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Management of psoriasis patients with hepatitis B or hepatitis C virus infection

World Journal of Gastroenterology 2016年第28期22卷 6444-6455页

作者： claudio Bonifati Viviana Lora Dario Graceffa Lorenzo Nosotti Center for the Study and Treatment of Psoriasis San Gallicano Dermatologic Institute IRCCS Gastrointestinal and Liver Department National Institute for Health Migration and Poverty

The systemic therapies available for the management of Psoriasis (PsO) patients who cannot be treated with more conservative options, such as topical agents and/or phototherapy, with the exception of acitretin, can worsen or reactivate a chronic infection. Therefore, before administering immunosuppressive therapies with either conventional disease-modifying drugs (cDMARDs) or biological ones (bDMARDs) it is mandatory to screen patients for some infections, including hepatitis B virus (HBV) and hepatitis C virus (HCV). In particular, the patients eligible to receive an immunosuppressive drug must be screened for the following markers: antibody to hepatitis B core, antibody to hepatitis B surface antigen (anti-HBsAg), HBsAg, and antibody to HCV (anti-HCV). In case HBV or HCV infection is diagnosed, a close collaboration with a consultant hepatologist is needed before and during an immunosuppressive therapy. Concerning therapy with immunosuppressive drugs in PsO patients with HBV or HCV infection, data exist mainly for cyclosporine a (CyA) or bDMARDs (etanercept, adalimumab, infliximab, ustekinumab). The natural history of HBV and HCV infection differs significantly as well as the effect of immunosuppression on the aforementioned infectious diseases. As a rule, in the case of active HBV infection, systemic immunosuppressive antipsoriatic therapies must be deferred until the infection is controlled with an adequate antiviral treatment. Inactive carriers need to receive antiviral prophylaxis 2-4 wk before starting immunosuppressive therapy, to be continued after 6-12 mo from its suspension. Due to the risk of HBV reactivation, these patients should be monitored monthly for the first 3 mo and then every 3 mo for HBV DNA load together with transaminases levels. Concerning the patients who are occult HBV carriers, the risk of HBV reactivation is very low. Therefore, these patients generally do not need antiviral prophylaxis and the sera HBsAg and transaminases dosing can be

关键词： Psoriasis Therapy Conventional disease-modifying drugs Biological disease-modifying drugs Hepatitis B virus infection Hepatitis C virus infection

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Central nervous system manifestations due to iatrogenic adrenal insuffi ciency in a Ewing sarcoma patient

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World Journal of Emergency Medicine 2019年第2期10卷 119-121页

作者： Coralie Galland-Decker Vanessa Kraege claudio Sartori Internal Medicine University HospitalLausanne-CHUV

Dear editor,Several types of tumors affect *** being rare,the Ewing sarcoma fami ly of tumors represents the second most common primary bone malignancy in children and *** Cushing syndrome i s a wel l-known condi t ion characterized by an ectopic secretion of ACTH(or CRH),and in turn of cortisol by tumor *** Cushing syndrome is however very rare in Ewing sarcoma,and to our knowledge,it was only described once.

关键词： Several types adolescents primary bone

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Anti-TNF alpha in the treatment of ulcerative colitis:A valid approach for organ-sparing or an expensive option to delay surgery?

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World Journal of Gastroenterology 2014年第17期20卷 4839-4845页

作者： Gianluca Rizzo Daniela Pugliese Alessandro Armuzzi claudio Coco Department of Surgical Sciences Complesso Integrato ColumbusCatholic University of the Sacred Heart00168 RomeItaly Internal Medicine and Gastroenterology Unit Complesso Integrato ColumbusCatholic University of the Sacred Heart00168 RomeItaly

Ulcerative colitis (UC) is an inflammatory bowel disease affecting large bowel with variable clinical course. The history of disease has been modified by the introduction of biologic therapy, in particular Infliximab (IFX), that has demonstrated efficacy in inducing fast symptoms remission, promoting mucosal healing and maintaining long-term remission. However, surgery is still needed for UC patients: in case of failure of medical therapy and if acute complications or a malignancy occurred. Surgical treatment is associated with a short-term post-operative mortality and morbidity respectively of 0%-4% and 30%. In this study we systematically analyzed: the role of IFX in reducing the colectomy rate, the risk of post-operative morbidity in pre-operatively IFX-treated patients and the cost-effectiveness of IFX therapy. Four of 5 analyzed randomized controlled trials demonstrated that therapy with IFX significantly reduces the colectomy rate. Moreover, pre-operative treatment with IFX doesn’t seem to increase post-operative infectious complications. By an economic point of view, the cost-effectiveness of IFX-therapy was demonstrated for UC patients suffering from moderate to severe UC in a study based on a cost estimation of the National Health Service of England and Wales. However, the argument is debated.

