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Postural Balance in the Elderly with Mild Cognitive Impairment: Relationship to Accidental Falls

Open Journal of Therapy and Rehabilitation 2016年第2期4卷 67-75页

作者： Josélia Braz dos santos Ferreira Selma Petra Chaves Sá Rosimere Ferreira Santana Ana Maria Domingos Juliana Peres da costa Pereira Luciana Krauss Rezende The Antô nioPedro Hospital/UFF/Niterói The Miguel Pedro Municipal Hospital of Geriatrics and Gerontology (SMS) Rio de Janeiro Brazil The Aurora Afonso costa Nursing School Fluminense Federal University (UFF) Niterói Brazil The AnaNeri Nursing School Federal University of Rio de Janeiro/UFRJ Rio de Janeiro Brazil The Estacio de Sa University The Redentor College Rio de Janeiro Brazil The Aurora Afonso costa Nursing School (UFF) Niterói Brazil

This study analyzed postural balance in the elderly with mild cognitive impairment and its relationship to accidental falls. A quantitative and quasi-experimental method was used in a sample of 43 elderlies between 64 and 88 years old, mostly females. Data collection was performed in two Basic Health Units in the city of Rio de Janeiro in 2014. The instruments used were the Mini-Mental State Examination (MMSE), Tinetti scale, Motor Scale for the Elderly (EMTI) scale, and Elderly Falls Diary. The data were analyzed with the SAS statistical software version 9.3.1. The scales were applied before and after the psychomotor interventions. A significant difference was observed between the evaluating moments. Balance improvements were observed in all age groups, suggesting that all elderlies, regardless of age, showed satisfactory responses to the implemented psychomotor activities. The elderlies who fell more frequently were those between 60 and 69 years old. It is noteworthy that the age group with the lowest incidence of falls was that of elderlies between 70 and 79 years old. It was concluded that psychomotor activities are beneficial, regardless of age, proving their effectiveness when continued stimuli with cognitive and psychomotor activities are carried out.

关键词： Postural Balance Accidental Falls Elderlies Mild Cognitive Impairment

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Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum(Vell.)Morong

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 945-949页

作者： Zildene de Sousa Silveira Nair Silva Macêdo Thiago Sampaio de Freitas Ana Raquel Pereira da Silva Joycy Francely Sampaio dos santos Maria Flaviana Bezerra Morais-Braga José Galberto Martins da costa Raimundo Nonato Pereira Teixeira Jean Paul Kamdem Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha Laboratorio de Bioprospeccao do Semioarido Universidade Regional do CaririCratoBrazil Laboratorio de Microbiologia e Biologia Molecular Universidade Regional do CaririCratoBrazil Laboratorio de Pesquisas de Produtos Naturais Universidade Regional do CaririCratoBrazil Departamento de Ciencias biologicas Universidade Regional do Cariri-URCACratoCEP:63105-000Brazil Programa de Pos-graduacao em Bioprospeccao Molecular Universidade Regional do Cariri–URCACratoBrazil

Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia ***: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution ***: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.

关键词： Antibiotic activity Enhancement Synergism Chemical compounds Bioactivity

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Clinical Application of Dynamic Gait Index-Brazilian Brief Version

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Advances in Aging Research 2018年第6期7卷 113-118页

作者： Carlos Kazuo Taguchi élida Pinto costa Lucas Vieira Alves Larissa Karoline santos Erbson Rodrigues de Oliveira Silva Brenda Carla de Lima Araújo Fabíola Andréa Andrade dos santos Allan Robert da Silva Audiology Departament Federal University of Sergipe S&atilde o Cristóvã o Brazil Federal University of Sergipe S&atilde o Cristóvã o Brazil Education Coordinator of Sergipe State Aracaju Brazil Speech Therapist and Audiology Departament Federal University of Sergipe S&atilde o Cristóvã o Brazil University Hospital Board Federal University of Sergipe S&atilde o Cristóvã o Brazil Statistical Departament Federal University of Sergipe S&atilde o Cristóvã o Brazil

Introduction: In elderly, the progressive degenerations in the nervous system and vestibular system compromise the human body balance leading to a greater risk of falls. The Dynamic Gait Index is a protocol that predicts risks to falls in seniors. Objective: To analyze the results of the application of the Dynamic Gait Index (DGI)-Brazilian brief proposal and establish correlation with the original version. Methods: Study approved by the Ethics and Research Committee of Federal University of Sergipe (number 0197.0.107000.09). We analyzed 223 files of socially active elderly, female gender, aged ranged 60 to 85 years, mean 68.54 (±7.61) years since 2014. The volunteers were evaluated by the DGI-Brazil. For the statistical analysis, the Pearson Correlation Momentum Correlation Test with Spearman Correlation was used, with p ≤ 0.05 and r = 1.0. Results: Sixty-three (27.8%) of the volunteers presented an altered DGI scores. The statistical analysis indicated that Task 1 and Task 2 did not contribute to decrease the total score in the test. The worst performances occurred in Tasks 3, 5 and 6. There was founded a positive correlation between Tasks 1 and 2;1 and 8;3 and 4;3 and 5;4 and 5;2 and 4;2 and 7. Negative correlation occurred between Tasks 4 and 8, and 6 was not correlated with another Task. Conclusion: The DGI-Brazilian brief version presented an excellent correlation with the original proposal and may be useful in clinical practice as a tool to evidence future risks of falls in the elderly people.

