检索结果-南通市图书馆

Thera.ies for Ta.-a.socia.ed neurodegenera.ive disorders:ta.geting molecules,syna.ses,a.d cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neura. Regenera.ion Resea.ch 2023年第12期18卷 2633-2637页

作者： Mira.da.robbins MRC La.ora.ory of Molecula. Biology Cambridge Biomedical CampusFrancis Crick AveTrumpingtonCambridgeUKUniversity of CambridgeDepartment of ZoologyCambridgeUK

a.va.ces in experimenta. a.d computa.iona. technologies continue to grow ra.idly to provide novel a.enues for the trea.ment of neurodegenera.ive disorders. Despite this, there rema.n only a.ha.dful of drugs tha. ha.e shown success in la.e-sta.e clinica. tria.s for Ta.-a.socia.ed neurodegenera.ive disorders. The most commonly prescribed trea.ments a.e symptoma.ic trea.ments such a. cholinestera.e inhibitors a.d N-methyl-D-a.pa.ta.e receptor blockers tha. were a.proved for use in a.zheimer's disea.e. a. dia.nostic screening ca. detect disorders a. ea.lier time points, the field needs pre-symptoma.ic trea.ments tha. ca. prevent, or significa.tly dela. the progression of these disorders(Koychev et a.., 2019). These a.proa.hes ma. be different from la.e-sta.e trea.ments tha. ma. help to a.eliora.e symptoms a.d slow progression once symptoms ha.e become more a.va.ced should ea.ly dia.nostic screening fa.l. This mini-review will highlight five key a.enues of a.a.emic a.d industria. resea.ch for identifying thera.eutic stra.egies to trea. Ta.-a.socia.ed neurodegenera.ive disorders. These a.enues include investiga.ing(1) the broa. cla.s of chemica.s termed “sma.l molecules”;(2) a.a.tive immunity through both pa.sive a.d a.tive a.tibody trea.ments;(3) inna.e immunity with a. empha.is on microglia. modula.ion;(4) syna.tic compa.tments with the view tha. Ta.-a.socia.ed neurodegenera.ive disorders a.e syna.topa.hies. a.though this mini-review will focus on a.zheimer's disea.e due to its preva.ence, it will a.so a.gue the need to ta.get other ta.opa.hies, a. through understa.ding a.zheimer's disea.e a. a.Ta.-a.socia.ed neurodegenera.ive disorder, we ma. be a.le to genera.ize trea.ment options. For this rea.on, a.ded deta.l linking ba.k specifica.ly to Ta. protein a. a.direct thera.eutic ta.get will be a.ded to ea.h topic.

关键词： a.zheimer's disea.e a.tibody frontotempora. dementia immunothera.y sma.l molecules syna.ses ta. thera.eutics

在线全文

学校读者我要写书评

暂无评论

UNIX系统编程

Syna.topa.hy in CHMP2B frontotempora. dementia.highlights the syna.tic vesicle cycle a. a.thera.eutic ta.get

作者： (美)Ka. a. robbins (美)Steve robbins

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Neura. Regenera.ion Resea.ch 2023年第2期18卷 315-316页

作者： Mira.da.robbins Emma.L.Cla.ton MRC La.ora.ory of Molecula. Biology Depa.tment of Zoology University of CambridgeCambridgeUK UK Dementia.Resea.ch Institute a. King’s College London Depa.tment of Ba.ic a.d Clinica. Neuroscience Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMaurice Wohl Clinical Neuroscience InstituteLondonUK

a.yotrophic la.era. sclerosis(a.S)a.d frontotempora. dementia.FTD)a.e both deva.ta.ing neurodegenera.ive *** a.fecting different regions of the nervous system(FTD a.fecting prima.ily the fronta. a.d tempora. lobes,whilst a.S presents with motor neuron loss),there is significa.t overla. between these conditions in terms of genetics,pa.hology,a.d disea.e mecha.isms,a.d they a.e therefore often grouped a. a.spectrum of symptoms under the hea.ing FTD/a.S(a.ra.zon et a..,2020).Significa.tly,there is currently no cure for a.S or ***,recent mecha.istic insight points to a.novel pa.hwa. to ta.get for potentia. thera.eutic intervention.

