检索结果-南通市图书馆

4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei Kato Daisuke Nishizaki Hirotaka miyashita Suzanna Lee mary K.Nesline Sarabjot Pabla Jeffrey m.conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States medical College of Wisconsin Cancer Center and Genomic Sciences and Precision medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基线舒张压对标准降压和强化降压效果的影响

引用

中华高血压杂志 2017年第12期25卷 1182-1184页

作者： Beddhu S Chertow Gm Cheung AK Cushman WC Rahman m Greene T Wei G Campbell RC conroy m Freedman BI Haley WE Horwitz EJ Kitzman DW Lash J Papademetriou V Pisoni R Riessen E Rosendorff C Watnick SG Whittle J Whelton PK medical Service Veterans Affairs Salt Lake City Health Care System UT (S.B. A.K.C.) Division of Nephrology and Hypertension (S.B. A.K.C. G.W.) Division of Biostatistics (T.G.) Division of General Internal Medicine (M.C.) University of Utah School of Medicine Salt Lake City. Stanford University Palo Alto CA (G.M.C.) Veterans Affairs Medical Center Memphis TN (W.C.C.) Case Western Reserve University Cleveland OH (M.R. E.H.) Medical University of South Carolina Charleston (R.C.C. R.P.) Section on Nephrology (B.I.F.) Section on Cardiology (D.K.) Wake Forest School of Medicine Winston-Salem NC. Division of Nephrology and Hypertension Mayo Clinic Jacksonville FL (W.H.) Metrohealth Medical Center Cleveland OH (E.H.) University of Illinois at Chicago IL (J.L.) Division of Cardiology Veterans Administration Medical Center Washington DC (V.P.) Ralph H. Johnson VA Medical Center Charleston SC (R.P.) Intermountain Medical Center Murray UT (E.R.) Icahn School of Medicine at Mount Sinai New York NY (C.R.) Oregon State Health University Portland (S.G.W.) Primary Care Division Clement J. Zablocki VA Medical Center Milwaukee WI (J.W.) Tulane University School of Public Health and Tropical Medicine New Orleans LA (P.K.W.).

血压升高是心血管病、终末期肾病（end—stage kidney disease，ESKD）和全因死亡的一个重要危险因素。自20世纪60年代开始，随机对照试验证明了治疗高舒张压，随后又证明了治疗高收缩压的价值。

关键词：降压效果舒张压标准基线随机对照试验终末期肾病心血管病血压升高

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

限制性Vβ可用于T细胞淋巴瘤白血病期的证据

引用

世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 39-39页

作者： Vonderheid E.C. Boselli C.m. conroy m. 张宪旗 Dr.550 N. Broadway Building Baltimore MD 21205 United States

Antibodies directed against the β chain of the T cell receptor (anti- Vβ antibodies) are useful to identify the Vβ repertoire of T cells in various diseases and to quantify numbers of Vβ - bearing T cells. The goals of this study were to identify Vβ + cases of leukemic phase cutaneous T cell lymphoma (CTCL) and to compare the percentage of positive calls with other measures of blood tumor burden, i.e., lymphocyte subsets with a CD4+ CD7- and CD4+ CD26- phenotype and Se′ zary cell counts. Thirty- three of 49 (67% ) cases of leukemic CTCL reacted with an anti- Vβ antibody. When combined with reports from the literature, the frequency of Vβ 5 (probably Vβ 5.1) usage was relatively high when compared with Vβ 2that is also frequently expressed by normal CD4+ T cells. The percentage of Vβ + cells correlated to the percentage of CD4+ CD7- and CD4+ CD26- cells for cases in which the neoplastic cells were deficient in expression of CD7 and CD26, respectively, but not the Se′ zary cell count. We hypothesize that the increased Vβ 5.1 usage in CTCL may be the result of depletion of Vβ 2 and other Vβ - bearing T cells by staphylococcal superantigens prior to neoplastic transformation, resulting in a relative increase in the frequency of Vβ 5.1 usage in CTCL.

