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Aquaculture and Fisheries 2023年第6期8卷 661-671页

作者： Tomas Araya-Schmidt Shannon M.Bayse Paul D.Winger colin h.frank Centre for Sustainable Aquatic Resources Fisheries and Marine InstituteMemorial University of NewfoundlandSt.John’sNLA1C 5R3Canada

The offshore Northern shrimp(Pandalus borealis)bottom trawl fishery in eastern Canada currently uses 22 and 28 mm bar spacing Nordmøre grids to limit bycatch from using small mesh ***,a recent rebound of juvenile redfish(Sebastes spp.),that can pass through the grids,has greatly increased *** address this concern,this study investigated the effectiveness of 17 and 15 mm bar spacing Nordmøre grids in a twin-trawl(paired)configuration against the traditional 22 mm bar spacing *** selectivity analyses showed that the 17 and 15 mm grids resulted in no significant reduction in shrimp catch across all length *** 17 mm grid significantly reduced redfish bycatch for all length classes and the 15 mm grid significantly reduced redfish bycatch for individuals larger than 95 mm total *** redfish entered the codend with the experimental grids,however,the overlap in width between redfish and Northern shrimp limits the overall sorting efficiency of the grids,leaving some redfish still vulnerable to capture.

关键词： Size selectivity Twin trawling Catch comparison Bycatch reduction device

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron holling colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason h.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi hou Andrew M.Intlekofer Richard M.higashi Teresa W.M.Fan Andrew N.Lane Kevin h.Eng Brahm h.Segal Elizabeth A.Repasky Kelvin P.Lee Scott h.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study

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Bioactive Materials 2023年第1期19卷 406-417页

作者： Roxane Bonithon colin Lupton Marta Roldo Joseph Nicholas Dunlop Gordon William Blunn frank Witte Gianluca Tozzi Zeiss Global Centre School of Mechanical and Design EngineeringUniversity of PortsmouthAnglesea RoadPO13DJPortsmouthUnited Kingdom School of Pharmacy and Biomedical Sciences University of PortsmouthWhite Swan RoadPO12DTPortsmouthUnited Kingdom School of the Environment Geography&GeosciencesUniversity of PortsmouthBurnaby RoadPO13QLPortsmouthUnited Kingdom Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitätsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Biotrics Bioimplants AG Ullsteinstr.10812109BerlinGermany

The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical *** study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating hanks’Balanced Salt Solution(hBSS)with and without in situ cyclic compression(30 N/1 hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume *** in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was *** changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(phe material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of ***,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs.

关键词： Magnesium alloys Bone regeneration In vitro corrosion X-ray computed tomography(XCT) Digital volume correlation(DVC)

TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data

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Molecular Plant 2020年第8期13卷 1194-1202页

作者： Chengjie Chen hao Chen Yi Zhang hannah R.Thomas Margaret h.frank Yehua he Rui Xia State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources South China Agricultural UniversityGuangzhouGuangdong 510640China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouGuangdong 510640China Key Laboratory of Biology and Germplasm Enhancement of horticultural Crops in South China Ministry of Agriculture and Rural AffairSouth China Agricultural UniversityGuangzhouGuangdong 510640China College of horticulture South China Agricultural UniversityGuangzhouGuangdong 510640China Oilseed Crops Institute Hunan Agricultural UniversityChangsha 410128China Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA

The rapid development of high-throughput sequencing techniques has led biology into the big-data *** analyses using various bioinformatics tools rely on programming and command-line environments,which are challenging and time-consuming for most wet-lab ***,we present TBtools(a Toolkit for Biologists integrating various biological data-handling tools),a stand-alone software with a userfriendly *** toolkit incorporates over 130 functions,which are designed to meet the increasing demand for big-data analyses,ranging from bulk sequence processing to interactive data visualization.A wide variety of graphs can be prepared in TBtools using a new plotting engine("JIGplot")developed to maximize their interactive ability;this engine allows quick point-and-click modification of almost every graphic *** is platform-independent software that can be run under all operating systems with Java Runtime Environment 1.6 or *** is freely available to non-commercial users at https://***/CJ-Chen/TBtools/releases.

