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Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms

World Journal of Clinical Oncology 2024年第6期15卷 717-729页

作者： Mihnea-Alexandru Găman Bahadar Singh Srichawla Yong-Feng Chen Poulami Roy Arkadeep Dhali Ahmed Nahian Muhammad Romail Manan Vincent Kipkorir Richard Christian Suteja Lakshmi Venkata Simhachalam Kutikuppala Amelia Maria Găman Camelia cristina Diaconu Faculty of Medicine “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Department of Hematology Center of Hematolog Department of Cellular and Molecular Pathology Stefan S Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Basic Medical Sciences School of Medicine of Taizhou UniversityTaizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Medicine North Bengal Medical College and HospitalWest Bengal 734012India Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation TrustSheffield S57AUUnited Kingdom Lecom at Seton Hill GreensburgPA 15601United States Faculty of Medicine Services HospitalLahore 54000Pakistan Department of Human Anatomy and Physiology University of NairobiNairobi 00100Kenya Faculty of Medicine Udayana UniversityDenpasarBali 80361Indonesia Department of General Surgery Dr.NTR University of Health SciencesVijayawada 520008Andhra PradeshIndia Department of Pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania Department of Internal Medicine Faculty of Medicine“Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 105402Romania

Myeloproliferative neoplasms(MPNs)occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral *** suffering from MPNs display a high burden of cardiovascular risk factors,and thrombotic events are often the cause of death in this population of ***,we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia,metabolic syndrome,and MPNs,with a special focus on cardio-vascular risk,atherosclerosis,and thrombotic ***,we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients,as well as the management of dyslipidemia in MPNs,and the impact of MPN treatment on serum lipid concentrations,particularly as side/adverse effects reported in the context of clinical trials.

关键词： Polycythemia vera Essential thrombocythemia Myelofibrosis Cardiovascular disease Hypercholesterolemia Hypertriglyceridemia Obesity Diabetes Inflammation Oxidative stress

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The Finite-dimensional Decomposition Property in Non-Archimedean Banach Spaces

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1833-1845页

作者： Albert KUBZDELA cristina PEREZ-GARCIA Institute of Civil Engineering Poznań University of TechnologyUl.Piotrowo 561-138 PoznańPoland Department of Mathematics Facultad de CienciasUniversidad de CantabriaAvda.de los Castros s/n39071SantanderSpain

A non-Archimedean Banach space has the orthogonal finite-dimensional decomposition property（OFDDP） if it is the orthogonal direct sum of a sequence of finite-dimensional *** property has an influence in the non-Archimedean Grothendieck＇s approximation theory,where an open problem is the following： Let E be a non-Archimedean Banach space of countable type with the OFDDP and let D be a closed subspace of *** D have the OFDDP？ In this paper we give a negative answer to this question; we construct a Banach space of countable type with the OFDDP having a one-codimensional subspace without the *** we prove that,however,for certain classes of Banach spaces of countable type,the OFDDP is preserved by taking finite-codimensional subspaces.

关键词： Non-Archimedean Banach spaces finite-dimensional decomposition property orthogonal base

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α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

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Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： Alessandra Bigi Roberta Cascella cristina Cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system *** such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial *** expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein ***,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient *** this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

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A new technique helps to uncover unknown peptides and disinfection by-products in water

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Journal of Environmental Sciences 2016年第4期28卷 6-8页

作者： Susan D.Richardson cristina Postigo Department of Chemistry and Biochemistry University of South Carolina Department of Environmental Chemistry Institute for Environmental Assessment and Water Research-Spanish National Research Council(IDAEA-CSIC)

Environmental water samples can be extremely complex,with potentially thousands of molecules that can derive from natural organic matter（NOM）and thousands that derive from anthropogenic *** complex as these samples are,drinking water can be even more *** to disinfectants that are used to treat drinking water（e.g.,chlorine,chloramines,

关键词： Disinfection by-products(DBPs) Drinking water Halogenated peptides Liquid chromatography Natural organic matter(NOM) Non-targeted analysis Tandem mass spectrometry Water contaminants

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Nonasthmatic eosinophilic bronchitis in an ulcerative colitis patient-a putative adverse reaction to mesalazine:A case report and review of literature

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World Journal of Clinical Cases 2020年第18期8卷 4162-4168页

作者： Andrei Tudor Cernomaz Gabriela Bordeianu cristina Terinte cristina Maria Gavrilescu Department of Internal Medicine Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Biochemistry Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Pathology Regional Oncology InstituteIasi 700483Romania

BACKGROUND Lung and airway involvement in inflammatory bowel disease are increasingly frequently reported either as an extraintestinal manifestation or as an adverse effect of *** SUMMARY We report a case of a patient with ulcerative colitis controlled under mesalazine treatment who presented with chronic cough and *** computed tomography and bronchoscopy findings supported tracheal involvement in ulcerative colitis;pathology examination demonstrated an unusual eosinophilrich inflammatory pattern,and together with clinical data,a nonasthmatic eosinophilic bronchitis diagnosis was *** recovery was observed within days of mesalazine *** Mesalazine-induced eosinophilic respiratory disorders have been previously reported,generally involving the lung *** the best of our knowledge,this is the first report of mesalamine-induced eosinophilic involvement in the upper airway.

