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Compromised nutritional status in patients with end-stage liver disease:Role of gut microbiota

Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 290-300页

作者： Maria Vasco Rossella Paolillo Concetta Schiano Linda Sommese Oreste Cuomo claudio napoli U.O.C.Division of Clinical Immunology ImmunohematologyTransfusion Medicine and Transplant ImmunologyRegional Reference Laboratory of Transplant ImmunologyDepartment of Internal and Specialty MedicineAzienda Ospedaliera UniversitariaUniversitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy IRCCS SDN NaplesItaly Department of Experimental Medicine Universitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy Department of Liver Transplant AORN A.CardarelliNaplesItaly Department of Medical SurgicalNeurologicalMetabolic and Geriatric SciencesUniversitàdegli Studi della Campania“Luigi Vanvitelli”NaplesItaly

Background: Patients with end-stage liver disease(ESLD) have a compromised nutritional status because of the liver crucial role in regulating metabolic homeostasis and energy *** sources: A systematic review of literature based on extensive relevant articles published from 2001 to 2017 in English in Pub Med database was performed by searching keywords such as liver disease, nonalcoholic liver disease, alcoholic liver disease, malnutrition, epigenetics, gut microbiota, and ***: Liver transplantation would be one eligible therapy for ESLD patients, even if, the clinical outcome is negatively influenced by malnutrition and/or infections. The malnutrition is a condition of nutrient imbalance with a high incidence in ESLD patients. An accurate evaluation of nutritional status could be fundamental for reducing complications and prolonging the survival of ESLD patients including those undergoing liver transplantation. In addition, the interaction among nutrients, diet and genes via epigenetics has emerged as a potential target to reduce the morbidity and mortality in ESLD patients. The malnutrition induces changes in gut microbiota causing dysbiosis with a probable translocation of bacteria and/or pathogen-derived factors from the intestine to the liver. Gut microbiota contribute to the progression of chronic liver diseases as well as hepatocellular carcinoma. The administration of probiotics modulating gut microbiota could improve all chronic liver ***: This review provides an update on malnutrition status linked to epigenetics and the potential benefit of some probiotics on the management of ESLD patients. In support of this view and to reveal the constant and growing interest in this field, some clinical trials are reported.

关键词： Liver diseases Liver transplantation Epigenetics Malnutrition Probiotics

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Novel epigenetic-based therapies useful in cardiovascular medicine

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World Journal of Cardiology 2016年第2期8卷 211-219页

作者： claudio napoli Vincenzo Grimaldi Maria Rosaria De Pascale Linda Sommese Teresa Infante Andrea Soricelli Division of Immunohematology Transfusion Medicine and Transplant ImmunologyDepartment of Internal Medicine and Specialistic UnitAzienda Ospedaliera Universitaria (AOU)Second University of Naples Institute of Diagnostic and Nuclear Development(SDN) IRCCS

Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of Cp G islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression(e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of micro RNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense micro RNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of eme-rging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols.

关键词： Epigenetics Cardiovascular diseases Heart failure Inhibitors of histone deacetylases Antisense microRNAs

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Bow hunter’s syndrome successfully treated with a posterior surgical decompression approach:A case report and review of literature

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World Journal of Clinical Cases 2022年第14期10卷 4494-4501页

作者： NiccolòOrlandi Francesco Cavallieri Ilaria Grisendi Antonio Romano Reza Ghadirpour Manuela napoli claudio Moratti Matteo Zanichelli Rosario Pascarella Franco Valzania Marialuisa Zedde Department of Biomedical Metabolic and Neural SciencesCenter for Neuroscience and NeurotechnologyUniversity of Modena and Reggio EmiliaModena 41121Italy Neurology Unit Neuromotor and Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModena 41121Italy Neurosurgery Unit Neuromotor and Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Neuroradiology Unit Department of Diagnostic Imaging and Laboratory MedicineAzienda USL-IRCCS di Reggio EmiliaReggio Emilia 41123Italy

