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Mortality of Amur tigers:The more things change,the more they stay the same

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Integrative Zoology 2015年第4期10卷 344-353页

作者： Hugh s.ROBINsON John M.GOODRICH Dale G.MIQUELLE clayton s.miller Ivan V.sERYODKIN Panthera New YorkNew YorkUSA Wildlife Conservation society BronxNew YorkUSA Wildlife Biology Program College of Forestry and ConservationUniversity of MontanaMissoulaMontanaUSA Pacific Geographical Institute Far Eastern Branch of the Russian Academy of SciencesVladivostokRussia Far Eastern Federal University VladivostokRussia

Poaching as well as loss of habitat and prey are identified as causes of tiger population *** some studies have examined habitat requirements and prey availability,few studies have quantified cause-specific mortality of *** used cumulative incidence functions(CIFs)to quantify cause-specific mortality rates of tigers,expanding and refining earlier studies to assess the potential impact of a newly emerging *** quantify changes in tiger mortality over time,we re-examined data first collected by Goodrich et al.(2008;study period 1:1992–2004)as well as new telemetry data collected since January 2005(study period 2:2005–2012)using a total of 57 tigers(27 males and 30 females)monitored for an average of 747 days(range 26–4718 days).Across the entire study period(1992 to 2012)we found an estimated average annual survival rate of 0.75 for all tigers *** was the primary cause of mortality during both study periods,followed by suspected poaching,distemper and natural/unknown *** 2005,poaching mortality has remained relatively constant and,if combined with suspected poaching,may account for a loss of 17–19%of the population each *** distemper virus(CDV)may be an additive form of mortality to the population,currently accounting for an additional 5%.Despite this relatively new source of mortality,poaching remains the main threat to Amur tiger survival and,therefore,population growth.

关键词： canine distemper virus cause-specific mortality cumulative incidence function Panthera tigris altaica poaching

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALs)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALs affecting upper and lower motor neurons),these two diseases are complexly *** and ALs exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Model Change Active Learning in Graph-Based semi-supervised Learning

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1270-1298页

作者： Kevin s.miller Andrea L.Bertozzi Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLos AngelesCA 90095USA

Active learning in semi-supervised classification involves introducing additional labels for unlabelled data to improve the accuracy of the underlying classifier.A challenge is to identify which points to label to best improve performance while limiting the number of new labels."Model Change"active learning quantifies the resulting change incurred in the classifier by introducing the additional label(s).We pair this idea with graph-based semi-supervised learning(ssL)methods,that use the spectrum of the graph Laplacian matrix,which can be truncated to avoid prohibitively large computational and storage *** consider a family of convex loss functions for which the acquisition function can be efficiently approximated using the Laplace approximation of the posterior *** show a variety of multiclass examples that illustrate improved performance over prior state-of-art.

关键词： Active learning Graph-based methods semi-supervised learning(ssL) Graph Laplacian

Geodynamics of oceanic plateau and plume head accretion and their role in Phanerozoic orogenic systems of China

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Geoscience Frontiers 2015年第1期6卷 49-59页

作者： Peter G.Betts Louis Moresi Meghan s.miller David Willis school of Earth Atmosphere and EnvironmentMonash UniversityClayton Campus school of Mathematical sciences Monash UniversityClayton Campus Department of Earth sciences University of Melbourne Department of Earth sciences University of Southern California

We present three 3D numerical models of deep subduction where buoyant material from an oceanic plateau and a plume interact with the overriding plate to assess the influence on subduction dynamics, trench geometry, and mechanisms for plateau accretion and continental growth. Transient instabilities of the convergent margin are produced, resulting in： contorted trench geometry; trench migration parallel with the plate margin; folding of the subducting slab and orocline development at the convergent margin; and transfer of the plateau to the overriding plate. The presence of plume material beneath the oceanic plateau causes fiat subduction above the plume, resulting in a ＂bowed＂ shaped subducting slab. In plateau-only models, plateau accretion at the edge of the overriding plate results in trench migration around the edge of the plateau before subduction is re-established directly behind the trailing edge of the plateau. The plateau shortens and some plateau material subducts. The presence of buoyant plume material beneath the oceanic plateau has a profound influence on the behaviour of the convergent margin. In the plateau ~ plume model, plateau accretion causes rapid trench advance. Plate convergence is accommodated by shearing at the base of the plateau and shortening in the overriding plate. The trench migrates around the edge of the plateau and subduction is re-established well behind the trailing edge of the plateau, effectively embedding the plateau into the overriding plate. A slab window forms beneath the accreted plateau and plume material is transferred from the subducting plate to the over- riding plate through the window. In all of the models, the subduction zone maintains a relatively stable configuration away from the buoyancy anomalies within the downgoing plate. The models provide a dynamic context for plateau and plume accretion in Phanerozoic accretionary orogenic systems such as the East China Orogen and the Central Asian Orogen （Altiads）, which ar

