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Novel economic treatment for coronary wire perforation:A case report

World Journal of Cardiology 2021年第6期13卷 177-182页

作者： Ahmed Abdalwahab conor mcquillan Mohamed Farag Mohaned Egred Department of Cardiothoracic Freeman HospitalNewcastle upon Tyne NE77DNUnited Kingdom Freeman Hospital&Department of Cardiovascular Medicine Tanta UniversityTanta 31512Egypt Freeman Hospital&Department of Cardiology Royal Victoria HospitalBelfast BT126BANorthern IrelandUnited Kingdom Freeman Hospital&School of Life and Medical Sciences University of HertfordshireHertfordshire AL109EUUnited Kingdom Freeman Hospital&Translational and Clinical Research Institute Newcastle UniversityNewcastle upon Tyne NE77DNUnited Kingdom

BACKGROUND Coronary artery perforation is a rare but potentially life-threatening complication of percutaneous coronary intervention(PCI),however if recognized and managed promptly,its adverse consequences can be *** factors include the use of advanced PCI technique(such as atherectomy and chronic total occlusion interventions)and treatment of severely calcified *** vessel perforation is usually treated with implantation of a covered stent,whereas distal and collateral vessel perforations are usually treated with embolization of coils,fat,thrombin,or *** describe a novel and cost-effective method of embolisation using a cut remnant of a used angioplasty balloon that was successful in sealing a distal wire *** advocate this method as a simple method of managing distal vessel *** SUMMARY A 73-year-old male with previous coronary Bypass graft operation and recurrent angina on minimal exertion had undergone rotablation and PCI to his dominant left *** the end of the procedure there was evidence of wire perforation at the distal branch and despite prolonged balloon tamponade there continued to be extravasation and the decision was made to seal this perforation.A cut piece of an angioplasty balloon was used and delivered on the original angioplasty wire to before the perforation area and released which resulted in sealing of the perforation with no unwanted clinical *** The use of a balloon remnant for embolization in coronary perforation presents a simple,efficient and cost-effective method for managing coronary perforations and may be an alternative for achieving hemostasis and preventing poor *** remains the most important part with meticulous attention to the distal wire position,particularly with hydrophilic wires.

关键词： Percutaneous coronary intervention Coronary perforation Coronary guide wire Collagen Coronary angioplasty balloon Coil Case report

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Use of rotablation to rescue a “fractured” micro catheter tip: A case report

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World Journal of Cardiology 2019年第7期11卷 189-194页

作者： Mohammad Alkhalil conor mcquillan Michael Moore Mark S.Spence Colum Owens Cardiology Department Royal Victoria HospitalBelfast BT12 6BAUnited Kingdom Cardiology Department Craigavon Area HospitalPortadown BT63 5QQUnited Kingdom

BACKGROUND High-speed rotational atherectomy (HSRA) is most commonly used to modify calcified coronary artery lesions to facilitate stent deployment and expansion. The use of HSRA as an emergency rescue technique to release a fractured microcatheter has not been described. We report the use of HSRA in a case of a fracture trapped corsair tip that was impeding coronary flow causing a ST elevation myocardial infarct. CASE SUMMARY A 79 years old male was scheduled for elective percutaneous coronary intervention (PCI) to his left anterior descending artery (LAD). Given its calcific nature, a decision was made for upfront rotablation. During procedural preparations, the tip of an employed micro-catheter was separated from the shaft resulting in obstructing coronary flow and ST-segment elevation. The consensus was for an attempt bail out PCI strategy. A rotafloppy wire was advanced to the distal LAD using a corsair micro-catheter which was placed proximal to the occlusion site. Modification of the mid LAD segment was performed, resulting in mobilising the corsair tip, and deflecting it to a small diagonal branch. Following serial predilation, the procedure was completed using two overlapping drug eluting stents, jailing the corsair tip in the diagonal branch. The patient made uneventful recovery and was clinically stable at one year follow up. CONCLUSION HSRA may be offered as a bailed-out strategy to rescue fractured and jailed micro-catheter tip in high risk surgical cases.