BACKGROUND Bow hunter’s syndrome(BHS)is a rare but surgically treatable cause of vertebrobasilar insufficiency due to dynamic rotational occlusion of the vertebral ***,patients present with posterior circulation transient ischaemic symptoms such as presyncope,syncope,vertigo,diplopia,and horizontal nystagmus,but irreversible deficits,including medullary and cerebellar infarctions,have also been *** SUMMARY A 70-year-old patient presented an acute onset of vertigo and gait instability triggered by right head *** medical history included previous episodes of unilateral left neck and occipital pain followed by light-headedness,sweating,and blurred vision when turning his head,and these episodes were associated with severe degenerative changes in the atlanto-dens and left atlanto-axial facet joints and right rotation of the C2 cervical *** magnetic resonance imaging revealed the presence of acute bilateral cerebellar ischaemic lesions,while static vascular imaging did not reveal any vertebral artery *** ultrasonography and angiography were performed and confirmed the presence of a dynamic occlusion of the vertebral artery V3-V4 segment when the head was rotated to the right secondary to left C1-C2 bone spur *** decompression led to complete resolution of paroxysmal symptoms without neurological *** BHS should be considered in cases of repeated posterior circulation transient ischaemic attack or ischaemic stroke,particularly when associated with high cervical spine abnormalities.

关键词： Bow hunter’s syndrome Stroke Non-invasive duplex ultrasonography Dynamic angiography Neurosurgery Case report

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A Matrix-Based Approach for Sustainability in Product Design

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Journal of Mechanics Engineering and Automation 2012年第2期2卷 102-109页

作者： claudio Rocco Sergio Rizzuti Luigi De napoli Department of Mechanical Engineering University of Calabria Rende （CS） 87036 Italy

The paper proposes a matrix-based approach that a designer can use to evaluate the sustainability of one or more design solutions in the conceptual phase of a product development process. The methodology is structured in two main phases. In the first one, a data structure, called Augmented-DSM （Design Structure Matrix）, has to be drawn in order to collect design information such as functional links among product components, indicators that provide information about the life cycle of each element, connections with the environment and toward other systems. The matrix is based on a DSM format, where new records were introduced to store and organize different types of data and an editing protocol was formalized. In the second stage, a set of procedures have to be applied in order to evaluate sustainability of a design solution and compare it with the others. The presented procedures, in fact, allow designers to assess a product in its proper characteristics, evaluate a device during its use stage and verify the coherence of links present in the functional model. This new approach is conceived to manage different performance indicators and, as a support tool, it is an attempt to aid designers in a quantitative evaluation.

关键词： A-DSM (augmented-design structure matrix) early sustainability assessment functional approach simplified LCA (life cycle assessment).

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Economic and Environmental Performance of Biowaste-to-energy Technologies for Small-scale Electricity Generation

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 12-18页

作者： Max J.A.Romero Rivas Davide Capuano claudio Miranda Graded S.p.A. NapoliNA 80141Italy

Electricity is predicted to be the energy vector that will undergo major changes in the future,and a transition would be observed in the resources such as waste and residual biomass that we use to satisfy the energy ***,this study aims to highlight the main economic and environmental performances of different biowaste-to-energy technologies for small-scale electricity generation by comparing the direct combustion of refined vegetable oil obtained from waste cooking oils(thermal pathway),anaerobic digestion of biowaste(biochemical pathway),and gasification of wood residues(thermochemical pathway).The economic analysis is mainly based on personal experiences in the energy sector and shows an overview of the performance in investment of combined heat and power(CHP)systems,ranging from 100 to 500 kW for a period of 20 *** environmental assessment is conducted considering the life-cycle thinking approach using support from the openLCA software,product environmental footprint(PEF)database,and previous studies that have reported environmental inventory data from real industrial cases.

关键词： Biowaste-to-energy small-scale generation economic assessment environmental assessment

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SOME PRELIMINARY INFORMATION ON SYNDIOTACTIC POLYSTYRENE CATALYSTS

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Chinese Journal of Polymer Science 1988年第4期6卷 365-369页

作者： Adolfo Zambelli,claudio Pellecchia,Leone Oliva,韩世敏 Dipartimento di Fisica Universita'di Salerno 84081 Baronissi (SA) Italy Dipartimento di Fisica Universita'di Salerno 84081 Baronissi (SA) Italy Dipartimento di Chimica Universita'di napoli Via Mezzocannone 4 Ⅰ-80134 napoli Italy Institute of Chemistry Academia Sinica Beijing China

