHANG Haifeng LI xu LIU xiang HAO State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Ningbo Research Institute Zhejiang UniversityNingbo 315100China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

With the development of computer science,more and more hardware implementations can be reproduced by software programming,bringing compact,cheap,and fast components to imaging *** recent years,computational methods have been introduced into spectral detection,and computational spectrum acquisition implementations have *** paper highlights the advantages of computational spectrum acquisition implementations by comparing them with traditional noncomputational ***,focusing on the compact feature,we review the most representative implementations,and finally make discussion and offer an outlook.

关键词： Spectral imaging Computational imaging Spectrometer

OsGRAS19 May Be a Novel Component Involved in the Brassinosteroid Signaling Pathway in Rice

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Molecular Plant 2013年第3期6卷 988-991页

作者： LishengChen Guosheng Xiong Xia cui Meixian Yan Ting xu Qian Qian Yongbiao xue Jiayang Li Yonghong Wang State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Present address: Molecular Cellular and Developmental Biology University of Michigan Ann Arbor MI 48105 USA State Key Laboratory of Rice Biology China National Rice Research Institute Chinese Academy of Agricultural Sciences Hangzhou 310006 China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China

Dear Editor, The brassinosteroid （BR） signaling pathway has been well elucidated in Arabidopsis. The identification of BR-signaling components in rice suggested that the primary pathway is conserved in both dicot a... 详细信息

关键词： BRASSINOSTEROIDS RICE GENETICS MOLECULAR aspects

河北省13价肺炎球菌多糖结合疫苗安全性监测分析

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实用预防医学 2024年第7期31卷 829-832页

作者：孙丽许晓萌李静王易寒崔世恒王亚菲郭玉河北省疾病预防控制中心河北石家庄050021

目的分析河北省13价肺炎球菌多糖结合疫苗(13-valent pneumococcal conjugate vaccine,PCV13)接种后疑似预防接种异常反应(adverse events following immunization,AEFI)的发生特征,评价该疫苗的安全性。方法通过中国疾病预防控制信息系统AEFI监测模块收集2020年1月1日—2022年12月31日河北省PCV13接种后AEFI个案,分析其接种后AEFI的报告发生情况。结果PCV13的总AEFI报告发生率为37.24/10万剂,不良反应发生率为36.84/10万剂,其中一般反应报告发生率为36.31/10万剂,异常反应报告发生率为0.27/10万剂。AEFI以一般反应为主,主要发生在接种后24 h内,且总体转归情况良好。结论截至目前,河北省所使用的PCV13安全性良好,异常反应发生率极低。

关键词： 13价肺炎球菌多糖结合疫苗疑似预防接种异常反应被动监测

基于脑梗死和脑脊液的影像组学预测急性脑卒中机械取栓术后恶性脑水肿发生的分析

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医学影像学杂志 2024年第1期34卷 7-10页

作者：徐敬敬王志楠徐翔马跃虎彭明洋陈国中谢光辉江苏省南京市中西医结合医院放射科江苏南京210000 南京医科大学附属南京医院(南京市第一医院)医学影像科江苏南京210006

目的探讨基于急性脑卒中弥散加权成像(diffusion weighted imaging,DWI)核心梗死区及脑脊液的影像组学特征,通过机器学习构建急性脑卒中机械取栓术后恶性脑水肿发生的预测模型。方法选取155例急性脑卒中患者的MRI图像,基于软件自动分割... 详细信息

目的探讨基于急性脑卒中弥散加权成像(diffusion weighted imaging,DWI)核心梗死区及脑脊液的影像组学特征,通过机器学习构建急性脑卒中机械取栓术后恶性脑水肿发生的预测模型。方法选取155例急性脑卒中患者的MRI图像,基于软件自动分割DWI高信号梗死区及脑脊液区,应用AK软件进行影像组学特征提取和降维,采用最小冗余最大相关特征选择方法筛选最佳影像组学特征,通过支持向量机分类器构建恶性水肿发生的预测模型。结果经筛选后具有10个特征的子集(包含7个DWI脑梗死特征和3个脑脊液特征)获得了最高的平均AUC值,并被指定为最终的特征子集纳入模型分析。ROC分析显示训练集患者预测恶性脑水肿的AUC为0.975,敏感度、特异度和准确度分别为90.3%、69.8%、93.5%;测试集患者预测恶性脑水肿的AUC为0.893,敏感度、特异度、准确度分别为86.8%、90.3%、87.1%。结论基于DWI脑梗死和脑脊液影像组学特征的机器学习,能够较为准确地预测急性脑卒中机械取栓术后恶性脑水肿的发生,为临床早期干预治疗提供指导。

关键词：卒中磁共振成像脑脊液恶性脑水肿机器学习

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Cross-Talk between Extracellular S1P/S1P2 and P42/44 MAPK in bcr/abl Positive Chronic Myeloid Leukemia Cells

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Chinese Journal of Cancer Research 2009年第1期21卷 20-27页

作者： Yin xu Fei-qun Zheng Qun-wei Zhang Yang Liu Hai-feng Duan Chun-ping cui Bin Wu Yi-de Qin Deparment of Biochemistry and Molecular Biology Anhui Medical University Hefei 230032 China Department of Experimental Hematology Beijing Institute of Radiation Medicine Beijing 100850 China Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of lnterventional Therapy Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： BCR/ABL oncoprotein-expression is associated with uncontrolled cell growth. Sphingosine kinase 1 （SPK1） regulates the production of sphingosine 1-phosphate （S1P）, a key lipid signal molecular in cell proliferation and survival. The objective of this study was to elucidate the roles of S1P and its receptors in bcr/abl positive chronic myeloid leukemia （CML） cells. Methods： The expressions of SIP receptors： S1P1, S1P2 and S1P3 in CML cells were detected by RT-PCR. SPK1 expression, activity and extracellular S1P were determined in ECV304 and HL-60 cells which were transfected with bcr/abl gene. To elucidate the relationship between the BCR/ABL, ERK/MAPK （extracellular signal-regulated kinase/mitogen-activated protein kinase）, SPK/S 1P and S 1P/S 1 P2 signal pathways, bcr/abl positive CML cell line K562 was treated with STI571, PD98059, N,N-dimethyl sphingosine （DMS） and JTE-013. Results： Retrovirus-mediated overexpression of bcr/abl gene in ECV304 and HL-60 cells resulted in upregulation of the expression, activity of SPK1 and increase of the secretion of SIP, whereas treatment of STI571 and PD98059 decreased the BCR/ABL-induced S1P secretion. Treatment of DMS reduced S1P secretion and P42/44MAPK phosphorylation. S1P2-selective antagonist JTE-013 could also decrease P42/44MAPK phosphorylation. Conclusion： These results suggest that BCR/ABL up-regulates extracellular sphingosine 1-phosphate through sphingosine kinase 1 and there is cross-talk between SPK1/S1P/S1P2 and P42/44MAPK in bcr/abl positive CML cells.

关键词： Sphingosine kinase Sphingosine 1-phosphate CML Extracellular signal-regulated kinase/mitogen-activated protein kinase Cross-talk