关键词： Ulcerative colitis Infliximab Colectomy Post-operative complications Cost-effectiveness Inflammatory bowel disease

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Analysis of the factors controlling performances of Au-modified TiO2 nanotube array based photoanode in photo-electrocatalytic(PECa)cells

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Journal of Energy Chemistry 2017年第2期26卷 284-294页

作者： claudio Ampelli Francesco Tavella Chiara Genovese Siglinda Perathoner Marco Favaro Gabriele Centi Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d’Alcontres 3198166 MessinaItaly Department of Chemical Sciences University of Paduavia Marzolo 135136 PaduaItaly Department of Mathematical ComputerPhysical and Earth SciencesUniversity of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d’Alcontres 3198166 MessinaItaly Advanced Light Source Joint Center for Artificial PhotosynthesisLawrence Berkeley National Laboratory1 Cyclotron Rd.M/S 30R0205 BerkeleyCA 94720USA.

The efficiency of photo-electrocatalytic（PECa） devices for the production of solar fuels depends on several limiting factors such as light harvesting, charge recombination and mass transport diffusion. We analyse here how they influence the performances in PECa cells having a photo-anode based on Au-modified TiOnanotube（TNT） arrays, with the aim of developing design criteria to optimize the photo-anode and the PECa cell configuration for water photo-electrolysis（splitting） and ethanol photo-reforming *** TNT samples were prepared by controlled anodic oxidation of Ti foils and then decorated with gold nanoparticles using different techniques to enhance the visible light response through heterojunction and plasmonic effects. The activity tests were made in a gas-phase reactor, as well as in a PECa cell without applied bias. Results were analysed in terms of photo-generated current, Hproduction rate and photoconversion efficiency. Particularly, a solar-to-hydrogen efficiency of 0.83% and a Faradaic efficiency of 91%were obtained without adding sacrificial reagents.

关键词： H2 production Au nanoparticles Solar fuels TiO2 nanotubes Electrodeposition Photoelectrochemical cells(PEC) Solar-to-hydrogen efficiency Anodic oxidation

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Search for heavy sterile neutrinos in trileptons at the LHC

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Chinese Physics C 2017年第10期41卷 31-36页

作者： claudio O.Dib C.S.Kim Kechen Wang CCTVal and Department of Physics Universidad Técnica Federico Santa María Department of Physics and IPAP Yonsei University DESY Center for Future High Energy Physics Institute of High Energy PhysicsChinese Academy of Sciences

We present a search strategy for both Dirac and Majorana sterile neutrinos from the purely leptonic decays of W^±→e^±e^±μ ν and μ^±^±e ν at the 14 TeV LHC. The discovery and exclusion limits for sterile neutrinos are shown using both the Cut-and-Count（CC） and Multi-Variate Analysis（MVA） methods. We also discriminate between Dirac and Majorana sterile neutrinos by exploiting a set of kinematic observables which differ between the Dirac and Majorana cases. We find that the MVA method, compared to the more common CC method, can greatly enhance the discovery and discrimination limits. Two benchmark points with sterile neutrino mass m N =20 GeV and 50 GeV are tested. For an integrated luminosity of 3000 fb^-1, sterile neutrinos can be found with 5σ significance if heavy-to-light neutrino mixings ｜U_（Ne）｜^2~｜U_（Nμ）｜^2~10^-6, while Majorana vs. Dirac discrimination can be reached if at least one of the mixings is of order 10^-5.

关键词： sterile neutrinos LHC trileptons BSM physics

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Protein kinase CK2: a potential therapeutic target for diverse human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1698-1717页

作者： Christian Borgo claudio D'Amore Stefania Sarno Mauro Salvi Maria Ruzzene Department of Biomedical Sciences University of PaduaPaduaItaly CNR Institute of Neuroscience University of PaduaPaduaItaly

CK2 is a constitutively active Ser/Thr protein kinase,which phosphorylates hundreds of substrates,controls several signaling pathways,and is implicated in a plethora of human *** best documented role is in cancer,where it regulates practically all malignant *** well-known functions of CK2 are in human infections;in particular,several viruses exploit host cell CK2 for their life *** recently,also SARS-CoV-2,the virus responsible for the COVID-19 pandemic,has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates(either viral and host proteins).CK2 is also considered an emerging target for neurological diseases,inflammation and autoimmune disorders,diverse ophthalmic pathologies,diabetes,and *** addition,CK2 activity has been associated with cardiovascular diseases,as cardiac ischemia-reperfusion injury,atherosclerosis,and cardiac *** hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many ***,psychiatric disorders and syndromes due to CK2 mutations have been recently *** these bases,CK2 is emerging as an increasingly attractive target in various fields of human medicine,with the advantage that several very specific and effective inhibitors are already ***,we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.

关键词： diseases inflammation potential

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Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk

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World Journal of Gastroenterology 2011年第26期17卷 3082-3091页

作者： Lucia Pacifico Valerio Nobili Caterina Anania Paola Verdecchia claudio Chiesa Department of Pediatrics Sapienza University of Rome Department of Hepato-gastroenterology and Nutrition Pediatric Hospital "Bambino Gesù" Institute of Translational Pharmacology National Research Council

Nonalcoholic fatty liver disease(NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol *** mildest form is simple steatosis in which triglycerides accumulate within hepatocytes.A more advanced form of NAFLD,nonalcoholic steatohepatitis,includes inflammation and liver cell injury,progressive to cryptogenic *** has become the most common cause of chronic liver disease in children and *** recent rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic *** is strongly associated with abdominal obesity,type 2 diabetes,and dyslipidemia,and most patients have evidence of insulin ***,NAFLD shares many features of the metabolic syndrome(MetS),a highly atherogenic condition,and this has stimulated interest in the possible role of NAFLD in the development of *** evidence suggests thatNAFLD is associated with a significantly greater overall mortality than in the general population,as well as with increased prevalence of cardiovascular disease(CVD),independently of classical atherosclerotic risk ***,several studies including the pediatric population have reported independent associations between NAFLD and impaired flow-mediated vasodilatation and increased carotid artery intimal medial thickness-two reliable markers of subclinical atherosclerosis-after adjusting for cardiovascular risk factors and ***,the rising prevalence of obesity-related MetS and NAFLD in childhood may lead to a parallel increase in adverse cardiovascular *** children,the cardiovascular system remains plastic and damage-reversible if early and appropriate interventions are established *** goals for NAFLD should address nutrition,physical activity,and avoidance of smoking to prevent not only end-stage liver disease but also CVD.

关键词： Nonalcoholic fatty liver disease Metabolicsyndrome Cardiovascular risk Children

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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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Applicability of the Arrhenius model for Ammonia Oxidizing Bacteria subjected to temperature time gradients

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Frontiers of Environmental Science & Engineering 2015年第6期9卷 988-994页

作者： Alberto MANNUCCI Giulio MUNZ Gualtiero MORI claudio LUBELLO Jan A. OLESZKIEWICZ Department of Civil and Environmental Engineering University of Florence Florence 50139 Italy Consorzio Cuoiodepur Pisa 56020 Italy Department of Civil Engineering University of Manitoba Winnipeg R3T 5V6 Canada

The aim of this work is to identify the range of applicability of Arrhenius type temperature dependence for Ammonia Oxidizing Bacteria （AOB） subjected to tem- perature time gradients through continuous titrimetric tests. An innovative online differential titrimetric technique was used to continuously monitor the maximum biologic ammonia oxidation rate of the biomass selected in a pilot scale membrane bioreactor, as a function of temperature time gradients. The monitoring technique is based on the measurement of alkalinity and hydrogen peroxide con- sumption rates in two parallel reactors operated in non- limiting substrate conditions for AOB; both reactors were continuously fed with mixed liquor and in one of them AOB were inhibited with allylthiourea. The effects of temperature decrease rates in the range 1 to 4℃h^-1 were evaluated by controlling the titrimetric reactor in the temperature range 10℃-20℃. The dependence of growth kinetics on temperature time gradients and the range of applicability of Arrhenius model for temperature depen- dency of AOB growth kinetics were assessed. The Arrhenius model was found to be accurate only with temperature gradients lower than 2℃·h^-1. The estimated Arrhenius coefficients （θ） were shown to increase from 1.07 to 1.6 when the temperature decrease rate reached 4℃.h^-1.

关键词： nitrification rate temperature effect contin-uous tilrimetric tests time-gradient temperature variations,Ammonia Oxidizing Bacteria (AOB)

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Pancreatic involvement in pediatric inflammatory bowel diseases

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World Journal of Pediatrics 2015年第3期11卷 207-211页

作者： Sabrina Cardile Antonino Randazzo Simona Valenti claudio Romano Department of Pediatrics IBD UnitUniversity of Messina Via Consolare ValeriaMessina 98125Italy

Background:Inflammatory bowel diseases(IBDs)are a group of chronic diseases affecting the gastrointestinal tract,with a disabling *** incidence of IBDs is increasing in different geographical areas,indicating its emergence as a global disease,especially in *** patients with IBDs develop extraintestinal manifestations(EIMs)during follow-up,as IBDs have a potential risk of systemic involvement..Data sources:A systematic review of the literature was made to analyze latest studies on pancreatic involvement in children with IBD including our experience in assessing possible implications and its future ***:The involvement of the hepatobiliary system is considered a rare EIM of children with IBD,with an incidence much higher than that in the general *** pancreatic hyperenzymemia,which occurs in the absence of typical symptoms and/or characteristic imaging findings,may be found in many patients with *** frequent causes of pancreatitis are drugs,bilio-pancreatic disorders,immunologic disturbances and pancreatic auto-antibodies,although in some cases idiopathic forms have been ***:It is important to establish a correct diagnostic approach based on etiology and to assess the most appropriate therapeutic strategy,thus avoiding complications and improving the quality of life of children with IBD.

关键词： Crohn's disease extraintestinal manifestations inflammatory bowel diseases pancreatitis ulcerative colitis

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