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渔业生态学

渔业生态学

作者： T.j.·皮切尔(T.j. Pitcher) P.j.B.·哈特(P.j.B. hart)

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哈利·布朗的永久投资组合

作者： (美)克雷格·罗兰(craig Rowland) (美)j.M. 劳森(j. M. Lawson)

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速度谱偏移的偏移速度分析

速度谱偏移的偏移速度分析

排球扣球的运动生理学分析及技术发展和训练方案的建议

美国勘探地球物理学家学会第61届年会

作者： craig j. Beasley Rolf Klotz 郭建 Western Atlas International Western Atlas International

地震数据偏移的精度既取决于选用的偏移方法的精度,也取决于偏移速度的精度。最近几年,人们已经发展了许多方法来改进偏移算法的精度和效率,但在大多数情况下,计算偏移速度场的方法由于需花费太多的计算量而不能作为常规处理。本文给出...

地震数据偏移的精度既取决于选用的偏移方法的精度,也取决于偏移速度的精度。最近几年,人们已经发展了许多方法来改进偏移算法的精度和效率,但在大多数情况下,计算偏移速度场的方法由于需花费太多的计算量而不能作为常规处理。本文给出了一种精确估算偏移速度的方法, 它在地震数据偏移前把波动方程法用在常规速度谱中。此外,这种方法的计算要求甚至对于三维测量也是容易满足的。偏移速度估计常常依靠经倾角时差校正（DMO）后数据上获得的叠加速度。而DMO速度比常规的叠加速度更加接近于真实的地下速度,但速度估算值取于未经偏移的位置,在用作为偏移速度前应移到正确的时空位置。通过合成和野外数据实例,我们打算表明常规偏移算法可用于把速度场置于正确的时空中经DMO校正后数据所求出的速度谱。所求的偏移速度场是真实地下速度的一种较好的估计,因此比未经偏移的速度信息更适用于数据偏移。

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山东体育科技 1993年第4期15卷 29-34页

作者： craig j.Cisar john Corbelli 陈军王明燕孙健

排球扣球是排球运动中最令人兴奋的进攻性技术之一。有力而落点好的扣球技能是每个优秀队员或排球队必备的重要进攻技术.由于良好的扣球涉及高度同步协调的运动姿势,因而扣球也是较难掌握的技术之一。本文从运动生理学角度对扣球技术进... 详细信息

排球扣球是排球运动中最令人兴奋的进攻性技术之一。有力而落点好的扣球技能是每个优秀队员或排球队必备的重要进攻技术.由于良好的扣球涉及高度同步协调的运动姿势,因而扣球也是较难掌握的技术之一。本文从运动生理学角度对扣球技术进行分析并对其有关技术发展和训练方案提出某些建议。

关键词：运动生理学训练方案进攻技术运动强度同步协调运动适应能力技术发展耐力训练强度训练水平速度

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克罗恩病及结肠癌中大肠埃希菌的黏附性和侵袭性增加

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 27-28页

作者： Martin H.M. Campbell B.j. hart C.A. j.M. Rhodes 翟惠虹 Department of Medicine Henry Wellcome Lab. Molec.Cell. G. Univ. of Liverpool United Kingdom Liverp oolUnited Kingdom

Background &Aims: Altered mucosal glycosylation in inflammatory bowel disease and colon cancer could affect mucosal bacterial adherence. This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria,particula rly Escherichia coli, in these conditions. Methods:Mucosa-associated bacteria w ere isolated, after dithiothreitol mucolysis, from biopsy samples obtained at co lonoscopy(Crohn’s disease, n = 14 patients; ulcerative colitis, n = 21;noninfla med controls, n = 24) and at surgical resection (colon cancer, n = 21). Intramuc osal bacteria were grown after gentamicin treatment followed by hypotonic lysis. Results:Mucosa-associated and intramucosal bacteria were cultured more commonl y in Crohn’s disease (79%, P = 0.03; and 71%,P < 0.01, respectively), but not ulcerative colitis (38%and48%), than in noninflamed controls (42%and 29%) a nd were commonly cultured from colon cancers (71%and 57%). Mucosa-associated E. coli, which accounted for 53%of isolates,were more common in Crohn’s diseas e (6/14; 43%) than in noninflamed controls (4/24, 17%), as also were intramuco sal E. coli: Crohn’s disease, 29%; controls, 9%. E. coli expressed hemaggluti nins in 39%of Crohn’s cases and 38%of cancers but only 4%of controls, and th is correlated (P = 0.01) with adherence to the I407 and HT29 cell lines. Invasio n was cell-line dependent. E. coli, including nonadherent isolates, induced int erleukin-8 release from the cell lines. E. coli adhesins showed no blood group specificity, excepting 1 cancer isolate (HM44)with specificity for the Thomsen- Friedenreich antigen, but they could be blocked by soluble plantain fiber. Concl usions: These studies support a central role for mucosally adherent bacteria in the pathogenesis of Crohn’s disease and colon cancer. Soluble plant fibers that inhibit their adherence have therapeutic potential.