关键词： TBtools bioinformatics big data data visulization gene family

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona Manon colin Marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo Rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda Jean Claude Mubenga Khazy Anga Noelly Mukuna Christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and h2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

Screening of phenolic compounds in australian grown grapes and their potential antioxidant activities

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Food Bioscience 2022年第3期47卷 544-556页

作者： Gia Toan Vo Ziyao Liu Osbert Chou Biming Zhong colin J.Barrow frank R.Dunshea hafiz A.R.Suleria School of Agriculture and Food Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkvilleVIC3010Australia CAS Key Laboratory of Quantitative Engineering Biology Synthetic Biochemistry CenterShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Centre for Chemistry and Biotechnology School of Life and Environmental SciencesDeakin UniversityWaurn PondsVIC3217Australia Faculty of Biological Sciences The University of LeedsLeedsLS2 9JTUK

Grapes(Vitis Vinifera)are one of the world's most utilised and prized *** are a great source of antioxidants due to the abundance of phenolic *** pulp is the main part of the grape being *** pulp of five Australian grown grapes–Dawn Seedless(DS),Calmeria(CG),Golden Globe(GG),Menindee Seedless(MS),and Thompson Seedless(TS)will be qualitatively and quantitatively analysed for its phenolic composition and antioxidant *** general trend followed:GG>TS>MS>DS>CG,and the phenolic content of the pulp also presented a significant positive correlation with the antioxidant *** revealing the highest levels of TPC(4.31±0.11 mg GAE/g)and TFC(0.48±0.09 mg QE/g)while TS were highest in TTC(0.94±0.12 mg CE/g).Similarly,GG exhibited higher antioxidant capacity in DPPh(5.84±0.17 mg AAE/g),FRAP(4.91±0.14 mg AAE/g),and TAC(6.78±0.12 mg AAE/g),while TS revealed highest radical scavenging ability for ABTS(4.56±0.19 mg AAE/g).The LC-ESI-QTOF-MS/MS tentatively identified 78 phenolic compounds consisting of flavonoids(36),phenolic acids(31),lignans(3),stilbenes(1),and other polyphenols(7)in five grapes *** most abundant fruit-based targeted polyphenols were *** had a higher phenolic concentration in hPLC-PDA quantification,particularly for phenolic acids(gallic acid and chlorogenic acid)and flavonoids(kaempferol).Our study provides relatively adequate information on grape pulp's phenolic content and antioxidant capacity,providing confidence and research prospects to promote grape pulp use in different food,pharmaceutical and supplement industries,and even influencing grape cultivation.

关键词： Australian grown grapes Phenolic compounds LC-ESI-QTOF-MS/MS Antioxidant activity hPLC-PDA

Effect of processing on bioaccessibility and bioavailability of bioactive compounds in coffee beans

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Food Bioscience 2022年第2期46卷 1-13页

作者： hanjing Wu Jingyu Gu Amrit BK Malik A.Nawaz colin J.Barrow frank R.Dunshea hafiz A.R.Suleria School of Agriculture and Food Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkville3010VICAustralia Commonwealth Scientific and Industrial Research Organisation(CSIRO) Agriculture and Food671 Sneydes RoadPrivate Bag 16WerribeeVictoria3030Australia Centre for Chemistry and Biotechnology School of Life and Environmental SciencesDeakin UniversityWaurn PondsVIC3217Australia Faculty of Biological Sciences The University of LeedsLeedsLS29JTUK

