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Systematic literature review of the antitumor effect of octreotide in neuroendocrine tumors

World Journal of Meta-Analysis 2018年第2期6卷 9-20页

作者： Stephanie M Barrows Beilei Cai Catherine Copley-Merriman Kelly R Wright colleen v castro Raoudha Soufi-Mahjoubi RTI Health Solutions Novartis Pharmaceuticals RTI Health Solutions Research Triangle Park

AIM To provide a comprehensive examination of the existing evidence of the antitumor effect of long-acting octreotide in neuroendocrine tumors(NETs).METHODS A systematic literature review of clinical trials and observational studies was conducted in PubM ed, EMBASE, and Cochrane through January 18, 2017. Conference abstracts for 2015 and 2016 from 5 scientific meetings were also *** Of 41 articles/abstracts identified, 13 unique studies compared octreotide with active or no treatment. Two of the 13 studies were clinical trials; the remaining were observational studies. The phase 3 Placebo-Controlled, Double-Blind, Prospective, Randomized Study of the Effect of Octreotide long-acting repeatable(LAR) in the Control of Tumor Growth in Patients with MetastaticNeuroendocrine Midgut Tumors clinical trial showed that long-acting octreotide significantly prolonged time to tumor progression compared with placebo in patients with functionally active and inactive metastatic midgut NETs; no statistically significant difference in overall survival(OS) was observed, possibly due to the crossover of placebo patients to octreotide. Retrospective observational studies found that long-acting octreotide use was associated with significantly longer OS than no octreotide use for patients with distant metastases although not for those with local/regional disease. CONCLUSION The clinical trial and observational studies with informative evidence support long-acting octreotide's antitumor effect on time to tumor progression and OS. This review showed the rarity of existing studies assessing octreotide's antitumor effect and recommends that future research is warranted.

关键词： Neuroendocrine tumors Antitumor effect Octreotide Overall survival Progression-free survival

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Exploring the impact of evaluation methods on Global South building design—A case study in Brazil

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Building Simulation 2024年第10期17卷 1871-1891页

作者： vítor Freitas Mendes Alexandre Santana Cruz Adriano Pinto Gomes Júlia castro Mendes Programa de Pós-Graduação em Engenharia Civil(PROPEC) Universidade Federal de Ouro Preto(UFOP).Ouro PretoMinas GeraisCEP 35400-000Brazil Instituto Federal de Educação Ciência e Tecnologia de Minas Gerais(IFMG)–Campus Santa Luzia.Santa LuziaMinas GeraisCEP 33115-390Brazil Programa de Pós-graduação em Arquitetura(PROARQ) Universidade Federal do Rio de Janeiro(UFRJ).Rio de JaneiroRio de JaneiroCEP 21941-972Brazil Área de Desenho e Projeto Instituto Federal de Minas Gerais(IFMG)–campus Ouro Preto.Ouro PretoMinas GeraisCEP 35400-000Brazil Programa de Pós-Graduação em Engenharia Civil(PEC) Universidade Federal de Juiz de Fora(UFJF).Juiz de ForaMinas GeraisCEP 36036-900Brazil

Energy simulation is a valuable tool for evaluating and improving the thermal performance and energy efficiency of buildings during the design *** evaluation methods are thermal load(TL),degree-hour(DH),and design days(DD).The choice of method and its settings may vary depending on regional factors and researchers’preferences,leading to diverse and often incompatible metrics and ***,this study aims to investigate the influence of these evaluation methods on the assessment of buildings’performance and,consequently,on design *** this purpose,this study compared the results of the 3 evaluation methods and different settings for 3 different wall systems,4 ranges of comfort temperature,and 2 residential models located in the 8 Brazilian bioclimatic *** result,the best and worst wall systems varied depending on the evaluation method and the threshold/setpoint temperature range *** regions showed greater variability in the *** noticed that it is not possible to compare and interpret results from different evaluation methods,and that the variation of only 1℃in the setpoint temperatures can lead to entirely different practices being considered the best for a given building *** conclusion,the most suitable evaluation method is the one that best portrays the operation and dynamic reality of the building to be designed,and building regulations and standards can occasionally lead to unrealistic assessments.

