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Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair

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Signal Transduction and Targeted Therapy 2022年第6期7卷 2053-2065页

作者： Yi Fan Chen Cui clifford JRosen Tadatoshi Sato Ruoshi Xu Peiran Li Xi Wei Ruiye Bi quan Yuan Chenchen Zhou State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Cariology and EndodonticsWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina Hospital of Stomatology Guanghua School of StomatologySun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Stomatology510055 GuangzhouGuangdongChina Maine Medical Center Research Institute ScarboroughME 04074USA Endocrine Unit Massachusetts General HospitalHarvard Medical SchoolBostonMA 02215USA State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Orthognathic and TMJ SurgeryWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral ImplantologyWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina

Maxillofacial bone defects are commonly seen in clinical practice.A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone *** fibroblast growth factor(FGF)signalling pathway is critical for the development of maxillofacial ***,a type I transmembrane protein,is an important components of FGF receptor *** studies have reported the presence of Klotho expression in ***,the role of Klotho in cranioskeletal development and repair remains ***,we use a genetic strategy to report that deletion of Klotho in Osx-positive mesenchymal progenitors leads to a significant reduction in osteogenesis under physiological and pathological ***-deficient mensenchymal progenitors also suppress osteoclastogenesis in vitro and in *** conditions of inflammation and trauma-induced bone loss,we find that Klotho exerts an inhibitory function on inflammation-induced TNFR signaling by attenuating Rankl *** importantly,we show for the first time that Klotho is present in human alveolar bone,with a distinct expression pattern under both normal and pathological *** summary,our results identify the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controls osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and ***-mediated signaling is an important component of alveolar bone remodeling and *** may also be a target for future therapeutics.

关键词： Klotho progenitor alveolar

Bose Description of Pauli Spin Operators and Related Coherent States

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Communications in Theoretical Physics 2005年第1期43卷 17-21页

作者： JIANGNian-quan FANHong-Yi LUHai-Liang DepartmentofPhysics WenzhouNormalCollegeWenzhou325027China／／DepartmentofMaterialScienceandEngineeringUniversityofScienceandTechnologyofChinaHefei230026China DepartmentofMaterialScienceandEngineering UniversityofScienceandTechnologyofChinaHefei230026China／／DepartmentofPhysicsShanghaiJiaoTongUniversityShanghai200030China DepartmentofPhysics ShanghaiJiaoTongUniversityShanghai200030China

Using both the fermionic-kike and the bosonic-like properties of the Paulispin operators σ_+, σ_-, and σ_z we discuss the derivation of Bose description of the Pauli spinoperators originally proposed by Shigefumi Naka, and deduce another new bosonic representation ofPauli operators. The related coherent states, which are nonlinear coherent state and coherent spinstates for two spins, respectively, are constructed.

关键词： bose description of pauli spin operators nonlinear coherent state coherentspin state

基于miRNA探讨补肾健脾方治疗糖尿病肾病的机制研究

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临床和实验医学杂志 2021年第15期20卷 1636-1639页

作者：谢政权潘娟季兵广东祈福医院内分泌科广东广州511495

目的研究基于miRNA探讨补肾健脾方治疗糖尿病肾病的机制。法前瞻性随机选取2019年10月至2020年10月广东祈福医院内分泌科收治的2型糖尿病肾病3期患者80例,按照随机数字表法分为治疗组和对照组,每组各40例。对照组予糖尿病常规治疗,治疗... 详细信息

