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Morphological integration and functional modularity in the crocodilian skull

Integrative Zoology 2014年第4期9卷 498-516页

作者： Paolo PIRAS Angela DBUSCALIONI Luciano TERESI pasquale RAIA Gabriele SANSALONE Tassos KOTSAKIS Jorge CUBO Pierre and Marie Curie University ParisFrance Center for Evolutionary Ecology RomeItaly department of Sciences ‘Roma Tre’UniversityRomeItaly Biology department Universidad Autónoma de MadridMadridSpain department of Mathematics and Physics ‘Roma Tre’UniversityRomeItaly Earth Sciences department Federico II UniversityNaplesItaly Sorbonne Universités UPMC Univ Paris 06UMR 7193ISTePFrance CNRS UMR 7193ISTePParisFrance

We explored the morphological organization of the skull within Crocodylidae,analyzing functional and phylogenetic interactions between its 2 constituent functional modules:the rostrum and the *** used geometric morphometrics to identify localized shape changes,focusing on the differences between the major clades of the crown-group Crocodylia:Alligatoridae and *** used published bite performance data to correlate rostral function with postrostral *** skull modules appear more integrated within Alligatoridae than within *** effects on shape variation are more evident in Alligatoridae than in Crocodylidae,where functional parameters concerning the rostral morphology are proportionally more important than ***-snouted species are characterized by low structural performance,which is significantly associated with a reduction of the pterygoid-quadrate cranial nipper,suggesting that the nipper is important for the ingestion of large food items in generalist *** functional association is coupled with a significant evolutionary allometry at the clade level,while Alligatoridae and Crocodylidae show different degrees of evolutionary allometry for their entire shape and *** postrostrum is more conservative than the rostrum in terms of morphospace occupation,evolutionary allometry and phylogenetic signal.

关键词： crocodilian skull functional performance geometric morphometrics modularity morphological integration

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Lamb-dip saturated-absorption cavity ring-down rovibrational molecular spectroscopy in the near-infrared

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Photonics Research 2022年第8期10卷 1803-1809页

作者： ROBERTO AIELLO VALENTINA DI SARNO MARIA GIULIA deLLI SANTI MAURIZIO de ROSA IOLANDA RICCIARDI GIOVANNI GIUSFREDI PAOLO de NATALE LUIGI SANTAMARIA pasquale MADDALONI Consiglio Nazionale delle Ricerche-Istituto Nazionale di Ottica Via Campi Flegrei 3480078 PozzuoliItaly Istituto Nazionale di Fisica Nucleare Sez.di NapoliComplesso Universitario di M.S.AngeloVia Cintia80126 NapoliItaly ppqSense S.r.l. Via Gattinella 2050013 Campi BisenzioItaly Consiglio Nazionale delle Ricerche-Istituto Nazionale di Ottica Largo E.Fermi 650125 FirenzeItaly Agenzia Spaziale Italiana Contrada Terlecchia75100 MateraItaly

The high-detection-sensitivity saturated-absorption cavity ring-down(SCAR)technique is extended to Lambdip spectroscopy of rovibrational molecular transitions in the near-infrared ***-comb-referenced sub-Doppler saturation measurements,performed on the acetylene(ν_(1)+ν_(3)+ν_(4)←ν_(4))R(14)e line at6562 cm^(-1),are analyzed by a SCAR global line profile fitting routine,based on a specially developed theoretical *** to a conventional cavity ring-down evaluation,our approach yields dip profiles with a linewidth freed from saturation broadening effects,reduced by 40%,and a signal-to-noise ratio increased by 90%.Ultimately,an overall(statistical and systematic)fractional uncertainty as low as 7×10^(-12)is achieved for the absolute line-center *** the same time,our method is also able to accurately infer the linear(nonsaturated)behavior of the gas absorption,providing Lamb-dip-based line strength measurements with a relative uncertainty of 0.5%.