关键词：淋巴瘤白血病 T细胞淋巴瘤细胞亚群肿瘤负荷计数检测肿瘤形成阳性反应抗原刺激 β链文献资料

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of a field enhanced photocatalytic device for biocide of coliform bacteria

引用

Journal of Environmental Sciences 2016年第6期28卷 38-44页

作者： Jeff m.Huber Krista L.Carlson Otakuye conroy-Ben mano misra Swomitra K.mohanty Departments of Civil Engineering University of Utah Departments of metallurgical Engineering University of Utah Departments of Chemical Engineering University of Utah

A field enhanced flow reactor using bias assisted photocatalysis was developed for bacterial disinfection in lab-synthesized and natural waters. The reactor provided complete inactivation of contaminated waters with flow rates of 50 mL/min. The device consisted of titanium dioxide nanotube arrays, with an externally applied bias of up to 6 V. Light intensity, applied voltage, background electrolytes and bacteria concentration were all found to impact the device performance. Complete inactivation of Escherichia coli W3110（- 8 × 10^3CFU/mL） occurred in 15 sec in the reactor irradiated at 25 mW/cm^2 with an applied voltage of 4 V in a 100 ppm NaCl solution. Real world testing was conducted using source water from Emigration Creek in Salt Lake City, Utah. Disinfection of natural creek water proved more challenging, providing complete bacterial inactivation after 25 sec at 6 V. A reduction in bactericidal efficacy was attributed to the presence of inorganic and organic species, as well as the increase in robustness of natural bacteria.

关键词： Titanium dioxide Nanotubes Immobilized Photocatalysis Escherichia coli Inactivation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Co-delivery of PARP and PI3K inhibitors by nanoscale metal-organic frameworks for enhanced tumor chemoradiation

引用

Nano Research 2019年第12期12卷 3003-3017页

作者： megan J.Neufeld Allison N.DuRoss madeleine R.Landry Hayden Winter Andrea m.Goforth conroy Sun Department of Pharmaceutical Sciences College of PharmacyOregon State UniversityPortlandOregon 97201USA Department of Chemistry Portland State University1719 SW 10th AvePortlandOregon 97201USA Department of Radiation medicine Oregon Health&Science University3181 S.W.Sam Jackson Park RdPortlandOregon 97239USA

Due to their complementary activity,the use of DNA damage repair(DDR)inhibitors during radiotherapy(RT)has yielded promising ***,this approach is often hindered by toxicity and poor in vivo stability of the DDR in *** scale metal-organic frameworks(nmOFs)represent an emerging class of crystalline materials which exhibit advantageous properties over traditional nanomaterials and demonstrate great potential in ***,a unique,synergistic treatment strategy for enhancing the therapeutic efficacy of RT vianmOF-mediated drug delivery and RT enhancement was evaluated.A nmOF containing the high-Zelement Hf and the ligand 1,4-dicarboxybenzene(Hf-BDC)was synthesized and loaded with the two DDR inhibitor drugs,talazoparib and buparlisib(TB@Hf-BDC-PEG).TB@Hf-BDC-PEGaugmented RT by increasing reactive oxygen species generation and thus DNA damage of which repair was inhibited *** enhancement was demonstrated in vivo where the combination of concurrent radiation with in travenous TB@Hf-BDC-PEG administration resulted in improved tumor control and increased ***,no apparent toxicity was observed with nmOF treatment,supporting its potential as an attractive candidate over traditional nano *** work provides the first report of nmOFs employed to enhance thetherapeutic response to RT through DDR inhibitor delivery and physical radiation dose enhancement.

