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Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution

Plant Communications 2023年第3期4卷 80-98页

作者： Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles coral del val muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour Hatice Gozel Nergiz C¸oban Nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming Department of Horticulture Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Center for Genomics and Biotechnology Haixia Institute of Science and TechnologySchool of Future TechnologyFujian Agriculture and Forestry UniversityFuzhouChina Key Laboratory of Orchid Conservation and Utilization of National Forestry and Grassland Administration Fujian Agriculture and Forestry UniversityFuzhouChina Departamento de Genética Facultad de CienciasCampus de Fuentenueva s/n18071 GranadaSpain Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamen 361102China Department of Computer Science University of GranadaGranadaSpain Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI Institute) 18014 GranadaSpain German Cancer Research Center Omics IT and Data Management Core FacilityHeidelbergGermany Department of Biological Sciences Youngstown State UniversityYoungstownOH 44555USA Department of Field Crops Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Pistachio Research Institute SxahinbeyGaziantep 27060Turkey Diversity Arrays Technology University of CanberraCanberraACTAustralia Genome Center University of California Davis451 Health Sciences DriveDavisCA 95616USA

Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex *** sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and *** ***,the male *** chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were *** ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 *** inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining *** W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in *** W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or *** history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in *** identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought *** findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks.

关键词： Pistacia vera pistachio sequencing reference genome sex chromosome domestication

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Old-age inflammatory bowel disease onset:A different problem?

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World Journal of Gastroenterology 2011年第22期17卷 2734-2739页

作者： Joaquin Hinojosa del val Gastroeneterology Service Hospital de Manises Valencia 46940 Spain

Inflammatory bowel disease （IBD） in patients aged 60 accounts for 10%-15% of cases of the disease. Diganostic methods are the same as for other age groups. Care has to be taken to distinguish an IBD colitis from other forms of colitis that can mimick clinically, endoscopically and even histologically the IBD entity. The clinical pattern in ulcerative colitis （UC） is proctitis and left-sided UC, while granulomatous colitis with an inflammatory pattern is more common in Crohn’s disease （CD）. The treatment options are those used in younger patients, but a series of considerations related to potential pharmacological interactions and side effects of the drugs must be taken into account. The safety profile of conventional immunomodulators and biological therapy is acceptable but more data are required on the safety of use of these drugs in the elderly population. Biological therapy has risen question on the possibility of increased side effects, however this needs to be confirmed. Adherence to performing all the test prior to biologic treatment administration is very important. The overall response to treatment is similar in the different patient age groups but elderly patients have fewer recurrences. The number of hospitalizations in patients 65 years is greater than in younger group, accounting for 25% of all admissions for IBD. Mortality is similar in UC and slightly higher in CD, but significantly increased in hospitalized patients. Failure of medicaltreatment continues to be the most common indication for surgery in patients aged 60 years. Age is not considered a contraindication for performing restorative proctocolectomy with an ileal pouch-anal anastomosis. However, incontinence evaluation should be taken into account an individualized options should be considered

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn’s disease Eldery population

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SutteARIMA:A Novel Method for Forecasting the Infant Mortality Rate in Indonesia

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Computers, Materials & Continua 2022年第3期70卷 6007-6022页

作者： Ansari Saleh Ahmar Eva Boj del val M.A.El Safty Samirah AlZahrani Hamed El-Khawaga Business School Faculty of Economics and BusinessUniversitat de BarcelonaBarcelona08034Spain Department of Statistics Faculty of Mathematics and Natural ScienceUniversitas Negeri MakassarMakassar90224Indonesia Department of Economic Financial and Actuarial MathematicsFaculty of Economics and BusinessUniversitat de BarcelonaBarcelona08034Spain Department of Mathematics and Statistics Colleage of SciencesTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Statistics Mathematicsand InsuranceFaculty of CommerceTanta UniversityEgypt Department of Economics and Finance College of Business AdministrationTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

