检索结果-南通市图书馆

Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF:not just ICSI failure

Asian Journal of Andrology 2024年第2期26卷 175-182页

作者： Jian-Fang Che Hui-Xia wu Si-cong Zeng Yue-Ren wu Jing Dai De-Hua Cheng Fei Gong Guang-Xiu Lu ge Lin Can Dai School of Medicine Hunan Normal UniversityChangsha 410013China Reproductive and genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and genetics in Hunan Province Changsha 410078China National Engineering and Research Center of Human Stem Cell Changsha 410205China

Phospholipase C zeta(PLC)is a key sperm-borne oocyte-activating factor that triggers Ca^(2+)oscillations and the subsequent block to polyspermy following gamete fusion.Mutations in PLCZ1,the gene encoding PLCζ,cause male infertility and intracytoplasmic sperm injection(ICSI)fertilization failure;and PLCζ expression and localization patterns are significantly correlated with ICSI fertilization rate(FR).However,in conventional in vitro fertilization(cIVF),whether and how sperm PLCζ affects fertilization remain unclear.Herein,we identified one previously reported and two novel PLCZ1 mutations associated with polyspermy in vitro that are characterized by excessive sperm-zona binding and a delay in pronuclei(PN)formation.Immunofluorescence staining and oocyte activation testing revealed that virtually all spermatozoa from patients lacked functional PLCζ and were thus unable to evoke Ca^(2+) oscillations.ICSI with an artificial oocyte activation treatment successfully rescued the polyspermic phenotype and resulted in a live birth.Furthermore,we analyzed PLCζ in an additional 58 males after cIVF treatment in the Reproductive and genetic Hospital of CiTiC-Xiangya(Changsha,China)between February 2019 and January 2022.We found that the proportion of spermatozoa that expressed PLCζ was positively correlated with both 2PN rate and total FR.The optimal cutoff value below which males were likely to experience low FR(total FR≤30%)after clVF was 56.7%for the proportion of spermatozoa expressing PLC5.Our study expands the mutation and the phenotypic spectrum of PLCZ1 and further suggests that PLCζ constitutes a promising biomarker for identifying low FRs cases in cIVF due to sperm-related oocyte activation deficiency and that sperm PLCζ analysis may benefit the widermale population and not onlymen with IcsI failure.

关键词： conventional IVF gene variants PLCζ polyspermy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Iron-Catalyzed Reductive C(aryl)—Si Cross-Coupling of Diaryl Ethers with Chlorosilanes

引用

Chinese Journal of Chemistry 2024年第6期42卷 578-584页

作者： Pei Liu Baowei wu Xuefeng cong Jie Kong School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi'anShaanxi710072 China Institute of Molecular Plus Department of Chemistry and Haihe Laboratory of Sustainable Chemical TransformationsTianjin University92 Weijin RoadTianjin300072 China

The reductive cross-coupling between C(aryl)—O and Si—Cl bonds is of much importance as a valuable strategy for the construction of C(aryl)—Si bonds but has remained a great challenge.Herein,we report a reductive cross-coupling of diaryl ethers and chlorosilanes via strong electrophilic C(aryl)—O and Si—Cl bonds cleavage by iron catalysis,which constitutes an efficient protocol for the synthesis of a range of functionalized arylsilanes.The combination of low cost FeCl2 as the precatalyst and iPrMgCl as the reductant shows high activity in the successive cleavage of unactivated C(aryl)—O bonds of diaryl ethers and strong electrophilic Si—Cl bonds of chlorosilanes,allowing their cross-coupling in a reductive fashion.The low-valent iron species generated in situ by reduction of FeCl2 with iPrMgCl was proposed,which prefers to initially cleavage the C(aryl)—O bond of diaryl ethers with the chelation help of an o-amide auxiliary.

