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Food Bioscience 2022年第3期47卷 1358-1367页

作者： Ricardo Gómez-García Ana A.Vilas-Boas Manuela Machado Débora A.Campos cristóbal n.aguilar Ana R.Madureira Manuela Pintado Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina – Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal BBG-DIA.Bioprocesses and Bioproducts Group.Food Research Department School of ChemistryAutonomous University of CoahuilaSaltilloCoahuilaMexico

The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products,considering (i) the recovery and accessibility indexes,(ii) the changes on antioxidant activity,and (iii) the prebiotic *** exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were ***,these both parameters exhibited stable accessibility,accounting with 81.89%,76.55%,and 54.07% for TPC,ABTS and DPPH,*** gastrointestinal digestion,the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains,possibly associated with the high content of simple sugar (glucose and fructose).This fraction also showed to be safe on Caco-2 intestinal *** findings suggest that MPJ might be used as a potential food functional ingredient.

关键词： Melon by-products Functional ingredients Phenolic antioxidants Simulated digestion Prebiotic effect

Recent trends and technical advancements in biosensors and their emerging applications in food and bioscience

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Food Bioscience 2022年第3期47卷 1023-1050页

作者： Oluwatosin E.Bankole Deepak Kumar Verma Mónica L.Chávez González Juan Guzmán Ceferino JoséSandoval-Cortés cristóbal n.aguilar Department of Chemical Sciences Faculty of Science and Science EducationAnchor UniversityLagos StateNigeria Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpur721302West BengalIndia Bioprocesses Research Group Food Research DepartmentSchool of ChemistryUniversidad Autonoma de CoahuilaUnidad Saltillo25280CoahuilaMexico Los Ríos Multidisciplinary Academic Division Universidad Juárez Autónoma de TabascoTabascoMexico Department of Analytical Chemistry School of ChemistryUniversidad Autonoma de CoahuilaUnidad Saltillo25280CoahuilaMexico

Biosensor development has recently advanced as a result of their strong and indisputable uses as analytical methods in a variety of sectors,including medicine,food industry,environmental monitoring,metabolism,agriculture,military,and *** popularity of biosensors as devices for a variety of applications may be ascribed to their distinct advantages of fast or rapid analysis,high sensitivity,minimal sample demand and preparation,and no need for the specific skill of operation that traditional analytical procedures *** attempted to update earlier studies in this study by incorporating other materials that have been in use but have received less attention,such as carbon nano-onions(CnOs),metal-organic frameworks(MOFs),and biopolymers for biosensor manufacturing and design based on their unique *** assessment also took into account applicable applications in many *** considerable progress has been made in the application of biosensors,there is still a need for research development and enhancement,particularly in transforming most of the laboratory experiments that have already been published into portable on-site and implementable in the public domains.

关键词： Biosensors nanotechnology nano-materials Food quality and safety Food snd biomedical industry Industrial application

Total phenolic content,in vitro antioxidant activity and chemical composition of plant extracts from semiarid Mexican region

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Asian Pacific Journal of Tropical Medicine 2015年第2期8卷 104-111页

作者： Jorge E.Wong-Paz Juan C.Contreras-Esquivel Raúl Rodríguez-Herrera María L.Carrillo-Inungaray Lluvia I.López Guadalupe V.nevárez-Moorillón cristóbal n.aguilar Laboratory of Bioprocesses and natural Products Food Research DepartmentSchool of ChemistryUniversidad Autónoma de CoahuilaSaltillo25280México Laboratory of Biochemistry Multidisciplinary Academic Unit-HuastecaUniversidad Autónoma de San Luis Potosí79060Cd.VallesS.L.P.Mexico Department of Microbiology School of ChemistryUniversidad Autónoma de Chihuahua31125 ChihuahuaMexico