目的研究基于miRNA探讨补肾健脾方治疗糖尿病肾病的机制。法前瞻性随机选取2019年10月至2020年10月广东祈福医院内分泌科收治的2型糖尿病肾病3期患者80例,按照随机数字表法分为治疗组和对照组,每组各40例。对照组予糖尿病常规治疗,治疗组在常规治疗基础上加补肾健脾方。统计分析2组患者治疗前、治疗3个月后的尿微量白蛋白、24 h尿蛋白、miRNA-93、空腹葡萄糖(FPG)、餐后2 h葡萄糖(2 h PBG)、空腹血清C肽、餐后2 h血清C肽、低密度脂蛋白胆固醇(LDC-L)、糖化血红蛋白(HbA1c)值。结果治疗前,2组患者尿微量白蛋白、24 h尿蛋白及miRNA-93表达水平比较,差异均无统计学意义(P>0.05)。治疗3个月后,治疗组患者的尿微量白蛋白、24 h尿蛋白水平分别为(0.10±0.03)g/24 h、(0.22±0.03)mg/L,显著低于对照组[(0.22±0.06)g/24 h、(0.26±0.04)mg/L],miRNA-93表达(1.84±0.05)均显著高于对照组(1.15±0.06),差异均有统计学意义(P0.05)。治疗3个月后,治疗组患者的FPG、2 h PBG、LDC-L、HbA1c水平分别为(6.7±1.8)mmol/L、(9.2±1.3)mmol/L、(2.00±0.82)mmol/L、(6.40±1.90)%,显著低于对照组[(7.3±1.2)mmol/L、(11.8±1.4)mmol/L、(2.11±0.44)mmol/L、(7.60±1.30)%],空腹血清C肽、餐后2 h血清C肽水平分别为(2.38±0.21)、(3.06±1.01)μg/L,显著高于对照组[(2.10±0.44)、(2.20±0.07)μg/L],差异均有统计学意义(P<0.05)。结论在常规治疗基础上加补肾健脾方治疗糖尿病肾病可以提高miRNA-93表达水平,降低尿微量白蛋白、尿蛋白、血糖、血脂水平。miRNA可能作为中间因素参与补肾健脾方对糖尿病肾病尿微量白蛋白的调节作用。

关键词：糖尿病肾病补肾健脾方 miRNA-93 尿微量白蛋白

对酉clifford矩阵的补充说明(英文)

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苏州大学学报（自然科学版） 2001年第2期17卷 16-20页

作者：孙桂荣顾权苏州大学理学院数学系江苏苏州215006

俞祖国与王健在题为“高维M bius群的拓扑与共轭不变量”的文章中对酉clifford矩阵进行了讨论 ,并得到了这样一个有趣的结论 :如果clifford矩阵A =abcd 是一酉clifford矩阵 ,则变换gA(x) =(ax+b) (cx +d) - 1 是弦度量空间 ( Rn,D)上的... 详细信息

俞祖国与王健在题为“高维M bius群的拓扑与共轭不变量”的文章中对酉clifford矩阵进行了讨论 ,并得到了这样一个有趣的结论 :如果clifford矩阵A =abcd 是一酉clifford矩阵 ,则变换gA(x) =(ax+b) (cx +d) - 1 是弦度量空间 ( Rn,D)上的一个等距同胚我们可以证明其逆命题也成立另外 ,我们还证明了 2 维空间中酉矩阵与M bius变换的一些等价条件在n

关键词： clifford 酉clifford矩阵 Moebius变换

正规列幂半群的刻画与clifford半群的幂半群

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陕西理工学院学报（自然科学版） 2006年第3期22卷 12-14页

作者：邵海琴权双燕王贵军天水师范学院数信学院数学系甘肃天水741001 陕西理工学院数学系陕西汉中723001

首先在正规子群与同余的关系的基础上,采用类比的方法,从同余的角度给出了群的正规列幂半群的另一种刻画。其次,根据C lifford半群是群强半格的特殊结构,得到了C lifford半群的幂半群的两个重要的结构定理。

关键词：幂半群正规列同余列幂半群强半格幂群强半格

自拟补肾降糖方对肥胖2型糖尿病Homa-IR及FFA的影响

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医学信息（医学与计算机应用） 2014年第11期18卷 64-65页

作者：陈先明林靖谢政权刘峰季兵广州中医药大学祈福医院内分泌科广东广州511495

目的观察补肾降糖方对肥胖2型糖尿病Homa-IR及FFA的影响。方法75例肥胖2型糖尿病患者随机分成两组,其中治疗组45例,对照组30例。所有患者均血糖、血压控制平稳。治疗组在糖尿病常规治疗的基础上,加用自拟补肾降糖方(黄芪24 g、山药18 g... 详细信息

目的观察补肾降糖方对肥胖2型糖尿病Homa-IR及FFA的影响。方法75例肥胖2型糖尿病患者随机分成两组,其中治疗组45例,对照组30例。所有患者均血糖、血压控制平稳。治疗组在糖尿病常规治疗的基础上,加用自拟补肾降糖方(黄芪24 g、山药18 g、沙苑子15 g、黄精15 g、制大黄9 g、鹿角胶15 g、金银花15 g、川芎18 g、丹参18 g)。水煎200 mL。服用汤药期间1剂/d,服用中药3个月。密切监测血糖。观察两组中医证候、游离脂肪酸(FFA)、胰岛素抵抗指数(Homa-IR)的变化。结果两组在中医证候疗效方面,治疗组明显优于对照组(0.05)。治疗组FFA、Homa-IR与治疗前相比明显下降(<0.05),下降幅度明显优于对照组,具有统计学差异(<0.05)。治疗过程中除了少数的低血糖反应,均未出现其余明显不良反应。结论自拟补肾降糖方能降低肥胖2型糖尿病Homa-IR与FFA,在改善胰岛素抵抗方面中药具有一定的优势,其作用机制可能与降低FFA有关。