关键词： saturated cavity absorption

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Fluoroquinolone-based protocols for eradication of Helicobacter pylori

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World Journal of Gastroenterology 2014年第27期20卷 8947-8956页

作者： Antonio Rispo Pietro Capone fabiana Castiglione Luigi pasquale Matilde Rea Nicola Caporaso Division of Gastroenterology Department of Clinical Medicine and Surgery-University "Federico Ⅱ" of Naples 80131 Napoli Italy Division of Gastroenterology P.O. "Sant’ Ottone Frangipane" Ariano Irpino 80131 Napoli Italy

Helicobacter pylori (H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastric malignancies such as cancer and mucosa-associated lymphoid tissue-lymphoma; hence, its eradication is strongly recommended. The Maastricht IV consensus, which focused on the management of H. pylori infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. The aim of the present paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori.

关键词： Helicobacter pylori eradication fluoroquinolone therapy

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Molecular Partners of Escherichia coil Transcriptional Modulator AidB

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Journal of Chemistry and Chemical Engineering 2013年第9期7卷 876-884页

作者： Pamela Di pasquale Angela Amoresano Francesca de Maria Angela Duilio department of Chemical Sciences University Federico H of Naples Naples 80126 Italy

The AidB protein is involved in the adaptive response to DNA alkylation damages in Escherichia coli. Functional proteomic experiments were designed to elucidate AidB biological functions in the presence and in the absence of methyl methanesulfonate as methylating agent. Several proteins were identified in both conditions and according to their reported biological activities, the inter-actors were grouped into three different functional categories： stress response, energetic metabolic pathways and nucleic acid metabolism. Particularly, the interaction between AidB and UvrA, a member of the UvrABCD nucleotide excision system, suggested a new interesting putative role for AidB.

关键词： AidB protein adaptive response UvrA protein DNA alkylation damages functional proteomics.

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Choroidal vascularity index in thyroidassociated ophthalmopathy:a crosssectional study

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Eye and Vision 2021年第4期8卷 175-182页

作者： pasquale Loiudice Marco Pellegrini Michele Marinò Barbara Mazzi Ilaria Ionni Giuseppe Covello Michele Figus Marco Nardi Giamberto Casini department of Surgical Ophthalmology UnitMedicalMolecular and Critical Area PathologyUniversity of PisaVia Savi1056126 PisaItaly Ophthalmology Unit S.Orsola-Malpighi University HospitalUniversity of BolognaBolognaItaly department of Clinical and Experimental Medicine Endocrinology Unit IUniversity Hospital of PisaPisaItaly

Background:Hemodynamic changes have been observed in patients with Graves’*** aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index(CVI)in patients with thyroidassociated ophthalmopathy(TAO).Methods:In this cross-sectional observational study,40 patients affected by TAO were *** healthy individuals,matched for age and sex,served as *** enhanced-depth imaging optical coherence tomography scans were obtained from all *** were binarized using the ImageJ software and luminal area(LA)and total choroidal area(TCA)were *** was calculated as the proportion of LA to *** relation between CVI or subfoveal choroidal thickness(SFCT)and clinical activity score,exophthalmometric value,diplopia status,gender,and age was ***:CVI was significantly higher in patients with TAO(P=0.004).No significant difference was observed in SFCT(P=0.200)and TCA(P=0.153)comparing TAO patients and healthy *** was significantly higher in TAO group(P=0.045).On multiple regression analysis,CVI was associated with TCA(P=0.043).No association was found between SFCT or CVI and TCA,clinical activity score,exophthalmometric value,Inami value,diplopia status,gender or age(P>0.05).Conclusions:This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.

