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Metabolic-associated fatty liver disease is associated with low muscle mass and strength in patients with chronic hepatitis B

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World Journal of Hepatology 2022年第8期14卷 1652-1666页

作者： Cecy Maria de Lima Santos Matheus Duarte Brito Pedro Alves Soares Vaz de Castro Thais Pontello de Vries Nataly Lopes Viana Marta Paula Pereira Coelho Olívio Brito Malheiro Tatiana Bering Maria cristina gonzalez Rosangela Teixeira Rodrigo Dias Cambraia Gifone Aguiar Rocha Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Locomotor System Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Food and Nutrition Universidade Federal de Mato GrossoCuiabá78060-900Mato GrossoBrazil Postgraduate Program in Health and Behaviour Catholic University of PelotasPelotas 96015-560Rio Grande do SulBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Internal Medicine Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(CHB).Beyond virus-related factors,nutritional and metabolic aspects can be associated with skeletal muscle abnormalities in these patients and should not be *** To evaluate the association between components of sarcopenia and demographic,clinical,lifestyle,nutritional,and biochemical variables in CHB *** Dual-energy X-ray absorptiometry(DXA)was used to assess muscle mass by quantifying appendicular lean mass(ALM)adjusted for body mass index(ALMBMI).Muscle function was evaluated by hand grip strength(HGS)and the timed up and go ***-associated fatty liver disease(MAFLD)was defined according to the criteria proposed by an international expert panel.A body shape index and the International Physical Activity Questionnaire were used to assess central obesity and physical activity level,*** This cross-sectional study included 105 CHB outpatients followed at the tertiary care ambulatory centre(mean age,48.5±12.0 years;58.1%males;76.2%without cirrhosis;23.8%with compensated cirrhosis).The DXA-derived fat mass percentage was inversely correlated with the ALMBMI(r=-0.87)and HGS(r=-0.63).In the multivariable analysis,MAFLD,sedentarism and central obesity were positively and independently associated with low *** and central obesity were independently associated with low *** MAFLD and central obesity were associated with low muscle mass and strength in patients with chronic hepatitis B,independent of the liver disease stage.

关键词： Chronic hepatitis B Appendicular lean mass Muscle strength Metabolic associated fatty liver disease Central obesity Physical performance

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Microfluidics-enabled phenotyping of a whole population of *** worms over their embryonic and post-embryonic development at single-organism resolution

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Microsystems & Nanoengineering 2018年第1期4卷 345-355页

作者： Maria cristina Letizia Matteo Cornaglia Raphaël Trouillon Vincenzo Sorrentino Laurent Mouchiroud Maroun S.Bou Sleiman Johan Auwerx martin A.M.Gijs Ecole Polytechnique Fédérale de Lausanne Laboratory of MicrosystemsLausanneSwitzerland Ecole Polytechnique Fédérale de Lausanne Laboratory of Integrative Systems PhysiologyLausanneSwitzerland

The organism Caenorhabditis elegans is a performant model system for studying human biological processes and diseases,but until now all phenome data are produced as population-averaged *** of individual responses to drug treatments would however be more ***,a new strategy to track different phenotypic traits of individual *** nematodes throughout their full life-cycle-i.e.,embryonic and post-embryonic development,until adulthood onset,differently from life-span-is *** an automated fashion,single worms were synchronized,isolated,and cultured from egg to adulthood in a microfluidic device,where their identity was preserved during their whole *** phenotypes were monitored and quantified for each animal,resulting in high-content phenome ***,the method was validated by analyzing the response of *** to doxycycline,an antibiotic fairly well-known to prolong the development and activate mitochondrial stress-response pathways in different ***,the obtained extensive single-worm phenome not only confirmed the dramatic doxycycline effect on the worm developmental delay,but more importantly revealed subtle yet severe treatment-dependent phenotypes that are representative of minority subgroups and would have otherwise stayed hidden in an averaged *** heterogeneous response started during the embryonic development,which makes essential having a dedicated chip that allows including this early developmental stage in the drug *** approach would therefore allow elucidating pharmaceutical or therapeutic responses that so far were still being overlooked.