关键词：补肾降糖肥胖 2型糖尿病 Homa-IR FFA

中医临床路径在内分泌病科实习带教中的应用效果

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中国当代医药 2017年第18期24卷 150-152页

作者：王珍刘峰黎展鸿季兵谢政权夏春兰广州中医药大学祈福医院科教办广东广州511495 广州中医药大学祈福医院内分泌科广东广州511495

目的观察中医临床路径在内分泌病科实习带教中的应用效果。方法将2013年6月~2015年5月到我院内分泌病科的临床实习生按随机数字表法分为临床路径带教组和传统带教组,临床路径带教组严格按照临床路径单内容执行诊疗计划,传统带教组根据... 详细信息

目的观察中医临床路径在内分泌病科实习带教中的应用效果。方法将2013年6月~2015年5月到我院内分泌病科的临床实习生按随机数字表法分为临床路径带教组和传统带教组,临床路径带教组严格按照临床路径单内容执行诊疗计划,传统带教组根据既往理论教学学习的内容来诊治患者,比较两组学生实习前后的综合成绩和所诊治患者的疗效差异。结果入科前摸底成绩,两组之间无差异,经过不同模式的临床带教后,两组成绩较入科前均有所提高(P<0.05),但中医临床路径带教组学生平均成绩优于传统带教组(P<0.01)。临床路径教学组学生所管患者的疗效亦好于传统带教组(P<0.05)。结论与传统带教方法相比,临床路径带教方法具有明显优势,建议在临床带教中广泛推广。

关键词：中医临床路径临床带教带教方法内分泌

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季兵教授治疗糖尿病肾病临证经验浅析

成都中医药大学学报 2018年第1期41卷 87-90页

作者：黄艳梅伍慧慧刘峰谢政权季兵广州中医药大学广东广州510405 广州中医药大学祈福医院广东广州511495

糖尿病肾病(DKD)是糖尿病常见的慢性微血管并发症,近年来其发病率逐渐升高。季兵教授从医二十余年,结合前人治疗经验,对本病的治疗有其独特认识,认为DKD其病位主要在肾,总体病机以脾肾亏虚为主,兼夹血瘀浊毒之邪,为缓解其发展进程,须从... 详细信息

糖尿病肾病(DKD)是糖尿病常见的慢性微血管并发症,近年来其发病率逐渐升高。季兵教授从医二十余年,结合前人治疗经验,对本病的治疗有其独特认识,认为DKD其病位主要在肾,总体病机以脾肾亏虚为主,兼夹血瘀浊毒之邪,为缓解其发展进程,须从补肾健脾入手,先天后天同治,兼以活血化瘀,并且强调在疾病早期的中西医结合干预,重视微观辨证与宏观辨证相结合,针对疾病的不同阶段,注重预防与调护,可获良效。笔者有幸跟师学习,现将季兵教授运用中医药疗法诊察DKD的临床经验整理如下,为中医药治疗DKD提供更多临床依据。

关键词：糖尿病肾病中医药疗法季兵

Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update

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Journal of Nutritional Oncology 2022年第2期7卷 64-74页

作者： Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center of the First Hospital of Jilin University Changchun 130021Jilin China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Surgery The First Affiliated Hospital of SunYat-Sen UniversityGuangzhou 510080GuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Nutrition and Metabolism of Oncology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial Cancer HospitalHefei 230031AnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina Department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanChina Department of Clinical Nutrition The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006ZhejiangChina Department of Clinical Nutrition Chongqing General HospitalChongqing 400014China Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Oncology Xingtai Peo

Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of *** Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since *** is an extension to the previous 2013-2020 study *** study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of *** and study design This is an observational,multi-centered,hospital-based prospective cohort *** collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital ***-up will be conducted for 1-20 years after *** primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of *** factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of

关键词： Cancer Malnutrition Nutritional status Nutritional assessment Survival Patient-Generated Subjective Global Assessment