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A red herring: An unusual case of pneumothorax

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World Journal of Emergency Medicine 2021年第2期12卷 160-161页

作者： Joseph H.Walline Koon-ho Cheung Priscilla P.Song colin A.graham Accident and Emergency Medicine Academic Unit Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Accident and Emergency Medicine Prince of Wales HospitalHong Kong Hospital AuthorityHong KongChina Centre for the Humanities and Medicine the University of Hong KongHong KongChina

Dear editor,A 67-year-old Chinese man presented to our emergency department (ED) complaining of right-sided chest wall *** noticed these symptoms three hours prior to arrival. He denied any shortness of breath or recent injury. Past medical history was significant only for hypertension. Social history was significant for a history of smoking (40 packs per year).

关键词： sided editor hypertension

A new risk stratification score for patients with suspected cardiac chest pain in emergency departments,based on machine learning

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Chinese Medical Journal 2020年第7期133卷 879-880页

作者： Hai-Feng Mao Xiao-Hui Chen Yun-Mei Li Si-Yuan Zhang Jun-Rong Mo Min Li Pei-Yi Lin Timothy HRainer colin Agraham Hui-Lin Jiang Department of Emergency The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China The Sixth Clinical Medical Institute of Guangzhou Medical University GuangzhouGuangdong 511436China Accident and Emergency Medicine Academic Unit Chinese University of Hong KongPrince of Wales HospitalHong Kong999077China

To the Editor:Chest pain is one of the most common complaints for patients attending emergency departments(EDs)*** is important to accurately stratify risk of possible acute coronary syndrome(ACS)for these patients.[1]Several risk stratification scores such as thrombolysis in myocardial infarction(TIMI),global registry for acute coronary events(GRACE),Banach and HEART are helpful.[2]Previous research in our setting compared these four scores and found that the HEART score,with a C-statistic of 0.731,was the best for predicting 7-day major adverse cardiac events(MACE)The purpose of this study was to develop risk stratification prediction models for 7-day MACE in patients with chest pain,utilizing machine learning algorithms such as eXtreme Gradient Boosting(XGBoost),Support Vector Machine(SVM).

关键词： patients pain cardiac

Participation in cooperative prey capture and the benefits gained from it are associated with individual personality

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Current Zoology 2017年第5期63卷 561-567页

作者： James L.L. LICHTENSTEIN colin M. WRIGHT Lauren P. LUSCUSKIE graham A. MONTGOMERY PINTER-WOLLMAN Jonathan N. PRUITT Department of Biological Sciences University of Pittsburgh Pittsburgh PA 15260 USA Department of Ecology and Evolutionary Biology University of California Los Angeles CA 90095 USA Department of Ecology Evolution and Marine Biology University of California Santa Barbara Santa Barbara CA 93106 USA

In animal societies, behavioral idiosyncrasies of the individuals often guide which tasks theyshould perform. Such personality-specific task participation can increase individual task efficiency,thereby improving group performance. While several recent studies have documented group-levelbenefits of within-group behavioral （i.e., personality） diversity, how these benefits are realized atthe individual level is unclear. Here we probe the individual-level benefits of personality-driven taskparticipation in the social spider Stegodyphus dumicola. In S. dumicola, the presence of at leastone highly bold individual catalyzes foraging behavior in shy colony members, and all group con-stituents heavily compete for prey. We assessed boldness by examining how quickly spidersresumed normal movement after a simulated predator attack. We test here whether （1） participantsin collective foraging gain more mass from prey items and （2） whether bold individuals are less re-sistant to starvation than shy spiders, which would motivate the bold individuals to forage ***, we assembled colonies of shy spiders with and without a bold individual, added one preyitem, and then tracked the mass gain of each individual spider after this single feeding event. Wefound that spiders that participated in prey capture （whether bold or shy） gained more mass thannonparticipators, and colonies containing a single bold spider gained more total mass than purelyshy colonies. We also found that bold spiders participated in more collective foraging events andwere more susceptible to starvation than shy spiders, suggesting that the aggressive foraging ofbold individuals may represent a strategy to offset starvation risk. These findings add to the bodyof evidence that animal personality can shape social organization, individual performance, andgroup success.

关键词： animal personality, keystone individuals, social behaviour, task allocation.

Does the Location of the Cutting Flute of Self-Tapping Screws in Bony Substrate Affect the Removal Torque?

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Open Journal of Orthopedics 2015年第1期5卷 1-5页

作者： David James Chapman graham Alistair Spiers Eric Swarts colin Whitewood Royal Perth Hospital Perth Australia Department of Engineering and Medical Physics Royal Perth Hospital Perth Australia Princess Margaret Hospital Perth Australia

Introduction: An observation was made that when removing self-tapping cortical screws from patients bones, stripping or shearing of the head of the screw occurred more often in screws whose cutting flutes sat in cortical bone compared with screws that had penetrated the distal cortex with flutes exposed. Method: A model was designed to simulate screws with their cutting flutes either in contact with cortical bone or deep to cortical bone. Screws were grouped depending on the location of their cutting flutes and removal torque was measured. Results: Eighteen screws were included in final analysis. There was a statistically significant difference in average initial removal torque and average maximal removal torque with screws with their cutting flutes in substrate requiring significantly more torque to remove. Conclusion: We conclude that self-tapping cortical screws whose cutting flutes sit in cortical substrate require more torque to remove and are therefore more likely to fail. This finding may be used as a guide in pre-operative planning for removal of metalwork from patients.