Objective:To determine the extraction suitable conditions of total phenolic content(TPC) by heat-reflux system,antioxidant activities and HPLC characterization of the aqueous-ethanolic extracts of Jatropha dioica(***)(Dragon's blood).Flourensia cernua(***)(Tar bush).Eucalyptus camaldulensis(***)(Eucalyptus) and Turnera diffusa(***)(Damiana).Methods:TPC was evaluated by the well-known colorimetric assay using FolinCiocalteu *** antioxidant activities were assayed by three methods based on scavenging of DPPH,ABTS and by lipid oxidation *** chemical composition of the extracts obtained was subject to HPLC ***:TPC in the plant extracts ranged from 2.3 to14.12 mg gallic acid equivalents/g for *** and ***,*** plant extracts of ***,*** and *** showed similar strong antioxidant activities on scavenging of DPPH and lipid oxidation *** contrast,*** extracts had lowest potential antioxidant in three assays *** assay showed the presence of several phenolic compounds in the extracts ***:The results obtained suggest that ***,*** and *** are potential sources to obtain bioactive phenolic compounds with high antioxidant properties which can be used in the factories as antioxidant agents or for treatments in diseases.

关键词： Plant-extracts Polyphenols natural antioxidants Mexican plants Heat-reflux system

Deep learning for broadleaf weed seedlings classification incorporating data variability and model flexibility across two contrasting environments

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Artificial Intelligence in Agriculture 2024年第2期12卷 29-43页

作者： Lorenzo León cristóbal Campos Juan Hirzel Instituto de Investigaciones Agropecuarias(InIA) INIA QuilamapuAvda.Vicente Méndez 515ChillánChile Fundacion ObservatorioÑuble Arauco 340ChillanChile

The increasing deployment of deep learning models for distinguishing weeds and crops has witnessed notable strides in agricultural ***,a conspicuous gap endures in the literature concerning the training and testing of models across disparate environmental *** methodologies either delineate a single dataset distribution into training,validation,and testing subsets or merge datasets from diverse condi-tions or distributions before their division into the *** study aims to ameliorate this gap by extending to several broadleaf weed categories across varied distributions,evaluating the impact of training convolutional neural networks on datasets specific to particular conditions or distributions,and assessing their performance in entirely distinct settings through three *** evaluating diverse network architectures and training approaches(finetuning versus feature extraction),testing various architectures,employing different training strategies,and amalgamating data,we devised straightforward guidelines to ensure the model's deployability in contrasting environments with sustained precision and *** Experiment 1,conducted in a uniform environment,accuracy ranged from 80%to 100%across all models and training strategies,with finetune mode achieving a superior performance of 94%to 99.9%compared to the feature extraction mode at 80%to 92.96%.Experiment 2 underscored a significant performance decline,with accuracy fig-ures between 25%and 60%,primarily at 40%,when the origin of the test data deviated from the train and valida-tion *** 3,spotlighting dataset and distribution amalgamation,yielded promising accuracy metrics,notably a peak of 99.6%for Resnet in finetuning mode to a low of 69.9%for InceptionV3 in feature extraction *** pivotal findings emphasize that merging data from diverse distributions,coupled with finetuned training on advanced architectures like Resnet and Mobilenet,markedly enhances

关键词： Artificial neural networks Deep learning Transfer learning Precision farming Feature extraction Finetuning Generalization Out-of-domain distribution Domain adaptation Multi-domain learning

Accuracy of tree mapping based on hand-held laser scanning comparing leaf-on and leaf-off conditions in mixed forests

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Journal of Forestry Research 2024年第5期35卷 14-25页

作者： Frederico Tupinambá-Simões Adrián Pascual Juan Guerra-Hernández cristóbal Ordóñez Tiago de Conto Felipe Bravo iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Department of Geographical Sciences University of MarylandCollege ParkMD 20742USA Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use of mobile laser scanning to survey forest ecosystems is a promising,scalable technology to describe forest 3D structures at high *** confirm the con-sistency in the retrieval of forest structural parameters using hand-held laser scanning(HLS),before operationalizing the method,confirming the data is *** analyzed the per-formance of tree-level mapping based on HLS under differ-ent phenology conditions on a mixed forest in western Spain comprising Pinus pinaster and two deciduous species,Alnus glutinosa and Quercus *** area was surveyed twice during the growing season(July 2022)and once in the deciduous season(February 2022)using several scan-ning *** reference data(418 trees,15 snags)was used to calibrate the HLS data and to assess the influence of phenology when converting 3D data into tree-level attrib-utes(DBH,height and volume).The HLS-based workflow was robust at isolating tree positions and recognizing stems despite changes in ***-six percent of all pairs matched below 65 *** DBH,phenology barely altered *** observed a strong agreement when comparing HLS-based tree height *** values exceeded 2 m when comparing height measurements,confirming height data should be carefully used as reference in remote sensing-based inventories,especially for deciduous *** volume was more precise for pines(r=0.95,and rela-tive RMSE=21.3–23.8%)compared to deciduous species(r=0.91–0.96,and relative RMSE=27.3–30.5%).HLS data and the forest structural complexity tool performed remark-ably,especially in tree positioning considering mixed forests and mixed phenology conditions.