关键词： fluid treatment otherwise

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Influence of laser polarization on collective electron dynamics in ultraintense laser-foil interactions

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High Power Laser Science and Engineering 2016年第3期4卷 120-126页

作者： Bruno gonzalez-Izquierdo Ross J.Gray martin King Robbie Wilson Rachel J.Dance Haydn Powell David A.Mac Lellan John McCreadie Nicholas M.H.Butler Steve Hawkes James S.Green Chris D.Murphy Luca C.Stockhausen David C.Carroll Nicola Booth Graeme G.Scott Marco Borghesi David Neely Paul McKenna SUPA Department of Physics University of Strathclyde Central Laser Facility STFC Rutherford Appleton Laboratory Department of Physics University of York Centro de Láseres Pulsados (CLPU) Centre for Plasma Physics Queens University Belfast

The collective response of electrons in an ultrathin foil target irradiated by an ultraintense(~6×10^(20)W cm^(-2)) laser pulse is investigated experimentally and via 3D particle-in-cell simulations. It is shown that if the target is sufficiently thin that the laser induces significant radiation pressure, but not thin enough to become relativistically transparent to the laser light, the resulting relativistic electron beam is elliptical, with the major axis of the ellipse directed along the laser polarization axis. When the target thickness is decreased such that it becomes relativistically transparent early in the interaction with the laser pulse, diffraction of the transmitted laser light occurs through a so called ‘relativistic plasma aperture', inducing structure in the spatial-intensity profile of the beam of energetic electrons. It is shown that the electron beam profile can be modified by variation of the target thickness and degree of ellipticity in the laser polarization.

关键词： laser–plasmas interaction ultraintense ultrashort pulse laser interaction with matters

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Pulmonary arterial hypertension related to human immunodeficiency virus infection:A case series

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World Journal of Cardiology 2014年第6期6卷 495-501页

作者： Inês Araújo cristina Enjuanes-Grau Carmen Jimenez Lopez-Guarch Dariusz Narankiewicz Maria J Ruiz-Cano Teresa Velazquez-martin Juan Delgado Pilar Escribano 3~(rd) Medicine Department S?o Francisco Xavier HospitalCHLO1449-005 LisboaPortugal Cardiology Department University Hospital of Canarias38320 La LagunaTenerifeSpain Teresa Velazquez-martin Juan DelgadoPilar EscribanoPulmonary Hypertension UnitUniversity Hospital of 12 de Octubre28041 MadridSpain Internal Medicine Department Carlos Haya Hospital29010 MálagaSpain Pulmonary Hypertension Unit University Hospital of 12 de Octubre28041 MadridSpain

AIM: To present 18 new cases of human immunodeficiency virus(HIV)-related pulmonary arterial hypertension(PAH) with presenting features,treatment options and follow-up ***: This is a single-centre,retrospective,observational study that used prospectively collected data,conducted during a 14-year period on HIV-related PAH patients who were referred to a pulmonary hy-pertension unit. All patients infected with HIV were consecutively admitted for an initial evaluation of PAH during the study period and included in our study. Right heart catheterisation was used for the diagnosis of PAH. Specific PAH treatment was started according to the physician's judgment and the recommendations for idiopathic PAH. The data collected included demographic characteristics,parameters related to both HIV infection and PAH and disease ***: Eighteen patients were included. Intravenous drug use was the major risk factor for HIV infection. Risk factors for PAH,other than HIV infection,were present in 55.5% patients. The elapsed time between HIV infection and PAH diagnoses was 12.2 ± 6.9 years. At PAH diagnosis,94.1% patients had a CD4 cell count > 200 cells/μL. Highly active antiretroviral therapy(present in 47.1% patients) was associated with an accelerated onset of PAH. Survival rates were 93.8%,92.9% and 85.7% at one,two and three years,respectively. Concerning specific therapy,33.3% of the patients were started on a prostacyclin analogue,and the rest were on oral drugs,mainly phosphodiesterase-5 inhibitors. During the follow-up period,specific therapy was de-escalated to oral drugs in all of the living ***: The survival rates of HIV-related PAH patients were higher,most likely due to new aggressive specific therapy. The majority of patients were on oral specific therapy and clinically stable. Moreover,sildenafil appears to be a safe therapy for less severe HIVrelated PAH.