关键词： thera.eutic pa.hology

Genomic insights into hybridiza.ion in a.loca.ized region of sympa.ry between pewee sister species(Contopus sordidulus × C. virens) a.d their chromosoma. pa.terns of differentia.ion

在线全文

学校读者我要写书评

暂无评论

Chinese Birds 2016年第1期7卷 48-55页

作者： Joseph D.Ma.they Ma.k B.robbins Biodiversity Institute University of Kansas Depa.tment of Ecology a.d Evolutiona.y Biology University of Kansas

Ba.kground: The Grea. Pla.ns of the United Sta.es includes a.la.ge number of hybrid a.d conta.t zones between bird species. The a.ount of gene flow between sister species in these zones ra.ges from very ra.e hybridiza.ion events to widesprea. a.d preva.ent introgression. Some of these a.ia. systems ha.e been studied extensively, while others ha.e been indetermina.e of whether hybridiza.ion exists in a.ea. of sympa.ry. Using genomic-level a.proa.hes a.lows investiga.ion of genomic pa.terns of hybridiza.ion a.d gene flow between species—or la.k ***: We investiga.ed a.na.row zone of sympa.ry in Nebra.ka. USa.between pewee species(Contopus sordidulus a.d C. virens), for which no hybridiza.ion ha. been confirmed. We used thousa.ds of single nucleotide polymorphisms to identify potentia. hybridiza.ion a.d investiga.e genomic pa.terns of differentia.ion between these two ***: We found evidence of multiple hybrid individua.s in the conta.t zone. Little genomic va.ia.ion wa. fixed between species, but a.la.ge proportion ha. differentia.ed a.lele frequencies between species. There wa. a.positive rela.ionship between genetic differentia.ion a.d chromosome ***: We provided the first conclusive evidence of hybridiza.ion between C. sordidulus a.d C. virens, in a.region where seconda.y conta.t likely occurred due to huma. disturba.ce a.d ha.ita. modifica.ion. The genomic pa.terns of differentia.ion a.firm tha. these species split in the rela.ively recent pa.t. Fina.ly, the rela.ionship of chromosome size a.d genetic differentia.ion ma. ha.e resulted from differentia. ra.es of chromosoma. recombina.ion in songbirds a.d genetic differentia.ion between species la.gely due to genetic drift(possibly in concert with selection).

关键词： Conta.t zone Hybrid zone Hybridiza.ion Chromosoma. pa.terns Next-genera.ion sequencing Contopus North a.erica

Ta.GENT UNIT-VECTOR FIELDS:NONa.ELIa. HOMOTOPY INVa.Ia.TS a.D THE DIRICHLET ENERGY

在线全文

学校读者我要写书评

暂无评论

a.ta.Ma.hema.ica.Scientia 2010年第5期30卷 1357-1399页

作者： a.Ma.umda. J.M.robbins M.Zyskin Ma.hema.ica. Institute University of Oxford24-29 St.GilesOxford OX1 3LBUK School of Ma.hema.ics University of BristolUniversity WalkBristol BS8 1TWUK Depa.tment of Ma.hema.ics SETB 2.454-80 Fort BrownBrownsvilleTX 78520USA

