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Microglia in drug addiction:A perspective from neuroimmunopharmacology

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Zoological Research 2024年第3期45卷 704-706页

作者： cong lin Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China Beijing National Laboratory for Molecular Sciences Beijing 100190China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China

Drug addiction refers to a state of dependence that arises from habitual drug intake and can result in specific withdrawal symptoms upon *** most commonly abused substances include psychostimulants,cannabinoids,and *** drugs are consumed,they stimulate the release of dopamine,a neurotransmitter crucial for the pleasure and reward centers of the *** repeated drug use,the brain undergoes various changes,leading to tolerance,dependence,and addiction(Lüscher et al.,2020).The mechanisms involved in drug addiction are highly complex and involve diverse cell types within the brain.

关键词： addiction drugs intake

Enhanced ferro-/piezoelectric properties of tape-casting-derived Er^(3+)-doped Ba_(0.85)Ca_(0.15)Ti_(0.9)Zr_(0.1O3) optoelectronic thick films

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Journal of Advanced Ceramics 2020年第6期9卷 693-702页

作者： Jie XU Qiling LU Jinfeng lin cong lin Xinghua ZHENG Tengfei lin Xiao WU Key Laboratory of Eco-materials Advanced Technology College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China

Er^(3+)-doped Ba_(0.85)Ca_(0.15)Ti_(0.9)Zr_(0.1O3)(xEr-BCTZ,x=0,0.005,0.01,0.015)multifunctional thick films were prepared by the tape-casting method,using sol-gel-derived nano-sized powders as the matrix *** surface morphologies,photoluminescence,and electrical properties were *** microstructures with pure perovskite structure were obtained in the thick *** doping an appropriate amount of Er^(3+),the samples exhibit superior up-conversion photoluminescence performance and simultaneously enhanced electrical *** addition,relatively higher texture fractions(with the largest value of 83.5%)were realized through introducing plate-like BaTiO_(3) templates to make the thick film grow by the[001]_(c) *** the ferro-/piezoelectric properties of the thick films were further improved,showing potential in the applications of micro-optoelectronic devices.

关键词： thick films texture ferroelectric piezoelectric photoluminescence

Feedback maximization of reliability of MDOF quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1245-1251页

作者： lin-cong CHEN Rong-hua HUAN Wei-qiu ZHU Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

We studied the feedback maximization of reliability of multi-degree-of-freedom （MDOF） quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations. First, the partially averaged Ito equations are derived by using the stochastic averaging method for quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations. Then, the dynamical programming equation and its boundary and final time conditions for the control problems of maximizing the reliability is established from the partially averaged equations by using the dynamical programming principle. The nonlinear stochastic optimal control for maximizing the reliability is determined from the dynamical programming equation and control constrains. The reliability function of optimally controlled systems is obtained by solving the final dynamical programming equation. Finally, the application of the proposed procedure and effectiveness of the control strategy are illustrated by using an example.

关键词： Stochastic optimal control Dynamical programming Quasi integrable-Hamiltonian system Stochastic averaging Combined harmonic and white noise excitation Reliability

MicroED as a powerful technique for the structure determination of complex porous materials

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Chinese Journal of Structural Chemistry 2024年第3期43卷 41-54页

作者： Chao Ma cong lin Jian Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong China

Porous materials have garnered significant attention in recent *** the intrinsic relationship between their structures and properties requires precise knowledge of their atomic ***-crystal X-ray diffraction(SCXRD)has traditionally been the primary method for elucidating such structures,but it demands large,high-quality crystals,often exceeding 5μm in *** growth of these crystals can be a time-consuming process,especially for one-and two-dimensional *** explore structures at the nanoscale,MicroED(microcrystal electron diffraction(ED))offers unprecedented insights into the realm of *** revolutionary technique enables researchers to uncover intricate details within nanoscale structures,promising to reshape our fundamental understanding of *** this review,we delve into the applications of MicroED in the study of various porous materials,including zeolites,metal-organic frameworks(MOFs),and covalent organic frameworks(COFs).We emphasize the pivotal role of MicroED in nanomaterial characterization,enabling precise crystallographic analysis and phase identification.

关键词： Atomic structure MicroED Porous materials Three-dimensional electron diffraction

Multiple generation effects of high temperature on the development and fecundity of Bemisia tabaci （Gennadius）（Hemiptera Aleyrodidae） biotype B

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Insect Science 2013年第4期20卷 541-549页

作者： Jian-Ying Guo lin cong Fang-Hao Wan State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of AgriculturalSciences Beijing China

Insects are ectotherms and their ability to resist temperature stress is limited. The immediate effects of sub-lethal heat stress on insects are well documented, but longer- term effects of such stresses are rarely reported. In this study, survival, development and reproduction of the whitefly, Bemisia tabaci （Gennadius）（Hemiptera： Aleyrodidae） biotype B, were compared over five consecutive generations at 27, 31 and 35℃ and for one generation at 37 ℃. Both temperature and generation significantly affected the fitness of the whitefly. These impacts were more dramatic with increasing generations and temperatures. Among the experimental temperatures, the most favorable for development and reproduction were 27 ℃ and 31 ℃. At 27 ℃, survival, development and fecundity were all stable over these five generations. At 31 ℃, immature survival rate was the highest in the fifth generation, but female fecundities decreased in the fourth and fifth generations. At 35 ℃, egg hatching rate, immature survival rate and female fecundity decreased significantly in the fourth and fifth generations. At 37 ℃, survival ofB. tabaci was not adversely affected, but female fecundity at 37 ℃ was less than 10% of that at 27 ℃ or 31 ℃. These results demonstrate that the lethal high temperature for B. tabaci is over 37 ℃, and the whitefly population continued expanding in the five generations at 35 ℃. The ability orB. tabaci biotype B to survive high temperature stress will play an important role in its population extension under global warming.

