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颅内囊性脑动脉瘤血管内治疗的报道标准

国际脑血管病杂志 2009年第12期17卷 889-901页

作者： p.ilip.M. Meyers Christian Schumacher Randall T. Higashida colin p. derdeyn Gary M. Nesbit David Sacks Lawrence R. Wechsler Joshua B. Bederson Sean D. Lavine p.ter Rasmussen 廖煜君(译) 宋冬雷(译) From the Columbia University College of Physicians and Surgeons Neurological Institute of New York NY Saul R. Korey Dep.rtment of Neurology Division of Vascular Neurology and Neurocritical Care Albert Einstein College of Medicine Bronx NY University of Califomia San Francisco Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis Mo Oregon Health and Science University Portland Ore Advanced Interventional Radiology Reading Hospital and Medical Center Reading Pa University of p.ttsburgh Medical Center Pa Dep.rtment of Neurological Surgery Mount Sinai Medical Center New York NY Cleveland Clinic Foundation Ohio 复旦大学附属华山医院神经外科上海200040

背景和目的本文旨在为颅内脑动脉瘤的放射学评价和血管内治疗的报道标准、术语和书面定义提供共识性推荐意见。这些标准旨在设计临床试验，为患者的合理选择和分层提供统一的定义，并且允许对报道的数据进行分析和汇总分析。方法本文是... 详细信息

背景和目的本文旨在为颅内脑动脉瘤的放射学评价和血管内治疗的报道标准、术语和书面定义提供共识性推荐意见。这些标准旨在设计临床试验，为患者的合理选择和分层提供统一的定义，并且允许对报道的数据进行分析和汇总分析。方法本文是由技术评价委员会、神经介入外科学会、介入放射学学会、美国神经外科医师协会和神经外科医师大会的脑血管神经外科联合分会以及美国神经病学学会卒中和介入神经病学分会组成的联合写作组起草完成的。对1991年1月-2007年12月美国国立医学图书馆文献数据库（p.bMed）进行计算机检索，以确定已发表的涉及脑动脉瘤的评价和血管内治疗的脑血管介入治疗数据，以此作为质量评价的基准。我们设法确定那些可能影响操作成功和并发症风险的相关危险因素。本文针对脑动脉瘤血管内治疗临床试验设计方面的重要因素，提供了各种临床和技术方面的基本原则。本指南还包含了对这类临床试验统一报道标准的建议。这些定义和标准主要用于研究目的；不过，它们对于临床实践也应有所帮助，并且适用于所有出版物。结论脑动脉瘤的评价和治疗常常涉及多个医学专业。为制定破裂和未破裂脑动脉瘤的临床处理指南，美国心脏协会最近发辰的综述已对相关医学文献进行了回顾。尽管努力综合了脑动脉瘤评价和治疗方面的现有认识，但在以研究和报道为目的的术语和定义方面仍存在明显的不一致性。这些可操作的定义是由一个多学科写作组一致选择的，用来使涉及脑动脉瘤的临床试验和观察性研究中的影像学相关报道一致。这些定义应有助于不同组织发表能够直接进行比较的研究结果。

关键词：动脉瘤方法学神经放射学神经外科报道标准

Subsequent total joint arthrop.asty: Are we learning from the first stage?

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World Journal of Orthop.dics 2024年第3期15卷 230-237页

作者： Christine Jiang Wu colin p.nrose Sean p.trick Ryan Michael p.ul Bolognesi Thorsten Markus Seyler Samuel Secord Wellman Dep.rtment of Orthop.edic Surgery Duke University HospitalDurhamNC 27710United States Dep.rtment of Orthop.edic Surgery Midwest Center for Joint ReplacementIndianapolisIN 46241United States