关键词： Precision forestry Forest monitoring Mobile laser scanning Forest inventory

On the functions of astrocyte-mediated neuronal slow inward currents

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neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic n-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,n-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization nMDA receptor paroxysmal depolarizational shift slow inward current

Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease

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neural Regeneration Research 2024年第3期19卷 529-535页

作者： Sandro Huenchuguala Juan Segura-aguilar Escuela de Tecnología Médica Facultad de SaludUniversidad Santo TomásLos CarrerasOsornoChile Molecular&Clinical Pharmacology Instituto de Ciencias Biomedicas(ICBM)Faculty of medicineUniversity of ChileIndependenciaSantiagoChile

The positive effect of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effects,has encouraged the scientific community to look for new drugs that can stop the neurodegenerative process or even regenerate the neuromelanin-containing dopaminergic nigrostriatal *** preclinical studies with coenzyme Q10,mitoquinone,isradipine,nilotinib,TCH346,neurturin,zonisamide,deferiprone,prasinezumab,and cinpanemab prompted clinical ***,these failed and after more than 50 years levodopa continues to be the key drug in the treatment of the disease,despite its severe side effects after 4–6 years of chronic *** lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the human body as new drugs for Parkinson’s disease treatment is a big *** our opinion,the cause of these failures lies in the experimental animal models involving neurotoxins that do not exist in the human body,such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine,that induce a very fast,massive and expansive neurodegenerative process,which contrasts with the extremely slow one of neuromelanin-containing dopaminergic *** exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to(i)a degenerative model in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron,(ii)a neurotoxic event that is not expansive and(iii)the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neuromelanin-containing dopaminergic *** endogenous neurotoxin that fits this degenerative model involving one single neuron at a time is aminochrome,since it(i)is generated within neuromelanin-containing dopaminergic neurons,(ii)does not cause an expansive neurotoxic effect and(iii)triggers all the mechanisms involved in t

关键词： 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine aminochrome dopaminergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase M2-2

Chi-square automatic interaction detection(CHAID)analysis of the use of safety goggles and face masks as personal protective equipment(PPE)to protect against occupational biohazards

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Journal of Biosafety and Biosecurity 2024年第2期6卷 125-133页

作者： Raúl aguilar-Elena Juán JoséAgún-González Universidad Internacional de Valencia ValenciaSpain

Background:This study represents the first Spanish investigation to rigorously evaluate compliance with the use of safety goggles and face masks as essential personal protective equipment(PPE)in companies with workplaces involving exposure to biological ***:This study aimed to examine the degree of use of face masks and safety goggles as personal protective equipment(PPE),the factors that influence their use,and the profile of workers exposed to occupational biological agents in Spanish companies in the health sector,farming sector,meat industry,waste treatment plants,food industry,and veterinary ***:We conducted a cross-sectional descriptive study involving 590 Spanish workers from 51 *** developed a 34-item questionnaire to assess workers’perception of risk related to exposure to biological agents in their *** the questions,three were designed to measure the degree of use of key protective equipment in sectors with biological agent exposure:protective gloves,safety goggles or face *** only analyzed safety goggles and face *** performed various statistical analyses,including Cronbach’s alpha,frequency of endorsement,content validity ratio using Lawshe’s method,varimax rotation,the Kaiser-Meyer-Olkin test,and Bartlett’s sphericity test,to assess the internal consistency and reliability of the ***,we employed a chi-square automatic interaction detection(CHAID)segmentation analysis,using workers’responses regarding their attitudes toward safety goggles and face mask usage as PPE for protection against biological risks,with demographic variables as independent ***:In the current study,CHAID analysis revealed that workers exposed to group 2 biological agents used more safety goggles and face shields compared with workers exposed to other groups of biological ***,workers in laboratories and the food industry used face masks more than workers of other ***

