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植物环蛋白的结构

云南植物研究 2008年第2期30卷 232-238页

作者：唐军谭宁华许文彦嵇长久潘蓄林 conan wang Norelle L.Daly David J.Craik 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室 Institute for Molecular Bioscience University of QueenslandBrisbaneQLD 4072Australia

简要介绍了植物环蛋白的定义、结构特点、研究历史、分布、提取分离方法、化学合成与生物合成、生物活性与生物功能。并主要以从紫花蔓地丁(Viola labridorica)中分离得到的六个环蛋白之一,cy-cloviolacinO2为例介绍通过还原酶解-质谱... 详细信息

简要介绍了植物环蛋白的定义、结构特点、研究历史、分布、提取分离方法、化学合成与生物合成、生物活性与生物功能。并主要以从紫花蔓地丁(Viola labridorica)中分离得到的六个环蛋白之一,cy-cloviolacinO2为例介绍通过还原酶解-质谱与二维核磁共振谱结合鉴定环蛋白结构的研究方法。

关键词：紫花蔓地丁堇菜科环蛋白 cycloviolacin O2

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植物环蛋白的检测方法与结构研究

植物环蛋白的检测方法与结构研究

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

第五届全国化学生物学学术会议

作者：唐军许文彦嵇长久潘蓄林 conan wang Norelle L.Daly David J.Craik 谭宁华中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室 Institute for Molecular Bioscience University of QueenslandBrisbane4072 Australia Institute for Molecular Bioscience University of QueenslandBrisbane4072 Australia Institute for Molecular Bioscience University of QueenslandBrisbane4072 Australia 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室

＜正＞植物环蛋白（cyclotides）是植物中一类富含半胱氨酸残基、由28～37个氨基酸残基通过肽键首尾连接的大环肽。环蛋白的胱氨酸结（cyclic cystine knot,CCK）结构特征使其具有抗化学降解和酶解的特性。同时环蛋白也具有广泛而多样... 详细信息

＜正＞植物环蛋白（cyclotides）是植物中一类富含半胱氨酸残基、由28～37个氨基酸残基通过肽键首尾连接的大环肽。环蛋白的胱氨酸结（cyclic cystine knot,CCK）结构特征使其具有抗化学降解和酶解的特性。同时环蛋白也具有广泛而多样的生物活性,如子宫收缩、抗 HIV、抗微生物活性、胰蛋白酶抑制剂、抗肿瘤活性等。因此,一方面环蛋白可能被直接用作药物

关键词：环蛋白检测方法堇菜科葫芦科

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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赛马“银光”

疯狂英语（新悦读） 2024年第3期 42-44,76页

作者：阿瑟·柯南·道尔不详

作品简介:侦探必须眼观六路,耳听八方,还得记住与案件相关的所有细节。他们必须通晓人情世故,对狗、羊和马都得有所知。甚至,他们还必须了解赛马这项帝王的娱乐运动……一匹著名赛马——“银光”——失踪了,夏洛克·福尔摩斯和华生医生... 详细信息

作品简介:侦探必须眼观六路,耳听八方,还得记住与案件相关的所有细节。他们必须通晓人情世故,对狗、羊和马都得有所知。甚至,他们还必须了解赛马这项帝王的娱乐运动……一匹著名赛马——“银光”——失踪了,夏洛克·福尔摩斯和华生医生来到了位于达特穆尔的马厩。

关键词：作品简介人情世故赛马银光娱乐运动

Capillaric field effect transistors

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Microsystems & Nanoengineering 2022年第2期8卷 59-71页

作者： Claude Meffan Julian Menges Fabian Dolamore Daniel Mak conan Fee Renwick C.J.Dobson Volker Nock Department of Electrical and Computer Engineering University of CanterburyChristchurch 8041New Zealand Department of Microengineering Kyoto University615-8540 KyotoJapan School of Biological Sciences University of CanterburyChristchurch 8041New Zealand Biomolecular Interaction Centre School of Biological SciencesUniversity of CanterburyChristchurch 8041New Zealand School of Product Design University of CanterburyChristchurch 8041New Zealand Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology InstituteUniversity of MelbourneParkvilleVIC 3010Australia The MacDiarmid Institute for Advanced Materials and Nanotechnology Wellington 6140New Zealand

Controlling fluid flow in capillaric circuits is a key requirement to increase their uptake for assay *** action off-valves provide such functionality by pushing an occluding bubble into the channel using a difference in capillary ***,we utilized the binary switching mode of this structure to develop a powerful set of fundamental fluidic valving *** this work,we study the transistor-like qualities of the off-valve and provide evidence that these structures are in fact functionally complementary to electronic junction field effect *** view of this,we propose the new term capillaric field effect transistor to describe these types of *** support this conclusion,we present a theoretical description,experimental characterization,and practical application of analog flow resistance *** addition,we demonstrate that the valves can also be *** show modulation of the flow resistance from fully open to pinch-off,determine the flow rate-trigger channel volume relationship and demonstrate that the latter can be modeled using Shockley's equation for electronic ***,we provide a first example of how the valves can be opened and closed repeatedly.

关键词： transistors effect field