检索结果-南通市图书馆

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词：

Neuroinflammation revisited through the microglial lens

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Road distance and travel time for an improved house price Kriging predictor

在线全文

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2018年第3期21卷 185-194页

作者： Henry crosby Theo Damoulas Alex Caton Paul Davis João Porto de Albuquerque Stephen A.Jarvis Warwick Institute for the Science of Cities University of WarwickCoventryUK Department of Computer Science University of WarwickCoventryUK Department of Statistics University of WarwickCoventryUK Assured Property Group WarwickUK Center of Interdisciplinary Methodologies University of WarwickCoventryUK

The paper designs an automated valuation model to predict the price of residential property in Coventry,United Kingdom,and achieves this by means of geostatistical Kriging,a popularly employed distance-based learning *** traditional applications of distance-based learning,this papers implements non-Euclidean distance metrics by approximating road distance,travel time and a linear combination of both,which this paper hypothesizes to be more related to house prices than straight-line(Euclidean)*** that–to undertake Kriging–a valid variogram must be produced,this paper exploits the conforming properties of the Minkowski distance function to approximate a road distance and travel time metric.A least squares approach is put forth for variogram parameter selection and an ordinary Kriging predictor is implemented for *** predictor is then validated with 10-fold crossvalidation and a spatially aware checkerboard hold out method against the almost exclusively employed,Euclidean *** a comparison of results for each distance metric,this paper witnesses a goodness of fit(r2)result of 0.6901±0.18 SD for real estate price prediction compared to the traditional(Euclidean)approach obtaining a suboptimal r2 value of 0.66±0.21 SD.

关键词： Kriging Minkowski travel time road distance realestate valuation

Hierarchically Clustered HMM for Protein Sequence Motif Extraction with Variable Length

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2014年第6期19卷 635-647页

作者： cody Hudson Bernard Chen Dongsheng Che Department of Computer Science University of Central Arkansas ConwayAR 72034 USA Department of Computer Science East Stroudsburg University East Stroudsburg PA 18301 USA

Protein sequence motifs extraction is an important field of bioinformatics since its relevance to the structural analysis. Two major problems are related to this field：（1） searching the motifs within the same protein family; and（2） assuming a window size for the motifs search. This work proposes the Hierarchically Clustered Hidden Markov Model（HC-HMM） approach, which represents the behavior and structure of proteins in terms of a Hidden Markov Model chain and hierarchically clusters each chain by minimizing distance between two given chains＇ structure and behavior. It is well known that HMM can be utilized for clustering, however, methods for clustering on Hidden Markov Models themselves are rarely studied. In this paper, we developed a hierarchical clustering based algorithm for HMMs to discover protein sequence motifs that transcend family boundaries with no assumption on the length of the motif. This paper carefully examines the effectiveness of this approach for motif extraction on 2593 proteins that share no more than 25% sequence identity. Many interesting motifs are *** example motifs generated by the HC-HMM approach are analyzed and visualized with their tertiary *** believe the proposed method provides a unique protein sequence motif extraction strategy. The related data mining fields using Hidden Markova Model may also benefit from this clustering on HMM themselves approach.

关键词： Hidden Markov Model hierarchical clustering sequential motif bioinformatics

A Neuro-Muscular Elasto-Dynamic Model of the Human Arm Part 2:Musculotendon Dynamics and Related Stress Effects

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2009年第2期6卷 108-119页

作者： cody B.Moody Alan A.Barhorst Lawrence Schovanec Texas Tech University Department of Mechanical Engineering Texas Tech University Department of Mathematics and Statistics

In this paper we develop an elasto-dynamic model of the human arm that includes effects of neuro-muscular control upon elastic deformation in the *** elasto-dynamic model of the arm is based on hybrid parameter multiple body system variational projection principles presented in the companion *** the technique is suitable for detailed bone and joint modeling,we present simulations for simplified geometry of the bones,discretized as Rayleigh beams with elongation,while allowing for large *** of the upper extremity is simulated by incorporating muscle forces derived from a Hill-type model of musculotendon *** effects of muscle force are modeled in two *** one approach,an effective joint torque is calculated by multiplying the muscle force by a joint moment ann.A second approach models the muscle as acting along a straight line between the origin and insertion sites of the *** arm motion is simulated by utilizing neural feedback and feedforward *** illustrate the combined effects of neural control strategies, models of muscle force inclusion,and elastic assumptions on joint trajectories and stress and strain development in the bone and tendon.

关键词： elasto-dynamics hybrid parameter system musculo skeletal model neuro-muscular model

Salvage locoregional therapies for recurrent hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第3期29卷 413-424页

作者： cody R Criss Mina S Makary Heritage College of osteopathic Medicine Ohio UniversityAthensOhio 45701United States Department of Radiology The Ohio State University Wexner Medical CenterColumbusOhio 43210United States

Hepatocellular carcinoma(HCC)is the second most common cause of cancerrelated death *** the advent of screening efforts and algorithms to stratify patients into appropriate treatment strategies,recurrence rates remain *** contrast to first-line treatment for HCC,which relies on several factors,including clinical staging,tumor burden,and liver function,there is no consensus or general treatment recommendations for recurrent HCC(R-HCC).Locoregional therapies include a spectrum of minimally invasive liver-directed treatments which can be used as either curative or neoadjuvant therapy for ***,we provide a comprehensive review of recent evidence using salvage loco-regional therapies for R-HCC after failed curative-intent.

关键词： Recurrent hepatocellular carcinoma Locoregional therapy Transarterial chemoembolization Transarterial embolization Transarterial radioembolization Ablation Salvage therapy