关键词： PPE Safety googles and breath mask CHAID Biological Agents Occupational Biosafety

Transcriptomic responses to drought stress in the Patagonian southern beech nothofagus alpina

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Ecological Processes 2024年第2期13卷 192-203页

作者： Rita Maria Lopez Laphitz María Verónica Arana Santiago Agustín Varela Leandro Aníbal Becker Carolina Soliani María Marta Azpilicueta Paula Marchelli nicolás Bellora Instituto de Diversidad y Evolución Austral (CEnPAT COnICET ) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB InTA COnICET ) Instituto de Tecnologías nucleares para la Salud (COnICET )

Background Deciphering the genetic architecture of drought tolerance could allow the candidate genes identification responding to water stress. In the Andean Patagonian forest, the genus nothofagus represents an ecologically relevant species to be included in different genomic studies. These studies are scarce in South American ecosystems however represent an important source of genomic data in order to interpret future climate-change environment scenarios of these emblematic forests. Here, we achieved the assemblage of the transcriptome of n. alpina while searching for key genes of activated or suppressed metabolic pathways in response to drought *** De novo transcriptome assembly resulted in 104,030 transcripts. Following confirmation of drought conditions, based on reduction of leaf water potential and stomatal conductance, a differential gene expression analysis resulted in 2720 significantly expressed genes(1601 up-regulated and 1119 down-regulated). Enrichment analysis(over-representation analysis and gene set enrichment analysis) resulted in more than one hundred stress-responsive term ontologies(i.e. biological processes) and pathways. Terms such as response to abscisic acid and pathways such as plant hormone signal transduction or starch and sucrose metabolism were over-represented. Protein–protein interaction assessment resulted in networks with significantly expressed top common hub gene clusters(e.g. planttype cell wall biogenesis among down-regulated or ABA-signalling among up-regulated). These networks evidenced important regulators at gene expression such as transcriptional *** Responses of n. alpina seedlings to drought stress were evidenced by the activation of several genes linked to GO biological processes and KEGG pathways, which were mainly based on over-expression of specific protein kinases, phosphatases, synthases and transcription factors. This suggests an up-regulation of signalling pathways, triggered through pla

关键词： Climate change Differential gene expression Hub genes Patagonia Temperate forest

Cerebral venous sinus thrombosis:changing trends in the incidence,age and gender(findings from the CMC Vellore CVT registry)

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Stroke & Vascular neurology 2024年第3期9卷 252-257页

作者： Angel Miraclin T John Davis Prasad George Abraham ninan Mahasampath Gowri Deepti bal Atif Iqbal Ahmed Shaikh Rohit n Benjamin Appaswamy Thirumal Prabhakar Ajith Sivadasan Vivek Mathew Sanjith Aaron Department of neurological Sciences Christian Medical CollegeVelloreTamil NaduIndia Department of Biostatistics Christian Medical CollegeVelloreTamil NaduIndia

Background Multiple cerebral venous sinus thrombosis(CVT)registries from various geographical regions indicate that female gender,the use of contraceptive pills,pregnancy and puerperium are important risk *** this study,we report the changes in the epidemiology of patients with CVT managed over the past 26 *** The CMC Vellore CVT registry is a prospectively maintained database at the Christian Medical College,Vellore since January *** software was used to analyse the data and assess the changes in the incidence,age and gender distribution over the previous 26 *** Among 1701 patients treated during the study period,908(53%)were women and 793(47%)were *** mean incidence of CVT was 49 per 100000 admissions before 2010,which increased to 96 per 100000 after *** gender had a higher odds of developing CVT OR–2.07(CI 1.68 to 2.55,pning incidence of postpartum CVT after 2010 compared with the decade before 2010(50%vs 20%).The mean age at presentation had increased from 24.5 to 33.2 years in the last *** There was a clear change in the gender pattern from being a condition with female preponderance,to one where equal or more men are being *** incidence of postpartum CVT cases could be the driving *** increase in the overall incidence of CVT cases was noted,probably due to a higher index of clinical suspicion and better diagnostic imaging modalities.

关键词： CVT driving maintained