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应用三维重建超声组织多普勒成像技术测量心肌梗死左室不同部位的射血分数:活体羊实验研究(英文)

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中国现代医学杂志 2004年第18期14卷 6-10页

作者：王慧芳 LI Xiao-kui David J.Sahn Michael Jones crispin h.davies Rosemary A.Rusk Arthur D.Zetts 暨南大学医学院附属第二教学医院超声科广东深圳518020O Oregon health &Science University PortlandOregonUSA. National heart Lung and Blood Institute(NHLBI)BethesdaMarylandUSA.

目的用三维重建超声组织多普勒成像(3DTDI)方法,研究左室壁运动特点及左室不同部分的射血分数(EF)。方法用重建的3DTDI的方法,对8只心尖部心肌梗死的活体羊模型在四种不同的血流状态下进行左室壁运动的测定和左室不同部分的EF测量。结... 详细信息

目的用三维重建超声组织多普勒成像(3DTDI)方法,研究左室壁运动特点及左室不同部分的射血分数(EF)。方法用重建的3DTDI的方法,对8只心尖部心肌梗死的活体羊模型在四种不同的血流状态下进行左室壁运动的测定和左室不同部分的EF测量。结果在四种不同的血流状态下,左室梗死区域的室壁运动振幅明显低于正常部分(P<0.001),整个左室、左室正常部分的EF明显高于梗死部分(P<0.001),左室正常部分的EF明显高于整个左室(0.0001

关键词：三维超声心动图室壁瘤组织多普勒成像

Ionic thermoelectric materials and devices

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Journal of Energy Chemistry 2021年第10期30卷 88-103,I0003页

作者： Dan Zhao Alois Würger Xavier crispin Laboratory of Organic Electronics Linkoping UniversityNorrkoping 60247Sweden Univ.Bordeaux&CNRS LOMA(UMR 5798)F-33405 TalenceFrance Wallenberg Wood Science Center ITNLinköping UniversityNorrköpingSweden

The tremendous amount of wasted heat from solar radiation and industry dissipation has motivated the development of thermoelectric concepts that directly convert heat into *** main challenge in practical applications for thermoelectrics is the high cost from both materials and ***,breakthrough progresses in ionic thermoelectrics open up new possibilities to charge energy storage devices when submitted to a temperature *** charging voltage is internally from the ionic Seebeck effect of the electrolyte between two *** electrolytes with high thermoelectric figure of merit are classified as ionic thermoelectric *** ionic thermoelectric materials are composed of abundant elements,and they can generate hundreds of times larger thermal voltage than that of electronic *** emerging thermoelectric category brings new hope to fabricate low cost and large area heat-to-energy conversion devices,and triggers a renewed interest for ionic *** this review,we summarize the state of the art in the new field of ionic thermoelectrics,from the driving force of the ionic thermodiffusion to material and application *** present a general map of ionic thermoelectric materials,discuss the unique characters of each type of the reported electrolytes,and propose potential optimization and future topics of ionic thermoelectrics.

关键词： Electrolytes Soret effect Thermodiffusion Thermal energy conversion

Charge qubits based on ultra-thin topological insulator films

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Frontiers of physics 2024年第3期19卷 71-81页

作者： Kexin Zhang hugo V.Lepage Ying Dong crispin h.W.Barnes Research Center for Quantum Sensing Intelligent Perception Research InstituteZhejiang LabHangzhou 311121China Cavendish Laboratory Department of PhysicsUniversity of CambridgeCambridge CB30HEUnited Kingdom

We study how to use the surface states in a Bi2Se3 topological insulator ultra-thin film that are affected by finite size effects for the purpose of quantum *** demonstrate that:(i)surface states under the finite size effect can effectively form a two-level system where their energy levels lie in between the bulk energy gap and a logic qubit can be constructed,(ii)the qubit can be initialized and manipulated using electric pulses of simple forms,(iii)two-qubit entanglement is achieved through a√SWAP operation when the two qubits are in a parallel setup,and(iv)alternatively,a Floquet state can be exploited to construct a qubit and two Floquet qubits can be entangled through a Controlled-NOT *** Floquet qubit offers robustness to background noise since there is always an oscillating electric field applied,and the single qubit operations are controlled by amplitude modulation of the oscillating field,which is convenient experimentally.

关键词： topological insulator quantum computing nanodevices

hall measurements reveal band-like transport in high-mobility solution-processed organic semiconductor films

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National Science Review 2024年第8期11卷 53-54页

作者： Reverant crispin Igor Zozoulenko Laboratory of Organic Electronics Department of Science and Technology Link?ping University

Organic semiconductors, composed of conjugated molecules or polymers,can be designed with specific chemical compositions, crystalline structures,nano-morphologies and electronic properties using extensive chemical synthesis tools. high charge-carrier mobility,which is crucial for device performance in transistors, organic light emitting diodes(OLEDs) and solar cells, is influenced by the overlap between the π-orbitals of adjacent molecules.

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Current research on pharmacologic and regenerative therapies for osteoarthritis

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Bone Research 2015年第4期3卷 185-198页

作者： Wei Zhang hongwei Ouyang crispin R Dass Jiake Xu Center for Stem Cell and Tissue Engineering School of MedicineZhejiang University School of Pathology and Laboratory Medicine The University of Western Australia School of Pharmacy Building 306Curtin UniversityBentley

Osteoarthritis（OA）is a degenerative joint disorder commonly encountered in clinical practice,and is the leading cause of disability in elderly *** to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers,OA is a challenging disease with limited treatment *** pharmacologic therapies such as acetaminophen,non-steroidal anti-inflammatory drugs,and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse *** research focuses on the development of new OA drugs（such as sprifermin/recombinant human fibroblast growth factor-18,tanezumab/monoclonal antibody againstβ-nerve growth factor）,which aims for more effectiveness and less incidence of adverse effects than the traditional ***,regenerative therapies（such as autologous chondrocyte implantation（ACI）,new generation of matrix-induced ACI,cell-free scaffolds,induced pluripotent stem cells（iPS cells or iPSCs）,and endogenous cell homing）are also emerging as promising alternatives as they have potential to enhance cartilage repair,and ultimately restore healthy ***,despite currently available therapies and research advances,there remain unmet medical needs in the treatment of *** review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations.

关键词： cartilage regenerative articular challenging pluripotent disability restore repair degenerative advances

Resection of giant gastric GIST with a new generation ultrasonic scalpel device

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World Journal of Clinical Cases 2014年第1期2卷 9-11页

作者： crispin Schneider David F hewin Division of Surgery and Interventional Science University College London Bloomsbury Campus London WC1E 6AU United Kingdom Department of General Surgery Gloucestershire Royal Hospital Gloucester GL1 3NN United Kingdom

Gastrointestinal stroma tumours(GIST) are the most common mesenchymal tumour in the digestive tract and commonly found in the stomach. The patient described in this report presented with collapse and a palpable abdominal mass. he was found to have a large gastric GIST that penetrated through the mesocolon. Resection of the GIST was technically challenging but facilitated by a new generation ultrasonic scalpel device. In resection of gastric cancer the use of ultrasonic scalpels has been shown to reduce operating time, blood loss and length of stay. We feel that in technically challenging cases of gastric GIST the use of an ultrasonic scalpel device may be justified as well.

关键词： Gastrointestinal stroma tumours Ultrasonic scalpel harmonic Giant tumour Stomach

Stability of freeze-dried ph-responsive dextrin nanogels containing doxorubicin

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 648-654页

作者： Somkamol Manchun crispin R.Dass Pornsak Sriamornsak Department of Pharmaceutical Technology Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand Pharmaceutical Biopolymer Group(PBiG) Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand School of Pharmacy Faculty of Health SciencesCurtin UniversityPerth 6845Australia Curtin health Innovation Research Institute of Ageing and Chronic Disease Bentley 6102Australia

Induction of non-specific toxicities by doxorubicin(DOX) has restricted conventional DOXbased chemotherapy. p h-responsive dextrin nanogels(DNGs) have been fabricated in order to incorporate and deliver DOX to specific(targeted) sites. however, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated(25 °C/60% Rh) and long-term(5 °C) stability of DNGs prepared with formaldehyde(FDNGs) and glyoxal(GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared(initial day) and after storage at 5 °C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different(p > 0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was ph-dependent. however, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5 °C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5 °C.

关键词： Stability Nanogels Dextrin

The past,present,and future of piezoelectric fluoropolymers:Towards efficient and robust wearable nanogenerators

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Nano Research Energy 2023年第4期2卷 41-77页

作者： Md.Mehebub Aam Xavier crispin Laboratory of Organic Electronics Department of Science and TechnologyLinköping UniversityNorrköping SE-60174Sweden

Polyvinylidene difluoride(PVDF)derivatives in metal/PVDF/metal(MPM)sandwich structures have been studied extensively since *** copolymers of the same family have been discovered with fascinating piezoelectric,pyroelectric,electrocaloric,and ferroelectric *** processing,flexibility,lightweight,and thermal stability make this class of materials complementary to ***,PVDF based polymers potentially compete with inorganic materials for a broad range of technologies such as energy generators,loudspeakers,coolers,and ***,the stable non-electroactiveα-phase and hydrophobic nature of PVDF are the main barriers for developoing high performing and robust MPM devices in electronic *** this review,we present an up-to-date overview on different methods to induce the electroactiveβ-phase and improve the adhesion strength with metals to ensure robust and durable MPM *** go through advantages and disadvantages of several methods and pinpoint future opportunities in this research area.A special attention is paid to wearable piezoelectric nanogenerators for energy harvesting from human body motion,where flexible PVDF derivatives are compared with rigid piezoelectric *** the piezoelectric coefficient of PVDF(d_(33)~24–34 pm/V)is one order lower than ceramic materials,novel co-polymers of PVDF display d_(33)>1000 pm/V upon *** shows promise to bring piezoelectrics to flexible and large-area applications such as smart *** also discussed challenges to improve wearability,such as light weight,breathability,and flexibility.

关键词： polyvinylidene difluoride(PVDF) nanogenerators energy harvesting piezoelectric polymer surface modification metal-PVDF adhesion wearable generators

Aquatic photo-transformation and enhanced photoinduced toxicity of ionizable tetracycline antibiotics

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FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING 2024年第11期18卷 139页

作者： Ge, Linke Zheng, Jinshuai halsall, crispin Chen, Chang-Er Li, Xuanyan Cao, Shengkai Zhang, Peng Shaanxi Univ Sci & Technol Sch Environm Sci & Engn Xian 710021 Peoples R China Univ Lancaster Lancaster Environm Ctr Lancaster LA1 4YQ England South China Normal Univ Environm Res Inst Sch Environm Guangzhou 510006 Peoples R China

Most antibiotics contain ionizable groups that undergo acid-base dissociation giving rise to diverse dissociated forms in aquatic systems depending on the ph of the system. In sunlit surface waters, photochemical transformation plays a crucial role in determining the fate of antibiotics. This study presents a comprehensive examination of the photo-transformation degradation kinetics, pathways and photoinduced toxicity of three widely detected tetracyclines (TCs): tetracycline (TC), oxytetracycline (OTC), and chlortetracycline (CTC). Under simulated sunlight (lambda > 290 nm), their apparent photolysis followed pseudo-first-order kinetics, with rate constants significantly increasing from h2TCs0 to TCs2-. Through competition kinetic experiments and matrix calculations, it was found that the anions hTCs- or TCs2- (ph similar to 8-10) were more reactive toward hydroxyl radicals (center dot Oh), while TCs2- (ph similar to 10) reacted the fastest with singlet oxygen (O-1(2)). Considering the dissociated species, the total environmental photo-transformation half-lives of TCs were determined, revealing a strong dependence on the water ph and seasonal variation in sunlight. Generally, apparent photolysis was the dominant photochemical process, followed by O-1(2) and center dot Oh oxidation. Different transformation pathways for the three reactions were determined based on the key photoproducts identified using hPLC-MS/MS. Toxicity tests and ECOSAR software calculations confirmed that the intermediates produced by the center dot Oh and O-1(2) photo-oxidation processes were more toxic than the parent compounds. These findings significantly enhance our understanding of the complex photochemical fate and associated risks of TCs in aqueous environments.

关键词： Tetracyclines Dissociation Photodegradation kinetics Reactive oxygen species Transformation products Risks