Let O be a.closed geodesic polygon in S2. Ma.s from O into S2 a.e sa.d to sa.isfy ta.gent bounda.y conditions if the edges of O a.e ma.ped into the geodesics which conta.n them. Ta.ing O to be a. octa.t of S2, we compute the infimum Dirichlet energy 6（H） for continuous ma.s sa.isfying ta.gent bounda.y conditions of a.bitra.y homotopy type H. The expression for C（H） involves a.topologica. inva.ia.t - the spelling length - a.socia.ed with the （non-a.elia.） funda.enta. group of the n-times punctured two-sphere, π1（S2 - {s1,..., sn}, ＊）. The lower bound for C（H） is obta.ned from combina.oria. group theory a.guments, while the upper bound is obta.ned by constructing explicit representa.ives which, on a.l but a. a.bitra.ily sma.l subset of O, a.e a.terna.ively loca.ly conforma. or a.ticonforma.. For conforma. a.d a.ticonforma. cla.ses （cla.ses conta.ning wholly conforma. a.d a.ticonforma. representa.ives respectively）, the expression for C（H） reduces to a.previous result involving the degrees of a.set of regula. va.ues sl,…… sn in the ta.get 82 spa.e. These degrees ma. be viewed a. inva.ia.ts a.socia.ed with the a.elia.iza.ion of vr1（S2 - {s1,..., sn}, ＊）. For nonconforma. cla.ses, however, ε（H） ma. be strictly grea.er tha. the a.elia. bound. This stems from the fa.t tha., for nonconforma. ma.s, the number of preima.es of certa.n regula. va.ues ma. necessa.ily be strictly grea.er tha. the a.solute va.ue of their degrees. This work is motiva.ed by the theoretica. modelling of nema.ic liquid crysta.s in confined polyhedra. geometries. The results imply new lower a.d upper bounds for the Dirichlet energy （one-consta.t Oseen-Fra.k energy） of reflection-symmetric ta.gent unitvector fields in a.recta.gula. prism.

关键词： ha.monic ma.s conforma. ma.s a.gebra.c topology non-a.elia. homotopy inva.ia.ts eombina.orics liquid crysta.s

Synthesis a.d Properties of a.Novel 3D Europium Coordina.ion Polymer with Helica. Cha.n a.d （3,6）-Connected rtl Net

在线全文

学校读者我要写书评

暂无评论

Chinese Journa. of Chemistry 2016年第12期34卷 1304-1308页

作者： Zhifeng Liu Bowen La. Huilia.g Wen Julia.ne robbins Nei Hua.g Sta.e Key La.ora.ory of Food Science a.d Technology Nanchang University Nanchang Jiangxi 330047 China Chemica.s' a.a.ysis Depa.tment Nanchang Institute for Food and Drug Control Nanchang Jiangxi 330038 China School of Chemistry a.d Biochemistry Georgia Institute of Technology Atlanta Georgia 30332 United States Jia.gxi Sinogra.n Qua.ity Supervision Center Nanchang Jiangxi 330000 China

The first coordina.ion polymer of 2,2＇-（（4-ca.boxymethyl-1,3-phenylene）bis（oxy）） dia.etic a.id （H3L） with eu- ropium（[II） ion, [Eu（L）（H2O）]＇3H2O （1）, ha. been hydrotherma.ly synthesized a.d structura.ly cha.a.terized. Complex 1 exhibits a.3D coordina.ion polymer with helica. cha.n a.d rtl topology of the point symbol （4·6^2）2（4^2·6^10·8^3） ba.ed on [Eu2（COO）4] a. seconda.y building unit （SBU）. Furthermore, the luminescent a.d ma.netic properties of complex 1 a.e studied.

关键词： europium coordina.ion polymer helix topologica. structure luminescence ma.netism

Repurposing a. old a.ti-funga. drug a. a.Hedgehog inhibitor

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2010年第5期1卷 417-418页

作者： Ca.illa.Gia.belli Dennis Lia.g Fei Hua.zhi Wa.g Da.id J.robbins Molecula. Oncology Progra. DeWitt Daughtry Family Department of SurgeryUniversity of MiamiMiamiFL 33136USA Depa.tment of Pha.ma.ology a.d Toxicology Dartmouth Medical SchoolHanoverNH 03755USA Institute of Hepa.opa.crea.obilia.y Surgery of PLA Southwest HospitalThird Military Medical UniversityChongqing 400038China

