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Joint effect among p53, CYP1A1, GSTM1 polymor.hism combinations and smoking on pr.state cancer.r.sk： an explor.tor. genotype-envir.nment inter.ction study

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Asian Jour.al of Andr.logy 2006年第A3期8卷 349-355页

作者： Luis A. Quinones Car.os E. Ir.r.ázabal claudio r. rojas Cr.stian E. Or.llana Cr.stian Acevedo Chr.stian Huidobr. Nelson E. Var.la Dante D. Cáicer.s Labor.tor. of Chemical Car.inogenesis and Phar.acogenetics Faculty of Medicine Biomedical Science Institute（ICBM） University of Chile lndependencia 1027 Santiago Chile Depar.ment of Ur.logy National Cancer Corporation Chile Capellán Abarzúa 027 Providencia Santiago Chile Epidemiology Division School of Public Health Faculty of Medicine University of Chile lndependencia 939Santiago Chile

Aim： To assess the r.le of sever.l genetic factor. in combination with an envir.nmental factor.as modulator. of pr.state cancer.r.sk. We focus on allele var.ants of low-penetr.nce genes associated with cell contr.l, the detoxification pr.cesses and smoking. Methods： In a case-contr.l study we compar.d people car.ying p53cd72 Pr. allele, CYP1A1 M1 allele and GSTM1 null genotypes with their.pr.state cancer.r.sk. r.sults： The joint r.sk for.smoker. car.ying Pr.^＊ and MI^＊, Pr.^＊ and GSTM1null or.GSTM1 null and CYP1A1 MI^＊ var.ants was significantly higher.（odds r.tio [Or.： 13.13, 95% confidence inter.al [CI]： 2.41-71.36; Or. 3.97, 95% CI： 1.13-13.95 and Or. 6.87, 95% CI： 1.68-27.97, r.spectively） compar.d with that for.the r.fer.nce gr.up, and for.non-smoker. was not significant. Or.for.combinations among p53cd72, GSTM1 and CYP1A1 M1 in smoker. wer. positively and significantly associated with pr.state cancer.r.sk compar.d with non-smoker. and compar.d with the putative lowest r.sk gr.up （Or. 8.87, 95% CI： 1.25-62.71）. Conclusion： Our.r.sults suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant r.le in modified pr.state cancer.r.sk on the study population, which means that smoker. car.ying susceptible genotypes might have a significantly higher.r.sk than those car.ying non-susceptible genotypes.

关键词： p53cd72 GSTM1 CYP1A1 genetic polymor.hism pr.state cancer r.sk smoking

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CO_(2) conver.ion to solar.fuels and chemicals:Opening the new paths

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Jour.al of Ener.y Chemistr. 2024年第4期91卷 680-683页

作者： Gabr.ele Centi claudio Ampelli Depar.ment of Chemical BiologicalPharmaceutical and Environmental Sciences(ChiBioFarAm)University of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d'Alcontres 3198166 MessinaItaly

This futur. ar.icle discusses the new pr.spects and dir.ctions of CO_(2)conver.ion via the photo-electr.catalytic(PEC)*** second(2nd)gener.tion solar.fuels and chemicals(SFs)ar. gener.ted dir.ctly in PEC systems via electr.ns/pr.tons r.actions without for.ing molecular.H_(2)as an inter.ediate,over.oming the ther.odynamics limitations and pr.ctical issues encounter.d for.electr.-fuels pr.duced by multistep ther.ocatalytic pr.cesses(***_(2)conver.ion with H_(2)coming fr.m water.electr.lysis).A distr.buted and decentr.lized pr.duction of SFs r.quir.s ver. compact,highly integr.ted,and intensified *** the existing r.actor. of advanced design(based on ar.ificial leaves or.photosynthesis),the integr.ted photovoltaic plus electr.catalytic(PV-EC)device is the only system(demonstr.ted at lar.e scale)to pr.duce SFs with high solar.to-fuel(STF)***,while the liter.tur. indicates STF efficiency as the main(and only)measur. of pr.cess per.or.ance,we r.mar. her. the need to r.fer.to pr.ductivity(in ter.s of cur.ent density)and make tests with r.liable flow PEC systems(with electr.des of at least 5–10 cm^(2))to acceler.te the scaling-up *** appr.aches that minimize downstr.am separ.tion costs is also *** limitations exist in PEC systems,but most can be over.ome by pr.per.electr.de and cell engineer.ng,thus going beyond the pr.per.ies of the *** examples of cur.ent developments,we pr.sent the pr.gr.ss of(i)ar.ificial leaf/tr.e devices for.gr.en H_(2)distr.buted pr.duction and(ii)a PEC device pr.ducing the same chemicals at both cathode and anode par.s without downstr.am oper.tions for.gr.en solvent distr.buted *** on these developments,futur. dir.ctions,such as pr.ducing fer.ilizer. and food components fr.m the air.ar. *** aim is to pr.vide new ideas and r.sear.h dir.ctions fr.m a per.onal per.pective.

