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The role of computer-assisted systems for upper-endoscopy quality monitoring and assessment of gastric lesions

Gastroenterology Report 2021年第3期9卷 185-204,I0001页

作者： Daniela cornelia Lazar Mihaela Flavia Avram Alexandra Corina Faur Ioan Romosan Adrian Goldis Department V of Internal Medicine I Discipline of Internal Medicine IV“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania Department of Surgery X 1st Surgery Discipline“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania Department I Discipline of Anatomy and Embriology“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania Department VII of Internal Medicine II Discipline of Gastroenterology and Hepatology“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania

This article analyses the literature regarding the value of computer-assisted systems in esogastroduodenoscopy-quality monitoring and the assessment of gastric *** data show promising results in upper-endoscopy quality control and a satisfactory detection accuracy of gastric premalignant and malignant lesions,similar or even exceeding that of experienced ***,artificial systems enable the decision for the best treatment strategies in gastriccancer patient care,namely endoscopic vs surgical resection according to tumor *** so doing,unnecessary surgical interventions would be avoided whilst providing a better quality of life and prognosis for these *** these performance data have been revealed by numerous studies using different artificial intelligence(AI)algorithms in addition to white-light endoscopy or novel endoscopic techniques that are available in expert endoscopy *** is expected that ongoing clinical trials involving AI and the embedding of computer-assisted diagnosis systems into endoscopic devices will enable real-life implementation of AI endoscopic systems in the near future and at the same time will help to overcome the current limits of the computer-assisted systems leading to an improvement in *** benefits should lead to better diagnostic and treatment strategies for gastric-cancer ***,the incorporation of AI algorithms in endoscopic tools along with the development of large electronic databases containing endoscopic images might help in upper-endoscopy assistance and could be used for telemedicine purposes and second opinion for difficult cases.

关键词： artificial intelligence computer-assisted diagnosis gastric cancer premalignant gastric lesion upper-endoscopy quality control

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Heterosis in plants:Manifestation in early seed development and prediction approaches to assist hybrid breeding

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Chinese Science Bulletin 2009年第14期54卷 2363-2375页

作者： THIEMANN Alexander meyer Stephanie SCHOLTEN Stefan Developmental Biology and Biotechnology Biocenter Klein FlottbekUniversity HamburgOhnhorststraβe 1822609 HamburgGermany Developmental Biology and Biotechnology Biocenter Klein FlottbekUniversity HamburgOhnhorststraβe 18 22609 HamburgGermany

Heterosis, or hybrid vigour, describes the superior performance of heterozygous hybrid individuals compared with their homozygous parental inbred lines. Although heterosis has been intensively used in plant breeding, the molecular and genetic mechanism underlying the phenomenon remains largely unknown. During the last years numerous laboratories initiated genomic approaches with new, often genome wide tools toward the elucidation of the molecular basis of heterosis. Various studies described differences in genome organization and gene expression of hybrids and their parental inbred lines. In maize, a considerable loss of co-linearity at many loci between different inbred lines was observed. Expression profile comparisons between inbred lines and hybrids revealed complex transcriptional networks specific for different developmental stages and tissues mainly in maize (Zea mays), rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana). Allele-specific expression data resolved the relative parental contributions and allowed figuring out the regulatory basis for expression variation in hybrids. Integrating all these complex expression data might help to get an idea about the molecular basis of heterosis. Thereby molecular processes during early seed development shortly after fertilization might be of particular importance, because the allelic interplay has to be coordinated after the unification of two diverse genomes and these processes might contribute to establish the basis for future performance of the sporophyte. Besides these fundamental interests in the molecular basis and manifestation of hybrid vigour applied aspects of the phenomenon are of high importance to support plant breeding and agriculture. Prediction methods are of special interest to identify the most promising parental lines of hybrid varieties, greatly reducing the financial effort and increasing the efficiency to develop new hybrid cultivars. Until now, most prediction approaches were based on g

关键词：植物育种方法水稻基因表达

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Effect of surface roughness on sliding friction of micron-sized glass beads

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Friction 2014年第3期2卷 255-263页

作者： Jan meyer Regina FUCHS Thorsten STAEDLER Xin JIANG Chair of Surface and Materials Technology University of Siegen57068 SiegenGermany

In order to understand the contact phenomena of micron‐sized particles,which have a tremendous impact on a variety of applications in industry and technology,direct access to the loads as well as the displacements accompanying such contacts are *** particle ensembles show a size variation ranging from the nanometer to the tenths of micron *** the contact behavior of particles featuring radii of several up to several tenths of microns is scarcely studied as these particles are typically too large for atomic force microscopy(AFM)based approaches and too small for conventional macroscopic testing *** this work a nanoindenter based approach is introduced to gain insight into the contact mechanics of micron‐sized glass beads sliding on rough silicon surfaces at various constant low normal *** results are analyzed by a simple modified Coulomb friction law,as well as Hertz,JKR,and DMT contact theory.

关键词： sliding friction roughness colloid probe technique particle technology nanoindentation

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Development and validation of an LC-MS/MS method for tyrphostin A9

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Journal of Pharmaceutical Analysis 2019年第3期9卷 163-169页

作者： Lyndsey F.meyer Dhaval K.Shah Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical SciencesThe State University of New York at Buffalo

Here we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective inhibitor for platelet derived growth factor receptor tyrosine kinase and has been investigated in vitro as a potent oxidative phosphorylation uncoupler. The murine analytical method was developed for three biological matrices: cell culture media, 3T3-L1 cell lysate, and murine plasma. For each matrix the limit of detection and the limit of quantification were found to be 0.5 ng/mL and 1.0 ng/ mL, respectively. The range of standard curve for each matrix was 1.0-100 ng/mL, linearity was >0.99, and the precision and accuracy were within 20%. 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoic acid was found to be the most suitable internal standard. The validated LC-MS/MS method was used to investigate stability and in vitro pharmacokinetics of tyrphostin A9. It was found that tyrphostin A9 is susceptible to hydrolysis, and the degradation product was identified as 3,5-di-tert-butyl-4- hydroxybenzaldehyde. Tyrphostin A9 was not stable in biological matrices, and the rate of its degradation in murine plasma was faster than that in cell culture media. In vitro pharmacokinetic studies revealed that tyrphostin A9 concentrations in the cell culture media declined in a bi-exponential manner and the concentrations inside the adipocytes remained constant, suggesting tyrphostin A9 has an intracellular binding site and is retained within the cell. The LC-MS/MS method presented here paves the way for further quantitative investigations involving tyrphostin A9.

关键词： Tyrphostin 9/ A9/AG-9/Malonoben/SF6847 LC-MS/MS Stability Pharmacokinetics Tyrosine kinase inhibitor

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Urban Space and Civil War： Hefei, 1853-1854

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Frontiers of History in China 2013年第4期8卷 469-492页

作者： Tobie meyer-Fong History Department Johns Hopkins University Baltimore MD 21218 USA

Previous scholarship has made it abundantly clear that the Taiping War impacted urban hierarchies in the Yangzi delta region, wreaking havoc in economic, commercial, administrative, and cultural centers like Hangzhou, Suzhou, Yangzhou, Changzhou, and Wuxi, thereby hastening the rise of Shanghai. But how did this war affect cities beyond the core Jiangnan region？ In a case study of the prefectural city of Hefei （Luzhou）, this article explores the ways in which war led to the reconfiguration and reimagining of urban space, both through wartime destruction and the patronage of post-war reconstruction.