关键词： Aged Postural Balance Accidental Falls Clinical Protocols

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Central depressant effects of Piper tuberculatum Jacq essential oil in mice

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Food Bioscience 2022年第4期48卷 620-629页

作者： Valterlúcio dos santos Sales Francisco Romero Cabral Emmily Petícia do Nascimento Sales Tatyelle Bezerra Carvalho Maria Haiele Nogueira costa Victor Afonso Pereira de Oliveira Cristina Kelly de Souza Rodrigues Francisco Rodolpho Sobreira Dantas Nobrega de Figueiredo Daniel Souza Bezerra Gyllyandeson de Araújo Delmondes Henrique Douglas Melo Coutinho Jose Galberto Martins da costa Irwin Rose Alencar de Menezes Cícero Francisco Bezerra Felipe Marta Regina Kerntopf Universidade Regional do Cariri Departamento de Química Biol´ogicaCratoCear´aBrazil Universidade Federal de S˜ao Paulo-Departamento de Fisiologia S˜ao PauloSPBrazil Faculdade de Ciˆencias M´edicas da Santa Casa de S˜ao Paulo S˜ao PauloSPBrazil Universidade Federal da Paraíba Departamento de Biologia MolecularJo˜ao PessoaParaíbaBrazil

This study aims to investigate the toxicity and possible effects and mechanism of action of the essential oil obtained from the Piper tuberculatum Jacq.‘s fruit(EOPT)on the central nervous system(CNS)of *** the Hippocratic test,it was observed ambulation reduction,sedation,piloerection and mortality of 25%at the dose of 1000 mg/kg and 50%at the dose of 5000 mg/*** results found demonstrate that the EOPT is endowed with a possible depressant effect,and is characterized by a likely sedative(open field test),anxiolytic-like(elevated plus maze test),anticonvulsant(pentylenetetrazole-induced seizure test)and hypnotic action(pentobarbital-induced sleeping time).These effects may possibly occur due to the interaction between the monoterpenes,present in its essential oil,and the GABAergic pathway confirmed by reversion of the effects by ***,these results demonstrate the therapeutic potential and the validation of the ethnopharmacological use of this species in the treatment of disorders affecting the central nervous system.

关键词： Piper tuberculatum Jacq. Essential oil Sedative Anxiolytic Hypnotic

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Assessment of Comprehensive Health Care of the Elderly in Primary Health Care

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Health 2015年第3期7卷 365-370页

作者： Fábia Barbosa de Andrade Iris do Ceu Clara costa Tainara Lorena dos santos Ferreira Isabelle Christine Fonseca G.A.Silva Ingrid Katianne Marques Araujo Dídia de Oliveira Pereira Joymara Railma Gomes de Assuncao Jéssica Isabelle dos santos Dutra Aline de Lima Cabral Nursing Faculty of Health Sciences of Trairi(FACISA)Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil

Objective: To assess comprehensive care in the elderly population, as well as the quality of care in Primary Health Care. Methods: This is an exploratory descriptive study with a quantitative approach, conducted from July to December 2012, in the city of Santa Cruz, Rio Grande do Norte, Brazil. A sample of 130 subjects chosen by drawn was calculated, and data collection was performed at their homes. Results: There were interviewed 130 people, 92 (70.8%) women and 38 men (29.2%), with a minimum age of 60 and maximum of 96 years, with a mean of 72.8, median of 72.0 and a standard deviation of 8.3. Regarding the quality of care ratings of the PHC team, 48.5% (n = 63) of respondents stated this to be good, while 32.3% (n = 42) rated this as fair. Conclusions: In this perspective, one of the most appreciated meanings that were given to comprehensive care by health care professionals refers to holistic knowledge of each patient, resulting in the non-fragmentation of care. Thus, it is noticed that comprehensiveness has some weaknesses that need to be corrected, which shows the need for education and training of professionals assigned to primary health care services.