关键词： Mesalamine Ulcerative colitis Hemoptysis Bronchitis Drug-related side effects Case report

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Visual rating and the use of image analysis for assessing canopy density in a pecan provenance collection during leaf fall

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林业研究:英文版 2023年第6期34卷 1843-1854页

作者： cristina Pisani Clive H.Bock Jennifer Randall United States Department of Agriculture−Agricultural Research Service (USDA-ARS)Southeastern Fruit and Tree Nut Research Station(SEFTNRS)ByronGA 31008USA Department of Entomology Plant Pathology and Weed ScienceNew Mexico State UniversityLas CrucesNM 88003USA

A collection representing the native range of pecan was planted at the US DA-ARS Southeastern Fruit and Tree Nut Research Station,Byron,*** collection(867 trees)is a valuable genetic resource for characterizing important horticultural *** density during leaf fall is important as the seasonal canopy dynamics provides insights to environmental cues and breeding potential of *** ability of visual raters to estimate canopy density on a subset of the provenance collection(76 trees)as an indicator of leaf shed during autumn along with image analysis values was *** canopy density using the image analysis software was less compared to visual estimates(11.9%vs 18.4%,respectively).At higher canopy densities,the raters overestimated foliage density,but overall agreement between raters and measured values was good(ρc=0.849 to 0.915),and inter-rater reliability was high(R^(2)=0.910 to 0.953).The provenance from Missouri(MOL),the northernmost provenance,had the lowest canopy density in November,and results show that the higher the latitude of the provenance,the lower the canopy *** on regression,the source provenance latitude explained 0.609 of the variation using image analysis,and0.551 to 0.640 when based on the rater estimates of canopy *** assessment of pecan canopy density due to late season leaf fall for comparing pecan genotypes provides accurate and reliable estimates and could be used in future studies of the whole provenance collection.

关键词： Carya illinoinensis Accuracy Reliability Canopy Foliage density Leaf area density Leaf area index

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Model Identification and Control of Electromagnetic Actuation in Continuous Casting Process With Improved Quality

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 203-215页

作者： Isabela Birs cristina Muresan Dana Copot Clara Ionescu Research Group of Dynamical Systems and Control Faculty of Engineering and ArchitectureGhent University and with EEDT Decision&ControlFlanders Make ConsortiumTech Lane Science Park 125 and 131B-9052 GhentBelgium.I.Birs the Automation Department Faculty of Automation and Applied InformaticsTechnical University of Cluj-NapocaRomania IEEE

This paper presents an original theoretical framework to model steel material properties in continuous casting line process. Specific properties arising from non-Newtonian dynamics are herein used to indicate the natural convergence of distributed parameter systems to fractional order transfer function models. Data driven identification from a real continuous casting line is used to identify model of the electromagnetic actuator device to control flow velocity of liquid steel. To ensure product specifications, a fractional order control is designed and validated on the system. A projection of the closed loop performance onto the quality assessment at end production line is also given in this paper.

关键词： Electromagnetic actuator fractional order control fractional order system model non-Newtonian material

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Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

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Evolving strategies for liver fibrosis staging: Non-invasive assessment

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World Journal of Gastroenterology 2017年第2期23卷 191-196页

作者： cristina Stasi Stefano Milani Department of Experimental and Clinical Medicine University of Florence Department of Biomedical Experimental and Clinical SciencesUniversity of Florence

Transient elastography and the acoustic radiation force impulse techniques may play a pivotal role in the study of liver fibrosis. Some studies have shown that elastography can detect both the progression and regression of fibrosis. Similarly, research results have been analysed and direct and indirect serum markers of hepatic fibrosis have shown high diagnostic accuracy for advanced fibrosis/cirrhosis. The prognosis of different stages of cirrhosis is well established and various staging systems have been proposed, largely based on clinical data. However, it is still unknown if either noninvasive markers of liver fibrosis or elastography may contribute to a more accurate staging of liver cirrhosis, in terms of prognosis and fibrosis regression after effective therapy. In fact, not enough studies have shown both the fibrosis regression in different cirrhosis stages and the point beyond which the prognosis does not change- even in the event of fibrosis regression. Therefore, future studies are needed to validate noninvasive methods in predicting the different phases of liver cirrhosis.

关键词： Elastography Non-invasive methods Chronic liver diseases Stiffness Non-invasive serum markers

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Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2691-2692页

作者： cristina Municio Eva Carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neurobiology of Alzheimer’s disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain

Lactoferrin is an antimicrobial prote in characterized by the exertion of many protective functions,including antibacterial,antifungal,antiviral,and antiparasitic properties,as well as anti-inflammatory and immunomodulatory activities(Kruzel et al.,2017).Lactoferrin is one of the major proteins present in exocrine secretions,including saliva,and is therefore associated with host defense against oral pathogens and control of the oral *** recent years,it has become clear that alterations in the oral microbiome may contribute to opportunistic pathogen infections in the brains of Alzheimer’s disease(AD)patients and thus participate in or contribute to the development of this neurodegenerative disease(Sureda et al.,2020).Pathogenic oral microbes can affect neurological processes by entering brain tissue through various pathways and directly damaging the central nervous *** the central nervous system,oral microbes may trigger an immune response that increases amyloidβ(Aβ)production and may even trigger the Aβcascade to promote the onset of AD,as we discuss in our previous study supporting the“infectious hypothesis”in AD(González-Sánchez et al.,2020).

关键词： Alzheimer infections protective

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