关键词： Taiping Rebellion Hefei Luzhou Anhui province Li Hongzhang,Zhou Bangfu wartime destruction urban space

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Black locust(Robinia pseudoacacia L.)as a multi-purpose tree species in Hungary and Romania:a review

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Journal of Forestry Research 2018年第6期29卷 1449-1463页

作者： Valeriu-Norocel Nicolescu cornelia Hernea Beatrix Bakti Zsolt Keseru Borbála Antal Károly Rédei Faculty of Silviculture and Forest Engineering Transylvania University of BrassovSirul Beethoven no.1500123 BrasovRomania Faculty of Horticulture and Forestry Banat’s University of Agricultural Sciences and Veterinary Medicine“King Michael I of Romania”from Timi.oaraCalea Aradului 119300645 TimisoaraRomania Department of Plantation Forestry National Agricultural Research and Innovation Centre Forest Research InstituteFarkasszigetPu¨spo¨klada′ny 4150Hungary Hungarian Horticultural Propagation Material Non-profit Ltd. Sa′rva′rBudapestHungary

Black locust(Robinia pseudoacacia L.) was the first North-American tree species imported to Europe at the beginning of the seventeenth century. It is commonly planted worldwide because of its adaptability to environmental stresses, its valuable wood, easy propagation, frequent and abundant seed production, excellent coppicing,high seedling survival, and relatively high wood yield. In Europe, Romania and Hungary have the most highly-developed black locust growing techniques and *** a result of increasing interest in black locust in many countries, this review aims to provide a comprehensive overview of state-of-the-art site requirements, propagation, improvement and management(including growth and yield as well as use in energy plantations).

关键词： Robinia pseudoacacia Site requirements Selection Propagation Silviculture

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F?(H2O)+CH3I Ligand Exchange Reaction Dynamics

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Chinese Journal of Chemical Physics 2020年第2期33卷 210-216,I0003,I0039-I0040页

作者： Bjorn Bastian Tim Michaelsen Milan Oncák Jennifer meyer Roland Wester Institut für Ionenphysik und Angewandte Physik Universitat InnsbruckTechnikerstraβe 256020 InnsbruckAustria

Single hydration of the gas phase F^-+CH3I→CH3F reaction allows to probe solvent effects on a fundamental nucleophilic substitution *** the same time,the addition of a solvent molecule opens alternative product ***,we present crossed beam imaging results on the dynamics of the F^-(H2O)+CH3I→[FCH3I]^-+H2O ligand exchange pathway at collision energies between 0.3 and 2.6 *** kinetic energies are constrained by the stability requirement of the weakly bound product *** implies substantial internal excitation of the water molecule and disfavors effcient energy redistribution in an intermediate complex,which is reflected by the suppression of low kinetic energies as collision energy *** 0.3 eV,internal nucleophilic displacement is important and is discussed in light of the competing nucleophilic substitution pathways that form I^- and I^-(H2O).

关键词： Reaction dynamics Ligand exchange Microsolvation Crossed beams Velocity map imaging

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Evaluating system of rice intensification using a modified transplanter:A smart farming solution toward sustainability of paddy fields in Malaysia

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International Journal of Agricultural and Biological Engineering 2019年第2期12卷 54-67页

作者： Redmond R.Shamshiri Bala Ibrahim Siva K.Balasundram Sima Taheri cornelia Weltzien Leibniz Institute for Agricultural Engineering and Bioeconomy Max-Eyth-Allee 10014469 Potsdam-BornimGermany Smart Farming Technology Research Center Department of Agricultural and Biological EnginieeringUniversiti Putra Malaysia Department of Agriculture Technology Faculty of AgricultureUniversiti Putra Malaysia43400SerdangSelangorMalaysia Centre of Research in Biotechnology for Agriculture(CEBAR) University of Malaya50603Kuala LumpurMalaysia Agromechatronics Institute of Machine Design and SystemsTechnische Universitaet BerlinGermany

