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Hypopharyngeal cancer trends in a high-incidence region:A retrospective tertiary single center study

World Journal of Clinical Cases 2023年第24期11卷 5666-5677页

作者： Alina-Georgiana Vulcu Cordunianu Gabriel Ganea Mihai Alexandru Cordunianu Daniel Cochior cosmin Alec moldovan Razvan Adam Doctoral School of Medicine Titu Maiorescu University of BucharestBucharest 040317Romania Department of Ear Nose Throat Head and Neck Surgery Carol Davila Central University Emergency Military HospitalBucharest 10825Romania Department of Pediatric Orthopedics Victor Gomoiu HospitalBucharest 022102Romania Department of Medical-Surgical and Prophylactic Disciplines Faculty of MedicineTitu Maiorescu UniversityBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania

BACKGROUND Hypopharyngeal cancer has the bleakest prognosis among head and neck cancers due to its extensive submucosal involvement,advanced tumor stage,and limited surgical reconstruction *** primary causes include alcohol consumption,tobacco use,genetic predisposition,1`diet,and socioeconomic *** squamous cell carcinoma(SCC)accounts for 95%of hypopharyngeal tumors,it remains a rare form,comprising only 3%-5%of all SCC cases in the head and neck ***,Central and Eastern Europe have the highest incidence rates for males(3.9 per 100000)and the third highest for females(2.26 per 100000),underscoring the significance of this seemingly uncommon *** Romania,hypopharyngeal cancer ranked 24th in incidence rate,with 634 new cases in *** To study the incidence,treatment and survival rates of hypopharyngeal tumor cases in a major ear,nose,throat(ENT)surgical *** A retrospective epidemiological clinical study was conducted on patients diagnosed and treated for hypopharyngeal cancer at the ENT department of"Carol Davila Central University Emergency Military Hospital"in Bucharest between January 2018 and August *** study included 53 patients and was authorized by the Ethics Committee of Titu Maiorescu Doctoral School(Bucharest,Romania)and the Ethics Committee of Carol Davila Central University Emergency Military Hospital(Bucharest,Romania).Inclusion criteria required a positive histopathological diagnosis of hypopharyngeal cancer,tumor localization in the hypopharyngeal region,and informed consent for data *** criteria involved major psychiatric pathologies and disagreement for data *** was based on ENT assessment,imaging reports,and laboratory *** methods were determined based on various *** tools,such as Adult Comorbidity Evaluation-27 and Karnofski Performance Status Scale,were used for risk assessment and functional capacity *** of life aspects were

关键词： Hypopharyngeal Cancer Organ conservation therapy Chemotherapy Radiotherapy Surgery

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Ten-year multicentric retrospective analysis regarding postoperative complications and impact of comorbidities in hemorrhoidal surgery with literature review

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World Journal of Clinical Cases 2023年第2期11卷 366-384页

作者： cosmin moldovan Elena Rusu Daniel Cochior Madalina Elena Toba Horia Mocanu Razvan Adam Mirela Rimbu Adrian Ghenea Florin Savulescu Daniela Godoroja Florin Botea Department of Medical Surgical Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Preclinic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of Ear Nose and ThroatIlfov County Clinical Emergency HospitalBucharest 022104Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania Medical Doctoral School Titu Maiorescu University of BucharestBucharest 040317Romania Department of Coloproctology MedLife SA Băneasa HyperclinicBucharest 013693Romania nd Department of Surgery Carol Davila Central Military Emergency University HospitalBucharest 010242Romania Department of Anesthesia Ponderas Academic HospitalBucharest 014142Romania Florin Botea 2nd Department of SurgeryFundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Hemorrhoidal disease(HD)is considered a low-severity pathology by both general population and physicians,but the lengthy conservative therapy and postoperative complications suggest *** To assess the effectiveness of different treatment options,both conservative and surgical,in contrast with some preexisting *** We conducted a retrospective,10-yearlong study between January 2011 and December 2021 in two surgical centers,a private and a state-owned *** compared the efficacy and safety of several treatment options,such as open hemorrhoidectomy,stapled hemorrhoidopexy,rubber band ligation and infrared coagulation in terms of complication rates and types and their correlation with different preexisting comorbidities such as inflammatory bowel disease(IBD),use of anticoagulant medication(AM)and liver *** also conducted a 20-years long PubMed research(1.263 articles)for relevant *** Our study recorded 10940 patients with HD,10241 with conservative and 699 with surgical *** of these,the male-to-female ratio of 1.3,and a peak in age distribution between 59 and 68 years old(32%of patients).For the entire study,we recorded a 90%incidence of immediate pain,immediate bleeding in 1.5%(11 cases),delayed bleeding in 1.0%(7 cases),and 0.6%surgical site *** retention was also present,with 0.2%of patients,anal stricture in 1%and fecal incontinence for 0.5%of patients(4 cases).We recorded no severe complications such as Fournier`s gangrene or rectovaginal *** accounted for 6%of the patients,with ulcerative colitis in 12%and Chron`s disease in 10.5%.6.6%of the patients had AM,determining 4%immediate and 2%delayed bleeding,in surgically treated *** Our study determined that most common complications(pain,urinary retention,bleeding,and stricture)are correlated with each surgical technique and pre-existing comorbidities.