关键词： Stainless Steel Screws Removal Failure Metalwork Removal Self-Tapping Screws

Improved bridge pier collar for reducing scour

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International Journal of Sediment Research 2022年第1期37卷 37-46页

作者： Christopher Valela colin David Rennie Ioan Nistor Department of Civil Engineering University of Ottawa

This study performed a bridge pier collar comparison for the purpose of reducing scour,while introducing a new collar *** new collar,referred to as Collar Prototype Number 3,was designed based on an equilibrium scour hole and provides a method of controlling the horseshoe *** modelling was utilized to show the flow field and bed shear stress as a result of using Collar Prototype Number 3.A prototype model of Collar Prototype Number 3 and a flat plate collar were constructed for the purpose of comparing both experimentally under different flow *** Prototype Number 3 proved to be an effective device as it reduced scour in terms of the maximum depth downstream of the pier and overall volume,in some instances,by up to 69.7%and 75.7%,***,Collar Prototype Number 3 outperformed the flat plate collar,especially because,unlike the flat plate collar,Collar Prototype Number 3 did not experience undermining.

关键词： Bridge pier Scour Horseshoe vortex Pier collar Scour countermeasure

Robust model predictive control:reflections and opportunities

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Journal of Control and Decision 2014年第2期1卷 115-148页

作者： graham C.Goodwin He Kong Galina Mirzaeva María M.Seron School of Electrical Engineering and Computer Science The University of NewcastleCallaghanAustralia

The past three decades have witnessed important developments in the theory and practice of model predictive control(MPC).In particular,considerable effort has been devoted to robust MPC *** have also been many successful *** paper will give a brief overview of existing results and summarise experience gained in two real-world *** also present some reflections on issues which,in the authors’opinion,deserve further attention.

关键词： robust MPC application of MPC power electronics induction heating

Lifespan Modulation in Mice and the Confounding Effects of Genetic Background

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Journal of Genetics and Genomics 2014年第9期41卷 497-503页

作者： Lorna Mulvey Amy Sinclair colin Selman Institute of Biodiversity Animal Health and Comparative MedicineCollege of MedicineVeterinary and Life SciencesGraham Kerr BuildingUniversity of Glasgow

We are currently in the midst of a revolution in ageing research, with several dietary, genetic and pharmacological interventions now known to modulate ageing in model organisms. Excitingly, these interventions also appear to have beneficial effects on late-life health. For example, dietary restriction （DR） has been shown to slow the incidence of age-associated cardiovascular disease, metabolic disease, cancer and brain ageing in non-human primates and has been shown to improve a range of health indices in humans. While the idea thai DR＇s ability to extend lifespan is often thought of as being universal, studies in a range of organisms, including yeast, mice and monkeys, suggest that this may not actually be the case. The precise reasons underlying these differential effects of DR on lifespan are currently unclear, but genetic background may be an important factor in how an individual responds to DR. Similarly, recent findings also suggest that the responsiveness of mice to specific genetic or pharmacological interventions that modulate ageing may again be influenced by genetic background. Consequently, while there is a clear driver to develop interventions to improve late-life health and vitality, under- standing precisely how these act in response to particular genotypes is critical if we are to translate these findings to humans. We will consider of the role of genetic background in the efficacy of various lifespan interventions and discuss potential routes of utilising genetic heterogeneity to further understand how particular interventions modulate lifespan and healthspan.

关键词： Ageing Dietary restriction Genotype Longevity

养猪生产生命周期评估(LCA)专题(综述)(续完)

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国外畜牧学（猪与禽） 2017年第8期37卷 106-108页

作者：张江陈建康 graham McAuliffe Deborah Chapman colin Sage 上海农林职业技术学院农生系

2．3粪便处理生命周期评估虽然研究表明饲料始终是家畜生产最大的环境压力，但在养殖地区，粪便处理是更大的问题，因为如果排泄物管理不善，N和P有可能流失进入淡水和地下水，NH，也存在酸化风险。可通过厌氧消化等技术减少直接施肥等... 详细信息

2．3粪便处理生命周期评估虽然研究表明饲料始终是家畜生产最大的环境压力，但在养殖地区，粪便处理是更大的问题，因为如果排泄物管理不善，N和P有可能流失进入淡水和地下水，NH，也存在酸化风险。可通过厌氧消化等技术减少直接施肥等传统处理方式带来的风险，同时沼气生产还可获得新效益。有效施肥也可减少化肥用量。LCA分析方法已经大量应用于猪粪分析。

关键词：生命周期评估养猪生产综述专题粪便处理环境压力家畜生产养殖地区

Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks