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Colorectal cancer screening:A review of current knowledge and progress in research

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1119-1133页

作者： sara Ramos Lopes claudio martins.inês.cos.a s.ntos.madalena teixeira Élia Gamito Ana Luisa Alves Department of Gastroenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide,being the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths *** the progress in screening,early diagnosis,and treatment,approximately 20%-25%of CRC patients still present with metastatic disease at the time of their initial ***,the burden of disease is still expected to increase,especially in individuals younger than 50 years old,among whom early-onset CRC incidence has been *** and early detection are pivotal to improve CRC-related *** is well established that CRC screening not only reduces incidence,but also decreases deaths from *** screening strategies have proven effective in decreasing both CRC incidence and mortality,though variations in efficacy have been reported across the ***,uncertainties persist regarding the optimal screening method,age intervals and ***,adherence to CRC screening remains globally *** recent years,emerging technologies,notably artificial intelligence,and non-invasive biomarkers,have been developed to overcome these ***,controversy exists over the actual impact of some of the new discoveries on CRC-related outcomes and how to effectively integrate them into daily *** this review,we aim to cover the current evidence surrounding CRC *** will further critically assess novel approaches under investigation,in an effort to differentiate promising inno-vations from mere novelties.

关键词： Colorectal cancer screening Review Oncology Artificial intelligence

Phase angle and non-alcoholic fatty liver disease before and after bariatric surgery

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World Journal of Hepatology 2020年第11期12卷 1004-1019页

作者： Joise teixeira claudio Augusto Marroni Paula Rosales Zubiaurre Ana Henz Lais Faina Lilian KethelynPinheiro claudio Cora Mottin sabrina Alves Fernandes Department of Postgraduate Program in Medicine:Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Department of Gastroenterology and Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 91760470RSBrazil Department of Center of Morbid Obesity Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre 90610000RSBrazil Department of Nutrition Centro Universitario Metodista(IPA)Porto Alegre 90420060RSBrazil Department of Vascular surgery Hospital Federal dos Servidores do Estado do Rio de JaneiroRio de Janeiro 20221161RJBrazil Department of Obesity and Metabolic syndrome Center Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre 90619-900RSBrazil

BACKGROUND Obesity is a global health problem that is continuing to increase in the young *** Brazil,the frequency of obesity in 2018 was 19.8%.several comorbidities are directly associated with obesity,such as non-alcoholic fatty liver disease(NAFLD),which is considered the most common liver disorder in Western countries and affects up to 46%of *** surgery is effective in treating obesity and can improve NAFLD;however,the effect of bariatric surgery on body composition,phase angle(PA),and improving NAFLD needs to be further *** To analyze the PA in the postoperative period of bariatric surgery and to correlate it with changes in body composition and liver *** This study is a retrospective cohort study of the analysis of the medical records of patients undergoing bariatric surgery in a reference center of a teaching hospital in Porto Alegre over a 2-year *** older than 18 years whose record contained all information relevant to the study were *** data analyzed were body composition and PA through electrical bioimpedance and NAFLD through liver biopsy in the pre-and postoperative *** level of significance adopted for the statistical analyses was 5%.REsULTs We evaluated 379 patients with preoperative *** PA,169 patients were analyzed,and 33 patients had liver biopsy pre-and postoperatively with NAFLD *** total,79.4%were female,with a mean age of 39.1±10.6 *** average body mass index(BMI)was 45.9±7.5 kg/m².The PA showed a mean of 5.8±0.62°in the preoperative period and a significant reduction in the postoperative period.A postoperative reduction in body composition data(skeletal muscle mass,fat percentage,fat mass,body cell mass,BMI and visceral fat area)was shown as *** liver disease,all patients presented a reduction in the degrees and stages of liver disease in the postoperative period,and some had no degree of liver disease at *** PA decreased af

关键词： Obesity Body composition Bariatric surgery Phase angle Non-alcoholic fatty liver disease Liver disease

Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas

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World Journal of Gastroenterology 2018年第43期24卷 4928-4938页

