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A case history study on causation of the landslide in Santa Clara,California, USA

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第2期7卷 185-192页

作者： Yun Liao Sadek M. Derrega craig A. Hall Kleinfelder 1330 Broadway Suite 1200 Oakland CA 94612 USA Kleinfelder 4670 Willow Road Suite 100 Pleasanton CA 94588 USA

This paper presents a case history study on the geologic investigation and numerical modeling of areactivated landslide in the County of Santa Clara, California to identify the failure mechanism. Thelandslide occurred on an approximately 18.3-m high, north-facing slope during March 2011. The landslidemeasured about 33.5 m in width and about 51.8 m in length. Along the toe of the slope, a residentialstructure with a swimming pool was built on a cut and fill pad and there are several other structurespresent along the western side of the pad. The landslide occurred immediately to the south of theresidential building and moved northward between the County Road A and the house＇s side yard. Themovement of the landslide resulted in damaging the west-bound traffic lane of County Road A andencroached onto the paved driveway for the residential property. An investigation was performed toidentify the failure mechanism of the landslide to conclude whether Road A re-alignment by the Countyor prominent cutting performed along the lower portion of the slope by the homeowner during 2000through 2004 contributed to the reactivation of the old landslide deposit. The investigation included sitereconnaissance, reviewing available published geologic information, reviewing site-specific geologic andgeotechnical data developed by other consultants, and performing numerical modeling. The outcomes ofthe investigation indicate that the primary causation for the reactivation and failure of the subject preexistinglandslide is the prominent cutting performed along the lower portion of the slope during 2000through 2004 and water tank cut bench. The Road A re-alignment did not contribute to the reactivationof the old landslide deposit. 2015 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.

关键词： Pre-existing landslide ailure mechanism Slope stability

Proteomic composition of the acrostyle＂ Novel approaches to identify cuticular proteins involved in virus-insect interactions

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Insect Science 2017年第6期24卷 990-1002页

作者： craig Graham Webster Maelle Thillier Elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest INRA UMR 0385 BGPI CIRAD-INRA-Montpellier SupAgro Campus International de Baillarguet Montpellier Cedex France

The acrostyle is a distinct anatomical region present on the cuticle at the inner face of the common food/salivary canal at the tip of aphid maxillary stylets. This conserved structure is of particular interest as it harbors the protein receptors of at least l plant virus, Cauliflower mosaic virus＇, and presumably has other roles in plant-insect interactions. Previously we reported immunolabeling of a highly conserved motif of cuticular proteins from the CPR family （named for the presence of a Rebers and Riddiford consensus） within the acrostyle. Here we report the development of novel tools to further study the proteomic composition of this region and to identify proteins involved in insect- virus interactions. Using a series of antibodies against cuticular proteins from the RR-2 subfamily, we identified additional peptides present within the acrostyle. Our results demonstrated that the acrostyle is a complex structure containing multiple domains of cuticular proteins accessible for interaction. In addition, an array of overlapping peptides,which covers the diversity of the majority of the RR-2 subfamily, was ~tevelopect as a generic tool to characterize cuticular protein/pathogen interactions. Upon probing this array with Cucumber mosaic virus particles, consensus peptide sequences from hybridizing peptides were identified. Use of these novel tools has extended our knowledge of the proteomic composition of insect maxillary stylets and identified sequences that could be involved in virus binding, thus contributing to further elucidation of the various properties and functions of the acrostyle.

关键词： acrostyle aphid cuticular protein immunolabeling peptide array stylet

Integrating Sustainable Development into Global Institutions:Reforming the United Nations

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Chinese Journal of Population,Resources and Environment 2009年第4期7卷 3-14页

作者： Donna craig Michael I.Jeffery QC School of Law University of Western SydneyAustralia Social and Environment Responsibility Research Group School of LawUniversity of Western SydneyAustralia

This article will briefly outline the origins,structure and functions of United Nations Environment Program and the Commission on Sustainable Development in the context of the goals of ecologically sustainable development(ESD).Economic development,social development and environmental protection form the three interconnected parts of *** achievements of the key UN environmental institutions and programs in opening up the global system to civil society,the private sector and a diversity of actors and interests,promoting the role of poverty alleviation as part of ESD through the Millennium Development Goals,and facilitating important Multilateral Environmental Agreements should be ***,with these notable exceptions,organizations such as United Nations Environment Program and the Commission on Sustainable Development have become weak in scientific and technical leadership,global policy,co-ordination(inside and outside the UN) and has few achievements in the international and national implementation of obligations and standards in Global Environmental Governance-including enforcement,compliance and *** article will outline the key reasons for this *** will also be focused on the way forward through of a new United Nations Environment *** will require a clarification of purpose and function(within the UN system and as part of global governance structures) as well as consideration of whether it depends on system-wide UN *** is recommended that medium and long term strategies for reform are necessary.