关键词： Retrospective Hemorrhoidal Postoperative Complications Comorbidities

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Severe liver trauma with complex portal and common bile duct avulsion:A case report and review of the literature

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World Journal of Clinical Cases 2023年第16期11卷 3837-3846页

作者： Bianca Mitricof Alin Kraft Florentina Anton Alexandru Barcu Darina Barzan Carmen Haiducu Vladislav Brasoveanu Irinel Popescu cosmin Alec moldovan Florin Botea Medicine Doctoral School Titu Maiorescu University of BucharestBucharest 040441Romania Department of General Surgery Regina Maria Military Emergency HospitalBrasov 500007Romania Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Dan Setlacec Center for General Surgery and Liver Transplant Fundeni Clinical InstituteBucharest 022328Romania Department of Medical-Surgical and Prophylactic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania

BACKGROUND Given its size and location,the liver is the third most injured organ by abdominal *** to recent advances,it is unanimously accepted that the nonoperative management is the current mainstay of treatment for hemodynamically stable ***,those patients with hemodynamic instability that generally present with severe liver trauma associated with major vascular lesions will require surgical ***,an associated injury of the main bile ducts makes surgery compulsory even in the case of hemodynamic stability,thereby imposing therapeutic challenges in the tertiary referral hepato-biliopancreatic centers’*** SUMMARY We present the case of a 38-year-old male patient with The American Association for the Surgery of Trauma grade V liver injury and an associated right branch of portal vein and common bile duct avulsion,due to a crush *** patient was referred to the nearest emergency hospital and because of the hemorrhagic shock,damage control surgery was performed by means of ligation of the right portal vein branch and right hepatic artery,and hemostatic ***,the patient was referred immediately to our tertiary hepato-bilio-pancreatic *** performed depacking,a right hepatectomy and Roux-en-Y *** the 9th postoperative day,the patient developed a high output anastomotic bile leak that required a redo of the *** postoperative period was marked by a surgical incision site of incomplete evisceration that was managed non-operatively by negative wound *** follow-up was optimal,with no complications at 55 *** In conclusion,the current case clearly supports that a favorable outcome in severe liver trauma with associated vascular and biliary injuries is achieved thru proper therapeutic management,conducted in a tertiary referral hepato-bilio-pancreatic center,where a stepwise and complex surgical approach is mandatory.

关键词： Severe Liver Trauma Avulsion Right portal vein Common bile duct Case report

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Compositional asynchronous membrane systems

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Progress in Natural Science:Materials International 2007年第4期17卷 411-416页

作者： cosmin Bonchis Cornel Izbasa Gabriel Ciobanu Research Institute "e-Austria" Timisoara Romania "A. I. Cuza" University Faculty of Computer Science and Romanian AcademyInstitute of Computer Science Blvd. Carol I no. 8700505 IasiRomania

This paper presents an algorithmic way of building complex membrane systems by coupling elementary membranes. Its application seems particularly valuable in the case of asynchronous membrane systems, since the resulting membrane system remains asynchronous. The composition method is based on a handshake mechanism implemented by using antiport rules and promoters.

关键词： complex membrane systems coupling elementary membranes asynchronous membrane systems.

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Artificial Neural Network Methods for the Solution of Second Order Boundary Value Problems

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Computers, Materials & Continua 2019年第4期59卷 345-359页

作者： cosmin Anitescu Elena Atroshchenko Naif Alajlan Timon Rabczuk Institute of Structural Mechanics Bauhaus-Universität Weimar99423WeimarGermany School of Civil&Environmental Engineering University of New South WalesSydneyAustralia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia

We present a method for solving partial differential equations using artificial neural networks and an adaptive collocation *** this procedure,a coarse grid of training points is used at the initial training stages,while more points are added at later stages based on the value of the residual at a larger set of evaluation *** method increases the robustness of the neural network approximation and can result in significant computational savings,particularly when the solution is *** results are presented for benchmark problems for scalar-valued PDEs,namely Poisson and Helmholtz equations,as well as for an inverse acoustics problem.