关键词： energy efficiency energy simulation EnergyPlus thermal load degree-hour design days

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Multi-conductor Line Models for Harmonic Load-flow Calculations in Lv Networks with High Penetration of Pv Generation

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1288-1301页

作者： Fernando M.Camilo M.E.Almeida Rui castro v.Fernao Pires Institutode Engenhariade Sistemas e Computadores Investigacao eDesenvolvimento(INESC-ID)and TecnicoUniversity of LisbonLisbonPortugal ESTSetubal Polytechnics of SetubalSetuibalPortugal

Low-voltage(Lv) distribution networks are unbalanced and present loads with nonlinear behavior, which introduce harmonics in the networks. The predictable increase in photovoltaic microgeneration(Pv μG) accentuates this unbalanced characteristic, as well as poses new technical problems,namely voltage rise and reverse power flow. To accurately account for the distributed Pv and loads in the Lv network, unbalanced three-phase power flow algorithms should be utilized,where different approaches may be used to represent lines with various degrees of accuracy. The more accurate algorithm considers the electromagnetic coupling between the line conductors,whereas the simpler algorithm represents each conductor of the line as a single-phase line with pure resistive behavior. This paper aims to analyze the influence of the line model on the load flow in a highly unbalanced Lv network with a high penetration of Pv production, and considers the impact of the harmonics produced by nonlinear loads. Based on the results obtained,it is possible to identify the most suitable model to be used, depending on the study to be performed. Different scenarios of Pv generation and loads are addressed in this paper.

关键词： Line model nonlinear loads photovoltaic microgeneration unbalanced distribution network

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Laplace-Beltrami Differentiability of Positive Definite Kernels on the Sphere

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Acta Mathematica Sinica,English Series 2013年第1期29卷 93-104页

作者： M. H. castro v. A. MENEGATTO C. P. OLIvEIRA Faculdade de Matemática Universidade Federal de UberladiaCaixa Postal 593 38400-902 Uberlandia MG Brasil Departamento de Matemática ICMC-USPSao CarlosCaixa Postal 668 13560-970 Sao Carlos SP Brasil ICE-DMC Universidade Federal de Itajubá37500-903 Itajubá MG Brasil

This contribution gives results on the action of the Laplace-Beltrami derivative on suffi- ciently smooth kernels on the sphere, those defined by absolutely and uniformly expansions generated by a family of at least continuous functions. Among other things, the results show that convenient Laplace-Beltrami derivatives of positive definite kernels on the sphere are positive definite too. We also include similar results on the action of the Laplace-Beltrami derivative on condensed spherical harmonic expansions.

关键词： Sphere Laplace-Beltrami operator Laplace-Beltrami derivative positive definite kernels,spherical harmonics

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Hypothalamic circuits and aging:keeping the circadian clock updated

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Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa vázquez-Lizarraga Lucia Mendoza-viveros Carolina Cid-castro Sareni Ruiz-Montoya Erick Carreño-vázquez Ricardo Orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

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variable exponent Hardy spaces associated with discrete Laplacians on graphs

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Science China Mathematics 2019年第1期62卷 73-124页

作者： víctor Almeida Jorge J.Betancor AlejANDro J.castro Lourdes Rodríguez-Mesa Departamento de Análisis Matemático Universidad de La Laguna Department of Mathematics Nazarbayev University

In this paper we develop the theory of variable exponent Hardy spaces associated with discrete Laplacians on infinite graphs. Our Hardy spaces are defined by square integrals, atomic and molecular decompositions. Also we study boundedness properties of Littlewood-Paley functions, Riesz transforms, and spectral multipliers for discrete Laplacians on variable exponent Hardy spaces.

关键词： graphs discrete Laplacian Hardy spaces variable exponent square functions spectral multipliers

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Ruthenium-mediated assembly and enhanced stability of heterometallic polystannides[Ru_(2)Sn_(19)]^(4−)and[Ru_(2)Sn_(20)]^(6−)

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Nano Research 2022年第6期15卷 5705-5711页

作者： Wei-Xing Chen Nikolay v.Tkachenko Alvaro Muñoz-castro Alexander I.Boldyrev Zhong-Ming Sun State Key Laboratory of Elemento-Organic Chemistry Tianjin Key Lab of Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Chemistry and Biochemistry Utah State University0300 Old Main HillLoganUT 84322-0300USA Grupo de Química Inorgánicay Materiales Moleculares Facultad de IngenieriaUniversidad Autonoma de ChileEl Llano SubercaseauxSantiago 2801Chile

In this work,we report the synthesis and characterization of two novel Ru-containing Zintl clusters:[Sn_(19){Ru(COD)(en)}_(2)]^(4−)and[Sn_(20){Ru(COD)}_(2)]^(6−).The synthesized compounds not only expand the family of Ru-Sn cluster systems but also shed light on the structure of heterometallic complexes in a previously unknown range of tin *** single-crystal X-ray diffraction(XRD)analysis reveals the dimeric nature of the *** different assembly patterns of the formal[Sn(η^(3)-Sn_(9))]monomer were observed:the dimerization through the vertex fusion process and the direct dimerization through the formation of 2c–2e Sn–Snσ*** both clusters,the density functional theory calculations reveal the locallyσ-aromatic nature of the[Sn(η^(3)-Sn_(9))]monomer resulting in two independent magnetic shielding *** believe that our findings will help the community to further explore the fascinating chemistry of polystannide clusters.