关键词： subduction Accretion Plateau Plume Central Asian Orogen Geodynamics

Islands of misfit buildings: Detecting uncharacteristic electricity use behavior using load shape clustering

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Building simulation 2021年第1期14卷 119-130页

作者： Matias Quintana Pandarasamy Arjunan clayton miller National University of singapore SingaporeSingapore Berkeley Education Alliance for Research in singapore(BEARs) SingaporeSingapore

Many energy performance analysis methodologies assign buildings a descriptive label that represents their main activity,often known as the primary space usage(PsU).This attribute comes from the intent of the design team based on assumptions of how the majority of the spaces in the building will be *** reality,the way a building’s occupants use the spaces can be different than what was *** the recent growth of hourly electricity meter data from the built environment,there is the opportunity to create unsupervised methods to analyze electricity consumption behavior to understand whether the PsU assigned is *** or oversimplification of the use of the building is possible using these labels when applied to simulation inputs or benchmarking *** work towards accurate characterization of a building’s utilization,we propose a modular methodology for identifying potentially mislabeled buildings using distance-based clustering analysis based on hourly electricity consumption *** method seeks to segment buildings according to their daily behavior and predict which ones are misfits according to their assigned PsU *** process finds potentially uncharacteristic behavior that could be an indication of mixed-use or a misclassified *** results on two public data sets,from the Building Data Genome(BDG)Project and Washington DC(DGs),with 507 and 322 buildings respectively,show that 26%and 33%of these buildings are potentially mislabelled based on their load shape *** information provides a more realistic insight into their true consumption characteristics,enabling more accurate simulation *** of this process and a discussion of limitations and reproducibility are included.

关键词： uncharasteristic behaviour building energy use building energy benchmarking building performance rating primary-use-type analysis load profile clustering

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

structure and magnetostructural correlation of ferrimagnetic meso-tetraphenylporphinatoman- ganese（III） dimethyl-N,N＇-dicyanoquinone diiminide, [MnTPP]~[Me2DCNQI]＂-

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中国科学：化学 2012年第6期42卷 907-910页

作者： L.Arthur Jordan H.Lapidus saul W.stephens Peter s.miller Joel Department of Chemistry University of Utah salt Lake City Utah 84112-0850 UsA Department of Physics Photon sciences Directorate Brookhaven National Laboratory Upton NY 11973 UsA

The structure [MnⅢTPP][Me2DCNQI] (TPP = tetraphenylporphinato; Me2DCNQI = 2,5-dimethyl-N,N′- dicyanoquinone-diimine) has been determined from X-ray powder diffraction data. The nonsolvated structure is composed of linear (1-D) chains of alternating [MnⅢTPP]+and μ-[Me2DCNQI]·- with intrachain Mn···Mn separations of 12.83 Å, and a Mn-NDCNQIdistance of 2.18 Å. The dihedral angle between the mean Mn(N4)TPPand [Me2DCNQI]·-planes, and the Mn-(N-C)DCNQIangle are 84.18° and 143.6°, respectively. [MnⅢTPP][Me2DCNQI] has a Tcof 4.3 K from the 10 Hz c"(T) data, 2-K coercivity of 5,600 Oe, and 6,300 emuOe/mol remnant magnetization that are reduced from that observed for related materials, and their inclusion extends the magnetostructural correlation between the intrachain coupling and both the dihedral angle between the mean Mn(N4)TPPand [TCNE]·-(TCNE = tetracyanoethylene) planes and Mn-(N-C)TCNEangles. This is in accord with the intrachain coupling arising from the overlap of the MnⅢdz2-like singly occupied molecular orbital (sOMO) and the z component of the [TCNE]·-π*(πz*) sOMO, which increases with decreasing dihedral angle between the mean Mn(N4)TPPand [TCNE]·-planes and Mn-(N-C)TCNEangle.

关键词：结构组成二甲基亚铁磁性四苯基卟啉细观粉末衍射数据 TPP 二面角