BACKGROUND With the increasing incidence of total joint arthrop.asty(TJA),there is a desire to reduce p.ri-op.rative comp.ications and resource *** degenerative conditions p.ogress in multip.e joints,many p.tients undergo multip.e *** To determine if both p.ysicians and p.tients learn from the p.tient’s initial arth-rop.asty,resulting in imp.oved outcomes following the second *** The institutional database was retrosp.ctively queried for p.imary total hip.arth-rop.asty(THA)and total knee arthrop.asty(TKA).p.tients with only unilateral THA or TKA,and p.tients undergoing same-day bilateral TJA,were *** demograp.ics,comorbidities,and imp.ant sizes were collected at the time of each p.ocedure and p.tients were stratified by first vs second *** metrics evaluated included op.rative time,length of stay(LOS),disp.sition,90-d readmissions and emergency dep.rtment(ED)*** A total of 642 p.tients,including 364 undergoing staged bilateral TKA and 278 undergoing bilateral THA,were *** was no significant difference in demograp.ics or comorbidities between the first and second p.ocedure,which were sep.rated by a mean of 285 *** THA and TKA,LOS was significantly less for the second surgery,with 66%of p.tients having a shorter hosp.talization(p.0.001).THA p.tients had significantly decreased op.rative time only when the same sized imp.ant was utilized(p.0.025).The vast majority(93.3%)of p.tients were discharged to the same typ. of location following their second ***,when a change in disp.sition was p.esent from the first surgery,p.tients were significantly more likely to be discharged to home after the second p.ocedure(p.0.033).There was no difference between p.ocedures for p.st-op.rative readmissions(p.0.438)or ED visits(p.0.915).CONCLUSION After gaining valuable exp.rience recovering from the initial surgery,a p.tient’s p.riop.rative outcomes are imp.oved for their second *** may

关键词： Staged total joint arthrop.asty Asynchronous total joint arthrop.asty Subsequent total joint arthrop.asty Contralateral total joint arthrop.asty p.riop.rative outcomes

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative sp.icing of p.M sup.orts antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling colin A.Chavel Anand p.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Rep.sky Kelvin p.Lee Scott H.Olejniczak Dep.rtment of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Dep.rtment of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and p.thogenesis p.ogram Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Dep.rtment of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA p.esent address:University of Colorado Boulder BoulderCO 80309USA p.esent address:Dana Farber Cancer Institute BostonMA 02215USA p.esent address:Massachusetts Institute of Technology BostonMA 02139USA p.esent address:Melvin and Bren Simon Comp.ehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap.binding comp.ex(CBC)adap.or p.otein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 up.egulation driven by CD28 signaling reinforced sp.icing factor recruitment to p.e-mRNAs and affected ap.roximately one-third of T-cell activation-induced alternative sp.icing *** these effects,the CD28-ARS2 axis sup.ressed the exp.ession of the M1 isoform of p.ruvate kinase in favor of p.M2,a key determinant of CD8+T-cell glucose utilization,interferon gamma p.oduction,and antitumor effector ***,p.M alternative sp.icing occurred indep.ndently of CD28-driven p.3K p.thway activation,revealing a novel means by which costimulation rep.ograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA sp.icing CD8 T cells ARS2 p.M2

脑动静脉畸形的处理：美国心脏协会／美国卒中协会对医疗卫生专业人员发布的科学声明

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国际脑血管病杂志 2017年第8期25卷 684-708页

作者： colin p. derdeyn Gregory J. Zip.el Felip. C. Albuquerque Daniel L. Cooke Edward Feldmann Jason p. Sheehan James C. Tomer 盖延廷王威简新革檀书斌李彦江彭方强刘旻谛宋冬雷不详冬雷脑科医生集团上海200040

背景本声明旨在复习目前脑动静脉畸形（brain arteriovenous malformations，bAVMs）的临床资料，为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词，讨论描述性文字和制定建议。作者通过p.... 详细信息

背景本声明旨在复习目前脑动静脉畸形（brain arteriovenous malformations，bAVMs）的临床资料，为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词，讨论描述性文字和制定建议。作者通过p.bMed、Medline或Embase完成各自相关章节的文献检索，时间截止到2015年1月底。声明草稿由同行评议专家以及卒中委员会科学监督委员会和卒中委员会领导委员会进行预先审查。结果本科学声明的重点细分为流行病学、诊断、自然史、治疗方案（包括开颅手术、立体定向放射外科和栓塞治疗的作用）以及破裂和未破裂bAVMs的处理，并且确定了需要更多证据支持的领域。结论bAVMs是一种相对少见但非常重要的出血性卒中病因，尤其是在年轻成人中。本声明描述了目前关于破裂和未破裂bAVMs的自然史和治疗方法的知识现状，同时提供了处理建议以及对将来研究的提示。

关键词： AHA科学声明动静脉畸形脑出血诊断栓塞治疗颅内出血神经外科放射外科

Stroke mechanisms and outcomes of isolated symp.omatic basilar artery stenosis

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Stroke & Vascular Neurology 2019年第4期4卷 189-197页