作者： Carolina Rosal teixeira de souza Marcelli Carolini Alves Almeida Andre salim Khayat Emerson Lucena da silva Paulo Cardoso soares Luiz claudio Chaves Rommel Mario Rodriguez Burbano Laboratory of Human Cytogenetics Institute of Biological Sciences Federal University of Para Belem Para 66075-110 Brazil Oncology Research Center Federal University of Para Joao deBarros Barreto University Hospital Belem Para 66073-000Brazil Ophir Loyola Hospital Belem Para 66060-281 Brazil

AIM TO correlate Helicobacter pylori （H. pylorli）, EpsteinBarr virus （EBV） and human papillomavirus （HPV） with gastric cancer （GC） cases in Para state, *** Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eberl RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the *** The majority of the 302 samples analyzed were obtained from men （65%） aged 55 years or older （67%） and were classified as the intestinal subtype （55%）. All three pathogens were found in the samples analyzed in the present study （H. pylori： 87%, EBV： 20%, HPV： 3%）. Overall, 78% of the H. pylori-positive （H. pylorl＋） samples were cagA＋（H. pylori-cagA＋）, and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA＋ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the *** HPV was not involved in gastric tumorigenesis. Prophy- lactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms.

关键词： Gastric cancer Gastric adenocarcinomas Microorganisms Helicobacter pylori cagA Epstein-Barr virus Human papillomavirus

Identification and characterization of resistance and pathogenicity of Enterococcus *** samples of donor breast milk

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World Journal of Clinical Pediatrics 2020年第3期9卷 53-62页

作者： Luana Andrade Mendes santana Nivea Nara Novais Andrade Lucas santana Coelho da silva Caline Novais teixeira Oliveira Breno Bittencourt de Brito Fabricio Freire de Melo claudio Lima souza Lucas Miranda Marques Marcio Vasconcelos Oliveira Oliveira Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Breast milk is the primary source of nutrition for *** babies frequently need nutritional support from Human Milk *** bacterial species of the genus Enterococcus are part of the microbiota of healthy donors,they may contaminate samples of pumped breast *** To identify and characterize the bacterial virulence and resistance in samples isolated from the nipple-areolar region,hands,and breast milk aliquots from donors at the Human Milk Bank of Municipal Hospital EsauMatos in the city of Vitória da Conquista,Bahia state,*** The personal hygiene and sanitation of donors were analyzed with the aim of identifying possible reasons for contamination of pumped *** samples as well as aliquots of unpasteurized and pasteurized milk from 30 participants were *** Enterococcus *** underwent a disk diffusion susceptibility test and molecular biology techniques to determine resistance and virulence *** Enterococcus *** identified in 30%of donors(n=9),and 11 specimens were *** to tetracycline was highly prevalent,being detectable in 63%of the isolates(n=7)and followed by intermediate sensitivity to ciprofloxacin,observed in 27%of the specimens(n=3).The efaA gene was found in 63%(n=7)of the isolates,while the ace gene was detected in 27%(n=3).CONCLUsION This study illustrates the importance of microbiological monitoring by Human Milk Banks and the need for alternatives to prevent the presence of Enterococcus *** hospital settings.

关键词： Enterococcus spp. Breast milk Virulence Human milk Pasteurization Antimicrobial resistanc

Mortality Trends for Neglected Tropical Diseases in the state of sergipe,Brazil,1980-2013

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Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： Marcos Antonio costa de Albuquerque Danielle Menezes Dias Lucas teixeira Vieira Carlos Anselmo Lima Angela Maria da silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information system of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

Resting energy expenditure in cirrhotic patients with and without hepatocellular carcinoma

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第1期12卷 1-12页

作者： Ana Cristhina Henz claudio Augusto Marroni Daniella Miranda da silva Joise Munari teixeira ThiagoThomésilveira shaiane Ferreira Andresa Thomésilveira Natalia Perin schmidt Jessica Taina stein Roberta Goulart Rayn sabrina Alves Fernandes Department of Nutrition Centro Universitário Metodista(IPA)Porto Alegre 90420-060RSBrazil Department of Gastroenterology and Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 91760470RSBrazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050170RSBrazil Postgraduate Program in Medicine HepatologyUniversidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050170RSBrazil Hepatology Graduate Program Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050170RSBrazil

