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Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature

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World Journal of Clinical Oncology 2014年第2期5卷 177-190页

作者： claudio l battaglini Robert C Mills Brett l Phillips Jordan T lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney Department of Exercise and Sport Science Christina StoryChapel Hill NC 27599 United States lineberger Comprehensive Cancer Center Chapel Hill NC 27599 United States Exercise Oncology Research laboratory University of North CarolinaChapel Hill NC 27599 United States Centro Universitario de Brasilia (UniCeub) SEPN 707/907-Campus do UniCEUB-Asa Norte-Brasília-DF-70790-075Brazil Department of Nutrition University of North Carolina at Chapel HillChapel Hill NC 27599 United States

AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient ***:Pub Med, Medline Plus, the Cochrane library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all ***:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of ***:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise.

关键词： Breast cancer Exercise training Complementary Alternative Medicine Oncology VO2peak Patients reported outcomes

The Effect of Familiarization on the Reliability of Isokinetic Assessment in Breast Cancer Survivors

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Journal of Science in Sport and Exercise 2020年第3期2卷 220-225页

作者： Filipe D.de lima claudio l.battaglini Sandro N.Chaves lucas Ugliara Jonathan Sarandy Martim Bottaro College of Health Sciences University of BrasiliaBrasiliaBrazil College of Education and Health Sciences University Center of BrasiliaBrasiliaBrazil Department of Exercise and Sport Science and lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillUSA College of Physical Education University of BrasiliaBrasiliaDFBrazil Integrated College IESGO FormosaBrazil

Purpose To determine the amount of familiarization sessions required by breast cancer survivors to achieve a reliable meas-urement of muscle function assessed using isokinetic *** Twenty-six breast cancer survivors performed three isokinetic knee extension tests separated by,at least,48 *** isokinetic testing protocol included one warm-up set of 10 submaximal knee extensions at 120°/s,followed by two sets of four maximal knee extensions at 60°/s,with 2-min rest interval between *** torque(PT),time to peak torque(TPT),angle of peak torque(APT),and average power(AP)of each trial was used for the assessment of testing *** change in the mean,typical error,coefficient of variation and intraclass correlation coefficients(ICC2.1)were calculated to determine test-retest *** For PT,change in mean was lower between trials 2 and 3 than between trials 1 and 2(4.18% and 13.18%,respec-tively),and ICC was greater between trials 2 and 3 than between trials 1 and 2(0.962 and 0.818,respectively).For TPT and APT,ICC was clinically acceptable only between trials 2 and 3(0.757 and 0.803,respectively).For AP,change in mean was clinically acceptable between trials 2 and 3(9.84%),while ICC met acceptable reliability between both,trials 1 and 2 and,trials 2 and 3(0.756 and 0.891,respectively).Conclusion At least one familiarization session is adequate to achieve reliable measurements of muscle function using isokinetic dynamometry,while avoiding the impact of learning effect of the measurements in breast cancer survivors.

关键词： Muscle strength Breast cancer Isokinetic testing Resistance exercise Motor learning effect

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Editor Welcome

Journal of Science in Sport and Exercise 2020年第3期2卷 189-189页

作者： claudio l.battaglini Department of Exercise and Sport Science Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillUSA

This special issue of the Journal of Science in Sport and Exercise is devoted to scientific inquiry related to clinical exercise and sports *** article is authored by top researchers in the clinical exercise physiolog... 详细信息

关键词： Welcome devoted sports

Impact of community-based exercise program participation on aerobic capacity in women with and without breast cancer

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World Journal of Clinical Oncology 2021年第6期12卷 468-481页

作者： Jordan T lee Chad W Wagoner Stephanie A Sullivan Dean J Amatuli Kirsten A Nyrop Erik D Hanson lee Stoner Brian C Jensen Hyman B Muss claudio l battaglini Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNC 27599United States lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC 27599United States Department of Medicine Division of CardiologyUniversity of North Carolina at Chapel HillChapel HillNC 27599United States lineberger Comprehensive Cancer Center University of North CarolinaChapel HillNC 27599United States

