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protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress

World Journal of Gastroenterology 2003年第3期9卷 446-448页

作者： claudia p.m.s.oliveira paulo Kassab Fabio p.Lopasso Heraldo p.souza mariano Janiszewski Francisco R.m.Laurindo Kioshi Iriya Antonio A.Laudanna Department of Gastroenterology of medical school of University of so paulo (Usp) So PauloBrazil Department of Emergency medicine of mcdical school of University of so paulo (Usp) So PauloBrazil Heart Institute of medical school of University of so paulo (Usp) So PauloBrazil Depatment of pathology of medical school of University of so paulo (Usp) So PauloBrazil

AIm: Oxidative stress participates in the cell carcinogenesis by inducing DNA mutations. Our aim was to assess whether ascorbic acid, an antioxidant, could have a role in preventing ROs (Reactive Oxygen species) generation in experimental gastric carcinoma in a rat ***: Experimental gastric cancer was induced in twelve Wistar male rats (weighting 250-350 g) by profound duodeno-gastric reflux throught split gastrojenunostomy. The rats were allocated to the following groups: Group Ⅰ (n=6)was the control; Group Ⅱ (n=6) which was mantained with daily intake of tape water with Vitamin C (30 mg/Kg). After 6 or 12 months, samples of gastric tumor or non tumor mucosa were taken from the anastomosis of both *** stress was measured by superoxide quantification through lucigenin-amplified chemiluminescence base and by staining with Nitrobluetetrazolium. The histopathologic confirmation of adenocarcinoma was made by eosinhemathoxilin ***: The intestinal type of gastric adenocarcinoma was microscopically identified in all animals of group Ⅰwhereas only 3 rats of group Ⅱ showed an adenocarcinoma without macroscopic evidence of them. The cancers were located in the anastomosis in all cases. Basal luminescence from tumor gastric tissue generated 38.4±6.8 count per minute/mg/x106 (mean±sD) and 14.9±4.0 count per minute/mg/×106, respectively, in group Ⅰ and Ⅱ animals (p＜0.05). The Nitrobluetetrazolium method showed intense staining in tumor tissues but not in non neoplasic ***: Experimental gastric tumors seem to produce more reactive oxygen species than non neoplasic gastric tissue. The reduction of oxidative stress and gastric tumor incidence in rats were induced by the intake of ascorbic acid. Therefore, it may have a role in the prevention of gastric carcinoma.

关键词：维生素C酸胃癌氧化损伤作用机制动物模型

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Finding my way: The role of dirigent proteins in lignin assembly

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molecular plant 2024年第2期17卷 230-232页

作者： Dyoni m.oliveira Igor Cesarino Department of plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium VIB Center for plant systems Biology 9052 GhentBelgium Departamento de Botanica Instituto de BiocienciasUniversidade de Sao PauloRua do Matao277Sao Paulo 05508-090Brazil synthetic and systems Biology Center InovaUSPAvenida Professor Lucio Martins Rodrigues370SaoPaulo 05508-020Brazil

Lignin emerged around 450 million years ago in early tracheophytes and played a pivotal role in the colonization of terrestrial ecosystems by *** aromatic biopolymer provides mechanical strength to supportive tissues and hydrophobicity to water-transporting vasculature and acts as a physical barrier against herbivores and pathogens(Renault et al.,2019).The deposition of lignin in cell walls for proper cellular functionalization involves several molecular steps,including the tight regulation of tissue-or cell-type-specific expression of lignin biosynthetic genes,the biosynthesis of distinct lignin monomers and their transportation to the apoplast,and the polymerization of monomer radicals to produce tissue-or cell-type-dependent polymers with distinct physico-chemical properties.

关键词： properties. lignin walls

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Artemisia vulgaris Induces Tumor-selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) signaling

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Chinese Journal of Integrative medicine 2024年第6期30卷 525-533页

作者： Lucas dos santos Zamarioli michele Rosana maia santos Adolfo Garcia Erustes Vanessa marques meccatti Thais Cristine pereira soraya s smaili maria Cristina marcucci Carlos Rocha oliveira Gustavo Js pereira claudia Bincoletto Department of pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on phytocomplexes and Cell signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(mCF-7 and sKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HpLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BApTA-Am)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of mCF-7,sKBR-3 and K562 cells(ps was reduced compared to HEAV-exposed fibroblasts(pment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(pse of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(pse mainly from lysosomes in K562 cells(pmore,BApTA-Am,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(psions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt C.m.saporetti L.C.oliveira E.pereira Department of Computational and Applied mechanics Federal University of Juiz de Fora Department of Computational modeling Polytechnic Institute Rio de Janeiro State University petrobras Department of stratigraphy and paleontology Rio de Janeiro State University

Rock samples' TOC content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOC. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. Core samples from the YuDong-Nan shale gas field, located in the sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOC. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

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Background removal from global auroral images:Data-driven dayglow modeling

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Earth and planetary physics 2024年第1期8卷 247-257页