关键词： Micro-catheter Rotational atherectomy Calcification Case report

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Perceived value of microfinance and SME performance: The role of exploratory innovation

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International Journal of Innovation Studies 2024年第2期8卷 172-185页

作者： Christian Sarfo Jing A.Zhang conor O'Kane Paula O'Kane Department of Management University of LincolnBrayford PoolLincoln LN67TSUnited Kingdom Department of Management Otago Business SchoolUniversity of OtagoPO Box 56Dunedin9054New Zealand

This study examines how perceived value of microfinance and exploratory innovation affect small and medium-sized enterprises(SME)performance in the context of a developing *** on the strategic innovation and microfinance literature,we hypothesize that(1)perceived value of microfinance affects exploratory innovation and SME performance,and(2)exploratory innovation serves as an effective mechanism through which microfinance enhances SME *** employ partial least squares structural equation modeling(PLS-SEM)to test our *** a sample of 581 Ghanaian SMEs with microfinance,the results of the PLS SEM support our *** further conducted a qualitative analysis of comments provided by the SMEs(n=144)to gain a deeper understanding of exploratory innovation in developing *** findings show that SMEs purposefully attempt to strengthen their exploratory inno-vation in *** discuss the theoretical and practical implications of these findings as well as future research avenues.

关键词： Perceived value of microfinance Exploratory innovation SME performance

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Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

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World Journal of Orthopedics 2024年第2期15卷 129-138页

作者： Albert T Anastasio Anthony N Baumann Kempland C Walley Kyle J Hitchman conor O’Neill Jonathan Kaplan Samuel B Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States College of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

BACKGROUND The study investigates the connection between academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Database(OPD)data,it addresses a gap in understanding the relationship between scholarly achievements and financial outcomes,providing a basis for further exploration in this specialized medical *** To elucidate the trends between academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** This study is a retrospective analysis of the relationship between academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a combined total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD website was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).There was a significant but weak correlation between individual physician H-index and individual physician total life-time earnings(P<0.001;Spearman’s rho=0.334)and a significant and moderate positive correlation between combined fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).CONCLUSION There is a significant and positive correlation between academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** observation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

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Human-artificial intelligence interaction in gastrointestinal endoscopy

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 126-135页

作者： John R Campion Donal B O'Connor conor Lahiff Department of Gastroenterology Mater Misericordiae University HospitalDublin D07 AX57Ireland School of Medicine University College DublinDublin D04 C7X2Ireland Department of Surgery Trinity College DublinDublin D02 R590Ireland

The number and variety of applications of artificial intelligence(AI)in gastr-ointestinal(GI)endoscopy is growing *** technologies based on machine learning(ML)and convolutional neural networks(CNNs)are at various stages of development and deployment to assist patients and endoscopists in preparing for endoscopic procedures,in detection,diagnosis and classification of pathology during endoscopy and in confirmation of key performance *** based on ML and CNNs require regulatory approval as medical *** between humans and the technologies we use are complex and are influenced by design,behavioural and psychological *** to the substantial differences between AI and prior technologies,important differences may be expected in how we interact with advice from AI ***-AI interaction(HAII)may be optimised by developing AI algorithms to minimise false positives and designing platform interfaces to maximise *** factors influencing HAII may include automation bias,alarm fatigue,algorithm aversion,learning effect and *** of these areas merits further study in the specific setting of AI applications in GI endoscopy and professional societies should engage to ensure that sufficient emphasis is placed on human-centred design in development of new AI technologies.