关键词： Comprehensive Health Care Health Evaluation Health of the Elderly Primary Health Care Professional Practice

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Development of hepatorenal syndrome in bile duct ligated rats

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World Journal of Gastroenterology 2008年第28期14卷 4505-4511页

作者： Regina M Pereira Robson AS dos santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva Departamento de Ciências Biológicas Centro Universitário de Belo Horizonte-UNIBHAv.Mário WerneckBelo HorizonteMinas Gerais 30150-281Brazil Laboratório de Hipertenso Departamento de Fisiologia e BiofísicaInstituto de Ciências Biológicas (ICB)Universidade Federal de Minas Gerais (UFMG)Av.Antonio Carlos6627Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Pediatria Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Anatomia Patológica Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Laboratório de Imunofarmacologia Departamento de Bioquímica e ImunologiaICBUFMGAv.Antonio Carlos 6627Belo HorizonteMinas Gerais 30150-281Brazil

AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS.

关键词： Hepatorenal syndrome Bile duct ligation Renal function Renin angiotensin system

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Immunotherapy in glioblastoma treatment:Current state and future prospects

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World Journal of Clinical Oncology 2023年第4期14卷 138-159页

作者： Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Hanna santos Marques Marcel Silva Luz Luís Guilherme de Oliveira Silva Clara Faria Souza Mendes dos santos Karolaine da costa Evangelista Mariana santos Calmon Matheus Sande Loureiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Glioblastoma remains as the most common and aggressive malignant brain tumor,standing with a poor prognosis and treatment *** the aggressive standard care,such as surgical resection and chemoradiation,median survival rates are *** this regard,immunotherapeutic strategies aim to become more attractive for glioblastoma,considering its recent advances and *** this review,we provide an overview of the current status and progress in immunotherapy for glioblastoma,going through the fundamental knowledge on immune targeting to promising strategies,such as Chimeric antigen receptor T-Cell therapy,immune checkpoint inhibitors,cytokine-based treatment,oncolytic virus and vaccine-based *** last,it is discussed innovative methods to overcome diverse challenges,and future perspectives in this area.

关键词： Glioblastoma Immunotherapy Tumor microenvironment Chimeric antigen receptor T cell Oncolytic viruses Immune-checkpoint inhibitors Brain cancer

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Sociodemographic, Clinical and Quality of Life Aspects of People Aged over 50 Years Living with HIV/AIDS

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Open Journal of Nursing 2016年第6期6卷 435-442页

作者： Alexsandra Rodrigues Feijão Klebia Karoline dos santos Neco Jéssica Dayane Dantas costa Isabelle Christine Marinho de Oliveira Ana Luisa Brandão de Carvalho Lira Bertha Cruz Enders Nursing Department Federal University of Rio Grande do Norte Natal Brazil Multicampi School of Medical Sciences Federal University of Rio Grande do Norte Natal Brazil

Introduction: In the last few years, there has been a growth in the number of cases of people with HIV/AIDS aged 50 years and older. This is explained by the inclusion of antiretroviral therapy, increased survival of patients as well as by the growth in the number of infected people in this age group. Objective: To analyze the association between sociodemographic and clinical characteristics with the QOL of people aged 50 years or older living with HIV/AIDS. Methods: Quantitative, cross-sectional study conducted in the outpatient clinic of a reference hospital in Natal, Brazil. The sample consisted of 50 subjects, aged over 50, seropositive for HIV and with cognitive conditions to answer the interview. Authors used sociodemographic and clinical evaluation tools and the WHOQOL-HIV BREF scale. Results: Sociodemographic: respondents’ average age was 57.32 years, 58% male, 38% brown, 26% incomplete primary education, 46% single, 56% retired, 70% with a monthly income of 1 to 2 minimum wages and 70% Catholic. Clinical: 60% have a partner without the diagnosis of HIV/AIDS;62% had not been hospitalized previously;66% did not have opportunistic infections;40% indicated that there was a change in the physiological sexual function after the onset of the disease. Quality of life: people living with HIV/AIDS had low scores in QOL domains. When associating sociodemographic and clinical aspects, it was observed that they had associations with QOL, especially in regard to education, income, religion, change in sexual function and feelings. Conclusion: The spiritual domain was highlighted with the best performance, collaborating to facing, hope and resilience of HIV/AIDS.