关键词： Choroidal vascularity index Choroidal vasculature Enhanced depth optical coherence tomography Image binarization Luminal area Subfoveal choroidal thickness Thyroid-associate ophthalmopathy

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Monitoring gully erosion in the European Union: A novel approach based on the Land Use/Cover Area frame survey (LUCAS)

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International Soil and Water Conservation Research 2022年第1期10卷 17-28页

作者： pasquale Borrelli Jean Poesen Matthias Vanmaercke Cristiano Ballabio Javier Hervas Michael Maerker Simone Scarpa Panos Panagos department of Earth and Environmental Sciences University of PaviaVia Ferrata127100PaviaItaly department of Biological Environment Kangwon National UniversityChuncheon24341Republic of Korea department of Earth and Environmental Sciences KU LeuvenBelgium Faculty of Earth Sciences and Spatial Management Maria-Curie Sklodowska UniversityLublinPoland departement de Geographie Universite de LiegeLiegeBelgium European Commission Joint Research Centre(JRC)IspraItaly

The European Commission's Thematic Strategy for Soil Protection(COM(2012)46)identified soil erosion as an important threat to European Union's(EU)soil *** erosion is an important but hitherto poorly understood component of this *** we present the results of an unprecedented attempt to monitor the occurrence of gully erosion across the EU and *** integrate a soil erosion module into the 2018 LUCAS Topsoil Survey,which was conducted to monitor the soil health status across the EU and to support actions to prevent soil *** discuss and explore opportunities to further improve this *** 2018 LUCAS Topsoil Survey consisted of soil sampling(0-20 cm depth)and erosion observations conducted in ca.10%(n=24,759)of the 238,077 Land Use/Cover Area frame Survey(LUCAS)2018 in-field survey *** erosion channels were detected for ca.1%(211 sites)of the visited LUCAS Topsoil ***(false positives,2.5%)and omission errors(false negatives,5.6%)were found to be low and at a level that could not compromise the representativeness of the gully erosion ***,the findings indicate that the tested 2018 LUCAS Topsoil in-field gully erosion monitoring system is effective for detecting the incidence of gully *** morphogenesis of the mapped gullies suggests that the approach is an effective tool to map permanent gullies,whereas it appears less effective to detect short-lived forms like ephemeral *** patterns emerging from the LUCAS Topsoil field observations provide new insights on typical gully formation sites across the EU and *** can help to design further targeted research *** extension of this approach to all LUCAS sites of 2022 would significantly enhance our understanding of the geographical distribution of gully erosion processes across the *** every three years,LUCAS soil erosion surveys would contribute to assess the state of gully erosion in the EU over *** will also enable m

关键词： Soil erosion Soil Concentrated flow erosion Google earth Earth observations

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Post photorefractive keratectomy corneal ectasia

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 315-317页

作者： Anna M Roszkowska Margherita S Sommario Mario Urso pasquale Aragona Cornea and Refractive Surgery Section Ophthalmology UnitDepartment of Specialized SurgeriesUniversity Hospital of MessinaMessina 98125Italy

dear Editor,We write to describe two cases of corneal ectasia occurred after photorefractive *** to the wide diffusion of refractive surgery,many ophthalmologists attempted to identify the risk factors and prevention ... 详细信息

关键词： PRK Post photorefractive keratectomy corneal ectasia Figure

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Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 491-492页

作者： Claudia Covelli Paola Parente Francesco Pepe pasquale Pisapia Fabiola Fiordelisi Umberto Malapelle UOC di Anatomia Patologica Fondazione Casa Sollievo della SofferenzaViale Cappuccini 171013 San Giovanni RotondoFGItaly department of Public Health University of Naples Federico ⅡVia Pansini 580131 NapoliItaly

Solid pseudopapillary neoplasms (SPNs) are rare solid pancreatic tumors mainly affecting young women. despite the high percentage of favorable prognosis, they are considered as low grade malignant neoplasms, and metastases occur in 5%-15% of patients. Almost all SPNs (95%) have somatic activating mutations in the β-catenin gene [1].

