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A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome

World Journal of Cardiology 2012年第3期4卷 77-83页

作者： Flora Affuso Valentina Mercurio Antonio Ruvolo concetta pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio Department of Clinical Medicine Cardiovascular and Immunological SciencesFederico Ⅱ Uni-versity

AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled *** were performed at baseline and after 18 wk of *** homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome *** endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist ***:Fifty nine patients completed the study,2 withdrew because of adverse *** 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not *** addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP ***:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS.

关键词： Metabolic syndrome Insulin resistance Homeostasis model assessment index Nutraceuticals Berberine

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Valorisation of industrial hemp (Cannabis sativa L.) residues and cheese whey into volatile fatty acids for single cell protein production

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Environmental Science and Ecotechnology 2024年第5期21卷 369-380页

作者： Carlo Moscariello Silvio Matassa Francesco pirozzi Giovanni Esposito Stefano Papirio Department of Civil Architectural and Environmental EngineeringUniversity of Napoli Federico IIvia Claudio 2180125NapoliItaly

The production of single cell protein(SCP)using lignocellulosic materials stands out as a promising route in the circular bioeconomy ***,multiple steps are necessary for lignocellulosics-to-SCP processes,involving chemical pretreatments and specific aerobic *** there are no studies that investigated the SCP production from lignocellulosics by using only biological processes and microbial biomass able to work both anaerobically and *** this view,the valorisation of industrial hemp(Cannabis sativa L.)biomass residues(HBRs),specifically hurds and a mix of leaves and inflorescences,combined with cheese whey(CW)was investigated through a semi-continuous acidogenic co-fermentation process(co-AF).The aim of this study was to maximise HBRs conversion into VFAs to be further used as carbon-rich substrates for SCP *** process conditions were tested by either removing CW or increasing the amount of HBRs in terms of VS(i.e.,two and four times)to evaluate the performance of the co-AF *** HBRs resulted in a proportional increase in VFA production up to 3115 mg HAc L^(-1),with experimental production nearly 40%higher than theoretical *** synergy between HBRs and CW was demonstrated,proving the latter as essential to improve the biodegradability of the *** produced VFAs were subsequently tested as substrates for SCP synthesis in batch aerobic tests.A biomass concentration of 2.43 g TSS L^(-1) was achieved with a C/N ratio of 5.0 and a pH of 9.0 after two days of aerobic fermentation,reaching a protein content of 42%(g protein per g TSS).These results demonstrate the overall feasibility of the VFA-mediated HBR-to-SCP valorisation process.

关键词： Hemp biomass residues Cheese whey Volatile fatty acids Acidogenic fermentation Single cell protein

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Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction

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Journal of Geriatric Cardiology 2015年第4期12卷 346-352页

作者： Flora pirozzi AntoneUa Paglia Laura Sasso Pasquale Abete Angelo Carlomagno Carlo G Tocchetti Domenico Bonaduce Mario Petretta Department of Translational Medical Sciences Section of Internal Medicine Federico Ⅱ University Naples ltaly

Objective Doppler derived mitral peak early diastolic filling velocity to deceleration time ratio （E/DT） has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/DT over clinical, conven- tional eehocardiographic and mitral-Doppler variables in patients hospitalized for decompensated heart failure （HF）. Methods We analyzed 95 HF patients （mean age 64.8 ± 12.2 years） hospitalized at our institution from January 2010 to March 2012. The primary end-point was cardiac death or hospitalization, whichever occurred first. Cox regression analysis was performed to identify significant predictors of outcomes. Results During follow-up （median 37.7 months） 13 patients died and 44 were hospitalized for a cardiac event. At univariable analysis, New York Heart Association （NYHA） functional class, furosemide dosage, lateral tricuspidal annular plane systolic excursion, deceleration lime and E/DT were predictive of outcome. At multivariable analysis, E/DT was the only predictor of prognosis （hazard ratio = 1.02, P = 0.018）, giving incremental prognostic information to clinical and other echocardio-graphic measures （global chi-square from 15.4 to 25.2; P = 0.032）. Conclusions FJDT gives independent and incremental prognostic information in HF patients.