关键词： Artificial intelligence Machine learning Human factors Computer-aided detection Colonoscopy Adenoma detection rate

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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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Chimeric Antigen Receptors and Regulatory T Cells:The Potential for HLA-Specific Immunosuppression in Transplantation

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Engineering 2022年第3期8卷 30-43页

作者： Sabrina Wright conor Hennessy Joanna Hester Fadi Issa Nuffield Department of Surgical Sciences University of OxfordOxford OX39DUUK

Chimeric antigen receptors(CARs)are a breakthrough in genetic engineering that have revolutio nized the field of adoptive cellular therapy(ACT).Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific binding region within the synthetic CAR *** advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology,and it is clear that such cells have greater accuracy,potency,and reduced off-target therapeutic effects compared with their unmodified *** contrast to conventional T cells(Tconvs),regulatory T cells(Tregs)play a major role in suppressing immune activation and regulating the host immune *** expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases,graft-versus-host disease(GVHD),and organ transplant rejectio *** the latter,they hold immense potential as mediators of immune tolerance for recipients of ***,current research into CAR-Treg engineering is extremely limited,and there is uncertainty regarding optimal design for therapeutic *** review examines the rationale behind the development of CAR-Tregs,their significance for human transplantation,potential designs,safety considerations,and comparisons of CAR-Tregs in transplantation models to date.

关键词： Chimeric antigen receptors T cell Treg Alloimmunity Bioengineering Transplant Autoimmunity

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A broad scope, a broad readership, and a broad purpose

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Malignancy Spectrum 2024年第1期1卷 1-1页

作者： Qimin Zhan Weimin Li Wei Fu conor C.Lynch Peking University International Cancer Institute BeijingChina West China School of Medicine Sichuan UniversityChengduChina Department of General Surgery Peking University Third HospitalBeijingChina Department of Tumor Microenvironment and Metastasis H.Lee Moffitt Cancer Center and Research InstituteTampaFloridaUSA

The long battle with cancer began centuries ago and despite many victories,the overall incidence continues to rise and it sometimes feels like that we are losing the *** high rates and mortality of cancer have brought an increasing burden to society and so defeating the disease remains an urgent and unmet clinical *** recent years,there has been a profound development of new knowledge and technologies that are widely employed in cancer research across multiple disciplines and even moreso,across the *** modern times,it is hard to keep up with these breakthroughs,especially when they occur in varying *** address this,we are delighted to announce the launch of Malignancy Spectrum(MSP)in a bid to bring global advances in these disciplines together in one place.

关键词： mortality breakthrough urgent

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Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors:Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations

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Neuroscience Bulletin 2023年第12期39卷 1873-1886页

作者： Charlotte Sleurs Paul Fletcher conor Mallucci Shivaram Avula Thankamma Ajithkumar Department of Cognitive Neuropsychology Tilburg University5037 ABTilburgThe Netherlands Department of Oncology KU Leuven3000LeuvenBelgium Department of Psychiatry University of CambridgeAddenbrookes HospitalCambridgeCB20QQUK Wellcome Trust MRC Institute of Metabolic Science University of CambridgeCambridge Biomedical CampusCambridgeCB20QQUK Department of Neurosurgery Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Radiology Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Oncology Cambridge University Hospital NHS TrustCambridgeCB20QQUK

The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological *** the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and challenging to *** number of neurocognitive studies in this population grows exponentially worldwide,motivating modern neuroscience to provide guidance in follow-up before,during and after *** this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor *** on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.

关键词： Connectome Pediatric brain tumor Neuroimaging Neurocognition-Neuropsychological assessment

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Cascade electrocatalytic reduction of carbon dioxide and nitrate to ethylamine

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Journal of Energy Chemistry 2022年第2期31卷 367-370页

作者： Zixu Tao Yueshen Wu Zishan Wu Bo Shang conor Rooney Hailiang Wang Department of Chemistry Yale UniversityNew HavenCT 06520United States Energy Sciences Institute Yale UniversityWest HavenCT 06516United States

CO_(2) utilization,including electrochemical reduction of CO_(2) to fuels and useful chemicals,is explored to valorize carbon emissions[1–12].The value of CO_(2) electroreduction products originates from their C–H,C–C,and C–O *** further increase the value and expand the scope of products,it is desirable to integrate C–N bond formation with the electrochemical reduction of CO_(2).

关键词： nitrate dioxide carbon

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