This paper presents the study reports on evaluating a new transplanting operation by taking into accounts the interactions between soil,plant,and machine in line with the System of Rice Intensification(SRI)*** objective was to modify planting claw(kuku-kambing)of a paddy transplanter in compliance with SRI guidelines to determine the best planting spacing(S),seed rate(G)and planting pattern that results in a maximum number of seedling,tillers per hill,and *** separate experiments were carried out in two different paddy fields,one to determine the best planting spacing(S=4 levels:s_(1)=0.16 m×0.3 m,s_(2)=0.18 m×0.3 m,s_(3)=0.21 m×0.3 m,and s_(4)=0.24 m×0.3 m)for a specific planting pattern(row mat or scattered planting pattern),and the other to determine the best combination of spacing with seed rate treatments(G=2 levels:g1=75 g/tray,and g2=240 g/tray).Main SRI management practices such as soil characteristics of the sites,planting depth,missing hill,hill population,the number of seedling per hill,and yield components were *** of two-way analysis of variance with three replications showed that spacing,planting pattern and seed rate affected the number of one-seedling in all *** was also observed that the increase in spacing resulted in more tillers and more panicle per plant,however hill population and sterility ratio increased with the decrease in *** the maximum number of panicles were resulted from scattered planting at s_(4)=0.24 m×0.3 m spacing with the seed rate of g1=75 g/tray,the maximum number of one seedling were observed at s_(4)=0.16 m×0.3 *** highest and lowest yields were obtained from 75 g seeds per tray scattered and 70 g seeds per tray scattered treatment *** all treatments,the result clearly indicates an increase in yield with an increase in spacing.

关键词： system of rice intensification sustainable cultivation smart farming modified transplanter paddy fields Malaysia

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Failure of a T cell regulator: CD6 contributes to the aggravation of autoimmune inflammation

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Cellular & Molecular Immunology 2019年第9期16卷 733-734页

作者： Anja meyer David M.Kofler Division of Clinical Immunology and Rheumatology Department I of Internal MedicineUniversity of CologneCologne 50937Germany

The scavenger-like lymphocyte receptor CD6 is a regulator of T cell functions,and is associated with autoimmune ***,the specific contribution of CD6 to autoimmunity remains *** physiological conditions,CD6 associates with the T cell antigen receptor(TCR)/CD3 complex at the center of the immunological synapse and regulates T cell responses through activation-dependent recruitment of the positive regulator SLP-76 and other downstream signaling effectors.1,2 In recent years,immune-activating and immune-inhibiting functions of CD6 have been reported,indicating a dual role of CD6 in T cell activation.1 It has been postulated that the strength of TCR activation determines whether CD6 enhances or inhibits TCR signaling.1 This possible counter-regulatory role of CD6 may contribute to the control of T cell responses.

关键词： autoimmune inflammation CD6

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A CONVENIENT SYNTHETIC ROUTE FOR THE SEX PHEROMONE OF THE ASIAN CORN BORER MOTH (Ostrinia furnaculis Guenée)

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Science China Chemistry 1984年第7期27卷 679-686页

作者：李正名,meyer SCHWARZ Department of Biology Peking UniversityThe Research Institute of Elemento-Organic Chemistry Nankai University Tianjin OCSL AEQI BARC USDA USA OCSL AEQI BARC USDA USA

By hydroboration of 10-undecen-1-ol acetate, a new synthetic route for the sex phero-mone of the Asian corn-borer (Ostrinia furnacalis Guenee) was devised to shorten the origi-nal 5 steps to a 2 steps reaction. The E- and Z-12-tetradecen-1-ol acetates were obtainedseparately with a purity greater than 98%. The location of the double bond position was as-certained by capillary GC and GC-MS. The important intermediate 12-tetradecyn-1-ol was also obtained from 2-tridecyn-1-ol byusing a zipper reaction, then by methylation and aeetylation. The intermediate obtainedfrom 3 different routes were compared by GC and GC-MS spectra to be identical.

关键词： A CONVENIENT SYNTHETIC ROUTE FOR THE SEX PHEROMONE OF THE ASIAN CORN BORER MOTH Ostrinia furnaculis Guen GC

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