关键词： Solar.fuels Ar.ificial leaf PEC devices PV-EC devices Cell engineer.ng gr.en H_(2) Chemicals fr.m theair

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Pr.venting br.in aging by the ar.ificial enfor.ement of the unfolded pr.tein r.sponse:futur. dir.ctions

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Neur.l r.gener.tion r.sear.h 2024年第2期19卷 393-394页

作者： Felipe Cabr.l-Mir.nda claudio Hetz Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Center.for.Ger.science Brain Health and MetabolismSantiagoChile、Biomedical Neuroscience InstituteFaculty of MedicineUniversity of ChileSantiagoChile、Program of Cellular and Molecular BiologyInstitute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile、Buck Institute for Research on AgingNovatoCAUSA

As the life expectancy of the wor.d’s population incr.ases,age-r.lated diseases ar. emer.ing as one of the gr.atest pr.blems facing moder. *** onset of dementia and neur.degener.tive diseases is str.ctly dependent on aging as a major.r.sk factor.and has a pr.found impact on var.ous aspects of the lives of individuals and their.families.

关键词： diseases aging dir.ctions

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Digital twin-and extended r.ality-based telepr.sence for.collabor.tive r.bot pr.gr.mming in the 6G per.pective

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Digital Communications and Networ.s 2024年第2期10卷 315-327页

作者： Davide Calandr. F.Gabr.ele Pr.tticò Alber.o Cannavò claudio Casetti Fabr.zio Lamber.i Politecnico di Tor.no Department of Control and Computer EngineeringCorso Duca Degli Abruzzi2410129TurinItaly

In the context of Industr. 4.0,a par.digm shift fr.m tr.ditional industr.al manipulator. to Collabor.tive r.bots(Cr.)is ongoing,with the latter.ser.ing ever.mor. closely humans as auxiliar. tools in many pr.duction *** this scenar.o,continuous technological advancements offer.new oppor.unities for.fur.her.innovating r.botics and other.ar.as of next-gener.tion *** example,6G could play a pr.minent r.le due to its human-centr.c view of the industr.al *** par.icular.its expected dependability featur.s will pave the way for.new applications exploiting highly effective Digital Twin(DT)-and eXtended r.ality(Xr.-based *** this wor.,a novel application for.the above technologies allowing two distant user. to collabor.te in the pr.gr.mming of a Cr.is *** appr.ach encompasses demanding data flows(e.g.,point cloud-based str.aming of collabor.ting user. and r.botic envir.nment),with networ. latency and bandwidth *** obtained by analyzing this appr.ach fr.m the viewpoint of networ. r.quir.ments in a setup designed to emulate 6G connectivity indicate that the expected per.or.ance of for.hcoming mobile networ.s will make it fully feasible in pr.nciple.

关键词： 6G Digital twin Telepr.sence Collabor.tive r.bots Industr. 4.0 Augmented r.ality Vir.ual r.ality Point cloud str.aming

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Inter.eukin 1βr.ceptor.and synaptic dysfunction in r.cur.ent br.in infection with Her.es simplex vir.s type-1

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Neur.l r.gener.tion r.sear.h 2025年第2期20卷 416-423页

作者： r.ber.o Piacentini claudio Gr.ssi Depar.ment of Neur.science UniversitàCattolica del Sacro CuoreRomeItaly Fondazione Policlinico Univer.itar.o A.Gemelli IRCCSRomeItaly

Sever.l exper.mental evidence suggests a link between br.in Her.es simplex vir.s type-1 infection and the occur.ence of Alzheimer.s ***,the molecular.mechanisms under.ying this association ar. not completely *** the molecular.mediator. of synaptic and cognitive dysfunction occur.ing after.Her.es simplex vir.s type-1 infection and r.activation in the br.in neur.inflammator. cytokines seem to occupy a centr.l ***,we specifically r.viewed liter.tur. r.por.s dealing with the impact of neur.inflammation on synaptic dysfunction obser.ed after.r.cur.ent Her.es simplex vir.s type-1 r.activation in the br.in,highlighting the r.le of inter.eukins and,in par.icular.inter.eukin 1βas a possible tar.et against Her.es simplex vir.s type-1-induced neur.nal dysfunctions.

关键词： her.es simplex vir.s type 1 inter.eukin 1β micr.glia neur.inflammation synaptic dysfunction

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Differ.nt behavior.l pr.fles between invasive and native nudibr.nchs:means for.invasion success?

