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Use of mycophenolate mofetil in inflammatory bowel disease

2006年

作者： Albert M. craig ... [et al.].

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastroenterology 2009年第13期15卷 1594-1599页

作者： Terrence Tan Ian craig Lawrance Department of Gastroenterology Fremantle Hospital Centre for Inflammatory Bowel Diseases Fremantle Hospital Department of Medicine and Pharmacology University of Western AustraliaFremantle Hospital

AIM:To assess the efficacy and safety of mycophenolate mofetil(MMF)prospectively in inflammatory bowel disease(IBD)patients intolerant or refractory to conventional medical ***:Crohn's disease(CD)or ulcerative colitis/ IBD unclassified(UC/IBDU)patients intolerant or refractory to conventional medical therapy received MMF(500-2000 mg bid).Clinical response was assessed by the Harvey Bradshaw index(HBI)or colitis activity index(CAI)after 2,6 and 12 mo of therapy,as were steroid usage and adverse ***:Fourteen patients(9 CD/5 UC/IBDU;8M/6F;mean age 50.4 years,range 28-67 years)were treated and prospectively assessed for their response to oral *** the 11 patients who were not in remission on commencing MMF,7/11(63.6%)achieved remission by 8 *** 3 patients in remission on commencing MMF maintained their *** patients were still on MMF at 6 mo with 9/14(64.3%)in remission,while of 12 patients followed for 12 mo,8 were in remission without dose escalation(66.7%).Three patients were withdrawn from the MMF due to drug *** were no serious adverse events attributed due to the ***:MMF demonstrated efficacy in the management of difficult *** appeared safe,well tolerated and efficacious for both short and long-term therapy,without the need for dose *** evaluation of MMF comparing it to conventional immunosuppressants is required.

关键词： Inflammatory bowel disease Mycophenolatemofetil Therapy Crohn's disease Ulcerative colitis

Single-lens dynamic z-scanning for simultaneous in situ position detection and laser processing focus control

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Light(Science & Applications) 2023年第12期12卷 2655-2667页

作者： Xiaohan Du Camilo Florian craig B.Arnold Department of Mechanical and Aerospace Engineering Princeton UniversityPrincetonNJ 08544USA Department of Systems Engineering City University of Hong KongHong KongChina Institut für Werkstofftechnik Universität Kassel34125 KasselGermany Princeton Materials Institute Princeton UniversityPrincetonNJ 08544USA

Existing auto-focusing methods in laser processing typically include two independent modules,one for surface detection and another for z-axis *** latter is mostly implemented by mechanical z stage motion,which is up to three orders of magnitude slower than the lateral processing *** alleviate this processing bottleneck,we developed a single-lens approach,using only one high-speed z-scanning optical element,to accomplish both in situ surface detection and focus control quasi-simultaneously in a dual-beam *** probing beam scans the surface along the z-axis continuously,and its reflection is detected by a set of confocal *** on the temporal response of the detected signal,we have developed and experimentally demonstrated a dynamic surface detection method at 140-350 kHz,with a controlled detection range,high repeatability,and minimum linearity error of 1.10%.Sequentially,by synchronizing at a corresponding oscillation phase of the z-scanning lens,the fabrication beam is directed to the probed z position for precise focus ***,our approach provides instantaneous surface tracking by collecting position information and executing focal control both at 140-350 kHz,which significantly accelerates the axial alignment process and offers great potential for enhancing the speed of advanced manufacturing processes in three-dimensional space.

关键词： dynamic beam simultaneous

Multifaceted Bioinspiration for Improving the Shaft Resistance of Deep Foundations

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Journal of Bionic Engineering 2020年第5期17卷 1059-1074页

作者： Seyed Ali Aleali Paola Bandini craig Michael Newtson Center for Bio-mediated and Bio-inspired Geotechnics Department of Civil EngineeringNew Mexico State UniversityLas CrucesNew Mexico 88003-8001USA