关键词： Cross-coupling Diaryl ethers Chlorosilanes C—O bond cleavage Iron catalyst 3d transition metals Selectivity Regioselectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brain Cognition Mechanism-Inspired Hierarchical Navigation Method for Mobile Robots

引用

Journal of Bionic Engineering 2024年第2期21卷 852-865页

作者： Qiang Zou Chengdong wu Ming cong Dong Liu Faculty of Robot Science and Engineering Northeastern UniversityShenyang110819China School of Mechanical Engineering Dalian University of TechnologyDalian116024China

Autonomous navigation is a fundamental problem in robotics.Traditional methods generally build point cloud map or dense feature map in perceptual space;due to lack of cognition and memory formation mechanism,traditional methods exist poor robustness and low cognitive ability.As a new navigation technology that draws inspiration from mammal’s navigation,bionic navigation method can map perceptual information into cognitive space,and have strong autonomy and environment adaptability.To improve the robot’s autonomous navigation ability,this paper proposes a cognitive map-based hierarchical navigation method.First,the mammals’navigation-related grid cells and head direction cells are modeled to provide the robots with location cognition.And then a global path planning strategy based on cognitive map is proposed,which can anticipate one preferred global path to the target with high efficiency and short distance.Moreover,a hierarchical motion controlling method is proposed,with which the target navigation can be divided into several sub-target navigation,and the mobile robot can reach to these sub-targets with high confidence level.Finally,some experiments are implemented,the results show that the proposed path planning method can avoid passing through obstacles and obtain one preferred global path to the target with high efficiency,and the time cost does not increase extremely with the increase of experience nodes number.The motion controlling results show that the mobile robot can arrive at the target successfully only depending on its self-motion information,which is an effective attempt and reflects strong bionic properties.

关键词： Bionic navigation Spatial localization cells Global path planning Hierarchical motion controlling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamical pattern recognition for univariate time series and its application to an axial compressor

引用

Control Theory and Technology 2024年第1期22卷 39-55页

作者： Jingtao Hu Weiming wu Zejian Zhu cong Wang Center for Intelligent Medical Engineering School of Control Science and TechnologyShandong UniversityJinan250061ShandongChina School of Automation Science and Engineering South China University of TechnologyGuangzhou510641GuangdongChina

In this paper, a learning and recognition approach is proposed for univariate time series composed of output measurements of general nonlinear dynamical systems. Firstly, a class of dynamical systems in the canonical form is derived to describe the univariate time series by introducing coordinate transformation. An observer-based deterministic learning technique is then adopted to achieve dynamical modeling of the associated transformed systems of the training univariate time series, and the modeling results in the form of radial basis function network (RBFN) models are stored in a pattern library. Subsequently, multiple observer-based dynamical estimators containing the RBFN models in the pattern library are constructed for a test univariate time series, and a recognition decision scheme is proposed by the derived recognition indicator. On this basis, more concise recognition conditions are provided, which is beneficial for verifying the recognition results. Finally, simulation studies on the Rossler system and aero-engine stall warning verify the effectiveness of the proposed approach.

关键词： Dynamical pattern recognition Deterministic learning Stall warning Radial basis function network Sampled-data observer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tighter sum uncertainty relations via(α,β,γ)weighted Wigner–Yanase–Dyson skew information

引用

Communications in Theoretical Physics 2024年第3期76卷 91-99页

作者： cong Xu Zhaoqi wu Shao-Ming Fei School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Department of Mathematics Nanchang UniversityNanchang 330031China Max-Planck-Institute for Mathematics in the Sciences 04103 LeipzigGermany

We establish tighter uncertainty relations for arbitrary finite observables via(α,β,γ)weighted Wigner–Yanase–Dyson((α,β,γ)WWYD)skew information.The results are also applicable to the(α,γ)weighted Wigner–Yanase–Dyson((α,γ)WWYD)skew information and the weighted Wigner–Yanase–Dyson(WWYD)skew information.We also present tighter lower bounds for quantum channels and unitary channels via(α,β,γ)modified weighted Wigner–Yanase–Dyson((α,β,γ)MWWYD)skew information.Detailed examples are provided to illustrate the tightness of our uncertainty relations.