This study focuses on the novel forecasting method(SutteARIMA)and its application in predicting Infant Mortality Rate data in *** undertakes a comparison of the most popular andwidely used four forecasting methods:ARIMA,Neural Networks Time Series(NNAR),Holt-Winters,and *** data used were obtained from the website of the World *** data consisted of the annual infant mortality rate(per 1000 live births)from 1991 to *** determine a suitable and best method for predicting InfantMortality rate,the forecasting results of these four methods were compared based on the mean absolute percentage error(MAPE)and mean squared error(MSE).The results of the study showed that the accuracy level of SutteARIMA method(MAPE:0.83%andMSE:0.046)in predicting InfantMortality rate in Indonesia was smaller than the other three forecasting methods,specifically the ARIMA(0.2.2)with a MAPE of 1.21%and a MSE of 0.146;the NNAR with a MAPE of 7.95%and a MSE of 3.90;and the Holt-Winters with aMAPE of 1.03%and aMSE:of 0.083.

关键词： Forecasting infant mortality rate ARIMA NNAR holt-winters SutteARIMA

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Clinical impact of artificial intelligence-based solutions on imaging of the pancreas and liver

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World Journal of Gastroenterology 2023年第9期29卷 1427-1445页

作者： M Alvaro Berbís Felix Paulano Godino Javier Royuela del val Lidia AlcaláMata Antonio Luna Department of Radiology HT MédicaSan Juan de Dios HospitalCórdoba 14960Spain Faculty of Medicine Autonomous University of MadridMadrid 28049Spain Department of Radiology HT MédicaClínica las NievesJaén 23007Spain

Artificial intelligence(AI)has experienced substantial progress over the last ten years in many fields of application,including *** hepatology and pancreatology,major attention to date has been paid to its application to the assisted or even automated interpretation of radiological images,where AI can generate accurate and reproducible imaging diagnosis,reducing the physicians’*** can provide automatic or semi-automatic segmentation and registration of the liver and pancreatic glands and ***,using radiomics,AI can introduce new quantitative information which is not visible to the human eye to radiological *** has been applied in the detection and characterization of focal lesions and diffuse diseases of the liver and pancreas,such as neoplasms,chronic hepatic disease,or acute or chronic pancreatitis,among *** solutions have been applied to different imaging techniques commonly used to diagnose liver and pancreatic diseases,such as ultrasound,endoscopic ultrasonography,computerized tomography(CT),magnetic resonance imaging,and positron emission tomography/***,AI is also applied in this context to many other relevant steps involved in a comprehensive clinical scenario to manage a gastroenterological *** can also be applied to choose the most convenient test prescription,to improve image quality or accelerate its acquisition,and to predict patient prognosis and treatment *** this review,we summarize the current evidence on the application of AI to hepatic and pancreatic radiology,not only in regard to the interpretation of images,but also to all the steps involved in the radiological workflow in a broader ***,we discuss the challenges and future directions of the clinical application of AI methods.

关键词： Artificial intelligence Machine learning Deep learning Imaging Liver Pancreas

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Impact of a colorectal cancer screening program implantation on delays and prognosis of non-screening detected colorectal cancer

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World Journal of Gastroenterology 2021年第39期27卷 6689-6700页

作者： Joaquin Cubiella María Lorenzo Franco Baiocchi coral Tejido Alejandro Conde María Sande-Meijide Margarita Castro Department of Gastroenterology Complexo Hospitalario Universitario de OurenseOurense 32005OrenseSpain Department of Preventive Medicine Complexo Hospitalario Universitario de OurenseOurense 32003OrenseSpain Department of Gastroenterology Hospital del BierzoPonferrada 24404LeonSpain Dirección Xeral de Saúde Pública Conselleria de SanidadeSantiago de Compostela 15703Spain