关键词： Bemisia tabaci biotype B high temperature stress multiple generation ef-fects population expansion

Composition control and temperature inferential control of dividing wall column based on model predictive control and PI strategies

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1087-1101页

作者： Jianxin Wang Na Yu Mengqi Chen lin cong Lanyi Sun State Key Laboratory of Heavy Oil Processing College of Chemical Engineering China University of Petroleum (East China) College of Information and Control Engineering China University of Petroleum (East China)

The dividing wall column （DWC） is considered as a major breakthrough in distillation technology and has good prospect of industrialization. Model predictive control （MPC） is an advanced control strategy that has acquired extensive applications in various industries. In this study, MPC is applied to the process for separating ethanol, n-propanol, and n-butanol ternary mixture in a fully thermally coupled DWC. Both composition control and tem- perature inferent/al control are considered. The multiobjective genetic algor/thm function ＂gamult/obj＂ in Matlab is used for the weight tuning of MPC. Comparisons are made between the control performances of MPC and PI strategies. Simulation results show that although both MPC and PI schemes can stabilize the DWC in case of feed disturbances, MPC generally behaves better than the PI strategy for both composition control and tempera- ture inferential control, resulting in a more stable and superior performance with lower values of integral of squared error （ISE）.

关键词： Dividing wall column Composition control Temperature inferential control PI strategy Model predictive control Genetic algorithm

High-throughput structure determination of polycrystalline functional materials:a platform for automated 3DED/MicroED data collection

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Science China Chemistry 2024年第12期67卷 4158-4166页

作者： Zhenghan Zhang Zhengyin Liang Chao Ma cong lin Jian Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 99077China

Structure determination plays the most crucial role in the discovery of novel functional materials,because only by knowing the intrinsic structures can we accurately and completely understand their properties and ***,most new materials are obtained in polycrystalline form or even as mixtures with multiple phases when first synthesized,presenting significant challenges in their structure determination and phase ***,the developed three-dimensional electron diffraction(3DED/MicroED)has provided a promising solution to overcome these *** this study,we have constructed a state-of-the-art 3DED/MicroED data acquisition equipment by integrating a hybrid-pixel detector with a script developed for Serial EM,and thus successfully developed an automated 3DED/MicroED method for the high-throughput structure *** demonstrate its effectiveness,a multiphase sample with complex porous structures is employed,showcasing that individual phases and their structures can be identified and determined,*** remarkable finding is the identification of an impurity metal-organic framework(MOF)that is completely invisible to traditional powder X-ray diffraction in a supposedly“pure”commercial MOF ***,our method also enables the atomic-resolution structure determination of flexible covalent organic framework materials,which are highly sensitive to electron ***,a new microporous aluminoborate is discovered using this rapid structure determination *** experimental results highlight the enormous potential of our 3DED/MicroED method in the field of new materials discovery,offering a powerful tool for the structure determination of polycrystalline functional materials.

关键词： 3DED/MicroED high-throughput structure determination mixed phase porous materials

A monolithically integrated microcantilever biosensor based on partially depleted SOI CMOS technology

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Microsystems & Nanoengineering 2023年第3期9卷 273-283页

作者： Yi Liu Yuan Tian cong lin Jiahao Miao Xiaomei Yu School of Integrated Circuits Peking UniversityNational Key Laboratory of Science and Technology on Micro/Nano FabricationBeijing 100871China

This paper presents a monolithically integrated aptasensor composed of a piezoresistive microcantilever array and an on-chip signal processing *** microcantilevers,each of them embedded with a piezoresistor,form three sensors in a Wheatstone bridge *** on-chip signal processing circuit consists of a multiplexer,a chopper instrumentation amplifier,a low-pass filter,a sigma-delta analog-to-digital converter,and a serial peripheral *** the microcantilever array and the on-chip signal processing circuit were fabricated on the single-crystalline silicon device layer of a silicon-on-insulator(SOI)wafer with partially depleted(PD)CMOS technology followed by three micromachining *** integrated microcantilever sensor makes full use of the high gauge factor of single-crystalline silicon to achieve low parasitic,latch-up,and leakage current in the PD-SOI CMOS.A measured deflection sensitivity of 0.98×10^(−6) nm^(−1) and an output voltage fluctuation of less than 1μV were obtained for the integrated microcantilever.A maximum gain of 134.97 and an input offset current of only 0.623 nA were acquired for the on-chip signal processing *** functionalizing the measurement microcantilevers with a biotin-avidin system method,human IgG,abrin,and staphylococcus enterotoxin B(SEB)were detected at a limit of detection(LOD)of 48 pg/***,multichannel detection of the three integrated microcantilever aptasensors was also verified by detecting *** these experimental results indicate that the design and process of monolithically integrated microcantilevers can meet the requirements of high-sensitivity detection of biomolecules.

关键词： SOI amplifier cantilever

Continuity of the Polytope Generated by a Set of Matrices 36

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Continuity of the Polytope Generated by a Set of Matrices