This paper describes the bioinspiration process to derive design concepts for new deep foundation systems that have greater axial capacity per unit volume of pile material compared to conventional deep *** study led to bioinspired ideas that provide greater load capacity by increasing the pile shaft *** bioinspiration approach used problem-solving strategies to define the problem and transfer strategies from biology to geotechnical *** bioinspiration considered the load transfer mechanism of hydroskeletons and the anchorage of the earthworm,razor clam,kelp,and lateral roots of *** biostrategies that were transferred to the engineering domain included a flexible but incompressible core,passive behaviour against external loading,a longitudinally split shell that allows expansion for anchorage,and lateral root-type or setae-type anchoring *** concepts of three bioinspired deep foundation systems were proposed and *** advantage of this approach was illustrated with two examples of the new laterally expansive pile in drained sand under axial *** finite element analysis of these examples showed that the new laterally expansive pile can provide considerably greater load capacity compared to a conventional cylindrical pile due to the increased lateral confining pressure developed along the expanded pile core.

关键词： bioinspiration expansion anchorage deep foundation pile capacity frictional resistance

Rethinking random Hough Forests for video database indexing and pattern search

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Computational Visual Media 2016年第2期2卷 143-152页

作者： craig Henderson Ebroul Izquierdo Multimedia and Vision Research Group School of Electronic Engineering and Computer ScienceQueen Mary University of London

Hough Forests have demonstrated effective performance in object detection tasks, which has potential to translate to exciting opportunities in pattern search. However, current systems are incompatible with the scalability and performance requirements of an interactive visual search. In this paper, we pursue this potential by rethinking the method of Hough Forests training to devise a system that is synonymous with a database search index that can yield pattern search results in near real time. The system performs well on simple pattern detection, demonstrating the concept is ***, detection of patterns in complex and crowded street-scenes is more challenging. Some success is demonstrated in such videos, and we describe future work that will address some of the key questions arising from our work to date.

关键词： Hough Forests pattern detection pattern search machine learning

Stevens-Johnson syndrome complicating adalimumab therapy in Crohn's disease

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World Journal of Gastroenterology 2009年第35期15卷 4449-4452页

作者： Muna Salama Ian craig Lawrance Department of Gastroenterology Fremantle HospitalFremantle 6059WAAustralia Department of Gastroenterology Fremantle HospitalWAAustralia Centre for Inflammatory Bowel Diseases Fremantle HospitalWA Australia Department of Medicine and Pharmacology University of Western AustraliaFremantle HospitalFremantle 6059WA Australia

The anti-tumor necrosis factor(TNF)αmedications demonstrate efficacy in the induction of remission and its maintenance in numerous chronic inflammatory *** the increasing number of patients receiving anti-TNFαagents,however,less common adverse reactions will *** eruptions complicating treatment with an anti-TNFαagent are not uncommon,occurring in around 20%of patients. Adalimumab,a fully humanized antibody against TNFα, may be expected to cause minimal immune-mediated skin reactions compared to the chimeric monoclonal antibody,***,however,report a case of Stevens-Johnson syndrome that required hospitalization and cessation of adalimumab in a patient with Crohn’ s disease(CD).In this case report,a 29-year-old male with colonic and perianal CD with associated erythema nodosum and large joint arthropathy developed severe mucositis,peripheral rash and desquamation,fevers and respiratory symptoms concomitant with a second dose of 40 mg adalimumab after a 2 mo break from adalimumab *** biopsies of the abdominal wall confirmed erythema multiforme and the patient was on no other drugs and infective etiologies were *** patient responded rapidly to IV hydrocortisone and was able to be commenced on infliximab without recurrence of the Stevens-Johnson *** skin reactions have now been described in three of the TNFαantagonists(infliximab,etanercept and adalimumab).These reactions can be serious and prescribers need to be aware of the potential mucocutaneous side effects of these agents,especially as Stevens-Johnson syndrome is associated with significant morbidity and mortality.

关键词： Stevens-Johnson syndrome Crohn'sdisease Adalimumab Serious adverse effect

Estimation of food composition of Hodotermes mossambicus （Isoptera： Hodotermitidae） based on observations and stable carbon isotope ratios

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Insect Science 2011年第2期18卷 175-180页

作者： craig T. Symes Stephan Woodborne School of Animal Plant and Environmental Sciences University of the Witwatersrand Wits Natural Resources and the Environment CSIR Pretoria South Africa

The diet of the harvester termite Hodotermes mossambicus was investigated at two sites with distinct dietary components： C4 grasses （δ13 C isotope values, -13.8%0 to -14.0%0） and C3 plants （δ13C isotope values, -25.6%0 to -27.1%0）. By comparing observations of food items carried into the colony by the termites and carbon isotope ratios of whole termites （that determined assimilated carbon）, the relative proportion of the C3 and C4 plant food components of the termite diet was estimated. There was agreement between the observational data and stable carbon isotopic data, with grass representing approximately 93% of the diet ofH. mossambicus at two study sites （urban and rural） on the South African highveld. However, when correcting for mass of food items, that is, C3 and C4, carried by termites, the proportion of grass （C4） in the diet may be underestimated.