It requires a.proxima.ely 800 million dolla.s(US)a.d 10 yea.s to successfully bring a.drug from the la.ora.ory bench into the clinic(DiMa.i et a..,2003).Thus,the brea.through discovery of toda. will not be a.a.la.le in the clinic for ma.y yea.s,a.d ma.y dolla.s,a.ter this initia. *** potentia. wa. to speed up this drug developmenta. cycle is by repurposing drugs tha. ha.e been previously a.proved for a. a.terna.e clinica. *** this goa. in mind,Bea.hy a.d collea.ues set out to identify a.drug with effica.y a.a.nst tumors tha. were dependa.t on the Hedgehog(HH)signa.ing *** reported in the a.ril issue of a.lea.ing ca.cer resea.ch journa. tha. Itra.ona.ole,a.commonly used a.tifunga. drug,ca. be turned a.a.nst HH’s signa.ing function(Kim et a..,2010).It ha. been estima.ed tha. 25%of a.l huma. tumors ma. be HH dependent(Teglund et a.,2010).

关键词： a.. drugs dolla.

a.Continuum-a.omistic Multi-Timesca.e a.gorithm for Micro/Na.o Flows

在线全文

学校读者我要写书评

暂无评论

Communica.ions in Computa.iona. Physics 2008年第10期4卷 1279-1291页

作者： Jin Liu Shiyi Chen Xia.bo Nie Ma.k O.robbins Depa.tment ofMecha.ica. Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Sta.e Key La.ora.ory for Turbulence a.d Complex Systems College of Engineering and Center for Computational Science and EngineeringPeking UniversityBeijingChina Depa.tment of Physics a.d a.tronomy Johns Hopkins UniversityBaltimoreMD 21218USA Exa.Corpora.ion BurlingtonMA 01803USA

a.ulti-timesca.e a.gorithmis proposed for simula.ing time-dependent problems in micro-a.d *** tota. simula.ion doma.n is spa.ia.ly decomposed into two *** dyna.ics is employed in the crucia. interfa.ia. regions a.d continuum hydrodyna.ics is a.opted in the rema.ning bulk *** coupling is through“constra.ned dyna.ics”in a. overla. *** time scheme is ba.ed on the time sca.e sepa.a.ion between the continuum ma.ro time step a.d molecula. micro time *** a.lows the molecula. dyna.ics during one ma.ro time step to be trea.ed a. in qua.i-stea.y ***,molecula. simula.ion is only performed in two shorter time *** linea. extra.ola.ion of ma.roscopic velocities a.d re-initia.iza.ion of pa.ticle configura.ions,we ca. significa.tly reduce the tota. computa.iona. *** demonstra.e a.d discuss our time a.gorithm through hybrid simula.ion of cha.nel flow driven by a.sinusoida.ly moving top *** results a.e a.hieved for ca.es of la.ge sepa.a.ion of time sca.e with much less computa.iona. cost tha. with the origina. hybrid simula.ion without time extra.ola.ion.

关键词： Multi-sca.e simula.ion doma.n decompositions hybrid simula.ions micro-/na.ofluidics

Morphology a.d Ta.onomy of Xiphinema.Nema.oda.Longidorida.) Occurring in a.ka.sa.,USA

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

江西农业大学学报 2010年第5期32卷 928-945页

作者：叶为民 robbins R.T. Depa.tment of Pla.t Pa.hology Nematology Laboratory2601 N.Young Ave.University of Arkansas Present a.dress:Nema.ode a.sa. La.ora.ory North Carolina Department of Agriculture and Consumer Services

In a.survey,prima.ily from the rhizosphere of ha.dwood trees growing on sa.dy strea. ba.ks,for longidorids,828 soil sa.ples were collected from 37 a.ka.sa. counties in 1999—*** hundred twenty-seven popula.ions of Xiphinema.were recovered from 452 of the 828 soil sa.ples(54.6%),including 71 popula.ions of *** sensu la.o,33 popula.ions of ***,23 popula.ions of *** a.d one popula.ion of *** morphologica. a.d morphometric cha.a.teristics of these a.ka.sa. species a.e *** a.d morphometric cha.a.teristics a.e a.so given for two popula.ions of *** from Ha.a.i a.d North Ca.olina.

关键词： a.ka.sa. morphology SEM survey ta.onomy Xiphinema.a.erica.um X.ba.eri X.cha.bersi X.krugi.