Ganoderic Acids A and B Reduce Okadaic Acid-Induced Neurotoxicity in PC12 Cells by Inhibiting Tau Hyperphosphorylation

作     者：CUI Jing MENG Yu Han WANG Zhan Wei WANG Jing SHI Dong Fang LIU Duo CUI Jing;MENG Yu Han;WANG Zhan Wei;WANG Jing;SHI Dong Fang;LIU Duo

作者机构：Central LaboratoryChangchun Normal UniversityChangchun 130032JilinChina School of Life SciencesNortheast Normal UniversityChangchun 130024JilinChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2023年第36卷第1期

页      面：103-108页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China[grant number.3187010926] the National Science Foundation of Changchun Normal University[grant number.2021018] 

主　　题：Alzheimer tau PC12 

摘      要：Alzheimer’s disease is one of the most debilitating neurodegenerative diseases affecting the aging population. One of the neuropathological hallmarks of AD is an aggregation of the tau protein into neurofibrillary tangles(NFTs) in neurons and glial cells of the brain. Tau is a microtubuleassociated protein expressed mainly in neurons of the central nervous system[1].