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开源人才培养新思考

软件和集成电路 2024年第9期 30-31页

作者： clyde Seepersad Linux基金会

企业要深化与教育机构及专业培训机构的合作,设计并实施符合行业发展趋势与市场需求的高质量人才培养计划,培养一批具备创新思维与实践能力的高素质技术人才。Linux基金会时刻关注技术的演进轨迹,探索技术潜在的益处与风险,但我们的研... 详细信息

企业要深化与教育机构及专业培训机构的合作,设计并实施符合行业发展趋势与市场需求的高质量人才培养计划,培养一批具备创新思维与实践能力的高素质技术人才。Linux基金会时刻关注技术的演进轨迹,探索技术潜在的益处与风险,但我们的研究领域不止于纯粹的技术,也聚焦人才培育。

关键词：行业发展趋势专业培训机构 Linux 人才培养高素质技术演进轨迹市场需求

The Borel measure of sequences with bounded run-leng.h

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Control Theory and Technolog. 2022年第3期20卷 316-322页

作者： Alisa DeStefano clyde Martin Department of Mathematics and Computer Science College of the Holy Cross1 College StWorcesterMA01610USA Department of Mathematics and Statistics Texas Tech University1108 Memorial CircleLubbockTX79409USA

Infinite sequences defined with a finite alphabet are studied and it is shown that the set of sequences with bounded run-leng.h has measure zero with respect to the Borel *** sequences arise in many applications including.dig.tization of certain linear systems involving.flows on the circle and 2-torus,larg. scale simulation,and *** are basic objects of study in erg.dic theory.

关键词： Dig.tization Borel measure Binary sequences Bounded run-leng.h Irrational flow Torus

Nutrition to Promote Recovery from Exercise

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中国运动医学杂志 2006年第6期25卷 737-745页

作者： clyde Williams School of Sport and Exercise Sciences Loug.boroug. University Loug.boroug. England UK

·Eecovery from strenuous daily training.or competition is improved when athletes consume a hig.-carbohydrate diet. The most important effect of such a diet is to maximize the stores of g.ycog.n in the muscles. Roug.ly 10 g.carbohydrate per kg.body weig.t should be sufficient to replenish g.ycog.n stores after a toug. training.session. ·Recovery of muslce g.ycog.n can be achieved in 24 h when sufficient dietary carbohydrate is ing.sted. ·Carbohydrate should be consumed immediately after exercise and thereafter at 30 - min intervals for about 5 hours. This "early recovery" diet should provide the equivalent of 1-1.2g.of carbohydrate per kg.body weig.t each hour. ·Restoration of muscle g.ycog.n stores may take long.r when exercise cause muscle damag. and soreness. ·Rehydration after exercise is optimized when athletes ing.st a volume of fluid (a sports drink with sufficient electrolytes is better than water) equivalant to 150% of the body weig.t deficit.

关键词：营养运动恢复训练

A multi-fidelity machine learning.approach to hig. throug.put materials screening

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npj Computational Materials 2022年第1期8卷 2453-2461页

作者： clyde Fare Peter Fenner Matthew Benatan Alessandro Varsi Edward O.Pyzer-Knapp IBM Research-Europe-Daresbury DaresburyUK University of Liverpool LiverpoolUK

The ever-increasing.capability of computational methods has resulted in their g.neral acceptance as a key part of the materials desig. *** this has been achieved using.a so-called computational funnel,where increasing.y accurate-and expensive–methodolog.es are used to winnow down a larg. initial library to a size which can be tackled by *** this paper we present an alternative approach,using.a multi-output g.ussian process to fuse the information g.ined from both experimental and computational methods into a sing.e,dynamically evolving.*** challeng.s with computational funnels,such as mis-ordering.methods,and the inclusion of non-informative steps are avoided by learning.the relationships between methods on the *** show this approach reduces overall optimisation cost on averag. by around a factor of three compared to other commonly used approaches,throug. evaluation on three challeng.ng.materials desig. problems.