Syndiotactic specific polymerization of styrene has been investigated by13C NMR analysis and isotopic laelling methods. The value of the activation energy involved in the steric control has been determined. Some infor... 详细信息

关键词： We wish to thank prof. A. Di Donato Universita’ di napoli Italy for radioactivity measurements

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Selective Gold Deposition on a Nanostructured Block Copolymer Film Crystallized by Epitaxy

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Nano Research 2011年第3期4卷 241-248页

作者： claudio De Rosa Finizia Auriemma Rocco Di Girolamo Rossella Aprea Annette Thierry Dipartimento di Chimica ＂P. Corradini＂ Universit~t di Napoli ＂Federico II＂ Complesso Monte S. Angelo Via Cintia 80126 Napoli Italy Institut Charles Sadron University de Strasbourg CNRS-UPR 22 B. E 84047 23 rue du Loess 67034 Strasbourg France

An ordered nanostructure formed by epitaxial crystallization of a semicrystalline block copolymer on a substrate has been used as a patterned template for the selective deposition of thermally evaporated gold nanoparticles, resulting in the formation of structure-guiding host nanocomposites in which the ordered distribution of the guest particles is guided by the ordering of the host nanostructured block copolymer matrix. This opens new perspectives in the field of polymeric composites related to the maximum enhancement of effective physical properties and to the numerous possible applications that arise due to the presence of long-range order in the spatial distribution of functional nanoparticles.

关键词： Crystalline block copolymers nanostructures nanocomposites gold deposition

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An in-depth multi-technique characterization of rare earth carbonates-RE_(2)(CO_(3))_(3)·2H_(2)O-owning tengerite-type structure

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Journal of Rare Earths 2022年第8期40卷 1281-1290页

作者： Luca Spiridigliozzi Mauro Bortolotti Grazia Accardo Alessandro Vergara Domenico Frattini claudio Ferone Raffaele Cioffi Gianfranco Dell'Agli Department of Civil and Mechanical Engineering University of Cassino and Southern LazioVia G.Di Biasio 4303043Cassino(FR)Italy Department of Industrial Engineering University of TrentoVia Sommarive 938123TrentoItaly Center of Hydrogen-Fuel Cell Research Korea Institute of Science and TechnologyHwarang-ro 14-gilSeongbuk-guSeoul136-791Republic of Korea Centre for Cooperative Research on Alternative Energies(CIC EnergiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkCalle Albert Einstein 4801510Vitoria-GasteizSpain Department of Chemical Sciences University of Napoli“Federico II”Via Cintia80126NapoliItaly Graduate School of Energy and Environment Seoul National University of Science and TechnologyGongneung-ro 232Nowon-guRepublic of Korea Department of Engineering University of Napoli“Parthenope”Centro DirezionaleIsola C480143Napoli(NA)Italy INSTM-National Interuniversity Consortium of Materials Science and Technology

The present study has been conducted to contribute,once and for all,filling the lack of structural information for the whole class of rare earth(RE)carbonates owning the tengerite-(Y)structure.A complete structural characterization,carried out by Rietveld refinement of X-ray powder diffraction(XRD)data,was comparatively performed for the first time on several hydrated RE carbonates,having the general chemical formula RE_(2)(CO_(3))_(3)·χH_(2)O,RE=Y,Gd,Tb,Dy,Ho and *** samples share the same space group and lattice parameters similar to tengerite-(Y);the structures are also closely related,consisting in all cases of a three-dimensional framework of nine-fold coordinated RE atom polyhedral,linked together by carbonate *** addition to relatively minor changes in fractional coordinates of atom sites and corresponding interatomic distances,the only perceivable difference lies in the lattice parameters affected by the ionic radius of RE^(3+).However,in the case of Er,which has the lowest cationic radius among the analyzed RE,the stabilization of tengerite structure is at its limit condition,because the carbonate groups are heavily ***,FT-IR and Raman spectra confirm the main structural features obtained by Rietveld *** observed morphology of the various samples is almost the same,being characterized by the presence of bidimensional rod-like particles grouped in agglomerates,typical of tengerite crystals,thus indicating that the crystallization mechanism occurring during the hydrothermal synthesis is the same,irrespective of the involved RE cation.