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Cur.ent Zoology 2024年第3期70卷 406-417页

作者： Ar.ando Macali Sar. Fer.etti Ser.na Scozzafava Elia Gatto claudio Car.r. Ichthyogenic Exper.mental Mar.ne Centr.(CISMAr. Department of Ecological and Biological SciencesTuscia University01016 Borgo Le SalineTarquiniaItaly Depar.ment of Chemical Pharmaceutical and Agricultural SciencesFerrara Universityvia Luigi Borsari 4644121 FerraraItaly Depar.ment of Life Sciences and Biotechnology Ferrara Universityvia Luigi Borsari 4644121 FerraraItaly

Behavior.is pr.dicted to be a pr.mar. deter.inant of the success of the invasion pr.cess dur.ng the ear.y phases of *** invader. with sympatr.c native species may pr.vide a good appr.ach to unr.vel behavior.l tr.its involved in an invasion *** this study,we car.ied out an exper.mental simulation of the intr.duction and the acclimatization phase into a new envir.nment and assessed the expr.ssion of activity,aler.ness,and habituation in an invasive Mediter.anean population of the South Afr.can nudibr.nch Godiva quadr.color.compar.ng its pr.fles with those of the sympatr.c Mediter.anean native nudibr.nchs Cr.tena per.gr.na and Calor.a *** of these 3 species wer. subjected to 3 behavior.l tests:spontaneous activity,car.ied out in the intr.duction phase(immediately after.sampling)and after.a week of acclimatization;aler. test,in which a potential thr.at was simulated by means of a tactile stimulus,and habituation test,in which the same aler. test stimulus was r.peated 5 times at 30-min *** invasive *** showed higher.levels of explor.tion activity,thigmotaxis,aler.ness,and sensitization than the native *** behavior.l tr.its may r.pr.sent pivotal dr.ver. of the ongoing invasion pr.cess.

关键词： biological invasion invasive phenotype inver.ebr.te cognition molluscs per.onality.

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Hepatitis B vir.s genotypes in pr.cision medicine of hepatitis Br.lated hepatocellular.car.inoma:Wher. we ar. now

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第4期16卷 1097-1103页

作者： Caecilia H C Sukowati Sr. Jayanti Tur.adi Tur.adi David H Muljono claudio Tir.belli Eijkman r.sear.h Center.for.Molecular.Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver.Cancer.Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and Health University of SydneySydney 2050Australia

Hepatitis B vir.s(HBV)infection is a major.player.in chr.nic hepatitis B that may lead to the development of hepatocellular.car.inoma(HCC).HBV genetics ar. diver.e wher. it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geogr.phical distr.bution and possible differ.nt clinical outcomes in the *** diver.ity may be associated with the pr.cision medicine for.HBV-r.lated HCC and the success of ther.peutical appr.aches against HCC,r.lated to differ.nt pathogenicity of the vir.s and host *** Editor.al discusses r.cent updates on whether.the classification of HBV genetic diver.ity is still valid in ter.s of vir.l oncogenicity to the HCC and its pr.cision medicine,in addition to the r.cent advances in cellular.and molecular.biology technologies.

关键词： Hepatitis B vir.s Hepatocellular.car.inoma Genotypes Pathogenesis Pr.cision medicine

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Body Contour.in the Post-Bar.atr.c Male Patient

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Moder. Plastic Sur.er. 2024年第2期14卷 15-22页

作者： Er.ck Zúñiga-Gar.a Isr.el Salgado-Adame claudio D. rojas-Gutiér.ez Laur. Mar.a r.dr.guez-Bar.ios Guiller.o Álvar.z-Sánchez Eduar.o Camacho-Quinter. Depar.ment of Plastic Sur.er. National Medical Center &#822020 de Noviembre&#8221 Mexico City Mexico

Backgr.und: Obesity is cur.ently consider.d a public health pr.blem. Bar.atr.c pr.cedur.s have become an impor.ant par. of obesity management and, consequently, the number.of male patients seeking post-bar.atr.c r.constr.ctive pr.cedur.s have incr.ased. Ther.for., the clinical appr.ach and under.tanding of the body contour.of this population have become mor. r.levant. The goal of post-bar.atr.c r.constr.ction is to enhance the male silhouette thr.ugh r.moval of skin and adipose tissue excess, and abdominal r.ctus diastasis r.pair. Mater.al and Methods: We conducted a r.tr.spective study at the Plastic and r.constr.ctive Sur.er. Depar.ment of the National Medical Center.“20 de Noviembr.”. All male patients r.fer.ed to our.depar.ment to star. a post-bar.atr.c r.constr.ction pr.tocol fr.m Januar. 2018 to December.2022 wer. included in this study. r.sults: In total, 15 patients who under.ent cor.or.l contour.ng pr.cedur.s wer. included;median age was 49.2 year. with minimum of 33 year., and a maximum of 57 year.. Median Body mass index was 28.4 kg/m2 with minimum of 22 kg/m2 and maximum of 38 kg/m2. All patients wer. tr.ated 18 months after.their.bar.atr.c sur.er.. All patients under.ent an abdominoplasty as a body contour.ng pr.cedur.. 4 (26.7%) patients pr.sented complications r.lated to the sur.er.. Conclusion: We descr.bed a compr.hensive and systematic appr.ach to massive weight loss for.male patients, suggesting an abdominal mar.ing based on the patient’s clinical featur.s and the expected r.sults avoiding feminization of the abdominal body contour.

