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Effect of IL-6 on the expression of prohibitin in eutopic endometrium with endometriosis in vitro

生殖医学杂志 2009年第S2期18卷 39-46页

作者：王馥新舒黎冒韵东谢满鑫崔毓桂王炜侯振刘嘉茵 Center of Clinical Reproductive Medicine First Affiliated Hospital of Nanjing Medical University

Objective:Prohibitin(PHB) is a highly conserved protein with pleiotropic *** this manuscript,we evaluated the expression and localization of PHB in the endometriosis,and explored the effect of interleukin-6 (IL-6) on the regulation of PHB in the cultured eutopic endometrial stroma cells from endometriosis patients,so as to discuss the pathophysiological roles of PHB and IL-6 in endometriosis. Methods:Normal endometrial tissues were from three normal proliferate-stage endometrium of young married women,ovarian endometriosis and eutopic endometrium from three endometriosis *** expression of PHB was examined by immunohistochemistry and western blot *** endometrial cells from other 10 patients with endometriosis were cultured,purified and *** collected stromal cells were treated with IL-6 at various concentration(0 to 100 ng/ml) for 0-24 *** PHB expression in the treated cells was examined by real-time PCR and western blot. Results:PHB was located in the cytoplasm of both epithelial glands and *** expression in endom-etriotic tissue and eutopic endometrium of patients with endometriosis was lower than that in normal endometrium. PHB levels were remarkably increased by 10 ng/ml of IL-6,at both mRNA level and protein *** effect was reversed when the dosage of IL-6 was up to 100 ng/*** of PHB mRNA significantly increased(up to 7.6 folds) after 10 ng/ml IL-6 treatment at 4 h and 8 h,which returned to basal level at 12 h,while PHB protein expression significantly increased(up to 2.75 folds) after 10 ng/ml IL-6 treatment at 8 h and sustained through 24 h. Conclusion:PHB expression decreased in eutopic and ectopic endometrium tissues from patients with endometriosis. IL-6 had dual effect on the regulation of PHB in the cultured eutopic endometrial stroma *** study provided us new insights into the potential roles of PHB and IL-6 in the pathogenesis of endometriosis.

关键词： Prohibitin Endometriosis Endometrial stroma cell Interleukin-6

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Phenols/Al(C_(6)F_(5))_(3) Initiation Systems for Cationic Polymerizations of Isobutylene

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Chinese Journal of Polymer Science 2023年第5期41卷 713-719,I0008页

作者： Ling Cai Qi-Yuan wang Xin-Li Liu Dong-Mei cui State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China

We report herein the cationic polymerization of isobutylene(IB)under mild conditions is realized with a new binary initiation system generated by simply mixing a Lewis super acid Al(C_(6)F_(5))_(3) and a substituted phenol(RPhOH).Polymers with medium and/or high molecular weights(M_(W)=4.9×10^(4)-27.7×10^(4) g·mol^(-1))can be obtained in toluene and temperatures from-20℃to 0℃.NMR spectrum analysis and DFT sim ulation reveals the in situ generated acidic coordinating complex Ak(C_(6)F_(5))_(3)·RPhOH is the initiating active species,which fu rther tran sformed into the ion-pair[Al(C_(6)F_(5))_(3)ORPh]^(-)[PIB]^(+)of the active intermediates upon growing IB monomers where the counter anion[Al(C_(6)F_(5))_(3)R^(O)Ph]-coordinates to the macrocation via the phenoxy *** catalyst performances are the concert effects of the steric bulkiness and electronics of the counter anion on the coordinating strength to the macrocation,which is significant to the stability of the active species.

关键词： Cationic polymerization Phenols Lewis super acid Polyisobutylene

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Effect of Rotation Rate on Microstructure and Mechanical Properties of Friction Stir Processed Ni–Fe-Based Superalloy

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Acta Metallurgica Sinica(English Letters) 2021年第10期34卷 1407-1420页

作者： Miao wang Xing-Wei Huang Peng Xue Chuan-Yong cui Qing-Chuan Zhang CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of ChinaHefei 230027China Superalloy Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230027China

In this work, friction stir processing(FSP) was applied to the high-strength and high-melting-point Ni–Fe-based superalloy(HT700) for the first time with negligible wear of the stir tool. Different rotation rates were chosen to investigate the effect of heat input on microstructure and tensile properties at different temperatures of friction stir processed Ni–Fe-based superalloy. The results showed that with increasing rotation rate, the percentage of high-angle grain boundaries and twin boundaries gradually decreased whereas the grain size initially increased and then remained almost constant;the difference in tensile properties of FSP samples with rotation rates of 500–700 rpm was small attributing to their similar grain size, but the maximum strength was achieved in the FSP sample with a rotation rate of 400 rpm and traverse speed of 50 mm/min due to its finest grain size. More importantly, we found that the yield strength of all FSP samples tensioned at 700 ℃ was enhanced clearly resulting from the reprecipitation of γ′ phase. In addition, the grain refinement mechanism of HT700 alloy during FSP was proved to be continuous dynamic recrystallization and the specific refinement process was given.