关键词：克罗恩病大肠埃希菌侵袭性结肠癌黏附性溃疡性结肠炎炎症性肠病非炎症性结肠镜检红细胞凝集素

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裂缝型致密气藏和页岩气藏的流一固耦合机制分析

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海洋地质 2013年第1期29卷 31-32页

作者： George j. MORIDIS jihoon KIM craig M. FREEMAN

本文通过数值模拟分析了页岩和致密砂岩这两种类型的裂缝型致密气藏的流一固耦合机制和过程。数学模型包括基于达西定律的多相流方程和有关储层流体热物理性质的准确描述。

关键词：致密气藏耦合机制裂缝型页岩数值模拟分析热物理性质致密砂岩储层流体

Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy against Human Cervical Cancer Cells in Vitro and in Mice

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Advances in Biological Chemistry 2016年第6期6卷 193-215页

作者： jill A. Gadzinski jianxia Guo Brian j. Philips Per Basse Ethan K. craig Lisa Bailey joseph Latoche john T. Comerci julie L. Eiseman Department of Obstetrics/Gynecology/Reproductive Sciences Magee Women’s Hospital of the University of Pittsburgh Pittsburgh PA USA Cancer Therapeutics Program University of Pittsburgh Cancer Institute and Department of Pharmacology and Chemical Biology School of Medicine University of Pittsburgh Pittsburgh PA USA Cancer Immunology Program University of Pittsburgh Cancer Institute and Department of Immunology School of Medicine University of Pittsburgh Pittsburgh PA USA School of Medicine University of Pittsburgh Pittsburgh PA USA Department of Cardiology Molecular Imaging Center University of Pittsburgh School of Medicine Pittsburgh PA USA

Background: Cervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy using Pc 4 in vitro and in vivo against human cervical cancer cells. Methods: CaSki and ME-180 cancer cells were grown as monolayers and spheroids. Cell growth and cytotoxicity were measured using a methylthiazol tetrazolium assay. Pc 4 cellular uptake and intracellular distribution were determined. For in vitro Pc 4 photodynamic therapy, cells were irradiated at 667 nm at a fluence of 2.5 j/cm2 at 48 h. SCID mice were implanted with CaSki and ME-180 cells both subcutaneously and intracervically. Forty-eight hours after Pc 4 photodynamic therapy was administered at 75 and 150 j/cm2. Results: The IC50s for Pc 4 and Pc 4 photodynamic therapy for CaSki and ME-180 cells as monolayers were, 7.6 μM and 0.016 μM and >10 μM and 0.026 μM;as spheroids, IC50s of Pc 4 photodynamic therapy were, 0.26 μM and 0.01 μM. Pc 4 was taken up within cells and widely distributed in tumors and tissues. Intracervical photodynamic therapy resulted in tumor death, however mice died due to gastrointestinal toxicity. Photodynamic therapy resulted in subcutaneous tumor death and growth delay. Conclusions: Pc 4 photodynamic therapy caused death within cervical cancer cells and xenografts, supporting development of Pc 4 photodynamic therapy for treatment of cervical cancer. Support: P30-CA47904, CTSI BaCCoR Pilot Program.

关键词： Cervical Cancer Lasers Silicon Phthalocyanine 4 Photodynamic Therapy

Kinetic Characterization of Na,K-ATPase Inhibition by the Acetaminophen Metabolite N-Acetylbenzoquinoneimine

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Open journal of Molecular and Integrative Physiology 2015年第1期5卷 1-17页

作者： jeff B. Helms Lauren P. Saunders jamie Meyer Charles j. Costa Eric Plowman Nick Williford Matthew Corbitt jeremy P. Holden craig Gatto Department of Biology Upper Iowa University Fayette IA USA Division of Neuroscience and Physiology Department of Biological Science Illinois State University Normal IL USA Department of Internal Medicine University of Wisconsin-Madison Medical Center Madison WI USA

N-acetylbenzoquinoneimine (NABQI) is a toxic metabolite of the common analgesic acetaminophen (APAP). NABQI is an electrophilic intermediate formed via the oxidation of APAP within the cytochrome P450 system. Within the normally recommended low-dose use of APAP, NABQI is a minor metabolite which is either quickly reduced back to APAP or conjugated to Glutathione (GSH) producing an innocuous by-product. However, with overdose or prolonged high-dose usage of acetaminophen, GSH levels can become depleted and the bioactive NABQI is thought to form adducts with proteins and oxidize protein sulfhydryls producing intra- and intermolecular disulfide bridges in proteins. In this work we investigated the effect of NABQI on purified kidney Na,K-ATPase to see if the clinical renal insufficiencies seen in APAP overdose may be linked to inhibition of the Na,K-ATPase. Our work has shown that NABQI does indeed inhibit the Na,K-ATPase in a dose dependent (IC50 = 19.8 ± 2.9 μM) and irreversible manner. Interestingly, brief storage of NABQI at -20°C eliminates the irreversible effects of the compound, and leads to a product that remains a potent reversible inhibitor of the Na,K-ATPase (IC50 = 58.7 ± 19.5 μM). Further, the reversible inhibition produced by stored NABQI competes with para-nitrop.

关键词： Na K-ATPase Paracetamol N-Acetylbenzoquinoneimine Overdose Renal Electrophillic

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders joseph Nelson Siewe Fodjo Olivia Kamoen Luis-jorge Amaral Amber Hadermann Chiara Trevisan Mark j.Taylor julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

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