关键词： Deep learning adaptive collocation inverse problems artificial neural networks

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Micro-alloying of Zn and Ca in vacuum induction casted bioresorbable Mg system:Perspectives on corrosion resistance,cytocompatibility,and inflammatory response

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Journal of Magnesium and Alloys 2024年第7期12卷 2812-2825页

作者： Manisha Behera Agnès Denys Rajashekhara Shabadi Fabrice Allain cosmin Gruescu UnitéMatériaux et Transformations(UMET) Universitéde LilleCNRSINRAENSCLUMR 8207UMETF-59000 LilleFrance Universitéde Lille CNRSUMR 8576-UGSF-Unitéde Glycobiologie Structurale et FonctionnelleF-59000 LilleFrance

There is an increasing interest in biodegradable materials,such as magnesium,for orthopaedic *** is driven by their potential to address challenges like stress shielding and the need for secondary removal *** this study,biodegradable magnesium alloys were produced using the Vacuum Induction Casting *** impact of micro-alloying Zn and Ca in Mg-xZn-0.2Ca(x=0.1,0.2,0.3,and 0.4 wt%)alloys on corrosion resistance,cytocompatibility,and early-stage inflammatory response was *** and SEM-EDS analysis confirmed the presence of Ca_(2)Mg_(6)Zn_(3)secondary phases in all *** Mg-0.3Zn-0.2Ca alloy exhibited the lowest corrosion rate and an elastic modulus of 36.8 GPa,resembling that of natural *** measurements indicated a correlation between grain size and secondary phase volume fraction in explaining corrosion *** vitro degradation in simulated body fluid(SBF)for 21 days showed hydroxyapatite formation on alloy surfaces,aligning with electrochemical *** vitro cytotoxicity tests demonstrated the cytocompatibility of all alloys,with Mg-0.3Zn-0.2Ca having the highest cell viability over a 6-day cell *** into the inflammatory response with RAW-Blue macrophages revealed the anti-inflammatory properties of Mg-0.3Zn-0.2Ca ***-alloying with 0.3 wt%Zn and 0.2 wt%Ca enhanced mechanical properties,corrosion resistance,cytocompatibility,and immunomodulatory *** positions the Mg-0.3Zn-0.2Ca alloy as a promising biodegradable implant for bone fixation applications.

关键词： Micro-alloying MgZnCa Corrosion resistance In vitro Anti-inflammatory response

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Open anterior glenohumeral dislocation with associated supraspinatus avulsion: A case report

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World Journal of Clinical Cases 2019年第7期7卷 849-854页

作者： cosmin Ioan Faur Bogdan Anglitoiu Ana-Maria Ungureanu 2~(nd) Department of Orthopaedics and Traumatology University of Medicine and Pharmacy "Victor Babes" Department of Radiology and Medical Imaging University of Medicine and Pharmacy "Victor Babes"

BACKGROUND Open dislocation of the glenohumeral joint is a very rare complication with only six cases described in the literature. Most cases resulted in severe complications like avascular necrosis of the humeral head or septic arthritis with poor functional results. The "mandatory" treatment of choice is surgery, with accurate debridement and reconstruction of the damaged soft tissues. However, the results in these cases do not approach those seen in classical *** SUMMARY This case report is the first description of an anterior open glenohumeral dislocation without associated fractures, but with complete avulsion of the soft tissue envelope of the proximal humerus. Surgical treatment consisted of copious lavage with saline solution, meticulous debridement of the nonviable soft tissues,reduction of the dislocated humeral head and reconstruction of the soft tissue envelope of the humeral head. The selected surgical approach was an inferior extension of the wound at the level of the delto-pectoral groove, as the best choice to be able to perform an adequate debridement and capsulo-tendinous reinsertion. At 6 mo there were no clinical signs of instability of the glenohumeral joint, the functionality of the joint was restricted to 90o of anterior elevation,internal rotation to L2, with severe limitation of abduction(60o) and external rotation(0o) but without residual pain, with an Oxford shoulder Score of *** Thorough reconstruction of the soft tissues surrounding the shoulder joint and an early rehabilitation program are key points to a good functional result.