BACKGROUND The diagnosis of malnutrition in patients with independent hepatocellular carcinoma(HCC)varies from 20%to 50%,is related to important complications and has a direct impact on the *** of the resting energy expenditure(REE)has become an important parameter in this population,as it allows therapeutic adjustments to recover their nutritional *** REE in cirrhosis,with and without HCC,is not clearly defined,and requires the identification and definition of the best nutritional *** To evaluate the REE of patients with cirrhosis,with and without *** This is a prospective observational study evaluating the REE of 118 patients,33 with cirrhosis and hepatocellular carcinoma and a control group of 85 patients with cirrhosis without HCC,using indirect calorimetry(IC),bioimpedance,and predictive *** The REE determined by IC in cirrhotic patients with HCC was 1643±364 and in those without HCC was 1526±277(P=0.064).The REE value as assessed by bioimpedance was 1529±501 for those with HCC and 1660±385 for those without HCC(P=0.136).When comparing the values of REE determined by IC and predictive formulas in cirrhotics with HCC,it was observed that only the formulas of the Food and Agriculture Organization(FAO)/World Health Organization(WHO)(1985)and Cunningham(1980)presented values similar to those determined by *** comparing the REE values determined by IC and predictive formulas in cirrhotics without HCC,it was observed that the formulas of schofield(1985),FAO/WHO(1985),WHO(2000),Institute of Medicine(IOM)(2005)and Katch and McArdie(1996)presented values similar to those determined by *** The FAO/WHO formula(1985)could be used for cirrhotic patients with or without HCC;as it is the one with the values closest to those obtained by IC in these cirrhotic patients.

关键词： Carcinoma Hepatocellular Liver cirrhosis Calorimetry Indirect Rest energy expenditure

The burden of prolonged sedentary behavior imposed by uberization

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sports Medicine and Health science 2023年第2期5卷 159-163页

作者： Thalles Guilarducci costa Vinnycius Nunes de Oliveira Douglas Assis Teles santos Ricardo Borges Viana Marilia santos Andrade Rodrigo Luiz Vancini Katja Weiss Beat Knechtle claudio Andre Barbosa de Lira Laboratório de Avaliação do Movimento Humano Faculdade de Educação Física e DançaUniversidade Federal de GoiásGoiâniaBrazil Colegiado de Educação Física Universidade do Estado da BahiaCampus XTeixeira de FreitasBahiaBrazil Instituto de Educação Física e Esportes Universidade Federal do CearáFortalezaBrazil Departamento de Fisiologia Universidade Federal de São PauloSão PauloBrazil Centro de Educação Física e Desportos Universidade Federal do Espírito SantoVitóriaBrazil Institute of Primary Care University of Zurich8006ZurichSwitzerland Medbase st.Gallen Am Vadianplatz 9000St.GallenSwitzerland

Mobility applications are rapidly growing in cities worldwide due to their convenience and low *** applications drivers experience vast flexibility in work hours,often work longer than in fixed-hours jobs,and can constantly transport passengers in their vehicles for up to 12 h;after this,they must go offline for eight consecutive hours before driving ***,drivers have found an easy way around this limitation by switching to other apps and continuing *** burden of prolonged work can increase sedentary behavior among mobility applications *** behavior is any waking activity in which the individual expends 1.5 metabolic equivalents(METs)or less while sitting or *** behavior can increase the risk of detrimental effects on *** this opinion article,we aim to discuss the possible effects of the burden of prolonged work on the sedentary behavior of mobility applications drivers and propose possible strategies to face this concerning situation.

关键词： Mobility application Drivers Health outcomes sedentary lifestyle Quality of life

Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho sousa Isabella Fernandes da silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais.cos.a Alves Bruna Letícia Rosa da silva Domingos Magno santos Pereira saulo JoseFigueiredo Mendes Joao Francisco silva Rodrigues Jaqueline Pessoa Pontes simone Aparecida teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-souza Lidio Goncalves Lima-Neto Vera Lucia dos santos Ana Paula Azevedo-santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de souza Monteiro Luis claudio Nascimento da silva Elizabeth soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation