Aquatic photo-transformation and enhanced photoinduced toxicity of ionizable tetracycline antibiotics

作     者：Linke Ge Jinshuai Zheng Crispin Halsall Chang-Er Chen Xuanyan Li Shengkai Cao Peng Zhang 

作者机构：School of Environmental Science and EngineeringShaanxi University of Science&TechnologyXi’an 710021China Lancaster Environment CentreLancaster UniversityLancaster LA14YQUK Environmental Research Institute/School of EnvironmentSouth China Normal UniversityGuangzhou 510006China 

出 版 物：《Frontiers of Environmental Science & Engineering》 (环境科学与工程前沿（英文）)

年 卷 期：2024年第18卷第11期

页      面：111-120页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by the Key Research and Development Program of Shaanxi Province(No.2024SF-YBXM-567) the National Natural Science Foundation of China(Nos.21976045 and 22076112) the China Scholarship Council(CSC)Scholarship(No.202308610123) the Shaanxi Key Laboratory of Environmental Monitoring and Forewarning of Trace Pollutants(No.SHJKFJJ202318) 

主　　题：Tetracyclines Dissociation Photodegradation kinetics Reactive oxygen species Transformation products Risks 

摘      要：Most antibiotics contain ionizable groups that undergo acid-base dissociation giving rise to diverse dissociated forms in aquatic systems depending on the pH of the *** sunlit surface waters,photochemical transformation plays a crucial role in determining the fate of *** study presents a comprehensive examination of the photo-transformation degradation kinetics,pathways and photoinduced toxicity of three widely detected tetracyclines(TCs):tetracycline(TC),oxytetracycline(OTC),and chlortetracycline(CTC).Under simulated sunlight(λ290 nm),their apparent photolysis followed pseudo-first-order kinetics,with rate constants significantly increasing from H_(2)TCs^(0)to TCs^(2–).Through competition kinetic experiments and matrix calculations,it was found that the anions HTCs–or TCs^(2–)(pH~8–10)were more reactive toward hydroxyl radicals(•OH),while TCs^(2–)(pH~10)reacted the fastest with singlet oxygen(^(1)O_(2)).Considering the dissociated species,the total environmental photo-transformation half-lives of TCs were determined,revealing a strong dependence on the water pH and seasonal variation in ***,apparent photolysis was the dominant photochemical process,followed by^(1)O_(2)and•OH *** transformation pathways for the three reactions were determined based on the key photoproducts identified using HPLC-MS/*** tests and ECOSAR software calculations confirmed that the intermediates produced by the•OH and 1O_(2)photo-oxidation processes were more toxic than the parent *** findings significantly enhance our understanding of the complex photochemical fate and associated risks of TCs in aqueous environments.