关键词： Echocardiographic evaluation Left venlricular function Risk stratification

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Predictive factors for anastomotic leakage after laparoscopic colorectal surgery

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World Journal of Gastroenterology 2018年第21期24卷 2247-2260页

作者： Antonio Sciuto Giovanni Merola Giovanni D De Palma Maurizio Sodo Felice pirozzi Umberto M Bracale Umberto Bracale Department of Abdominal Surgery Casa Sollievo della Sofferenza Research Hospital Department of General Surgery Casa di Cura Villa Berica Department of Gastroenterology Endocrinology and Endoscopic SurgeryUniversity Hospital of Naples Federico Ⅱ Department of Public Health University of Naples Federico Ⅱ

Every colorectal surgeon during his or her career is faced with anastomotic leakage(AL); one of the most dreaded complications following any type of gastrointestinal anastomosis due to increased risk of morbidity, mortality, overall impact on functional and oncologic outcome and drainage on hospital resources. In order to understand and give an overview of the AL risk factors in laparoscopic colorectal surgery, we carried out a careful review of the existing literature on this topic and found several different definitions of AL which leads us to believe that the lack of a consensual, standard definition can partly explain the considerable variations in reported rates of AL in clinical studies. Colorectal leak rates have been found to vary depending on the anatomic location of the anastomosis with reported incidence rates ranging from 0 to 20%, while the laparoscopic approach to colorectal resections has not yet been associated with a significant reduction in AL incidence. As well, numerous risk factors, though identified, lack unanimous recognition amongst researchers. For example, the majority of papers describe the risk factors for left-sided anastomosis, the principal risk being male sex and lower anastomosis, while little data exists defining AL risk factors in a right colectomy. Also, gut microbioma is gaining an emerging role as potential risk factor for leakage.

关键词： Laparoscopic colorectal surgery Colorectal surgery Anastomotic leakage Laparoscopy Risk factor Rectal cancer Diverting stoma

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High body mass index predicts multiple prostate cancer lymph node metastases after radical prostatectomy and extended pelvic lymph node dissection

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Asian Journal of Andrology 2020年第3期22卷 323-329页

作者： Antonio B Porcaro Alessandro Tafuri Marco Sebben Tania Processali Marco pirozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir Maria Angela Cerruto Matteo Brunelli Salvatore Siracusano Walter Artibani Department of Urology Azienda Ospedaliera Universitaria Integrata VeronaVerona 37126Italy USC Institute of Urology and Catherine and Joseph Aresty Department of Urology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Department of Pathology Azienda Ospedaliera Universitaria Integrata VeronaVerona 37126Italy.

Our aim is to evaluate the association between body mass index(BMI)and preoperative total testosterone(TT)levels with the risk of single and multiple metastatic lymph node invasion(LNI)in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node *** BMI,basal levels of TT,and prostate-specific antigen(PSA)were evaluated in 361 consecutive patients undergoing radical prostatectomy with extended pelvic lymph node dissection between 2014 and 2017・Patients were grouped into either nonmetastatic,one,or more than one metastatic lymph node invasion *** association among clinical factors and LNI was *** was detected in 52(14.4%)patients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic *** the overall study population,BMI correlated inversely with TT(r=-0.256;P28 kg m^2(P28 kg m^2(P-0.048).In our study,overweight and obese patients had a higher risk of harboring multiple prostate cancer lymph node metastases and lower TT levels when compared to patients with normal BMI.

关键词： body mass index metastatic prostate cancer multiple lymph node invasion overweight-obesity preoperative testosterone level

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Depression and chronic heart failure in the elderly： an intriguing relationship

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Journal of Geriatric Cardiology 2018年第6期15卷 451-459页

作者： Ilaria Liguori Gennaro Russo Francesco Curcio Giuseppe Sasso David Della-Morte Gaetano Gargiulo Flora pirozzi Francesco Cacciatore Domenico Bonaduce Pasquale Abete Gianluca Testa Department of Translational Medical Sciences University of Naples 'Federico Ⅱ' Naples Italy Department of Systems Medicine University of Rome Tor Vergata Rome ltaly IRCCS San Raffaele Pisana Rome Italy Division of Internal Medicine A OU San Giovanni di Dio e Ruggi di Aragona Salerno Italy Azienda Ospedaliera dei Colli Monaldi Hospital Heart Transplantation Unit Naples Italy Department of Medicine and Health Sciences University of Molise Campobasso Italy

Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outcomes and vice versa, especially in the elderly. The negative synergism between chronic heart failure and depression in the elderly may be approached only taking into account the multifaceted pathophysiological characteristics underlying both these conditions, such as behavioural factors, neurohormonal activation, inflammatory mediators, hypercoagulability and vascular damage. Nevertheless, the pathophysiological link between these two conditions is not well established yet. Despite the high prevalence of depression in chronic heart failure elderly patients and its negative prognostic value, it is often unrecognized especially because of shared symptoms. So the screening of mood disorders, using reliable questionnaires, is recommended in elderly patients with chronic heart failure, even if cannot substitute a diagnostic interview by mental health professionals. In this setting, treatment of depression requires a multidisciplinary approach including： psychotherapy, antidepressants, exercise training and electroconvulsive therapy. Pharmacological therapy with selective serotonin reuptake inhibitors, despite conflicting results, improves quality of life but does not guarantee better outcomes. Exercise training is effective in improving quality of life and prognosis but at the same time cardiac rehabilitation services are vastly underutilized.

关键词： Chronic heart failure Depression The elderly

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Gelatin-biofermentative unsulfated glycosaminoglycans semi-interpenetrating hydrogels via microbial-transglutaminase crosslinking enhance osteogenic potential of dental pulp stem cells

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Regenerative Biomaterials 2021年第3期8卷 110-123页

作者： Annalisa La Gatta Virginia Tirino Marcella Cammarota Marcella La Noce Antonietta Stellavato Anna Virginia Adriana pirozzi Marianna Portaccio Nadia Diano Luigi Laino Gianpaolo Papaccio Chiara Schiraldi Dipartimento di Medicina Sperimentale Universita`della Campania“Luigi Vanvitelli”via L.De Crecchio 7Naples 80138Italy Dipartimento Multidisciplinare di Specialita’Medico-Chirurgiche e Odontoiatriche via Luigi De Crecchio6Napoli 80138Italy

Gelatin hydrogels by microbial-transglutaminase crosslinking are being increasingly exploited for tissue engineering,and proved high potential in bone *** study aimed to evaluate,for the first time,the combination of enzymatically crosslinked gelatin with hyaluronan and the newly developed biotechnological chondroitin in enhancing osteogenic *** enzymatic crosslinking was carried out in the presence of hyaluronan or of a hyaluronan–chondroitin mixture,obtaining semi-interpenetrating *** latter proved lower swelling extent and improved stiffness compared to the gelatin matrix alone,whilst maintaining high *** heteropolysaccharides were retained for 30 days in the hydrogels,thus influencing cell response over this *** evaluate the effect of hydrogel composition on bone regeneration,materials were seeded with human dental pulp stem cells and osteogenic differentiation was *** expression of osteocalcin(OC)and osteopontin(OPN),both at gene and protein level,was evaluated at 7,15 and 30 days of *** electron microscopy(SEM)and two-photon microscope observations were performed to assess bone-like extracellular matrix(ECM)deposition and to observe the cell penetration *** the presence of the heteropolysaccharides,OC and OPN expression was upregulated and a higher degree of calcified matrix formation was *** with hyaluronan and chondroitin improved both the biophysical properties and the biological response of enzymatically crosslinked gelatin,fastening bone deposition.

关键词： hydrogels gelatin hyaluronan biotechnological chondroitin bone regeneration human dental pulp stem cells

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Reliability of nephrolithometric nomograms in patients treated with minimally invasive percutaneous nephrolithotomy: A precision study

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Asian Journal of Urology 2023年第1期10卷 70-80页

作者： Giorgio Mazzon Francesco Claps Nicola Pavan Simon Choong Guohua Zeng Wenqi Wu Jiehui Zhong Maida Bada Marco pirozzi Raffaele Vitale Antonio Celia Department of Urology San Bassiano HospitalBassano del GrappaItaly Department of Urology University of TriesteTriesteItaly Institute of Urology University College Hospitals LondonLondonUK Department of Urology Minimally Invasive Centrethe first affiliated hospital of Guangzhou Medical UniversityGuangzhouChina