关键词： ecologically sustainable development united nations environment organization UNEP global environmental governance commission on sustainable development

The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma:Single Institution Experience

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Clinical oncology and cancer researeh 2012年第1期9卷 29-33页

作者： Hany Eldeeb craig Macmillan Christine Elwell Abdulla Hammod Northamptonshire Centre for Oncology NorthamptonNorthamptonshire NN1 5BDUK

Objective To assess the impact of close or positive surgical margins on the outcome, and to determine whether margin status influence the recurrence rate and the overall survival for patients with head and neck cancers. Methods Records from 1996 to 2001 of 413 patients with primary head and neck squamous cell carcinoma （SCC） treated with surgery as the first line treatment were analysed. Of these patients, 82 were eligible for the study. Patients were followed up for 5 years. Results Patients with margins between 5-10 mm had 50% recurrence rate （RR）, those with surgical margins between 1-5 mm had RR of 59% and those with positive surgical margins had RR of 90% （P=O.O04）. The 5-year survival rates were 54%, 39% and 10%, respectively （P=0.002）. Conclusions Unsatisfactory surgical margin is an independent risk factor for recurrence free survival as well as overall survival regardless of the other tumor and patient characteristics.

关键词： carcinoma squamous Cell chemoradiotherapy

Evaluation of steroidogenic capacity after follicle stimulating hormone stimulation in bovine granulosa cells of Revalor 200~ implanted heifers

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Journal of Animal Science and Biotechnology 2014年第3期5卷 280-285页

作者： ANDrea D Stapp craig A Gifford Dennis M Hallford Jennifer A Hernandez Gifford Department of Animal Science Oklahoma State University Department of Animal and Range Science New Mexico State University Department of Animal Science 114B Animal Science BuildingOklahoma State University

Background： Heifers not used as breeding stock are often implanted with steroids to increase growth efficiency thereby altering hormone profiles and potentially changing the environment in which ovarian follicles develop. Because bovine granulosa cell culture is a commonly used technique and often bovine ovaries are collected from abattoirs with no record of implant status, the objective of this study was to determine if the presence of an implant during bovine granulosa cell development impacts follicle stimulating hormone-regulated steroidogenic enzyme expression. Paired ovaries were collected from 16 feedlot heifers subjected to 1 of 3 treatments： non-implanted （n = 5）, Revalor 200 for 28 d （n = 5）, or Revalor 200 for 84 d （n = 6）. Small follicle （1 to 5 mm） granulosa cells were isolated from each pair and incubated with phosphate buffered saline （n = 16） or 100 ng/mL follicle stimulating hormone （n = 16） for 24 h. Results： Granulosa cells of implanted heifers treated with follicle stimulating hormone produced medium concentrations of progesterone similar （P = 0.22） to non-implanted heifers, while medium estradiol concentrations were increased （P 〈 0.10） at 28 and 84 d compared to non-implanted heifers indicating efficacy of treatment. Additionally, real-time PCR analysis in response to follicle stimulating hormone treatment demonstrated a decrease in steroidogenic acute regulatory protein （P = 0.05） mRNA expression in heifers implanted for 84 d and an increase in P450 side chain cleavage mRNA in granulosa cells of heifers implanted for 28 （P 〈 0.10） or 84 d （P 〈 0.05） compared to non-implanted females. However, no difference in expression of 3-beta-hydroxysteroid dehydrogenase （P= 0.57） and aromatase （P = 0.23） were demonstrated in implanted or non-implanted heifers. Conclusions： These results indicate follicles which develop in the presence of high concentrations of androgenic and estrogenic steroids via an implant tend to demonstrate an altered capacity to res

关键词： Bovine Follicle stimulating hormone Granulosa cells Implant Steroidogenesis

In situ biosynthesized silver nanoparticle-incorporated synthesized zeolite A using Orthosiphon aristatus extract for in vitro antibacterial wound healing

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Particuology 2022年第8期20卷 27-34页

作者： Muhammad Hariz Asraf Nor Suriani Sani craig Denver Williams Khairunadwa Jemon Nik Ahmad Nizam Nik Maliek Department of Biosciences Faculty of ScienceUniversiti Teknologi Malaysia81310 SkudaiJohorMalaysia Office of Deputy Vice Chancellor(Research and Innovation) Universiti Teknologi Malaysia81310 UTM SkudaiJohorMalaysia University of Wolverhampton Wulfuna StreetWolverhampton WV11SBEnglandUK Centre for Sustainable Nanomaterials(CSNano) Ibnu Sina Institute for Scientific and Industrial Research(ISI-SIR).Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia

The capability of synthesized zeolite A(SZ)to immobilize Ag ions(Ag-SZ)and Ag nanoparticles(AgNp-SZ)were comparatively studied.A novel approach of in situ biosynthesized AgNP-incorporated synthesized zeolite A(AgNp-SZ)was synthesized at an optimum volume of 0.4mL of the Orthosiphon aristatus(***)leaves plant extract(5%)using an in situ *** comparison,Ag-Sz was produced by loading the synthesized zeolite with Ag *** synthesized materials were characterized for their morphologies and *** characterization analysesvalidate thathe biosynthesized AgNP(<100 nm)using *** leaves extract was incorporated into the zeolite *** antibacterial testing confirmed that these materials have antibacterial activity against Escherichia coliATCC11229 and Staphylococcus aureus ATCC ***/MBC analysis demonstrated that in 0.9%saline solution,AgNP-SZ had higher antibacterial activity than *** in vitro cell viability and migration assays were further examined towards human skin fibroblast cells HSF *** show that the materials are not cytotoxicto HSF1184,and the biosynthesized AgNP-SZ promotes cell migration and proliferation higher than *** research proved that the biocompatible antibacterial wound healing agent of AgNP-SZ can be synthesized using an in situ approach where the reduction process of Ag ions in the zeolite Acan be performed using plant extract.

关键词： Zeolite Orthosiphon aristatus Biosynthesis Silver nanoparticles Antibacterial In vitro wound healing

DEEP-UV CONFOCAL FLUORESCENCE IMAGING AND SUPER-RESOLUTION OPTICAL MICROSCOPY OF BIOLOGICAL SAMPLES

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 24-32页

作者： TREVOR A.SMITH LIISA M.HIRVONEN craig N.LINCOLN XIAOTAO HAO School of Chemistry and ARC Centre of Excellence for Coherent X-ray Science University of Melbourne Parkville 3010Australia

A wide range of techniques has been developed to image biological samples at high spatial and temporal *** this paper,we report recent results from deep-UV confocal fAuorescence microscopy to image inherent emission from fuorophores such as tryptophan,and structured ilumination microscopy(SIM)of biological *** motivation for developing deep-UV fhuorescence imaging and SIM is to provide methods to complement our measurements in the emerging field of X-ray coherent diffractive imaging.

关键词： Time resolved fuorescence imaging structured ilumnina tion microscopy

Evaluation of clinical outcomes in an interdisciplinary abdominal pain clinic: A retrospective, exploratory review

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World Journal of Gastroenterology 2019年第24期25卷 3079-3090页

作者： Amanda D Deacy craig A Friesen Vincent S Staggs Jennifer V Schurman Division of Gastroenterology Children’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States Division of Developmental and Behavioral Sciences Children’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States Biostatistics and Epidemiology Health Services and Outcomes ResearchChildren’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States

BACKGROUND Pediatric functional gastrointestinal disorders(FGIDs)are common and wellaccepted to be etiologically complex in terms of the contribution of biological,psychological,and social factors to symptom ***,despite its documented benefits,interdisciplinary treatment,designed to address all of these factors,for pediatric FGIDs remains *** current study hypothesized that the majority of pediatric patients seen in an interdisciplinary abdominal pain clinic(APC)would demonstrate clinical resolution of symptoms during the study period and that specific psychosocial variables would be significantly predictive of GI symptom *** To evaluate outcomes with interdisciplinary treatment in pediatric patients with pain-related FGIDs and identify patient characteristics that predicted clinical *** Participants were 392 children,ages 8-18[M=13.8;standard deviation(SD)=2.7],seen between August 1,2013 and June 15,2016 in an interdisciplinary APC housed within the Division of Gastroenterology in a medium-sized Midwestern children's *** be eligible,patients had to be 8 years of age or older and have had abdominal pain for≥8 wk at the time of initial *** and psychosocial data collected as part of standard of care were retrospectively reviewed and analyzed in the context of the observational *** regression was used to model odds of reporting vs never reporting improvement,as well as to differentiate rapid from slower *** Nearly 70%of patients followed during the study period achieved resolution on at least one of the employed outcome *** those who achieved resolution during follow up,43%to 49%did so by the first follow up(i.e.,within roughly 2 mo after initial evaluation and initiation of interdisciplinary treatment).Patient age,sleep,ease of relaxation,and depression all significantly predicted the likelihood of *** specifically,the odds of clinical resolution w

关键词： Pediatric functional gastrointestinal disorders Integrated care Behavioral health consultation Treatment outcomes Abdominal pain clinic

Concomitant atopic dermatitis and narcolepsy type 1:psychiatric implications and challenges in management

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General Psychiatry 2019年第5期32卷 279-282页

作者： Justin Chin craig Bearison Nanette Silverberg Mary Lee Wong Department of Primary Care Touro College of Osteopathic MedicineNew York CityNew YorkUSA Department of Internal Medicine Beth Israel Medical CenterNew York CityNew YorkUSA Department of Pediatric Dermatology Mount Sinai Health SystemNew York CityNew YorkUSA Department of Allergy and Immunology Beth Israel Medical CenterNew York CityNew YorkUSA Department of Medicine Icahn School of Medicine at Mount SinaiNew York CityNew YorkUSA

Atopic dermatitis(AD)and narcolepsy type 1(NT1)are two distinct diseases that have not been classically shown to be *** potential connection between the known immunological aetiology of AD and the proposed autoimmune pathophysiology of dysregulation in NT1;however,is the subject of ongoing speculation and debate with advances in gene sequencing and ***,we present a case of a patient with concomitant refractory AD and NT1 and review the current research on their immunological relationship and the challenges in management relative to disease burden and psychiatric comorbidities.

关键词： dermatitis psychiatric diseases