关键词： carbon assimilation colony harvester termite Suikerbosrand

BioTRIZ Suggests Radiative Cooling of Buildings Can Be Done Passively by Changing the Structure of Roof Insulation to Let Longwave Infrared Pass

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Journal of Bionic Engineering 2008年第1期5卷 55-66页

作者： Salmaan craig David Harrison Andrew Cripps Daniel Knott School of Engineering and Design Brunel UniversityLondon UB8 3PHUKBuro Happold LtdLondon W1T 1PDUK School of Engineering and Design Brunel UniversityLondon UB8 3PHUK Buro Happold Ltd London W1T 1PDUK

This paper demonstrates the application of a design tool called BioTRIZ. Its developers claim that it can be used to access biological strategies for solving engineering problems. Our aim is to design a roof for hot climates that gets free cooling through radiant coupling with the sky. The insulation in a standard roof stops the sun and convection from warming the thermal mass. But it also restricts the mass＇s longwave view of the cool sky. Different solutions to this conflict are offered by BioTRIZ. The chosen solution is to replace the standard insulation component with an open cell honeycomb. The vertical cells would allow longwave radiation to pass, while arresting convection. The solutions offered by BioTRIZ＇s technological counterpart include no such changes in structure. It is estimated that the thermal mass in the biomimetic roof would remain on average 4.5℃ cooler than in a standard roof over a year in Riyadh, Saudi Arabia.

关键词： biomimetics TRIZ BioTRIZ radiative cooling building design passive design

Flip the switch: BTG2–PRMT1 protein complexes antagonize pre-B-cell proliferation to promote B-cell development

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Cellular & Molecular Immunology 2018年第9期15卷 808-811页

作者： Glendon S Wu craig H Bassing Immunology Graduate Group Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Divsion of Cancer Pathobiology Department of Pathology and Laboratory MedicineChildren’s Hospital of PhiladelphiaAbramson Family Cancer Research InstitutePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

B lymphocytes are vital components of vertebrate adaptive immune ***,B-cell dysfunction can promote autoimmunity and immunodefi-ciency,and errors in development can cause B-lineage lymphoid malignancies.B-cell development requires RAG1/RAG2(RAG)endonuclease-mediated assembly of immunoglobulin(Ig)*** assembly of Ig heavy chain(IgH)genes in G1-phase pro-B cells produces IgH proteins that pair with VpreB/λ5 to form pre-B-cell receptor(pre-BCR)*** pro-B cells,pre-BCR signaling inhibits Rag1/Rag2 transcription,stabilizes Cyclin D3 to drive cellular proliferation and promotes differentiation of large pre-B cells.

关键词： lymphocytes lymphoid complexes

The ESCRT protein CHMP5 escorts αβ T cells through positive selection

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Cellular & Molecular Immunology 2018年第7期15卷 654-656页

作者： Glendon S Wu craig H Bassing Immunology Graduate Group Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Divsion of Cancer Pathobiology Department of Pathology and Laboratory MedicineChildren’s Hospital of PhiladelphiaAbramson Family Cancer Research InstitutePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

αβ T lymphocytes are critical for host protection against pathogens and are notable for their recent use as immunotherapeutic agents for the treatment of human ***,their dysfunction is associated with a variety of disease states,including autoimmune and immunodeficient syndromes that frequently result from improper αβT cell development in the *** thymic egress,mature αβ T cells are activated when their surface T-cell receptor(TCR)engages peptide antigens displayed by major histocompatibility complex(MHC)proteins expressed on antigenpresenting *** the thymus,each developing αβ T cell(thymocyte)recombines its TCRβ and TCRαgenes in an attempt to assemble and express a unique functional αβ TCR。

关键词： lymphocytes autoimmune combine