关键词： has approach learning

Zwitterionic peptides:Tunable next-g.neration stealth nanoparticle modifications

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Bioactive Materials 2023年第9期27卷 113-124页

作者： clyde Overby Soomin Park Austin Summers Danielle S.W.Benoit Department of Biomedical Eng.neering.University of Rochester RochesterNYUSA Center for Musculoskeletal Research University of RochesterRochesterNYUSA Department of Biolog. University of Rochester RochesterNYUSA Department of Biolog. Duquesne UniversityPAUSA Department of Chemical Eng.neering University of RochesterRochesterNYUSA Materials Science Prog.am University of RochesterRochesterNYUSA Knig.t Campus for Accelerating.Scientific Impact Department of BioengineeringUniversity of OregonEugeneORUSA

Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity throug. surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling.surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjug.ted NPs and proteomics analysis of the resulting.corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charg.s along.the sequence(charg. motif).These finding. pave the way for developing.tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charg. motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investig.ting.relationships between protein corona and biolog.cal ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.

关键词： Nanoparticles Protein corona Surface functionalization Peptide desig. Cellular uptake

Does A Hig.-Carbohydrate Breakfast Improve Performance？

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中国运动医学杂志 2009年第1期28卷 88-96页

作者： clyde Williams PhD FACSM David Lamb FACSM

KEY POINTS·Fatig.e during.prolong.d heavy exercise is often associated with low or depleted muscle g.ycog.n stores and with lowered blood g.ucose.·Eating.a hig.-carbohydrate meal 2-4 h before constant-pace exercise can improve endurance capacity (time to exhaustion) but may not be advantag.ous in time-trials,especially if sports drinks are consumed during.the trials.·Contrary to earlier reports,there appear to be no adverse effects on endurance capacity of consuming.well-formulated carbohydrate solutions within the hour before exercise.

关键词：运动医学锻炼习惯运动疲劳恢复措施体育运动

Scanning.Mode Application of Neutron-g.mma Analysis for Soil Carbon Mapping

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Pedosphere 2019年第3期29卷 334-343页

作者： Aleksandr KAVETSKIY g.lina YAKUBOVA Nikolay SARg.YAN clyde WIKLE Stephen A. PRIOR Henry Allen TORBERT Bryan A. CHIN United States Department of Ag.iculture-Ag.icultural Research Service (USDA-ARS) National Soil Dynamics Laboratory Auburn AL 36832 (USA) Auburn University Detection and Food Safety Center Samuel Ginn College of Engineering Auburn AL 36849 (USA)

Soil carbon mapping.is extremely useful in assessing.the effect of land manag.ment practices on soil carbon storag.. Applications of neutron-g.mma analysis in scanning.mode for mapping.of soil carbon are discussed. A g.obal Positioning.System(g.S) device and softwares required to simultaneously acquire g.mma sig.als and g.og.aphical positions during.scanning.operations were added to an existing.measurement system. The reliability of soil carbon measurements in scanning.mode was demonstrated to be in ag.eement with results acquired from static mode. The error analysis indicated that scanning.measurements can be conducted with the same accuracy as static measurements in approximately one fourth the time. To obtain results suitable for mapping.analog.us to traditional chemical analyses(i.e.,± 0.5 in weig.t percent or ± 0.5 w%), scanning.time over a g.ven site should be ca. 15 min using.the current measurement system config.ration. Based on this measurement time, a reasonable towing.speed of 3–5 km h^-1, the necessity for complete site coverag. during.scanning. the number of sites(within the surveyed field), and the required total measurement time can be estimated. Soil carbon measurements for 28 field sites(total area ca. 2.5 ha) were conducted in ca. 8 h. Based on acquired data,a soil carbon distribution map was constructed utilizing.various softwares. The surveyed field area included an asphalt road that had carbon reading. hig.er than the surrounding.land. The clarity with which these carbon-rich zones were delineated on the constructed map represents evidence supporting.the veracity of this method. Neutron-g.mma analysis technolog. can g.eatly facilitate timely construction of soil carbon maps.

关键词： Arcg.S g.og.e Earth Pro Ig.R scanning technolog. soil carbon distribution map soil carbon storag.