关键词： Open shoulder dislocation Case report Functional impairment Surgical treatment Avascular necrosis

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Enabling direct microcalorimetric measurement of metabolic activity and exothermic reactions onto microfluidic platforms via heat flux sensor integration

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Microsystems & Nanoengineering 2023年第3期9卷 103-114页

作者： Signe L.K.Vehusheia cosmin Roman Olivier Braissant Markus Arnoldini Christofer Hierold Micro and Nanosystems Department of Mechanical and Process EngineeringETH ZurichTannenstrasse 38092 ZurichSwitzerland Center of Biomechanics and Biocalorimetry Department of Biomedical EngineeringUniversity of BaselHegenheimermattweg 167C4123 AllschwilSwitzerland Laboratory for Food Immunology Department of Health Sciences and TechnologyETH ZurichOtto-Stern-Weg 38093 ZurichSwitzerland

All biological processes use or produce *** microcalorimeters have been utilized to study the metabolic heat output of living organisms and heat production of exothermic chemical *** advances in microfabrication have made possible the miniaturization of commercial microcalorimeters,resulting in a few studies on the metabolic activity of cells at the microscale in microfluidic *** we present a new,versatile,and robust microcalorimetric differential design based on the integration of heat flux sensors on top of microfluidic *** show the design,modeling,calibration,and experimental verification of this system by utilizing Escherichia coli growth and the exothermic base catalyzed hydrolysis of methyl paraben as use *** system consists of a Polydimethylsiloxane based flow-through microfluidic chip with two 46µl chambers and two integrated heat flux *** differential compensation of thermal power measurements allows for the measurement of bacterial growth with a limit of detection of 1707 W/m^(3),corresponding to 0.021OD(2·10^(7) bacteria).We also extracted the thermal power of a single Escherichia coli of between 1.3 and 4.5 pW,comparable to values measured by industrial *** system opens the possibility for expanding already existing microfluidic systems,such as drug testing lab-on-chip platforms,with measurements of metabolic changes of cell populations in form of heat output,without modifying the analyte and minimal interference with the microfluidic channel itself.

关键词： system utilizing versatile

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An in vitro demonstration of a passive,acoustic metamaterial as a temperature sensor with mK resolution for implantable applications

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Microsystems & Nanoengineering 2024年第1期10卷 41-54页

作者： Lucrezia Maini Vicente Genovés Roman Furrer Nikola Cesarovic Christofer Hierold cosmin Roman Micro-and Nanosystems Department of Mechanical and Process EngineeringETH ZurichTannenstrasse 38092 ZurichSwitzerland. Translational Cardiovascular Technology Department of Health Science and TechnologyETH ZurichLeopold-Ruzicka-Weg 48093 ZurichSwitzerland. Transport at Nanoscale Interfaces Swiss Federal Laboratories for Materials Science and TechnologyEMPAÜberlandstrasse 1298600 DübendorfSwitzerland Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charite(DHZC)13353 BerlinGermany

Wireless medical sensors typically utilize electromagnetic coupling or ultrasound for energy transfer and sensor *** transfer and management is a complex aspect that often limits the applicability of implantable sensor *** this work,we report a new passive temperature sensing scheme based on an acoustic metamaterial made of silicon embedded in a polydimethylsiloxane *** to other approaches,this concept is implemented without additional electrical components in situ or the need for a customized receiving unit.A standard ultrasonic transducer is used for this demonstration to directly excite and collect the reflected *** metamaterial resonates at a frequency close to a typical medical value(5 MHz)and exhibits a high-quality *** the design features of the metamaterial with the high-temperature sensitivity of the polydimethylsiloxane matrix,we achieve a temperature resolution of 30 *** value is below the current standard resolution required in infrared thermometry for monitoring postoperative complications(0.1 K).We fabricated,simulated,in vitro tested,and compared three acoustic sensor designs in the 29-43℃(~302-316 K)temperature *** this concept,we demonstrate how our passive metamaterial sensor can open the way toward new zero-power smart medical implant concepts based on acoustic interrogation.

关键词： passive resolution utilize

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An artificial neural network based deep collocation method for the solution of transient linear and nonlinear partial differential equations

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1296-1310页

作者： Abhishek MISHRA cosmin ANITESCU Pattabhi Ramaiah BUDARAPU Sundararajan NATARAJAN Pandu Rang VUNDAVILLI Timon RABCZUK School of Mechanical Sciences Indian Institute of TechnologyBhubaneswar 752050India Institute of Structural Mechanics Bauhaus University of WeimarWeimar 99423Germany Department of Mechanical Engineering Indian Institute of Technology MadrasChennai 600036India

A combined deep machine learning(DML)and collocation based approach to solve the partial differential equations using artificial neural networks is *** developed method is applied to solve problems governed by the Sine–Gordon equation(SGE),the scalar wave equation and *** methods are studied:one is a space-time formulation and the other is a semi-discrete method based on an implicit Runge–Kutta(RK)time *** methodology is implemented using the Tensorflow framework and it is tested on several numerical *** on the results,the relative normalized error was observed to be less than 5%in all cases.

关键词： collocation method artificial neural networks deep machine learning Sine-Gordon equation transient wave equation dynamic scalar and elasto-dynamic equation Runge-Kutta method

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