关键词： Human immunodeficiency virus infection Pulmonary arterial hypertension Treatment

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Where to seek help? Barriers to beginning treatment during the first-episode psychosis

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International Journal of Nursing Sciences 2018年第3期5卷 249-254页

作者： Isabela dos Santos martin Bianca cristina Ciccone Giacon Kelly Graziani Giacchero Vedana Ana Carolina Guidorizzi Zanetti Lorena Fendrich Sueli Aparecida Frari Galera Department of Psychiatric Nursing and Human Sciences of University of Sao Paulo Ribeirao Preto College of NursingBrazil Federal University of Mato Grosso do Sul Brazil

Objective:As decreasing the duration of untreated psychosis has been highlighted as key indicator in relation to improved prognosis,this study aims to identify the access barriers to beginning early treatment of young people in first-episode psychosis(FEP),based on family reports on the experience of perceiving illness and ***:A qualitative research was carried out with 12 relatives of 12 young people passing through their first psychiatric hospital admission as a result of their *** interviews were used for data collection and thematic content method for data ***:Barriers to beginning treatment were lack of knowledge and difficulty in recognizing mental illness,lack of knowledge on where to seek specialized treatment,and stigma and resistance to psychiatric ***:It was demonstrated that the family members are protagonists in the search for treatment of young people in their FPE,given that the initiative for seeking treatment came from them.

关键词： Caregivers Family Mental health Psychiatry Psychotic disorders

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Aggressive Angiomyxoma: An Unusual Female Pelvic Tumour. Report of Three Cases and Review of the Literature

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Surgical Science 2010年第2期1卷 40-45页

作者： Juan Antonio martin-Cartes Manuel Bustos-Jimenez Maria Jesus Tamayo-Lopez Maria del Carmen Palacios-gonzalez Virginia Gomez-Cabeza de Vaca Antonio Muñoz Ortega Division of Surgery Abdominal Wall Surgery UnitSevilleSpain

Aggressive angiomyxoma was first described in 1983 by Steeper and Rosai, and fewer than 150 cases have been reported in the world medical literature. It is a soft-tissue tumour of the pelvis and perineum. The recurrence rate is high, and often extensive resections are performed with considerable morbidity. These tumours are benign, locally infiltrative mesenchymal neoplasms with a predilection for the female pelvis and perineum and they usually tend to recur. Furthermore, these tumours often reach too large dimensions before becoming clinically symptomatic;their incidence is higher in women of the reproductive age group;however a few cases of its occurrence outside the pelvis have also been reported. In this study, we reported three cases with aggressive pelvic angiomyxoma treated with surgical methods and used an approach that described by Kraske in order to get access to lower rectal cancers. Accurate preoperative diagnosis should alert the surgeon to the need for wide excision, which is essential for prevention of local recurrence.

关键词： Aggressive Angiomyxoma Soft Tissue Tumour Perineum and Pelvis Tumour

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A Comparative Study for Successful Treatment per Gender in a Specialized Smoking Cessation Unit in the Albacete University Hospital during Two Years

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Journal of Health Science 2015年第3期3卷 103-112页

作者： Francisco Javier Callejas gonzalez Genoves Crespo Marta Cruz Ruiz Javier Esquinas Lopez cristina Tarraga Lopez Pedro Juan Pablo Bermejo Lopez Tornero Molina Ana Isabel Pastrana Calderon Juan Molina Cano Angel Rodriguez Montes Jose Antonio Pneumonology Department The Albacete University Hospital Complex (CHUA) Albacete 02006 Spain Thoracic Surgery Department The Albacete University Hospital Complex (CHUA) Albacete 02006 Spain Pneumonology Department Vall d'Hebron University Hospital Barcelona 08035 Spain Integrated Care Management The Albacete University Hospital Complex (CHUA) Albacete 02006 Spain College of Computer Engineering Castilla-La Mancha University (UCLM) Albacete 02071 Spain General and Digestive Surgery Department La Paz University Hospital Madrid 28046 Spain