关键词： nano scale metal-organic frameworks chemoradiotherapy DNA damage repair inhibitors drug delivery radiation dose enhancement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long, thin transmission chains of Severe Acute Respiratory Syndrome Coronavirus 2 may go undetected for several weeks at low to moderate reproduction numbers: Implications for containment and elimination strategy

引用

Infectious Disease modelling 2021年第1期6卷 474-489页

作者： Gerry F.Killeen Patricia m.Kearney Ivan J.Perry Niall conroy School of Biological Earth&Environmental SciencesUniversity College CorkCorkIreland Environmental Research Institute University College CorkCorkIreland School of Public Health University College CorkCorkIreland Wide Bay Public Health Unit QueenslandAustralia Faculty of medicine University of QueenslandBrisbaneQueenslandAustralia

Severe Acute Respiratory Syndrome Coronavirus 1(SARS-CoV-1)infections almost always caused overt symptoms,so effective case and contact management enabled its effective eradication within ***,Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)usually causes only mild symptoms,so transmission chains may grow to include several individuals before at least one index case becomes ill enough to self-report for diagnosis and ***,simple mathematical models were developed to evaluate the implications of delayed index case detection for retrospective contact tracing and management ***,these simulations illustrate how:(1)Contact tracing and management may effectively contain most but not all large SARS-CoV-2 clusters arising at foci with high reproduction numbers because rapidly expanding transmission chains ensure at least one overtly symptomatic index case occurs within two viral generations a week or less apart.(2)However,lower reproduction numbers give rise to thinner transmission chains extending through longer sequences of non-reporting asymptomatic and paucisymptomatic individuals,often spanning three or more viral generations(2 weeks of transmission)before an overtly symptomatic index case occurs.(3)Consequently,it is not always possible to fully trace and contain such long,thin transmission chains,so the community transmission they give rise to is underrepresented in surveillance data.(4)Wherever surveillance systems are weak and/or transmission proceeds within population groups with lower rates of overt clinical symptoms and/or self-reporting,case and contact management effectiveness may be more severely limited,even at the higher reproduction numbers associated with larger outbreaks.(5)Because passive surveillance platforms may be especially slow to detect the thinner transmission chains that occur at low reproduction numbers,establishing satisfactory confidence of elimination may require that no confirmed cases are detec

关键词： Coronavirus COVID SARS2 Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 model Epidemiology Outbreak Case and contact management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Occupancy of avian foraging guilds in soybean fields and borders in Entre Ríos, Argentina: responses to vegetation structure and prey resources

引用

Avian Research 2020年第4期11卷 398-411页

作者： Andrea P.Goijman michael J.conroy Vanina D.Varni Jeffrey J.Thompson maría Elena Zaccagnini Instituto de Recursos Biológicos CIRNInstituto Nacional de Tecnología Agropecuaria(CNIA-INTA)HurlinghamBuenos AiresArgentina D.B.Warnell School of Forestry and Natural Resources University of GeorgiaAthensGA 30602USA Present Address:Athens GAUSA Present Address:Laboratorio de Genómica Ecológica y Evolutiva IrapuatoGtoMéxico Present Address:Guyra Paraguay-CONACYT Av.Cnel.Carlos BóvedaParque Ecológico Capital-Viñas CuéAsunciónParaguay Present Address:Instituto Saite AsunciónParaguay Present Address:The Ronin Institute MontclairNJUSA Present Address:Instituto Nacional de Tecnología Agropecuaria(INTA) CABAArgentina

Background:Reconciling agriculture and biodiversity conservation is a challenge given the growing demand for agricultural *** recent decades,Argentina has witnessed agricultural expansion and intensification affecting biodiversity and associated ecosystem *** agroecosystems,the level of habitat quality is critical for birds,and may depend on vegetation structure,availability of invertebrate prey,and the use of *** the relationship between vegetation structure and avian occurrence has been widely studied,to our knowledge,there are no studies that also incorporate prey availability throughout the cycle of soybean crops in *** estimated and predicted the effects of land cover and temporal variation on the occurrence of avian foraging guilds in Entre Ríos,Argentina,in order to guide management related to potential ecosystem services provided by *** also estimated temporal effects of vegetation structure and insecticides on the main arthropod orders consumed by birds to evaluate prey ***:We conducted bird and arthropod surveys for 2 years along transects located in 20 randomly selected soybean fields(N=60)and their adjacent borders(N=78)throughout the crop growing season,in four *** estimated avian occupancy,accounting for imperfect detection,and arthropod counts fitting generalized linear mixed ***:The number of native trees in field borders positively influenced the occurrence of most bird species,mainly *** foliage gleaners,also were positively affected by grass *** and aerial foragers were weakly affected by distance to forest and native *** general,the availability of invertebrates to birds was highest during the third *** counts in borders were greater during the last three crop stages than during the pre-sowing ***:We found that with 10 to 15 native tree species in borders,coupled with a complex vegetation structure w