作者： A.Ohma m.madelaire K.m.Laundal J.p.Reistad s.m.Hatch s.Gasparini s.J.Walker Birkeland Centre for space science Department of Physics and TechnologyUniversity of BergenBergenNorway

Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth ***,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by *** emissions and scattered sunlight can contribute to the background *** fully utilize such images in space science,background contamination must be removed to isolate the auroral *** we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical *** approach is robust,flexible,and iteratively deselects outliers,such as auroral *** final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the *** demonstrate the model by using the three far ultraviolet cameras on the Imager for magnetopause-to-Aurora Global Exploration(ImAGE)*** method can be applied to historical missions and is relevant for upcoming missions,such as the solar wind magnetosphere Ionosphere Link Explorer(smILE)mission.

关键词： aurora dayglow modeling global auroral images far ultraviolet images dayglow removal

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Enhanced entropy generation and heat transfer characteristics of magnetic nano-encapsulated phase change materials in latent heat thermal energy storage systems

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Applied mathematics and mechanics(English Edition) 2024年第6期45卷 1051-1070页

作者： p.s.REDDY p.sREEDEVI Department of mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage device filled with magnetic nanoencapsulated phase change materials(NEpCms).The versatile finite element method(FEm)is implemented to numerically solve the governing *** effects of various parameters,including the viscosity parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temperature,ranging from 1.0 to 1.2,the volume fraction of NEpCms,ranging from 2%to 6%,the stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours,isentropic lines,heat capacity ratio,and velocity ***,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are presented *** results indicate that the time taken by the NEpCms to transition from solid to liquid is prolonged inside the chamber region as the fusion temperatureθf ***,the contours of the heat capacity ratio Cr decrease with the increase in the stefan number ste.

关键词： volume fraction of nano-encapsulated phase change material(NEpCm) radiation stefan number heat capacity ratio entropy generation

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Ocular cicatricial pemphigoid:diagnosis and systemic management

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Annals of Eye science 2024年第2期9卷 38-52页

作者： claudia Castiblanco Department of Ophthalmology and Visual sciences Albert Einstein College of MedicineMontefiore Medical CenterBronxNYUSA

Ocular cicatricial pemphigoid(OCp)is a subcategory of mucous membrane pemphigoid(mmp)where the conjunctiva is the main site of *** is a chronic and autoimmune disease characterized by acute and chronic conjunctivitis that can progress to severe conjunctival cicatrization,corneal opacification,ocular surface keratinization,and eyelid *** can lead to structural damage that can result in visual impairment,visual loss,and blindness,and can have a significant impact in a patient’s quality of *** may manifest with varying symptoms,degrees of severity and may have different rates of *** diagnosis and appropriate systemic immunosuppression are of utmost importance for prompt and adequate disease *** systemic immunomodulatory therapies(ImTs),including anti-metabolites,alkylating,and biologic agents have been utilized to achieve inflammation control and *** monitoring of disease progression is important to assess response and to modify and escalate therapy if *** to alleviate symptoms of dry eye disease and address trichiasis and other eyelid abnormalities is recommended as well.A multidisciplinary approach to optimize clinical care is recommended in the management of patients with *** review will address the immunopathogenesis,clinical features,keys to diagnosis and staging of patients with *** will highlight the current immunomodulators utilized for disease management and proposed stepladder *** review will discuss the updated roles of combination therapy,novel use of biologics as well as the recent use of adrenocorticotropic hormone(ACTH)analog in severe recalcitrant cases.

关键词： Ocular cicatricial pemphigoid(OCp) mucous membrane pemphigoid(mmp) basement membrane zone(BmZ) symblepharon immunomodulatory therapy(ImT)

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Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese physics B 2024年第2期33卷 108-114页

作者： U.s.mahabaleshwar G.p.Vanitha L.m.pérez Emad H.Aly I.pop Department of studies in mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

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Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery?

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： Belinda sánchez-pérez Josém Ramia Department of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Department of surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAs)programs have been widely applied in liver surgery since the publication of the first ERAs guidelines in 2016 and the new recommendations in *** surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAs programs in oncological outcomes is not clearly *** advantages of ERAs programs are:ERAs decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving ***,ERAs could be another way to improve our oncological *** will discuss the literature about liver surgery ERAs focusing on its oncological implications and future investigations projects.

关键词： Enhanced recovery after surgery programs Liver surgery Key components Long-term oncological outcomes Enhanced recovery after surgery compliance

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magnesium oxide(mgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.C.s.perera V.Gurunanthanan Anoop singh m.m.m.G.p.G.mantilaka G.Das sandeep Arya Department of physics Khalifa UniversityAbu Dhabi12788United Arab Emirates postgraduate Institute of science University of PeradeniyaPeradeniyaSri Lanka Department of Humanities and sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India Centre for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Department of physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(mgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of mgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of mgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of mgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of mgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for mgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of mgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to mgO ***,there is a need to investigate the use of mgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： mgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption synthesis methods

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