Objective： Analysis of abstinence rates of smokers per gender at 3, 6, 9 and 12 months in a Smoking Cessation Unit from January 2008 to December 2009. Methods： Descriptive retrospective study. Analysis of socio-demographic variables, smoking patterns, associated comorbidities, continuous abstinence rates, success, relapses, failure and dropping out. Results： 278 smokers started treatment （33%）; 55.4% males and 44.6% females （mean age of 48.3 and 44.06 years, respectively）. The main associated comorbidities were： psychiatric （38.7%）, cardiovascular （dyslipemia 25%） and respiratory （COPD （chronic obstructive pulmonary disease） 9.7%） in females; cardiovascular （dyslipemia 34.4%）, psychiatric （34.4%） and respiratory （COPD 19.5%） in males. VRN （Varenicline） was prescribed in 40.2% males and 32.2% females; NRT （nicotine replacement therapy） was used in 46.6% and 38.7%, respectively; bupropion was employed in 6.5% and 21.8%, respectively. Psychological counseling was offered only to 7.8% males and 8.1% females. The continuous abstinence rates in males at 3, 6, 9 and 12 months were 51.3%, 37.7%, 32.5% and 30.5%, respectively, and were 45.2%, 29.8%, 25.0% and 24.2% for females. Failure was 9.7% for females and 18.8% for males. Success was more frequent for those on VRN （n = 41 males; n = 12 females）. No relapses were indicated for 42 females and 71 males. The percentage of relapses was higher at 3 months （29.0% females, 19.5% males）. Conclusions： The study observed differences in treating abstinence between genders （in the abstinence rates and failure index）. This implies having to consider incorporating the gender variable into the diagnosis, treatment and prevention of smoking.

关键词： Smoking smoking cessation gender continuous abstinence successful treatment failure relapse

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High-Resolution Esophageal Manometry in Teenagers with Esophageal Atresia

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Open Journal of Epidemiology 2020年第1期10卷 81-89页

作者： Cecilia Zubiri Rosa Ramos Cecilia Curvale Raúl Matanó Paula Borobia Anabella Zosi Verónica Garrido Julieta Hernández Lucía Gutierrez Luciana Guzmán María cristina Arregui Marina Prozzi Sandro Miculan Viviana Bernedo Maximiliano Fernández Rivas cristina Lorenzo Florencia Recalde Verónica Valdiviezo Darío Fajre Cintia Antonioli Mariana Allende Claudia Losada Teresita gonzalez Department of Gastroenterology at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Gastroenterology at Hospital de Alta Complejidad El Cruce Florencio Varela Buenos Aires Argentina Posadas Hospital Buenos Aires Argentina Department of Nutrition at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Surgery at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Otorhinolaryngology at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Pneumonology at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina

Introduction: Children with surgically repaired esophageal atresia (EA) show esophageal dysmotility. Due to the performance of high-resolution manometry (HRM), three motility alteration patterns have been described, which allowed to know the segmental alterations. Objective: To describe the esophageal motility patterns found through HRM in teenagers with EA and to relate these with the associated esophageal pathology and its severity. Materials and Method: Ten teenagers were included with no history of esophageal blockage or dilations in the last six months, who were orally fed and asymptomatic. Through performance of HRM, we found surgical and endoscopic history, as well as of esophageal biopsies and pH monitoring. Results: We found the following patterns: aperistalsis, pressurization and distal contraction. 70% showed distal contraction, and 100% of esophageal endoscopies and biopsies were normal. 57% of the esophageal pH monitoring analyzed was pathologic. In the pressurization and aperistalsis groups, we observed severe esophagitis and requirement of Nissen antireflux procedure in 100% of the cases. Esophageal pH monitoring analyzed was 100% pathologic. Conclusion: We described the esophageal segmental alterations in teenagers with atresia by means of HRM. The distal contraction group showed better development, without severe esophagitis or requirement of antireflux procedure. Therefore, by performing an HRM in teenagers with EA, we could predict the future esophageal behavior, according to the peristaltic pattern, since there are significant differences among the groups in study.