关键词： Rare Earth carbonates Tengerite Structural refinement Hydrothermal treatment

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Assessing spatial variability and erosion susceptibility of soils in hilly agricultural areas in Southern Italy

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International Soil and Water Conservation Research 2020年第4期8卷 354-362页

作者： Carmen Maria Rosskopf Erika Di Iorio Luana Circelli claudio Colombo Pietro P.C.Aucelli University of Molise Department of Biosciences and Territoryc.da Fonte Lappone86090PescheISItaly University of Molise Department of AgriculturalEnvironmental and Food SciencesVia F.De Sanctis186100CampobassoCBItaly University of napoli"Parthenope" Department of Environmental SciencesCentro Direzionale Isola C/480143NapoliItaly

Soil erosion is one of the main environmental problems in the Mediterranean *** problem is becoming even more important especially in Italy,in the Apennines,where severe erosive processes occur due to the action of concentrated running *** erodibility(K-Factor)of a soil,estimated using the Revised Universal Soil Loss Equation(RUSLE),is a measure of its susceptibility to erosion and depends on several soil properties such as organic matter,texture and permeability and *** assess the spatial variability of soil properties and soil erodibility in hilly agricultural areas and to investigate the relationships between soil features and landscape morphodynamics,a detailed study in Molise region(southern Italy),in a small drainange basin located along its hilly Adriatic flank,was carried *** this catchment,63 topsoil samples(A horizons)were collected and 10 soil profiles,forming a catena crossing 3 land units,were *** calculated K-Factors ranges between 0.012 and 0.048 t ha h ha-1 MJ-1 mm-1 indicating a complex spatial distribution,due to the several local pedological and geomorphological factors affecting soil *** results give clear evidence about the relationships among soil characteristics,soil erodibility and landscape morpho-dynamics(land units).Comparing the soil loss rates estimated for the study area with those reported in literature,a good correspondence can be observed only for the more stable land unit,not characterized by intense erosive *** proposed methodology is suitable to highlight areas characterized by similar morphodynamics features,and comparable soil erodibility,for a more effective spatialization of K factor.

关键词： Hillslope morphodynamics RUSLE equation K factor Mediterranean region Soil catena Land units

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Unveiling the controversial mechanism of reversible Na storage in TiO2 nanotube arrays： Amorphous versus anatase TiO2

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Nano Research 2017年第8期10卷 2891-2903页

作者： Federico Bella Ana B. Munoz-Garcia Giuseppina Meligrana Andrea Lamberti Matteo Destro Michele Pavone claudio Gerbaldi GAME Lab CHENERGY Group Department of Applied Science and Technology - DISAT Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy Department of Chemical Sciences University of Naples Fedefico II Via Cintia 21 University Campus of Monte Sant'Angelo 80126 Napoli Italy MPMNT Group Department of Applied Science and Technology - DISAT Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy LITHOPS S.r.l. Strada del Portone 61 10137 Torino Italy

Due to their inherent safety, low cost, and structural stability, TiO2 nanostructures represent a suitable choice as anode materials in sodiumion batteries. In the recent years, various hypotheses have been proposed regarding the actual mechanism of the reversible insertion of sodium ions in the TiO2 structure, and previous reports are often controversial in this respect. Interestingly, when tested as binder- and conducting additive-free electrodes in laboratory-scale sodium cells, amorphous and crystalline （anatase） TiO2 nanotubular arrays obtained by simple anodic oxidation exhibit peculiar and intrinsically different electrochemical responses. In particular, after the initial electrochemical activation, anatase TiO2 shows excellent rate capability and very stable long-term cycling performance with larger specific capacities, and thus a clearly superior response compared with the amorphous counterpart. To obtain deeper insight, the present materials are thoroughly characterized by scanning electron microscopy and ex situ X-ray diffraction, and the insertion of sodium ions in the TiO2 bulk phases is systematically modeled by density functional theory calculations. The present results may contribute to the development of more systematic screening approaches to identify suitable active materials for highly efficient sodium-based energy storage systems.

关键词： sodium battery TiO2 nanotube array anode modeling insertion mechanism

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