Coffee is one of the most prevalent and functional beverages around world owing to its rich content of bioactive *** compounds and alkaloids are two primary groups of bioactive compounds in coffee beans,which have been proven healthy benefits in regular and suitable daily *** have been recognized as protective factors,especially phenolic compounds,to perform high antioxidant capacities and potential to relieve the occurrence of chronic diseases and partial *** content and composition of bioactive and anti-nutritional compounds in coffee beans can be mainly influenced by variety,processing and storage *** cultivar of Arabica coffee beans(***)exhibits lower content of phenolic compounds but similar anti-nutritional substances with the comparison to Robusta(***).Comparing to green coffee beans,reasonable roasting contributes to the improvement of phenolic content and its total antioxidant activity because of the liberation of bound phenolic compounds and the generation of novel compounds with antioxidant *** intensive roasting will not only decrease the number of bioactive compounds within the coffee beans but also stimulate the generation of endogenous anti-nutritional compounds,which consequently reduce the coffee nutritional *** fluctuations of moisture content during storage would be the primary reason of the changes in the content of bioactive *** compounds in coffee beans perform outstanding bioaccessibility but relatively lower absorption efficiency because of the combination with other *** roasting would improve the bioavailability of bioactive *** interaction between phenolic compounds and proteins would also influence the bioavailability and bioactivity of bioactive compounds and final nutritional value after consumption.

关键词： Coffee beans Phenolic compounds Alkaloids Anti-nutritional compounds Roasting Bioavailability

毛细管电泳中获得稳定电渗流的毛细管预处理方法

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分析化学 2000年第9期28卷 1110-1113页

作者：刘学良王进防王俊德商振华 h.frank 中国科学院大连化学物理研究所!大连 116012 Environmental Chemistry and Ecotoxicology! University of Bayreuth D-95440 Bayreuty

报道了一种毛细管电泳分析中获得重复性分析结果的毛细管柱预处理方法。通过采用有机溶剂的碱性溶液对毛细管柱进行预冲洗，可得到内壁均一的能产生稳定电渗流的毛细管柱，实现了强极性有机化合物如硝基酚的毛细管区带电泳分析。

关键词：渗流毛细管预处理毛细管区带电泳硝基酚

Effectiveness of a Passive-active Vibration Isolation System with Actuator Constraints

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Chinese Journal of Mechanical Engineering 2014年第3期27卷 567-574页

作者： SUN Lingling SUN Wei SONG Kongjie hANSEN colin h Key Laboratory of high-efficiency and Clean Mechanical Manufacture Shandong University School of Mechanical Engineering University of Adelaide

In the prediction of active vibration isolation performance, control force requirements were ignored in previous work. This may limit the realization of theoretically predicted isolation performance if control force of large magnitude cannot be supplied by *** behavior of a feed-forward active isolation system subjected to actuator output constraints is investigated. Distributed parameter models are developed to analyze the system response, and to produce a transfer matrix for the design of an integrated passive-active isolation system. Cost functions comprising a combination of the vibration transmission energy and the sum of the squared control forces are proposed. The example system considered is a rigid body connected to a simply supported plate via two passive-active isolation mounts. Vertical and transverse forces as well as a rotational moment are applied at the rigid body, and resonances excited in elastic mounts and the supporting plate are analyzed. The overall isolation performance is evaluated by numerical simulation. The simulation results are then compared with those obtained using unconstrained control strategies. In addition, the effects of waves in elastic mounts are analyzed. It is shown that the control strategies which rely on tmconstrained actuator outputs may give substantial power transmission reductions over a wide frequency range, but also require large control force amplitudes to control excited vibration modes of the system. Expected power transmission reductions for modified control strategies that incorporate constrained actuator outputs are considerably less than typical reductions with unconstrained actuator outputs. In the frequency range in which rigid body modes are present, the control strategies can only achieve 5-10 dB power transmission reduction, when control forces are constrained to be the same order of the magnitude as the primary vertical force. The resonances of the elastic mounts result in a notable increase of

关键词： passive-active isolation transfer matrix control effort constraint feedforward control