关键词： High-Resolution Manometry Esophageal Atresia Teenagers

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The Children’s Faecal Matter Structure Is Built by Their Parents

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Open Journal of Epidemiology 2019年第1期9卷 64-74页

作者： Eduard Cueto Rua Ricardo Wright Cecilia Zubiri Luciana Guzmán Claudia Losada M. Inés Urrutia María T. gonzalez Ricardo Drut Mariela Espósito Norberto Recalde Jorge Fiad Ignacio Goni Natalia Belén María cristina Arregui Facultad de Ciencias Médicas Universidad Nacional de La Plata La Plata Argentina Comisión de Investigación Científica de la Provincia de Buenos Aires Buenos Aires Argentina Pediatric Hospital “Sor María Ludovica” La Plata Argentina Universidad Nacional de La Plata La Plata Argentina Consultant in Pediatrics Mar del Plata City Argentina Dolores City Argentina

Introduction: Humans have gone through physical changes over the last 4 million years. The mouth, however, has not changed teeth quantity or quality. Eight incisors for fruits, vegetables and tubers;four little canines for little animals;eight premolars and twelve flat molars are used for crushing these foods, especially whole grains and legumes. The teeth crushing foods are the first step in the building of faecal matter. Foods are selected mostly according to cultural guidelines than to biological needs. The patterns of consumption are induced by the publicity of industrialized or processed foods. Material and Methods: This study design was observational, analytical, correlational, transversal and prospective. One thousand children (0 - 12 years old) were questioned in order to learn about the relationship between Weekly Eating Frequency (WEF) and Faecal Matter (FM) characteristics. The FM was classified as soft, normal or hard and the outcome was expressed as Dry Faecal Residue (DFR). The WEF and Weekly Bowel Movement Frequency (WBMF) were determined and tabulated according to times per week. Environmental factors, parents’ education level and children’s birth order were examined. Results: There was a strong association between DFR, WBMF and WEF. Environment and education level did not play a key role although birth order did matter. Conclusions: Fibre-free foods (dairies, meats, flours and sweeties or sodas) increased DFR. Foods containing fibre from vegetables decreased DFR, which in turn contributed to the WBMF. Lowest DFR was observed in children under Exclusive Breastfeeding (EB). Distant last-born children had higher DFR. Comments: Daily examples support these results and it is clear that children’s FM is built by their parents. We encourage parents to follow the “mouth nature” rather than the “advertisements nature”.

关键词： Bowel Movement Frequency Constipation Culture Faecal Matter Foods

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拉普拉塔河流域以及巴塔哥尼亚地区及相关海域水生态栖息地的改变

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AMBIO－人类环境杂志 2004年第1期33卷 67-75页

作者： Ana cristina Mugetti Alberto Tomás Calcagno Carlos Alberto Brieva María Silvia Giangiobbe Andrea Pagani Silvia gonzalez 石秋池阿根廷水资源研究所 HIDRONOR(北巴塔哥尼亚水电局)董事会阿根廷国立Mar del Plata大学阿根廷国立Mar del Plata大学经济系布宜诺斯艾利斯大学

本文描述了南美大陆南部陆地和东南沿海地区环境特性及水生栖息地和群落的现状(GIWA巴塔哥尼亚大陆架亚区),结果来自一项GIWA项目框架任务所完成的一份全面评估,绝大部分依据的是公开发表的数据。分析主要集中在跨边界水资源目前的情况... 详细信息

本文描述了南美大陆南部陆地和东南沿海地区环境特性及水生栖息地和群落的现状(GIWA巴塔哥尼亚大陆架亚区),结果来自一项GIWA项目框架任务所完成的一份全面评估,绝大部分依据的是公开发表的数据。分析主要集中在跨边界水资源目前的情况和人类活动带来的影响。内陆水体的栖息地和群落变化主要是由为发电和其他用途而建的水坝和水库引起的。从活水环境到净水环境影响了生境,造成了生物群落的改变。在拉普拉塔(La Plata)河流域,外来入侵物种使本地物种消失。过度捕捞和污染影响了生物多样性,造成了海洋栖息地质量下降。本篇文章讨论了相关的原因,讨论了布宜诺斯艾利斯省和渔业资源由两国共享的阿根廷—乌拉圭公共渔业区对沿海生态环境的政策选择。

关键词：拉普拉塔河流域生态系统 GIWA 食物链环境保护

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