关键词： heterometallic clusters aromaticity polystannide ruthenium Zintl anion

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King's College criteria and the Clichy-villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade vivian vasconcelos Costa Juliano Felix castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula vieira Teixeira vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-villejuif criteria

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Thermodynamic analysis, synthesis, characterization, and evaluation of 1-ethyl-3-methylimidazolium chloride: Study of its effect on pretreated rice husk

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Chinese Journal of Chemical Engineering 2023年第8期60卷 143-154页

作者： Eileen Katherine Coronado-Aldana Cindy Lizeth Ferreira-Salazar Nubia Yineth Piñeros-castro Rubén vázquez-Medina Felipe A.Perdomo Universidad de BogotáJorge Tadeo Lozano Facultad de Ciencias Naturales e IngenieríaCra.422-61CundinamarcaBogotáColombia Instituto Politecnico Nacional CICATA QueretaroCerro Blanco 141Colinas del Cimatario76090 QueretaroMexico School of Engineering University of EdinburghEdinburgh EH93FBUnited Kingdom

This work is focused on the determination of the optimal reaction conditions to synthesize the ionic liquid 1-ethyl-3-methylimidazolium chloride([EMIM][Cl]) and assess its suitability for the pretreatment of rice husk. The modified UNIFAC(UNIversal quasi-chemical Functional-group Activity Coefficients)approach for ionic liquids is used to develop a thermodynamic model that describes the reactive system methylimidazole(MIM), chloroethane(C_(2)H_(5)Cl) and [EMIM][Cl]. The model allows to study the phase equilibria coexistence(vapor–liquid equilibria and solid–liquid equilibria) and yields the theoretically optimal conditions to synthesize the ionic liquid. The model predictions are validated with the available experimental and reported data. By implementing the developed model, a simple way to synthesize ionic liquid [EMIM][Cl] was found allowing to study its influence on the structure and morphology of pretreated rice husk. The lignocellulosic materials involved in this study are characterized by their composition, enzymatic digestibility, scanning electron microscopy, and crystallinity. Compared to untreated material, [EMIM][Cl]-pretreated rice husk produces cellulose that can be efficiently enzymatic hydrolyzed with high sugar yields. This work offers a suitable methodology to include the synthesis and thermodynamics of the solvent media within the design of low-cost ionic liquids for lignocellulosic biomass pretreatment.

关键词： Ionic liquids Fluid-phase equilibria Thermodynamics Waste treatment UNIFAC approach

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A regionalized IO-model to value seasonal recreational ecosystem services in a mountain National Park in Spain

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Journal of Mountain Science 2022年第1期19卷 211-227页

作者： víctor MARTIN BARROSO Mónica de castro-PARDO Pascual FERNÁNDEZ MARTÍNEZ João C.AZEvEDO Department of Applied Economics I and history and economic institutions Faculty of Law and Social SciencesUniversidad Rey Juan CarlosCampus of VicálvaroTulipanMóstoles 28933Spain Department of Financial and Actuarial Economics and Statistics-Statistics and Operational Research Complutense University of MadridCampus of SomosaguasPozuelo de Alarcon 28223Spain Centro de Investigação de Montanha Instituto Politécnico de BragançaCampus de Santa ApolóniaBragança 5300-253Portugal

Recreational Ecosystem Services(RES)are among the most frequently evaluated ecosystem *** are seen as a major opportunity for sustainable development in areas of high ecological value resulting from the presence of emblematic species,habitats or scenery,often integrated in conservation areas,in particular in mountain areas affected by depopulation,rising environmental risks and ***,the assessment of RES has been based on Contingent valuation and Choice Experiments,methods with limitations related to their ***,Input-Output(IO)models provide a very accurate and effective way of valuation of RES with regional information regarding interindustry *** data on nature tourist expenditure may be only available annually,tourism inflows have a strong seasonal behavior,which impacts the profitability of several local economic *** this paper,we firstly constructed a novel regionalized IO-model based on Cross-Industry Location Quotients using employment data and,secondly,based on Monte Carlo simulation,we estimated nature tourist expenditure monthly using data on nature tourism *** method allowed for a more precise RES evaluation,estimating direct,indirect and induced monthly economic impacts of nature-based *** method was applied to the Ordesa and Monte Perdido(OMP)National Park in the Spanish *** estimate the average tourist expenditure,we collected and analyzed spending on commerce,hospitality and restaurants,leisure,and transport of 385 *** suggest that using a regionalized IO model leads to a considerable reduction of over-estimation of the economic impact of tourist expenditure estimated by conventional *** into consideration the direct,indirect and induced effects of tourist expenditure in 2016-2018,the total annual output effect in the OMP National Park amounted to€208.8 million,while the total income effect amounted to€86.29 ***,a total of

关键词： Input-Output Monte Carlo Simulation Location quotients Recreational Ecosystem Services Nature tourism Sustainable mountain development

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