BACKGROUND The implementation of a colorectal cancer(CRC)screening programme may increase the awareness of Primary Care Physicians,reduce the diagnostic delay in CRC detected outside the scope of the screening programme and thus improve *** To determine the effect of implementation of a CRC screening programme on diagnostic delays and prognosis of CRC detected outside the scope of a screening *** We performed a retrospective intervention study with a pre-post *** identified 322 patients with incident and confirmed CRC in the pre-implantation cohort(June 2014–May 2015)and 285 in the post-implantation cohort(June 2017-May 2018)in the Cancer Registry detected outside the scope of a CRC screening *** each patient we calculated the different healthcare diagnostics delays:global,primary and secondary healthcare,referral and colonoscopyrelated *** addition,we collected the initial healthcare that evaluated the patient,the home location(urban/rural),and the CRC stage at *** determined the two-year survival and we performed a multivariate proportional hazard regression analysis to determine the variables associated with *** We did not detect any differences in the patient or CRC baseline-related variables.A total of 20.1%of patients was detected with metastatic *** was a significant increase in direct referral to colonoscopy from primary healthcare(25.5%,35.8%;P=0.04)in the post-implantation *** delay was reduced by 24 d(106.64±148.84 days,82.84±109.31 d;P=0.02)due to the reduction in secondary healthcare delay(46.01±111.65 d;29.20±60.83 d;P=0.02).However,we did not find any differences in CRC stage at diagnosis or in two-year survival(70.3%;P=0.9).Variables independently associated with twoyear risk of death were age(Hazard Ratio-HR:1.06,95%CI:1.04-1.07),CRC stage(II HR:2.17,95%CI:1.07-4.40;III HR:3.07,95%CI:1.56-6.08;IV HR:19.22,95%CI:9.86-37.44;unknown HR:9.24,95%CI:4.27-19.99),init

关键词： Colorectal cancer Population based screening Primary healthcare Diagnostic delay Prognosis

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Thermo-Stamping Process of Glass and Carbon-Fibre Reinforced Polymer Composites

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Materials Sciences and Applications 2020年第5期11卷 319-337页

作者： Walid Harizi Zoheir Aboura Mylène deléglise-Lagardère valérie Briand Département Ingénierie Mécanique Laboratoire Roberval FRE UTC-CNRS 2012 Université de Technologie de Compiègne Compiègne France Polymers and Composites Technology & Mechanical Engineering Department IMT Lille Douai Douai France Université de Lille Lille France Zodiac Aerosafety Systems Zodiac Elastomer Europe Caudebec Les Elbeuf France

In this work, manufacturing tools for thermoplastic (TP) composites have been developed. The chosen process involves the stacking alternately of oriented dry fabrics and TP films and does not use semi-products in order to reduce material costs. This study was specifically directed towards optimizing the impregnation of continuous glass and carbon fibres reinforcing two TP amorphous matrices, the polyphenylsulfone (PPSU) and polyetherimide (PEI), to obtain semi-finished products employed for aeronautical structures. The impregnation quality of inter and intra-yarns is analyzed and validated by optical and scanning micrographic observations conducted with an optical and a Scanning Electron Microscopies (SEM), respectively. The study showed that besides the process parameters and porosity distribution in the core of warp yarns, the impregnation quality depends on the surface properties of constituents. Desizing treatment has been carried out to improve the wettability of fibres by the TP matrices.

关键词： Thermoplastic Resin Carbon-Fibre Reinforced Polymer (CFRP) Glass-Fibre-Reinforced Polymer (GFRP) Porosity Scanning Electron Microscopy (SEM)

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西班牙长寿命半刚性基层沥青路面设计指南

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中外公路 2018年第4期38卷 64-68页

作者：付军(编译) 雷力(编译) 刘洁(编译) David Hernando Miguel A.del val 武汉理工大学交通学院湖北武汉430070 不详

频繁的路面破损修复会增加路段的全寿命成本,而对路面破坏机理清晰的认识是延长路面使用寿命的基础。通过回顾半刚性路面潜在的破坏机理,可以系统地考虑影响半刚性路面性能的主要因素,为半刚性长寿命路面的设计提供指导参考和指南。国... 详细信息

频繁的路面破损修复会增加路段的全寿命成本,而对路面破坏机理清晰的认识是延长路面使用寿命的基础。通过回顾半刚性路面潜在的破坏机理,可以系统地考虑影响半刚性路面性能的主要因素,为半刚性长寿命路面的设计提供指导参考和指南。国内外已有文献表明:半刚性路面结构层厚度主要控制疲劳开裂,但材料性能却是影响其他破坏机理的主要因素。基于长寿命设计理念,对西班牙交通量最大的一条半刚性路面进行了分析,结果表明:一部分路段满足长寿命路面的性能要求,另外两部分路段明显存在超安全标准的过度设计。另外,通过增加沥青层的厚度来延缓反射裂缝的产生不一定能节省全寿命周期成本。通过对不同路段进行的线性弹性分析以及路面潜在破坏机理研究,该文提出了更为有效的半刚性长寿命路面设计准则——其关键在于综合考虑路面结构层厚度和材料性能。

