Compromised nutritional status in patients with end-stage liver disease:Role of gut microbiota

作     者：Maria Vasco Rossella Paolillo Concetta Schiano Linda Sommese Oreste Cuomo Claudio Napoli 

作者机构：U.O.C.Division of Clinical ImmunologyImmunohematologyTransfusion Medicine and Transplant ImmunologyRegional Reference Laboratory of Transplant ImmunologyDepartment of Internal and Specialty MedicineAzienda Ospedaliera UniversitariaUniversitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy IRCCS SDNNaplesItaly Department of Experimental MedicineUniversitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy Department of Liver TransplantAORN A.CardarelliNaplesItaly Department of MedicalSurgicalNeurologicalMetabolic and Geriatric SciencesUniversitàdegli Studi della Campania“Luigi Vanvitelli”NaplesItaly 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2018年第17卷第4期

页      面：290-300页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a grant from“Ricerca Corrente 2013–15”from Italian Ministry of Health(RRC-2015-2360454) 

主　　题：Liver diseases Liver transplantation Epigenetics Malnutrition Probiotics 

摘      要：Background: Patients with end-stage liver disease(ESLD) have a compromised nutritional status because of the liver crucial role in regulating metabolic homeostasis and energy *** sources: A systematic review of literature based on extensive relevant articles published from 2001 to 2017 in English in Pub Med database was performed by searching keywords such as liver disease, nonalcoholic liver disease, alcoholic liver disease, malnutrition, epigenetics, gut microbiota, and ***: Liver transplantation would be one eligible therapy for ESLD patients, even if, the clinical outcome is negatively influenced by malnutrition and/or infections. The malnutrition is a condition of nutrient imbalance with a high incidence in ESLD patients. An accurate evaluation of nutritional status could be fundamental for reducing complications and prolonging the survival of ESLD patients including those undergoing liver transplantation. In addition, the interaction among nutrients, diet and genes via epigenetics has emerged as a potential target to reduce the morbidity and mortality in ESLD patients. The malnutrition induces changes in gut microbiota causing dysbiosis with a probable translocation of bacteria and/or pathogen-derived factors from the intestine to the liver. Gut microbiota contribute to the progression of chronic liver diseases as well as hepatocellular carcinoma. The administration of probiotics modulating gut microbiota could improve all chronic liver ***: This review provides an update on malnutrition status linked to epigenetics and the potential benefit of some probiotics on the management of ESLD patients. In support of this view and to reveal the constant and growing interest in this field, some clinical trials are reported.