BACKGROUND Evidence for exercise as an efficacious strategy to improve aerobic capacity of breast cancer survivors(BCS)has come largely from intervention studies conducted in laboratory *** is an increasing need to translate to community-type settings,but the efficacy of those interventions using gold standard evaluation is not *** To investigate whether similar improvement in aerobic capacity(maximal oxygen consumption[VO2])measured with gold standard testing can be achieved through a community-based setting in *** A peak cardiopulmonary exercise test(VO2peak),6-min walk test(6MWT),and timed up and go test(TUG)were assessed pre-and post-16 wk of progressive intensity aerobic and strength training exercise at a community *** The sample consisted of 31 early BCS(letion)and 15 controls(CTls).Both groups significantly improved VO2peak(+1.2 ml/kg/min;P=0.030),6MWT(+35 meters;Pllowing *** groups improved peak cycling power during the cardiopulmonary exercise test with BCS improving by+10 watts more than the CTls(P=0.020).Average exercise attendance was 71%(34 of 48 possible days),but compliant days averaged only 60%of total days for aerobic,andl function for early-stage BCS but potentially not to the same extent observed in laboratory-based randomized controlled *** research is needed to explore barriers and facilitators of exercise engagement in community-based centers to maximize training benefits for adults with cancer.

关键词： Aerobic capacity Breast cancer Community-based Exercise Physical function

Are dogs good at spotting movement?Velocity thresholds of motion detection in Canis familiaris

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Current Zoology 2020年第6期66卷 699-701页

作者： Miina looke Orsolya Kanizsar luca battaglini Cecile Guerineau Paolo Mongillo lieta Marinelli laboratory of Applied Ethology Department of Comparative Biomedicine and Food ScienceUniversity of PaduaViale delPUniversita 16Legnaro(PD)30202Italy Department of General Psychology University of PaduaVia Venezia 8Padua35131Italy

The ability to perceive motion is a fundamental property of the visual system,and one of its most basic aspects is the ability to discriminate moving objects from motionless ones,for example,motion *** thresholds represent the minimum rate of displacement over time unit that an animal is able to perceive as movement,any slower motion being not discriminable from a still *** such topic has grabbed the attention of scientists already at the beginning of the 20th century,the interest has waned in time,and velocity thresholds have thus far been assessed in only a handful of species.

关键词： Dogs methods of limits motion velocity threshold vision

New paths and research directions in CO_(2) conversion by electro-, photoand plasma catalysis

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Journal of Energy Chemistry 2024年第12期99卷 300-301页

作者： claudio Ampelli Maria l.Carreon Yuefeng liu University of Messina Italy Ralph E.Martin Department of Chemical Engineering-University of Arkansas3202 Bell Engineering Center FayetteilleAR72701USA Dalian Institute of Chemical Physics CASChina

CO_(2) conversion into value-added products by electro-, photoand plasma catalysis under mild operating conditions(ambient temperature and pressure) is an emerging area to achieve carbon circularity by producing chemicals and fuels using directly renewable energy. Among all CO_(2) conversion approaches, the electrocatalytic reduction of CO_(2) is the most mature technology, capable of achieving high productivity(i.e. high current densities) at large scale, especially for producing carbon monoxide(CO), but with many examples showing selectivity to C_(2) carbon products.

关键词： New paths and research directions in CO_(2)conversion by electro photoand plasma catalysis

Therapeutic potential of insulin-like growth factor 2 in Huntington's disease: controlling proteostasis to alleviate the load of misfolded protein

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Neural Regeneration Research 2021年第8期16卷 1564-1565页

作者： Paulina Troncoso-Escudero claudio Hetz Rene l.Vidal Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Center for Geroscience Brain Health and MetabolismSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesUniversity of ChileSantiagoChile Center for Integrative Biology Faculty of SciencesUniversity MayorChile Buck Institute for Research on Aging NovatoCAUSA

Huntington's disease(HD) is an inherited autosomal dominant neurodegenerative disorder characterized by the development of adult-onset motor dysfunction,psychiatric disturbances and intellectual *** is associated with an expansion of CAG repeat sequence in the huntingtin gene(Htt).Exon 1 of Htt normally contains between 6 to 35 CAG repeats,whereas in patients affected with HD it contains more than 40 trinucleotides.

关键词： Huntington Therapeutic stasis

Properties of nuclear pastas

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Frontiers of physics 2021年第2期16卷 119-173页

作者： Jorge A.lopez claudio O.Dorso Guillermo Frank Department of Physics University of Texax at El PasoEl PasoTexas 79968USA Departamento de Fisica FCENUniversidad de Buenos AiresNunezArgentina Unidad de Investigacion y Desarrollo de las Ingenierias Universidad Tecnologica NacionalFacultad Regional Buenos AiresBuenos AiresArentina

In this review we study the nuclear pastas as they are expected to be formed in neutron star *** start with a study of the pastas formed in nuclear matter(composed of protons and neutrons),we follow with the role of the electron gas on the formation of pastas,and we then investigate the pastas in neutron star matter(nuclear matter embedded in an electron gas).Nuclear matter(NM)at intermediate temperatures(1 MeV≤T≤***),at saturation and and sub-saturation densities,and with proton content ranging from 30%to 50%was found to have liquid,gaseous and liquid-gas mixed *** isospin-dependent phase diagram was obtained along with the critical points,and the symmetry energy was calculated and compared to experimental data and other *** low temperatures(T≤1 MeV)NM produces crystal-like structures around satura-tion densities,and pasta-like structures at sub-saturation *** of the pasta structures were studied with cluster-recognition algorithms,caloric curve,the radial distribution function,the lindemann coefficient,Kolmogorov statistics,Minkowski functionals;the symmetry energy of the pasta showed a connection with its *** star matter(NSM)is nuclear matter embedded in an electron *** electron gas is included in the calculation by the inclusion of an screened Coulomb *** connect the NM pastas with those in neutron star matter(NSM),the role the strength and screening length of the Coulomb interaction have on the formation of the pastas in NM was *** was found to exist even without the presence of the electron gas,but the effect of the Coulomb interaction is to form more defined pasta structures,among other ***,it was determined that there is a minimal screening length for the developed structures to be independent of the cell *** star matter was found to have similar phases as NM,phase transitions,symmetry energy,structure function and thermal *** in NM,pasta f

关键词： nuclear pasta neutron star matter nuclear symmetry energy molecular dynamics nuclear phase transitions

Preclinical concepts and results with the GABA_A antagonist S44819 in a mouse model of middle cerebral artery occlusion

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Neural Regeneration Research 2019年第9期14卷 1517-1518页

作者： Dirk M.Hermann Barbara Saba Aurore Sors claudio l.Bassetti Departments of Neurology University Hospital EssenEssenGermany Institut de Recherches Internationales Servier SuresnesFrance University Hospital(Inselspital)Berne BerneSwitzerland

Recent advancements in recanalizing therapies,i.e.,the combination of thrombolytic drugs with interventional thrombectomy,have considerably improved neurological outcome in ischemic stroke *** this progress,the large majority of stroke patients still exhibit neurological deficits in the long run,and ischemic stroke continues to be the most frequent cause of long-term ***,there is an unmet need for therapies that allow enhancing neurological recovery and brain plasticity in the post-acute stroke phase(Hermann and Chopp,2012).Preclinical studies,e.g.,delivering growth factors(Reitmeir et al.,2011)or neural precursor cells(NPC)(Bacigaluppi et al.,2016),have shown that brain plasticity can be successfully stimulated in the post-acute stroke phase,resulting in functional neurological *** findings raised the question whether it is possible to promote neurological recovery and brain plasticity in stroke patients.

关键词： Recent advancements interventional thrombectomy stroke patients