关键词： quantum channels (α,β,γ)WWYD skew information (α,β,γ)MWWYD skew information uncertainty relations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between central serous chorioretinopathy and Helicobacter pylori infection: a systematic review and Meta-analysis

引用

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1120-1127页

作者： Da-Wen wu Fei-Peng Jiang ge ge Mei-Xia Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the association between central serous chorioretinopathy(CSC)and Helicobacter pylori(Hp)by summarizing all available evidence.METHODS:The Scopus,Embase,EBSCO,PubMed,Web of Science,and Cochrane Library databases for all relevant studies published from inception to October 2022 were searched,and manually searched for relevant reference lists as a supplement.Studies investigating the association between CSC and Hp infection were included.Finally,8 case-control studies were included in the Meta-analysis after study selection.RESULTS:The results showed no significant correlation between Hp infection and CSC[odds ratio(OR)1.89,95%confidential interval(CI)0.58–6.15,I2=96%,P=0.29].After subgroup analysis based on the degree of development of the study(developing/developed countries),it was found that the results of the two subgroups were the same as the whole,and no significant difference between the two subgroups existed.Meta-regression showed that the effect of sample size on heterogeneity among studies was more prominent(Pgeneity.CONCLUSION:This Meta-analysis reveals no significant correlation between Hp infection and CSC,which still warrants further well-designed extensive sample studies to reach a more reliable conclusion and promote a better understanding of the treatment of CSC.

关键词： central serous chorioretinopathy Helicobacter pylori infection retinal diseases Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Attack-Resilient Distributed Cooperative Control of Virtually Coupled High-Speed Trains via Topology Reconfiguration

引用

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1066-1068页

作者： Shunyuan Xiao Xiaohua ge Qing wu the Institute of Advanced Technology Nanjing University of Posts and TelecommunicationsNanjing 210023China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia the School of Engineering and Technology Central Queensland UniversityRockhampton QLD 4701Australia

Dear Editor,This letter addresses the resilient distributed cooperative control problem of a virtually coupled train convoy under stochastic disturbances and cyber attacks.The main purpose is to achieve distributed coordination of virtually coupled high-speed trains with the prescribed inter-train distance and same cruise velocity.

关键词： prescribed Speed trains

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laboratory and field evaluation of a low-cost optical particle sizer

引用

Journal of Environmental Sciences 2024年第8期142卷 215-225页

作者： Mingzhen Tang Yicheng Shen Yanzhen ge Jian Gao Chong Wang Liqing wu Shuchun Si State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Jinan Grid-Based Supervision Center of Ecological and Environmental Protection Jinan 250100China Tai’an Ecological Environment Protection Control Center Tai’an 271000China School of Physics Shandong UniversityJinan 250013China

Low-cost sensors are widely used to collect high-spatial-resolution particulate matter data that traditional reference monitoring devices cannot.In addition to the mass concentration,the number concentration and size distribution are also fundamental in determining the origin and hazard level of particulate pollution.Therefore,low-cost optical sensors have been improved to establish optical particle sizers(OPSs).In this study,a low-cost OPS,the Nova SDS029,is introduced,and it is evaluated in comparison to two reference instruments—the GRIMM 11-D and the TSI 3330.We first tested the sizing accuracy using polystyrene latex spheres.Then,we assessed the mass and number size distribution accuracy in three application scenarios:indoor smoking,ambient air quality,and mobile monitoring.The evaluations suggest that the low-cost SDS029 rivals research-grade optical sizers in many aspects.For example,(1)the particle diameters obtained with the SDS029 are close to the reference instruments(usuallyge;(2)the number of particles and mass concentration are highly correlated(r≥0.99)with the values obtained with the reference instruments;and(3)the SDS029 slightly underestimates the number concentration,but the derived PM_(2.5)values are closer to monitoring station than the reference instruments.The successful application of the SDS029 in multiple scenarios suggests that a plausible particle size distribution can be obtained in an easy and cost-efficient way.We believe that low-cost OPSs will increasingly be used to map the sources and risk levels of particles at the city scale.

