检索结果-南通市图书馆

Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors:Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第12期39卷 1873-1886页

作者： Charlotte Sleurs Paul Fletcher conor Mallucci Shivaram Avula Thankamma Ajithkumar Department of Cognitive Neuropsychology Tilburg University5037 ABTilburgThe Netherlands Department of Oncology KU Leuven3000LeuvenBelgium Department of Psychiatry University of CambridgeAddenbrookes HospitalCambridgeCB20QQUK Wellcome Trust MRC Institute of Metabolic Science University of CambridgeCambridge Biomedical CampusCambridgeCB20QQUK Department of Neurosurgery Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Radiology Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Oncology Cambridge University Hospital NHS TrustCambridgeCB20QQUK

The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological *** the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and challenging to *** number of neurocognitive studies in this population grows exponentially worldwide,motivating modern neuroscience to provide guidance in follow-up before,during and after *** this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor *** on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.

关键词： Connectome Pediatric brain tumor Neuroimaging Neurocognition-Neuropsychological assessment

Surgical treatment for rectal cancer:An international perspective on what the medical gastroenterologist needs to know

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第21期14卷 3281-3289页

作者： Rolv-Ole Lindsetmo Yong-Geul Joh conor P Delaney Department of Gastrointestinal Surgery University Hospital of North Norway and Institute of Clinical MedicineUniversity of TromsTromsN-9036Norway Department of Surgery Hansol HospitalSeoul 138-844South Korea Division of Colorectal Surgery University Hospital Case Medical CenterClevelandOhio 44106-5047United States

Rectal cancer accounts for one third of all colorectal *** age adjusted death rates from colorectal cancer have declined over recent decades due to a combination of colorectal cancer screening,improved diagnostic tests,improved standardized surgical technique,improved medical support,neoadjuvant chemotherapies and radiation treatment or combinations of *** of complex treatment algorithms,use of multidisciplinary teams in the management of rectal cancer patients has also been *** gastroenterologists performing colonoscopies are frequently the first health care provider to raise the suspicion of a rectal *** the diagnosis depends on histological confirmation,the endoscopic presentation is almost diagnostic in many *** order to meet the patient's immediate needs for information,it is important that the endoscopist has knowledge about the investigations and treatment options that will be required for their *** aim of this paper is to describe the modern preoperative investigations and operative procedures commonly offered to rectal cancer patients taking into account perspectives of three colorectal surgeons,practicing in the USA,Europe and Asia.

关键词： Rectal cancer management Evaluation Staging Neoadjuvant Adjuvant Surgical treatment Surveillance

Dehydroepiandrosterone:a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2019年第1期7卷 248-260页

作者： conor Bentley Jon Hazeldine Carolyn Greig Janet Lord Mark Foster NIHR Surgical Reconstruction and Microbiology Research Centre University Hospital BirminghamBirmingham B152WBUK School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirminghamUK MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research Institute of Inflammation and AgeingBirmingham University Medical SchoolBirmingham B152TTUK NIHR Biomedical Research Centre University Hospital BirminghamBirminghamUK Royal Centre for Defence Medicine Birmingham Research ParkBirmingham B152SQUK.

Severe injuries are the major cause of death in those aged under 40,mainly due to road traffic ***,metabolic and immune pathways respond to limit the tissue damage sustained and initiate wound healing,repair and regeneration ***,depending on age and sex,the response to injury and patient prognosis differ *** are catabolic and immunosuppressive and are produced as part of the stress response to injury leading to an intra-adrenal shift in steroid biosynthesis at the expense of the anabolic and immune enhancing steroid hormone dehydroepiandrosterone(DHEA)and its sulphated metabolite dehydroepiandrosterone sulphate(DHEAS).The balance of these steroids after injury appears to influence outcomes in injured humans,with high cortisol:DHEAS ratio associated with increased morbidity and *** models of trauma,sepsis,wound healing,neuroprotection and burns have all shown a reduction in proinflammatory cytokines,improved survival and increased resistance to pathological challenges with DHEA *** supplementation studies,which have focused on post-menopausal females,older adults,or adrenal insufficiency have shown that restoring the cortisol:DHEAS ratio improves wound healing,mood,bone remodelling and psychological ***,there are no DHEA or DHEAS supplementation studies in trauma patients,but we review here the evidence for this potential therapeutic agent in the treatment and rehabilitation of the severely injured patient.

