Failure of a T cell regulator: CD6 contributes to the aggravation of autoimmune inflammation
作者机构：Division of Clinical Immunology and RheumatologyDepartment I of Internal MedicineUniversity of CologneCologne 50937Germany
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2019年第16卷第9期
页 面：733-734页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：autoimmune inflammation CD6
摘 要：The scavenger-like lymphocyte receptor CD6 is a regulator of T cell functions,and is associated with autoimmune ***,the specific contribution of CD6 to autoimmunity remains *** physiological conditions,CD6 associates with the T cell antigen receptor(TCR)/CD3 complex at the center of the immunological synapse and regulates T cell responses through activation-dependent recruitment of the positive regulator SLP-76 and other downstream signaling effectors.1,2 In recent years,immune-activating and immune-inhibiting functions of CD6 have been reported,indicating a dual role of CD6 in T cell activation.1 It has been postulated that the strength of TCR activation determines whether CD6 enhances or inhibits TCR signaling.1 This possible counter-regulatory role of CD6 may contribute to the control of T cell responses.
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