关键词：长寿命半刚性路面破坏机理设计

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A social media adoption strategy for cultural dissemination in municipalities with tourist potential:Lamas,Peru,as a case study

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Built Heritage 2024年第2期8卷 67-78页

作者： Pierre Vidaurre-Rojas Seidy Janice Vela-Reátegui Lloy Pinedo Miguel valles-coral Jorge Raul Navarro-Cabreraand Very Rengifo-Hidalgo Teresa del Pilar López-Sánchez JoséSeijas-Díaz Ángel Cárdenas-García Rosa Elena Cueto-Orbe ATEC Management Research Group Faculty of Economic SciencesUniversidad Nacional de San MartínJr.Maynas N°177TarapotoPerú Faculty of Systems and Informatics Engineering Universidad Nacional de San MartínJr.Maynas N°177TarapotoPerú Tourism Development and International Business Research Group Faculty of EconomicAdministrative and Accounting SciencesUniversidad Nacional Autónoma de Alto AmazonasProlongación Libertad 1220-1228YurimaguasPerú Tourism Development and International Business Research Group Faculty of International Business and TourismUniversidad Nacional Autonoma de Alto AmazonasProlongación Libertad 1220-1228YurimaguasPerú

Social media is commonly used by governments to disseminate information related to transparency and institutional promotion,but its potential for the dissemination of cultural resources is often *** research proposes a strategy for adopting social media to achieve cultural dissemination in the municipality of Lamas,Peru,which has tourism potential and has been awarded the“Best Tourism Villages”seal of the World Tourism ***,we propose a case study at a propositional exploratory *** start by determining the current state of dissemination of tangible and intangible resources,as well as the practical use of social media,through a survey of 20 *** results reveal that crafts are the most widely disseminated tangible resource in the municipality(according to 55%of officials),and intangible resources are occasionally disseminated(50%).We also find that Facebook is the only digital channel used to disseminate cultural *** this context,we formulate a strategy for adopting social media to improve cultural dissemination,which consists of six phases:(i)forming a work team,(ii)preparing a budget plan,(iii)strengthening capacities,(iv)taking inventory of cultural resources,(v)coordinating community interests and(vi)preparing a cultural dissemination *** findings can contribute to formulating public initiatives for the institutionalisation of social media in governments for the purposes of preserving,promoting and guaranteeing the accessibility of cultural heritage.

关键词： Cultural heritage Cultural preservation Cultural promotion Digital attraction Digital communication Government Social networks Tourism development Visitors

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Geovisualization with immersive virtual environments in theory and practice

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International Journal of Digital Earth 2019年第2期12卷 123-136页

作者： Florian Hruby Rainer Ressl and Genghis de la Borbolla del valle Department of Geomatics National Commission for the Knowledge and Use of Biodiversity(CONABIO)Mexico CityMexico

Virtual reality(VR)is a frequently emphasized issue on the Digital Earth(DE)*** current DE research is more engaged in the technical aspects of VR applications,this paper focuses on what is possible with immersive virtual environments(IVE)from the user’s *** a brief discussion of spatial presence and embodiment in the context of IVE,both concepts will be merged into a geovisualization immersion pipeline(GIP)as a framework with which to systematically link technical and cognitive aspects of *** will then analyze the general criteria that must be met by IVE in order to facilitate the experience of spatial *** these criteria to the special requirements of geospatial data,a definition of geovisualization immersive virtual environments(GeoIVE)is ***,the theoretical considerations of this paper are set into practice,using a GeoIVE of a coral reef ecosystem as an *** we shall see,while GIS do not provide data models or data compatibility for direct visualization of GeoIVE on VR output devices,game engines can serve as middleware to fill this gap.

关键词： Digital Earth geovisualization virtual reality immersive virtual environments spatial presence

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Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome

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World Journal of Gastrointestinal Oncology 2013年第2期5卷 34-37页

作者： Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda Department of Gastroenterology Rio Hortega Hospital

Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome.

关键词： Ganglioneuromatosis Gastrointestinal poliposis Phosphatase and tensin homolog Cowden síndrome Hamartoma

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