关键词： Dehydroepiandrosterone Dehydroepiandrosterone sulphate Traumatic injury Intensive care Immune Rehabilitation

货币政策宽松周期开启会如何影响美国房贷利率

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

商业周刊（中文版） 2024年第15期 7-7页

作者： conor Sen 逸思(译) 不详

美联储9月19日的降息让许多人开始思考这会对抵押贷款利率,即房贷利率产生什么影响。房地产网站Redfin指出,部分有意购房者并没有意识到我们早已预见到了大幅降息,还有人则在等待房贷利率进一步降低。

关键词：抵押贷款利率降息房贷利率房地产网站美联储购房者货币政策宽松

Cascade electrocatalytic reduction of carbon dioxide and nitrate to ethylamine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第2期31卷 367-370页

作者： Zixu Tao Yueshen Wu Zishan Wu Bo Shang conor Rooney Hailiang Wang Department of Chemistry Yale UniversityNew HavenCT 06520United States Energy Sciences Institute Yale UniversityWest HavenCT 06516United States

CO_(2) utilization,including electrochemical reduction of CO_(2) to fuels and useful chemicals,is explored to valorize carbon emissions[1–12].The value of CO_(2) electroreduction products originates from their C–H,C–C,and C–O *** further increase the value and expand the scope of products,it is desirable to integrate C–N bond formation with the electrochemical reduction of CO_(2).

关键词： nitrate dioxide carbon

Do the benefits outweigh the side effects of colorectal cancer surveillance? A systematic review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2014年第5期6卷 104-111页

作者： Knut Magne Augestad Johnie Rose Benjamin Crawshaw Gregory Cooper conor Delaney Department of Colorectal Surgery University Hospitals Case Medical Center Department of Gastrointestinal Surgery University Hospital North Norway Norwegian National Center of Integrated Care and Telemedicine Department of Family Medicine and Community Health Case Western Reserve University School of Medicine Gregory Cooper Department of Gastroenterology University Hospitals Case Medical Center Case Comprehensive Cancer Center Department of Gastroenterology University Hospitals Case Medical Center

Most patients treated with curative intent for colorectal cancer(CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. However, in a recent randomized trial, there was no survival benefit when a minimal vs an intensive follow-up program was compared. Less is known about the potential side effects of follow-up. Well-known side effects of preventive programs are those of somatic complications caused by testing, negative psychological conse-quences of follow-up itself, and the downstream impact of false positive or false negative tests. Accordingly, the potential survival benefits of CRC follow-up must be weighed against these potential negatives. The present review compares the benefits and side effects of CRC follow-up, and we propose future areas for research.

关键词： Colorectal cancer Follow-up Surveillance False positive Cancer survivorship

Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2018年第7期11卷 1129-1131页

作者： Aine Ni Mhealoid Taylor Lukasik William Power conor C.Murphy Education and Research Centre Royal Victoria Eye and Ear Hospital Dublin D02XK51 Ireland School of Medicine RCSI School of Medicine Dublin D02VN51 Ireland Ophthalmology Department Royal Victoria Eye and Ear Hospital Dublin D02XK51 Ireland

AIM： To evaluate the outcomes of alcohol delamination（ALD） of the corneal epithelium for the treatment of recurrent corneal erosion syndrome（RCES） and to implement a standardized treatment protocol for this condition utilizing evidence based practice and the findings of an internal audit. METHODS： A retrospective analysis of 42 eyes of 40 patients diagnosed with RCES who were treated with ALD between January 2006 and March 2016 was conducted. Patients had 20% alcohol applied to the cornea with the use of a well for 40 s. Patients were reviewed one week later in the Outpatient Department. Outcome criteria were established based on standards from other studies in the medical literature. These included, a treatment success rate of at least 72%（defined as complete resolution of symptoms one month after treatment）, a postoperative complication a rate of 〈5%（mainly infective keratitis, and subepithelial haze）, and the absence of any detrimental effect on visual acuity in ≥95% of patients. RESULTS： The mean age at the time of ALD was 41.17±13.44 y. Patients were followed for an average of 12.8±15.65 mo. The majority were female（52.5%, n=21） and the majority of eyes treated with ALD were left eyes（62.9%, n=26）. Trauma was the primary aetiology in our study population. Treatment was successful in 73.8%（n=31） of eyes and in 75%（n=30） of patients. Recurrence occurred in 26.2% of eyes at a mean of 10.41±12.63 mo post treatment. CONCLUSION： ALD is an efficacious and cost-effective primary surgical intervention for RCES.