Objectives:The study aimed to evaluate quality of nephrolithometric nomograms to predict stone-free rates(SFRs)and complication rates(CRs)in case of minimally invasive percutaneous nephrolithotomy(PNL).In the last decade,nomograms have been introduced to estimate the SFRs and CRs of ***,no data are available regarding their reliability in case of utilization of miniaturized *** we present a prospective multicentric study to evaluate reliability of Guy’s stone score(GSS),the stone size,tract length,obstruction,number of involved calyces,and essence of stone(S.T.O.N.E.)nephrolithometry score and Clinical Research Office of the Endourological Society(CROES)score in patients treated with minimally invasive ***:We evaluated SFRs and CRs of 222 adult patients treated with miniaturized *** were considered stone-free if no residual fragments of any size at post-operative unenhanced computed tomography *** demographics,SFRs,and CRs were reported and *** of nomograms were evaluated with the area under the curve(AUC).Results:We included 222 patients,the AUCs of GSS,CROES score,and *** score were 0.69(95%confidence interval[CI]0.61-0.78),0.64(95%CI 0.56-0.73),and 0.62(95%CI 0.52-0.71),*** SFRs,at multivariate binomial logistic regression,only the GSS had significance with an odds ratio of 0.53(95%CI 0.31e0.95,p=0.04).We did not find significant correlation with complications,with only a trend for ***:This is the first study evaluating nomograms in miniaturized *** still show good reliability;however,our data showed lower performances compared to standard *** emphasize the need of further studies to confirm this trend.A dedicated nomogram for minimally invasive PNL may be necessary.

关键词： Urolithiasis Nomogram Percutaneous nephrolithotomy Renal stone Clavien-Dindo

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Advances in paediatric nonalcoholic fatty liver disease:Role of lipidomics

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World Journal of Gastroenterology 2021年第25期27卷 3815-3824页

作者： Anna Di Sessa Simona Riccio Emilia pirozzi Martina Verde Antonio Paride Passaro Giuseppina Rosaria Umano Stefano Guarino Emanuele Miraglia del Giudice Pierluigi Marzuillo Department of Woman Childand General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaples 80138Italy

Due its close relationship with obesity,nonalcoholic fatty liver disease(NAFLD)has become a major worldwide health issue even in *** most accepted pathophysiological hypothesis is represented by the“multiple hits”theory,in which both hepatic intracellular lipid accumulation and insulin resistance mainly contribute to liver injury through several *** these,lipotoxicity has gained particular *** this view,the pathogenic role of different lipid classes in NAFLD(e.g.,sphingolipids,fatty acids,ceramides,etc.)has been highlighted in recent lipidomics *** there is some contrast between plasma and liver findings,lipidomic profile in the NAFLD context provides novel insights by expanding knowledge in the intricate field of NAFLD pathophysiology as well as by suggesting innovative therapeutic approaches in order to improve both NAFLD prevention and treatment *** changes of distinct lipid species might be an attractive therapeutic target for treating *** the most recent evidence in this attractive field has been summarized to provide a comprehensive overview of the lipidomic scenario in paediatric NAFLD.

关键词： Fatty Liver Lipidomics Children Nonalcoholic fatty liver disease

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低排放发动机管理系统智能解决方案

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电子设计应用 2006年第8期 90-92页

作者： F.pirozzi F.Carpentieri L.Li 意法半导体公司

引言如今,美国、加拿大和欧洲的汽车排放标准越来越严格,中国也将很快推出更为严格的机动车排放标准,因此,每一辆新上市的汽油机轻骑摩托车都需要安装一个三元催化转化器(TWC).通过与燃油喷射控制系统相配合,TWC能够降低污染物的排放量.... 详细信息

引言如今,美国、加拿大和欧洲的汽车排放标准越来越严格,中国也将很快推出更为严格的机动车排放标准,因此,每一辆新上市的汽油机轻骑摩托车都需要安装一个三元催化转化器(TWC).通过与燃油喷射控制系统相配合,TWC能够降低污染物的排放量.TWC的功能就是把燃烧过程产生的有毒废气(碳化氢、一氧化碳、氮氧化物)转化成无危害的物质(水、二氧化碳、氮气).空气燃油混合气只有接近理论配比,TWC才能发挥最大的转换效率.

关键词：发动机管理系统三元催化转化器排放汽车排放标准燃油喷射 TWC 控制系统燃烧过程一氧化碳

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