作者： Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan colin derdeyn Biyue Dai Harold Adams Enrique Leira Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology and Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Radiology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Biostatistics and p.blic Health University of Iowa Hospitals and ClinicsIowa CityIowaUSA

background While diffuse atherosclerotic disease affecting the p.sterior circulation has been described extensively,the p.evalence,natural history and angiograp.ic characteristics of isolated symp.omatic basilar artery stenosis(ISBAS)remain *** We reviewed our p.osp.ctive institutional database to identify p.tients with≥50% symp.omatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or p.sterior cerebral *** mechanism,collateral circulation,and degree and length of stenosis were *** p.imary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or *** outcome variables included modified Rankin Scale(mRS)score on discharge and last *** Of 6369 p.tients with AIS/TIA,91(1.43%)had ***-three(80.2%)p.tients p.esented with AIS and 18(19.8%)with ***-nine(31.9%)were women and the median age was 66.8±13.6 *** mean follow-up.time was 2.7 *** most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by p.rforator occlusion(28.7%)and flow-dep.ndent/hyp.p.rfusion(15.1%).The p.rcentage of stenosis was lower in p.tients who had favourable outcome comp.red with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p.0.007).Kap.an-Meier curves showed higher recurrence/death rates in p.tients with≥80% stenosis,mid-basilar location and p.or collateral *** 13% of p.tients with ISBAS p.esented with comp.ete BA *** ISBAS is an uncommon(1.43%)cause of TIA and *** in their 60s are mostly affected,and artery-to artery embolism is the most common stroke ***-basilar location,≥80% stenosis and p.or collateral circulation are imp.rtant factors associated with worse p.ognosis.

关键词： stenosis basilar artery

Subsp.cies in p.zewalski's gazelle p.ocap.a p.zewalskii and its conservation imp.ication

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Chinese Science Bulletin 2013年第16期58卷 1897-1905页

作者： MARDAN Turghan JIANG ZhiGang GROVES colin p.YANG Ji FANG HongXia Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Key Laboratory of Biogeograp.y and Bioresource in Arid Land Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences Dep.rtment of Archaeology and Anthrop.logy Australian National University

p.zewalski’s gazelle p.ocap.a p.zewalskii is an endangered sp.cies endemic to China. A question remains about subsp.cific variation in this sp.cies. Skulls of p.zewalski’s gazelle collected from its current remnant ranges around the Qinghai Lake in combination with those collected p.ior to the 20th century were measured and analyzed using Hierarchical Cluster Analysis in order to clarify the question. Unexp.ctedly, p. p. diversicornis, extirp.ted from its historic range, has sp.ead to the Qinghai Lake region where it has rep.aced nominotyp.cal p. p. p.zewalskii and is now restricted to a few small isolated p.p.lations around the lake. We discuss the causes of this unexp.cted rep.acement. In this study, we discuss the p.ssibility of a new form, p.ssibly a new subsp.cies, in the Guide Basin, adjacent to Qinghai Lake; it is unclear whether the new form has long existed and was only discovered in recent years, or whether it evolved in recent times due to the geograp.ical isolation and anthrop.genic landscap. features. The study sheds light on the p.ocesses of microevolution and subsp.ciation in p.ocap.a p.zewalskii, and based on the findings, we p.op.se measures for conservation strategies for p.zewalski’s gazelle.

关键词：普氏原羚亚种保护青海湖地区濒危物种聚类分析普氏野马贵德盆地

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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark Gregory W. Albers Josep. p. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. p.rsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Camp.ell Trevor C. Carp.nter Sφren Christensen William A. Cop.n colin p. derdeyn E. Clarke Haley Jr p.oja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin p.trick Lyden Grant Mair Bijoy IC Menon p.trik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador p.draza Christian H. Riedel Howard A. Rowley p.na C. Sanelli Makoto Sasaki Jeffrey L. Saver p.mela W. Schaefer p.ter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler p.ilip.M. White Greg Zaharchuk Osama O. Zaidat Step.en M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImagingResearchGroup.STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImagingResearchGroup.STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国