关键词： Massive Weight Loss Post-Bar.atr.c Male Abdominoplasty Contour.ng

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Color.ctal cancer.scr.ening:A r.view of cur.ent knowledge and pr.gr.ss in r.sear.h

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第4期16卷 1119-1133页

作者： Sar. r.mos Lopes claudio Mar.ins Inês Costa Santos Madalena Teixeir. Élia Gamito Ana Luisa Alves Depar.ment of Gastr.enter.logy Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Color.ctal cancer.Cr.)is one of the most pr.valent malignancies wor.dwide,being the thir. most commonly diagnosed malignancy and the second leading cause of cancer.r.lated deaths *** the pr.gr.ss in scr.ening,ear.y diagnosis,and tr.atment,appr.ximately 20%-25%of Cr. patients still pr.sent with metastatic disease at the time of their.initial ***,the bur.en of disease is still expected to incr.ase,especially in individuals younger.than 50 year. old,among whom ear.y-onset Cr. incidence has been *** and ear.y detection ar. pivotal to impr.ve Cr.-r.lated *** is well established that Cr. scr.ening not only r.duces incidence,but also decr.ases deaths fr.m *** scr.ening str.tegies have pr.ven effective in decr.asing both Cr. incidence and mor.ality,though var.ations in efficacy have been r.por.ed acr.ss the ***,uncer.ainties per.ist r.gar.ing the optimal scr.ening method,age inter.als and ***,adher.nce to Cr. scr.ening r.mains globally *** r.cent year.,emer.ing technologies,notably ar.ificial intelligence,and non-invasive biomar.er.,have been developed to over.ome these ***,contr.ver.y exists over.the actual impact of some of the new discover.es on Cr.-r.lated outcomes and how to effectively integr.te them into daily *** this r.view,we aim to cover.the cur.ent evidence sur.ounding Cr. *** will fur.her.cr.tically assess novel appr.aches under.investigation,in an effor. to differ.ntiate pr.mising inno-vations fr.m mer. novelties.

关键词： Color.ctal cancer Scr.ening r.view Oncology Ar.ificial intelligence

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Micr.r.As in inflammator. bowel disease:What do we know and what can we expect?

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Wor.d Jour.al of Gastr.enter.logy 2024年第16期30卷 2184-2190页

作者： Ellen Cr.stina Souza de Oliveir. Ana Elisa Valencise Quaglio Thais Gagno Gr.llo Luiz claudio Di Stasi Ligia Yukie Sassaki Depar.ment of Inter.al Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Ver.m Ingr.dients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Depar.ment of Biophysics and Phar.acology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

Micr.r.As(mir.As),small non-coding r.As composed of 18–24 nucleotides,ar. potent r.gulator. of gene expr.ssion,contr.buting to the r.gulation of mor. than 30%of pr.tein-coding *** that mir.As ar. r.gulator. of inflammator. pathways and the differ.ntiation of intestinal epithelial cells,ther. is an inter.st in explor.ng their.impor.ance in inflammator. bowel disease(IBD).IBD is a chr.nic and multifactor.al disease of the gastr.intestinal tr.ct;the main for.s ar. Cr.hn's disease and ulcer.tive *** studies have investigated the dysr.gulated expr.ssion of mir.As in IBD,demonstr.ting their.impor.ant r.les as r.gulator. and potential biomar.er. of this *** editor.al pr.sents what is known and what is expected r.gar.ing mir.As in *** the impor.ant r.gulator. r.les of mir.As in IBD ar. clear.y established,biomar.er. for.IBD that can be applied in clinical pr.ctice ar. lacking,emphasizing the impor.ance of fur.her.*** r.gar.ing the influence of mir.As on the inflammator. pr.cess and the explor.tion of their.r.le in gene r.gulation ar. expected to pr.vide a basis for.the use of mir.As not only as potent biomar.er. in IBD but also as ther.peutic tar.ets for.the contr.l of inflammator. pr.cesses in per.onalized medicine.

关键词： Micr.r.As Inflammator. bowel disease Cr.hn’s disease Ulcer.tive colitis Biomar.er Ther.py

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