关键词： Solid pseudopapillary neoplasms (SPNs) Mismatch repair proteins microsatellite instability

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Photorefractive keratectomy after cataract surgery in uncommon cases: long-term results

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 612-615页

作者： Anna Maria Roszkowska Mario Urso Giuseppe Alberto Signorino Leopoldo Spadea pasquale Aragona department of Surgery Ophthalmology Clinic University Hospital of Messina department of Ophthalmology Andrzej Frycz Modrzewski Krakow University department of Medical-Surgical Sciences and Biotechnologies La Sapienza University of Rome

AIM： To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens（IOL） implantation in uncommon ***： Totally 24 patients with high residual refractive error after cataract surgery with IOL implantation were examined. Twenty-two patients had a history of phacoemulsification and IOL implantation, and two had extra-capsular cataract extraction with IOL implantation. detailed examination of preoperative medical records was done to explain the origin of the post-cataract refractive errors. All patients underwent photorefractire keratectomy（PRK） enhancement. The mean outcome measures were refraction, uncorretted visual acuity（UCVA）, best corrected visual acuity（BCVA） and corneal transparency and follow up ranged from 1 to 8 ***： The principal causes of residual ametropia was inexact IOL calculation in abnormal eyes with high myopia and congenital lens abnormalities, followed by corneal astigmatism both suture induced and preexisting. After cataract surgery and before the laser enhancement the mean spherical equivalent（SE） was-0.56±3 D ranging from-4.62 to ＋2.25 D in high myopic patients, instead it was-1±1.73 D ranging from-3.25 to ＋3.75 D in the astigmatic eyes, with a mean cylinder of-3.75±0 ranging from-3 to ＋5.50 D. After laser refractive surgery the mean SE was 0.1±0.73, ranging from-0.50 to ＋1.50 in the myopic group, and it was-0.50±0.57 ranging from-1.25 to ＋0.50 in astigmatic patients, with a mean cylinder of-0.25±0.75. In myopic patients the mean UCVA and BCVA were 0.038±0.072 logMAR and 0.018±0.04 respectively, both ranging from 0.10 to 0.0. In astigmatic patients, the mean UCVA and BCVA were 0.213±0.132 and 0.00±0.0 respectively, UCVA ranging from 0.50 to 0.22 and BCVA was 0.00. All patients presented normal corneal transparency. No ocular hypertension was detected and no corneal haze was observed. All registered values remained stable also at the end line e

关键词： photorefractive keratectomy cataract residual ametropia intraocular lens error high myopia

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Advances in medical decision support systems for diagnosis of acute graft-versus-host disease: molecular and computational intelligence joint approaches

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Frontiers in Biology 2011年第4期6卷 263-273页

作者： Maurizio FIASCHÉ Maria CUZZOLA Giuseppe IRRERA pasquale IACOPINO Francesco Carlo MORABITO DIMET University“Mediterranea”of Reggio CalabriaItaly Transplant Regional Center of Stem Cells and Cellular Therapy “A.Neri”Reggio CalabriaItaly School of Hematology University of MessinaItaly

Acute graft-versus-host disease (aGVHD) is a serious systemic complication of allogeneic hematopoietic stemcell transplantation (HSCT) causing considerable morbidity and mortality. Acute GVHD occurs when alloreactivedonor-derived T cells recognize host-recipient antigens as foreign. These trigger a complex multiphase process thatultimately results in apoptotic injury in target organs. The early events leading to GVHD seem to occur very soon,presumably within hours from the graft infusion. Therefore, when the first signs of aGVHD clinically manifest, thedisease has been ongoing for several days at the cellular level, and the inflammatory cytokine cascade is fully ***, it comes as no surprise that progress in treatment based on clinical diagnosis of aGVHD has been limited in the past30 years. It is likely that a pre-emptive strategy using systemic high-dose corticosteroids as early as possible couldimprove the outcome of aGVHD. Due to the deleterious effects of such treatment particularly in terms of infection riskposed by systemic steroid administration in a population that is already immune-suppressed, it is critical to identifybiomarker signatures for approaching this very complex task. Some research groups have begun addressing this issuethrough molecular and proteomic analyses, combining these approaches with computational intelligence techniques,with the specific aim of facilitating the identification of diagnostic biomarkers in aGVHD. In this review, we focus on theaGVHD scenario and on the more recent *** also attempt to give an overview of the classical and noveltechniques proposed as medical decision support system for the diagnosis of GVHD.

关键词： computational intelligence gene selection GVHD machine learning personalized modelling wrapper

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