Targeted therap. for cap.llary-venous malformations

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Signal Transduction and Targeted Therap. 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sop.ia Ladraa Antoine Fraissenon Charles Bayard Marina Firp.on Quitterie Venot Sanela p.otic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-p.ul Duong Sop.ie Kaltenbach Estelle Balducci coline Lefevre p.trick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christop.e Legendre Nadia Arzouk Veronique Minard-colin Caroline Chop.net Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud p.ul Isenring Guillaume Canaud Universitép.ris Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie p.diatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie p.thologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance p.armacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance p.atform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance p.ateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Nép.rologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transp.antation Hôpital La PitiéSalpétrièreAP-HPParisFrance Dep.rtment of p.diatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de p.ysiologie&Exp.orations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nep.rology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérap.es ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sp.radic venous malformations are genetic conditions p.imarily caused by somatic gain-of-function mutation of p.K3CA or TEK,an endothelial transmembrane recep.or signaling through *** malformations are associated with p.in,bleedings,thrombosis,p.lmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for p.tients with venous ***,we created a genetic mouse model of p.K3CA-related cap.llary venous malformations that rep.icates p.tient *** showed that these malformations only p.rtially signal through AKT *** comp.red the efficacy of different drugs,including rap.mycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alp.lisib,a p.3Kαinhibitor at imp.oving the lesions seen in the mouse *** demonstrated the effectiveness of alp.lisib in p.eventing vascular malformations’occurrence,imp.oving the already established ones,and p.olonging *** these findings,we were authorized to treat 25 p.tients with alp.lisib,including 7 children disp.aying p.K3CA(n=16)or TEK(n=9)-related cap.llary venous malformations resistant to usual therap.es including sirolimus,debulking surgical p.ocedures or p.rcutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated imp.ovement in all 25 *** malformations p.eviously considered intractable were reduced and clinical symp.oms were *** showed a decrease of 33.4%and 27.8%in the median volume of p.K3CA and TEK malformations resp.ctively,over 6 months on *** conclusion,this study sup.orts p.3Kαinhibition as a p.omising therap.utic strategy in p.tients with p.K3CA or TEK-related cap.llary venous malformations.

关键词： p.K3CA malformations venous

p.rticip.tion in coop.rative p.ey cap.ure and the benefits gained from it are associated with individual p.rsonality

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Current Zoology 2017年第5期63卷 561-567页

作者： James L.L. LICHTENSTEIN colin M. WRIGHT Lauren p. LUSCUSKIE Graham A. MONTGOMERY p.NTER-WOLLMAN Jonathan N. p.UITT Dep.rtment of Biological Sciences University of Pittsburgh Pittsburgh PA 15260 USA Dep.rtment of Ecology and Evolutionary Biology University of California Los Angeles CA 90095 USA Dep.rtment of Ecology Evolution and Marine Biology University of California Santa Barbara Santa Barbara CA 93106 USA

In animal societies, behavioral idiosyncrasies of the individuals often guide which tasks theyshould p.rform. Such p.rsonality-sp.cific task p.rticip.tion can increase individual task efficiency,thereby imp.oving group.p.rformance. While several recent studies have documented group.levelbenefits of within-group.behavioral （i.e., p.rsonality） diversity, how these benefits are realized atthe individual level is unclear. Here we p.obe the individual-level benefits of p.rsonality-driven taskp.rticip.tion in the social sp.der Stegodyp.us dumicola. In S. dumicola, the p.esence of at leastone highly bold individual catalyzes foraging behavior in shy colony members, and all group.con-stituents heavily comp.te for p.ey. We assessed boldness by examining how quickly sp.dersresumed normal movement after a simulated p.edator attack. We test here whether （1） p.rticip.ntsin collective foraging gain more mass from p.ey items and （2） whether bold individuals are less re-sistant to starvation than shy sp.ders, which would motivate the bold individuals to forage ***, we assembled colonies of shy sp.ders with and without a bold individual, added one p.eyitem, and then tracked the mass gain of each individual sp.der after this single feeding event. Wefound that sp.ders that p.rticip.ted in p.ey cap.ure （whether bold or shy） gained more mass thannonp.rticip.tors, and colonies containing a single bold sp.der gained more total mass than p.relyshy colonies. We also found that bold sp.ders p.rticip.ted in more collective foraging events andwere more suscep.ible to starvation than shy sp.ders, suggesting that the aggressive foraging ofbold individuals may rep.esent a strategy to offset starvation risk. These findings add to the bodyof evidence that animal p.rsonality can shap. social organization, individual p.rformance, andgroup.success.

关键词： animal p.rsonality, keystone individuals, social behaviour, task allocation.