关键词： Agriculture Birds Ecosystem services Insecticide Insectivores Invertebrates management Native trees Occurrence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用于行星雷达的1mW连续波X波段发射机的初步设计

引用

现代雷达 1990年第6期12卷 19-28页

作者： A.m.Bhanji D.J.Hoppe B.L.conroy A.j.Freiley 吴燕

如何将现有的连续波X波段行星雷达发射机的输出功率由365kW提高到1mW呢?本文就此提出了一个初步设计。文章论及了由雷达技术规范确定的发射机系统的基本要求,讨论了发射饥的功率放大器系统,并涉及到了大功率速调管的特性及其预期性能,... 详细信息

如何将现有的连续波X波段行星雷达发射机的输出功率由365kW提高到1mW呢?本文就此提出了一个初步设计。文章论及了由雷达技术规范确定的发射机系统的基本要求,讨论了发射饥的功率放大器系统,并涉及到了大功率速调管的特性及其预期性能,还有激励器系统的设计问题。论述中给出了向天线系统传送1mW连续波信号的两个可供选择的馈电系统,并且还提到了电子束电源的预期性能,热交换器及监视与控制设备。最后对目前的技术水平能否满足系统要求做出了估价,并概括了可能出现的困难。

关键词：雷达发射机行星雷达 X波段

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using the Bacterial Protein NupC as a model for Human Nucleoside Drug Transporters

Using the Bacterial Protein NupC as a Model for Human Nucleo...

引用

The 4th ISGO International Conference on Structural Genomics

作者： Dawn A.Hadden Shaun K.Loewen Jean C.Ingram Simon G.Patching masao Yamashita matthew J.conroy David A.middleton Gary J.Litherland Richard B.Herbert maurice P.Gallagher Per A.Bullough Peter J.F.Henderson Carol E.Cass James D.Young Stephen A.Baldwin Institute of membrane and Systems Biology University of Leeds LS2 9JTUK Dept.of Physiology University of Alberta EdmontonAlberta T6G 1Z2Canada Institute of membrane and Systems Biology University of Leeds LS2 9JTUK Institute of membrane and Systems Biology University of Leeds LS2 9JTUK Dept.of molecular Biology and Biotechnology University of Sheffield Sheffield S10 2TNUK Dept.of molecular Biology and Biotechnology University of Sheffield Sheffield S10 2TNUK Faculty of Life Sciences The University Of manchester Manchester M60 1QDUK Institute of membrane and Systems Biology University of Leeds LS2 9JT UK Institute of Cell ＆ Molecular BiologyUniversity of EdinburghEdinburghUK Institute of membrane and Systems Biology University of Leeds LS2 9JTUK Institute of Cell ＆ molecular Biology University of Edinburgh Edinburgh UK Dept. of molecular Biology and Biotechnology University of Sheffield Sheffield S10 2TNUK Institute of membrane and Systems Biology University of Leeds LS2 9JTUK Dept.of Oncology Cross Cancer Institute 11560 University AvenueEdmonton Alberta T6G 1Z2Canada Dept.of Physiology University of Alberta Edmonton Alberta T6G 1Z2Canada Institute of membrane and Systems Biology University of Leeds LS2 9JTUK

＜正＞In humans, concentrative nucleoside transporters play important roles in the cellular uptake of chemotherapeutic nucleoside analogues. To provide insights into the mechanism of transport, we have utilised the homologous nucleoside transporter NupC of Escherichia coli as a model system. It proved possible to express this protein at levels up to 20% of the total membrane protein in E. coli and

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

引用

Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：