关键词： AIDS Quality of Life Aging

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Approach to Paroxysmal Atrial Fibrillation Type Arrhythmia in a Cardiology Service:A Case Report

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Modern Research in Inflammation 2020年第2期9卷 9-17页

作者： Miriam Viviane Baron Luis Manuel Ley Dominguez Carolina Paz Mohamad Isa Gabriela Di Lorenzo Garcia Scherer Michele Paula dos santos Vitoria Pereira Itaquy Talia Guimaraes dos santos Julia Braga da Silveira Paulo Ricardo Martins Amanda Correa dos santos Marcus Vinicius de Mello Pinto Janine Koepp Daiana Klein Weber Carissimi Joice Nedel Ott Carolina Goncalves Pinheiro Nathalia Ken Pereira Iketani Gabriela Feltez Bartira Ercília Pinheiro da costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil Improvement of Higher Education Personnel Brazil(CAPES)Distrito FederalBrazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil School of Health and Life Sciences of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil Celulare Institute PetrópolisBrazil Undergraduate Nursing Course of the University of Santa Cruz do Sul(UNISC) Santa Cruz do SulBrazil Postgraduate Program in Health Sciences of the Faculty of Medicine of ABC(FMABC) Sao PauloBrazil Undergraduate Physiotherapy Course of the Vale do Salgado Faculty(FVS) CearáBrazil Physiotherapy of the Hospital Beneficiente Portuguesa of Belém ParáBrazil Rehabilitation Sciences of the Federal University of Health Sciences of Porto Alegre Porto AlegreBrazil Postgraduate Program in Medicine and Health Sciences School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS)Porto AlegreBrazil

Atrial fibrillation is a cardiac arrhythmia of high prevalence in the population, especially in the elderly. Its main electrical characteristics are the interval between two successive irregular R waves, absence of P waves and presence of f waves between QRS complexes. The most common symptoms of atrial fibrillation are irregular palpitations associated with dyspnea, dizziness, feeling tired, fatigue and general malaise, but not all patients have any symptoms. The present report presents the history of an elderly patient who arrived at the hospital’s emergency department with irregular heart rhythm and palpitations. The patient’s symptoms, associated with the electrocardiogram results, indicated paroxysmal atrial fibrillation. Electrical cardioversion was performed, and after, cardiac ablation via the femoral vein at the hospital’s cardiology service. There were no complications during the procedure. As a routine imaging exam after ablation, control esophagogastroduodenoscopy was requested to verify that there was no formation of atrio-esophageal fistula developed by the invasive ablation procedure and electrocardiogram, which showed normal sinus rhythm. The patient remained in the cardiac intensive care unit for observation for 24 hours. After the electrical cardioversion and catheter ablation procedures, the patient improved his clinical picture of atrial fibrillation and was discharged after 24 hours of hospitalization. He received treatment to perform at home, to reduce acid reflux into the esophagus and to prevent thrombosis. He did not present pulmonary thromboembolism after hospital discharge. It is believed, therefore, that this form of treatment and management of paroxysmal atrial fibrillation is effective for the solution of the proposed problem and can also serve as a reference for other professionals within the cardiology service.

关键词： Atrial Fibrillation Electrical Cardioversion Catheter Ablation Hypertension Obstructive Sleep Apnea Syndrome

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Gas Exchange and Growth of Medicinal Plant Subjected to Salinity and Application of Biofertilizers

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American Journal of Plant Sciences 2014年第16期5卷 2520-2527页

作者： Sergiane Beatriz da Silva Mesquita Jose Adriano da Silva Rafael Santiago da costa Moises Wilkson Nunes dos santos Claudivan Feitosa de Lacerda Aiala Vieira Amorim Antonio Marcos Esmeraldo Bezerra Universidade da Integracao Internacional da Lusofonia Afro-Brasileira(UNILAB) Campus da LiberdadeRedencaoBrasil Universidade Federal do Ceará(UFC) FortalezaBrasil

The objective of this study was to evaluate the use of biofertilizers and saline waters on gas exchange and growth of medicinal plant Plectrantus amboinicus. The experiment was conducted in the period February to May 2013 in a greenhouse. The experimental design was completely randomized in a 2 × 4 factorial arrangement, with two levels of salinity of irrigation water (ECw: 0.7 and 3.1 dS m-1) and four levels of bovine liquid biofertilizer applied to the soil, corresponding to 0%, 10%, 20% and 30% of the soil volume, with five replications. The experiment lasted 60 days, counted from the beginning of the treatments. The stomatal conductance (gs), photosynthesis (A), transpiration (E), intrinsic water use efficiency (WUEi) were performed at the end of the experiment, and the height, number of leaves and stem diameter at the beginning and at the end. Generally plants subjected to salinity of irrigation water of 3.1 dS m-1 had the lowest values of gas exchange. Moreover, the application of biofertilizers and the interaction between this and salinity did not affect any growth variable studied except the stem length in the final phase which was influenced by salinity at 5% probability by F test. The average values of this variable were 57.22 cm and 69.65 cm when applied water ECw: 0.7 to 3.1 dS m-1, respectively. The application of biofertilizers can reduce the effect of salinity on the final plant height of Plectrantus amboinicus, especially when the plants were fertilized with a dose of 20% of biofertilizers.

关键词： Medicinal Plants Salt Stress Fertilizers

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