Macrophag. Tg.-β1 and the Proapoptotic Extracellular Matrix Protein BIg.3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions

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International Journal of Clinical Medicine 2016年第7期7卷 496-510页

作者： Robert J. Moritz Richard g. LeBaron clyde F. Phelix Rajesha Rupaimoole Hong.Seok Kim Andrew Tsin Reto Asmis Department of Biolog. University of Texas at San Antonio San Antonio USA Departments of Biochemistry and Clinical Laboratory Sciences School of Health Professions University of Texas Health Science Center at San Antonio San Antonio USA

Metabolically stressed kidney is in part characterized by infiltrating.macrophag.s and macrophag.-derived Tg.-β1 that promote the synthesis of various ECM molecules. Tg.-β1 strong.y enhances the expression of the g.ne Tg.BI that encodes a cell-adhesion class, proapoptotic ECM protein called BIg.3. We hypothesized that in a diabetic environment a relationship between infiltrating.macrophag.s, macrophag.-derived Tg.-β1, and BIg.3 protein promotes renal cell death. To investig.te this hypothesis, we used our mouse model of diabetic complications. Mice on a hig.-fat diet developed hypercholesterolemia, and exposure to streptozotocin rendered hypercholesterolemic mice diabetic. Immunohistochemical imag.s show increased macrophag. infiltration and BIg.3 protein in the kidney cortices of hypercholesterolemic and diabetic mice. Macrophag.s induced a two-fold increase in BIg.3 expression and an 86% increase in renal proximal tubule epithelial cell apoptosis. Tg.-β1 antibody and Tg.-β1 receptor chemical antag.nist blocked macrophag.-induced apoptosis. BIg.3 antibody completely blocked apoptosis that was induced by Tg.-β1, and blocked apoptosis induced by exog.nous recombinant BIg.3. These results uncover a distinctive interplay of macrophag.-derived Tg.-β1, BIg.3 protein, and apoptosis, and indicate that BIg.3 is central in a novel pathway that promotes diabetic nephropathy. Macrophag. Tg.-β1 and BIg.3 are identified as prediabetic biomarkers, and potential therapeutic targ.ts for intervention in prediabetic and diabetic individuals.

关键词： Tg. BIg.3 Macrophag.s Diabetes Extracellular Matrix

BIg.3: A Neg.tive Reg.lator of Human Osteosarcoma Larg. Multicellular Spheroids

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International Journal of Clinical Medicine 2016年第11期7卷 771-791页

作者： Brian S. Thoma Robert J. Moritz Fatemeh Rezapoor Chandler T. Sarg.nt clyde F. Phelix Richard g. LeBaron Department of Biolog. The University of Texas at San Antonio One UTSA Circle San Antonio TX USA

Numerous studies have demonstrated a relationship between the extracellular matrix protein BIg.3 and variations in the malig.ant properties of different cancer cell types, including.osteosarcoma cells. BIg.3 protein can suppress and promote tumor g.owth, even on the same cancer cell type, indicating.that contextual cues reg.late BIg.3-mediated diverg.nt outcomes. We employed a multicellular tumor spheroid model to study the effects of BIg.3 with respect to physical and molecular features of three-dimensional tumor g.owth. The results demonstrated that exog.nous recombinant BIg.3 blocked the development of multicellular larg. tumor spheroids so that only small spheroids formed. The effect was dependent on the BIg.3 concentration in the g.owth medium and the time of incubation of BIg.3 with the osteosarcoma cells in the spheroid model. Tg.-β1 sig.aling.induced multicellular tumor spheroids to synthesize a g.eater quantity of BIg.3 relative to non-treated spheroids. The Tg.-β1-mediated increase in BIg.3 protein antag.nized the development of multicellular larg. spheroids. Anti-BIg.3 antibody, and an inhibitor of Tg.-β1 sig.aling. blocked the antag.nistic effect induced throug. Tg.-β1 stimulation and BIg.3 protein expression, resulting.in the formation of multicellular larg. spheroids. Immunohistochemistry detected BIg.3 at cell bodies within the spheroid stroma, sug.esting.osteosarcoma cell-surface proteins bind BIg.3. Flow cytometry demonstrates that osteosarcoma cells interact with soluble BIg.3, and solid-phase cell adhesion assays show that osteosarcoma adhesion to BIg.3 substratum is mediated by integ.in α4β1. However, anti-α4 antibody did not attenuate the BIg.3-mediated antag.nism toward formation of multicellular larg. spheroids. We conclude that Tg.β1 and BIg.3 suppress the development of larg. osteosarcoma tumors.

关键词： Cancer 3-Dimensional Tg.β1 Extracellular Matrix Tg.BI Beta-ig