关键词： Superalloy Friction stir processing Grain refinement Processing parameter

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欣悦降压穴位贴辅助治疗老年单纯收缩期高血压临床观察

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老年医学与保健 2020年第5期26卷 737-739页

作者：王博深张玉龙任风英鲍婷婷王翠李跃华中国中医科学院西苑医院老年病科北京100091 北京中医药大学临床医学院北京100029 中山大学附属第七医院中医科深圳518107

目的观察欣悦降压穴位贴辅助治疗老年单纯收缩期高血压阴虚阳亢型的临床疗效。方法收集114例老年单纯收缩期高血压阴虚阳亢型患者,采用随机法数字表分为观察组和对照组,各57例。在不改变原有口服降压药的常规治疗基础上,观察组给予欣悦... 详细信息

目的观察欣悦降压穴位贴辅助治疗老年单纯收缩期高血压阴虚阳亢型的临床疗效。方法收集114例老年单纯收缩期高血压阴虚阳亢型患者,采用随机法数字表分为观察组和对照组,各57例。在不改变原有口服降压药的常规治疗基础上,观察组给予欣悦降压穴位贴贴敷治疗。1周为1疗程,连续治疗4个疗程后观察患者血压及中医阴虚阳亢证型症候积分变化情况。结果配合欣悦降压穴位贴的患者降压效果更好,并在中医证候积分上差异有统计学意义,临床疗效和中医临床疗效显著。结论欣悦降压穴位贴能明显改善老年单纯收缩期高血压阴虚阳亢型患者的中医证候,有辅助治疗作用。

关键词：收缩期高血压欣悦降压穴位贴穴位贴敷阴虚阳亢型

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Ganoderic Acids A and B Reduce Okadaic Acid-Induced Neurotoxicity in PC12 Cells by Inhibiting Tau Hyperphosphorylation

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Biomedical and Environmental Sciences 2023年第1期36卷 103-108页

作者： cui Jing MENG Yu Han wang Zhan Wei wang Jing SHI Dong Fang LIU Duo Central Laboratory Changchun Normal UniversityChangchun 130032JilinChina School of Life Sciences Northeast Normal UniversityChangchun 130024JilinChina

Alzheimer’s disease is one of the most debilitating neurodegenerative diseases affecting the aging population. One of the neuropathological hallmarks of AD is an aggregation of the tau protein into neurofibrillary tangles(NFTs) in neurons and glial cells of the brain. Tau is a microtubuleassociated protein expressed mainly in neurons of the central nervous system[1].

关键词： Alzheimer tau PC12

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婚姻状况对维持性血液透析患者生活质量影响的调查研究

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中国血液净化 2015年第4期14卷 227-229页

作者：王翠珍陶明芬王金宝周健美周加军武其文皖南医学院附属第一医院血液净化中心安徽芜湖241001 皖南医学院附属第一医院检验科安徽芜湖241001

目的探讨婚姻状况对血液透析患者生活质量的影响,以提供科学的干预措施和健康教育手段。方法采用生活质量调查表(SF-36)、婚姻质量调查表对60例维持性血液透析患者进行问卷调查,同时选择60例健康体检人群作为对照。结果统计结果显示有... 详细信息

目的探讨婚姻状况对血液透析患者生活质量的影响,以提供科学的干预措施和健康教育手段。方法采用生活质量调查表(SF-36)、婚姻质量调查表对60例维持性血液透析患者进行问卷调查,同时选择60例健康体检人群作为对照。结果统计结果显示有配偶的血液透析患者在总体健康、生理功能、生理职能、情感职能等多个维度的评分都高于无配偶者(P<0.05),其中总体健康的评分显著高于无配偶者(P=0.0011)。婚姻质量问卷表显示血液透析患者对婚姻满意度评分与正常人群无显著差异,但是男、女血液透析患者对性生活的评分均显著低于对照组(P<0.01,其中男性:P=0.0241;女性:P=0.003)。结论婚姻状况是影响血液透析患者生活质量的重要因素。

关键词：维持性血液透析婚姻状况生活质量

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Unconventional metamagnetic phase transition in R_(2)In(R=Nd, Pr)with lambda-like specific heat and nonhysteresis

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Journal of Materials Science & Technology 2022年第6期101卷 80-84页

作者： Weibin cui Guiquan Yao Shengyu Sun Qiang wang Jie Zhu Sen Yang Key Laboratory of Electromagnetic Processing of Materials Northeastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

The phase transition of Nd_(2)In and Pr_(2)In has been studied and found to be between the first-order and second-order *** any hysteresis nor obvious cell volume changes are *** the field-triggered metamagnetism is demonstrated with lambda-like peak on specific heat *** the field change of 7 T,giant magnetic entropy changes of 13.2 J kg^(-1)K^(-1) and 19.5 J kg^(-1)K^(-1) and adiabatic temperature changes of 6.5 K and 7.4 K have been achieved in Nd_(2)In and Pr_(2) In alloys respectively,which is partially contributed by strong magnetoelastic coupling represented by high saturation magnetostriction of~450 *** unique feature is proposed to be originated from the delocalized 5d electrons,as evidenced by the negative magnetoresistance caused by the phase transition.

关键词： Metamagnetic transition Magnetic entropy change Magnetocaloric effects Magnetostriction

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Obtaining tetragonal FeAs layer and superconducting K_(x)Fe_(2)As_(2)by molecular beam epitaxy

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Nano Research 2023年第2期16卷 3040-3045页

作者： cui Ding Yuanzhao Li Shuaihua Ji Ke He Lili wang Qi-Kun Xue State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China Collaborative Innovation Center of Quantum Matter Beijing 100084China Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Atomic characterization on tetragonal FeAs layer and engineering FeAs superlattices is highly desirable to get deep insight into the multi-band superconductivity in *** fabricate the tetragonal FeAs layer by topotactic reaction of FeTe films with arsenic and then obtain KxFe_(2)As_(2)upon potassium intercalation using molecular beam *** in-situ low-temperature√2×√2scanning tunneling microscopy/spectroscopy investigations demonstrate characteristic reconstruction of the FeAs layer and stripe pattern of KxFe_(2)As_(2),accompanied by the development of a superconducting-like *** ex-situ transport measurement with FeTe capping layers shows a superconducting transition with an onset temperature of 10 *** work provides a promising way to characterize the FeAs layer directly and explore rich emergent physics with epitaxial superlattice design.

关键词： tetragonal FeAs KxFe_(2)As_(2) interface enhanced superconductivity topotactic reaction molecular beam epitaxy

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骨肉瘤组织环氧合酶-2、CD_(105)表达与预后

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肿瘤研究与临床 2007年第9期19卷 602-604,607页

作者：欧阳振王栓科王翠芳康学文郭洪章兰州大学第二医院骨科研究所 730000

目的研究骨肉瘤组织中环氧合酶-2(COX-2)与 CD_(105)表达及其与预后的关系。方法应用免疫组织化学染色的方法检测人骨肉瘤中 COX-2和 CD_(105)的表达,并计算 CD_(105)标记的微血管密度(MVD),同时对预后进行 COX 多因素生存分析。结果 CO... 详细信息

目的研究骨肉瘤组织中环氧合酶-2(COX-2)与 CD_(105)表达及其与预后的关系。方法应用免疫组织化学染色的方法检测人骨肉瘤中 COX-2和 CD_(105)的表达,并计算 CD_(105)标记的微血管密度(MVD),同时对预后进行 COX 多因素生存分析。结果 COX-2在骨肉瘤中表达阳性率为77.5%,COX-2的表达与外科分期和肿瘤的转移密切相关(P0.05);转移组的骨肉瘤其 MVD 值高于未转移组,二者之间的差异有统计学意义(P<0.05);COX-2表达与 MVD 值呈正相关(P<0.05)。多因素生存分析显示,Enneking 外科分期、COX-2表达及是否发生转移是影响患者预后的独立危险因素。结论 COX-2在骨肉瘤组织中呈现高表达,其高表达可能促进了骨肉瘤新生血管的生成。COX-2和 CD_(105)标记的 MVD 可以作为骨肉瘤外科分期和是否发生转移的重要指标。

关键词：环氧化酶-2 微血管密度骨肉瘤预后

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Microstructure and Mechanical Properties of RAFM-316L Dissimilar Joints by Friction Stir Welding with Different Butt Joining Modes

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 135-146页

作者： Bin He Lei cui Dong-Po wang Hui-Jun Li Chen-Xi Liu Tianjin Key Laboratory of Advanced Joining Technology School of Materials Science and EngineeringTianjin UniversityTianjin 300354China

Dissimilar welded joints of reduced activation ferritic/martensitic(RAFM)steel and 316 L austenitic stainless steel were prepared by friction stir welding with different butt joining modes and welding *** weld quality of the joint was improved by placing the 316 L steel on the advancing side and the RAFM steel on the retreating side,and using a relatively high rotational speed of 400 *** microstructure of the stir zone on the 316 L steel side consisted of single-phase austenite,and the microstructure of the stir zone on the RAFM steel side mainly consisted of lath martensite and equiaxed ferrite.A mechanical mixture of the two steels and diffusion of Cr and Ni could be detected near the bonding *** of Ni from the 316 L steel to the RAFM steel resulted in the formation of a dual-phase structure consisting of austenite and *** as-welded joints showed good strength and ductility at room temperature and 550°C,which were nearly equal to those of the 316 L base *** heat-affected zone on the RAFM side had the lowest impact toughness throughout the weld with a value of 13.2 J at-40°C,~52%that of the RAFM base material.

关键词： Friction stir welding Dissimilar joint RAFM steel 316L steel Microstructures Mechanical properties

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