关键词： Optical particle sizer Particle size distribution Low-cost sensor Evaluation Field application

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Local-Global Attention Fusion Framework With Tensor Decomposition for Medical Diagnosis

引用

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1536-1538页

作者： Peishu wu Han Li Liwei Hu Jirong ge Nianyin Zeng Department of Instrumental and Electrical Engineering Xiamen UniversityFujian 361005China Key Research Laboratory of Osteoporosis Syndrome genomics Fujian Academy of Chinese Medical SciencesFuzhou 350003China

Dear Editor,In this letter,a novel hierarchical fusion framework is proposed to address the imperfect data property in complex medical image analysis(MIA)scenes.In particular,by combining the strengths of convolutional neural networks(CNNs)and transformers,the enhanced feature extraction,spatial modeling,and sequential context learning are realized to provide comprehensive insights on the complex data patterns.Integration of information in different level is enabled via a multi-attention fusion mechanism,and the tensor decomposition methods are adopted so that compact and distinctive representation of the underlying and high-dimensional medical image features can be accomplished[1].It is shown from the evaluation results that the proposed framework is competitive and superior as compared with some other advanced algorithms,which effectively handles the imperfect property of inter-class similarity and intra-class differences in diseases,and meanwhile,the model complexity is reduced within an acceptable level,which benefits the deployment in clinic practice.MIA has assumed a pivotal role in numerous critical clinical scenarios,where sophisticated image analysis techniques have proven instrumental in augmenting medical decision-making,facilitating individualized therapeutic interventions,and enhancing patient prognostication[2]−[4].

关键词： handle image property

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Variation of microbiological and small molecule metabolite profiles of Nuodeng ham during ripening by high-throughput sequencing and GC-TOF-MS

引用

Food Science and Human Wellness 2024年第4期13卷 2187-2196页

作者： cong Li Yingling Zou Guozhou Liao Zijiang Yang Dahai Gu Yuehong Pu Changrong ge Guiying Wang Livestock Product Processing and Engineering Technology Research Center of Yunnan Province Yunnan Agricultural UniversityKunming 650201China College of Food Science and Technology Yunnan Agricultural UniversityKunming 650201China

The internal microbial diversity and small molecular metabolites of Nuodeng ham in different processing years(the first,second and third year sample)were analyzed by high-throughput sequencing technology and gas chromatography-time of flight mass spectrography(GC-TOF-MS)to study the effects of microorganisms and small molecular metabolites on the quality of ham in different processing years.The results showed that the dominant bacteria phyla of Nuodeng ham in different processing years were Proteobacteria and Firmicutes,the dominant fungi phyla were Ascomycota and Basidiomycota,while Staphylococcus and Aspergillus were the dominant bacteria and fungi of Nuodeng ham,respectively.Totally,252 kinds of small molecular metabolites were identified from Nuodeng ham in different processing years,and 12 different metabolites were screened through multivariate statistical analysis.Further metabolic pathway analysis showed that 23 metabolic pathways were related to ham fermentation,of which 8 metabolic pathways had significant effects on ham fermentation(Impact>0.01,P<0.05).The content of L-proline,phenyllactic acid,L-lysine,carnosine,taurine,D-proline,betaine and creatine were significantly positively correlated with the relative abundance of Staphylococcus and Serratia,but negatively correlated with the relative abundance of Halomonas,Aspergillus and Yamadazyma.

关键词： Nuodeng ham Microbial diversity Small molecule metabolites High-throughput sequencing Gas chromatography-time of flight mass spectrography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：