关键词： recurrent comeal erosion alcohol delaminafion corneal abrasion corneal trauma corneal dystrophy

Novel economic treatment for coronary wire perforation:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2021年第6期13卷 177-182页

作者： Ahmed Abdalwahab conor McQuillan Mohamed Farag Mohaned Egred Department of Cardiothoracic Freeman HospitalNewcastle upon Tyne NE77DNUnited Kingdom Freeman Hospital&Department of Cardiovascular Medicine Tanta UniversityTanta 31512Egypt Freeman Hospital&Department of Cardiology Royal Victoria HospitalBelfast BT126BANorthern IrelandUnited Kingdom Freeman Hospital&School of Life and Medical Sciences University of HertfordshireHertfordshire AL109EUUnited Kingdom Freeman Hospital&Translational and Clinical Research Institute Newcastle UniversityNewcastle upon Tyne NE77DNUnited Kingdom

BACKGROUND Coronary artery perforation is a rare but potentially life-threatening complication of percutaneous coronary intervention(PCI),however if recognized and managed promptly,its adverse consequences can be *** factors include the use of advanced PCI technique(such as atherectomy and chronic total occlusion interventions)and treatment of severely calcified *** vessel perforation is usually treated with implantation of a covered stent,whereas distal and collateral vessel perforations are usually treated with embolization of coils,fat,thrombin,or *** describe a novel and cost-effective method of embolisation using a cut remnant of a used angioplasty balloon that was successful in sealing a distal wire *** advocate this method as a simple method of managing distal vessel *** SUMMARY A 73-year-old male with previous coronary Bypass graft operation and recurrent angina on minimal exertion had undergone rotablation and PCI to his dominant left *** the end of the procedure there was evidence of wire perforation at the distal branch and despite prolonged balloon tamponade there continued to be extravasation and the decision was made to seal this perforation.A cut piece of an angioplasty balloon was used and delivered on the original angioplasty wire to before the perforation area and released which resulted in sealing of the perforation with no unwanted clinical *** The use of a balloon remnant for embolization in coronary perforation presents a simple,efficient and cost-effective method for managing coronary perforations and may be an alternative for achieving hemostasis and preventing poor *** remains the most important part with meticulous attention to the distal wire position,particularly with hydrophilic wires.

关键词： Percutaneous coronary intervention Coronary perforation Coronary guide wire Collagen Coronary angioplasty balloon Coil Case report

Deep reinforcement learning for home energy management system control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

能源与人工智能(英文) 2021年第1期3卷 64-72页

作者： Paulo Lissa conor Deane Michael Schukat Federico Seri Marcus Keane Enda Barrett College of Science and Engineering National University of IrelandGalwayIreland Informatics Research Unit for Sustainable Engineering(IRUSE)Galway Ireland Ryan Institute National University of Ireland GalwayIreland

The use of machine learning techniques has been proven to be a viable solution for smart home energy *** techniques autonomously control heating and domestic hot water systems,which are the most relevant loads in a dwelling,helping consumers to reduce energy consumption and also improving their ***,the number of houses equipped with renewable energy resources is increasing,and this is a key ele-ment for energy usage optimization,where coordinating loads and production can bring additional savings and reduce peak *** this regard,we propose the development of a deep reinforcement learning(DRL)algorithm for indoor and domestic hot water temperature control,aiming to reduce energy consumption by optimizing the usage of PV energy ***,a methodology for a new dynamic indoor temperature setpoint definition is presented,thus allowing greater flexibility and *** results show that the proposed DRL al-gorithm combined with the dynamic setpoint achieved on average 8%of energy savings compared to a rule-based algorithm,reaching up to 16%of savings over the summer ***,the users’comfort has not been compromised,as the algorithm is calibrated to not exceed more than 1%of the time out the specified temperature *** analysis shows that further savings could be achieved if the time out of comfort is increased,which could be agreed according to users’*** demand side management,the DRL control shows efficiency by anticipating and delaying actions for a PV self-consumption optimization,performing over 10%of load ***,the renewable energy consumption is 9.5%higher for the DRL-based model compared to the rule-based,which means less energy consumed from the grid.

关键词： Deep reinforcement learning Residential home energy management Demand response Autonomous control