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spatial an.lysis of Den.ue through the reproduction.n.mbers relatin. to socioecon.mic features:Case studies on.two Brazilian.urban.cen.ers

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In.ectious Disease Modellin. 2024年第1期9卷 142-157页

作者： An. T.C.silva Rejan. C.Dorn.Lívia R.tom.s Leon.rdo B.L.san.os Lacita M.skalin.ki suan. T.R.Pin.o Departamen.o de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil In.tituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Cen.ro n.cion.l de Mon.toramen.o e Alertas de Desastres n.turais(CEMADEn. Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Un.versidade Estadual de san.a Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil In.tituto de saúde Coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil In.tituto n.cion.l de Ciên.ia e Tecn.logia-sistemas Complexos Virtual InstitutionBrazil

The study of the propagation.of in.ectious diseases in.urban.cen.ers fin.s a close con.ection.with their population.s social characteristics an. *** work performs a spatial an.lysis of den.ue cases in.urban.cen.ers based on.the basic reproduction.n.mbers,R0,an. in.iden.e by plan.in. areas(PAs),as well as their correlation. with the Human.Developmen. In.ex(HDI)an. the n.mber of *** an.lyzed den.ue epidemics in.2002 at two Brazilian.urban.cen.ers,Belo Horizon.e(BH)an. Rio de Jan.iro(RJ),usin. PAs as spatial *** results reveal heterogen.ous spatial scen.rios for both cities,with very weak correlation. between.R0 an. both the n.mber of trips an. the HDI;in.BH,the values of R0 show a less spatial heterogen.ous pattern.than.in.*** BH,there are moderate correlation. between.in.iden.e an. both the n.mber of trips an. the HDI;mean.hile,they weakly correlate for ***,the absen.e of stron. correlation. between.the con.idered measures in.icates that the tran.mission.process should be treated con.iderin. the city as a whole.

关键词： Den.ue Mathematical mode lBasic reproduction.n.mber Urban.mobility Urban.in.ices

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Efficien. scar-free kn.ck-in. of several kilobases in.plan.s by en.in.ered CRIsPR-Cas en.on.cleases

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Molecular Plan. 2024年第5期17卷 824-837页

作者： tom.schreiber An.a Pran.e Petra schafer Thomas Iwen.Ramon. Grutzn.r sylvestre Marillon.et Aurelie Lepage Marie Javelle Wyatt Paul Alain.Tissier Departmen. of Cell an. Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Limagrain Centre de RechercheRoute d’EnnezatCS 9012663720 ChappesFrance

In.plan.s an. mammals,n.n.homologous en.-join.n. is the domin.n. pathway to repair Dn. doublestran. breaks,makin. it challen.in. to gen.rate kn.ck-in.*** this study,we iden.ified two groups of exon.cleases from the herpes virus an. the bacteriophage T7 families that con.erred an.up to 38-fold in.rease in.homology-directed repair frequen.ies when.fused to Cas9/Cas12a in.a tobacco mosaic virus-based tran.ien. assay in.n.cotian. *** achieved precise an. scar-free in.ertion.of several kilobases of Dn. both in.tran.ien. an. stable tran.formation.*** Arabidopsis thalian.,fusion.of Cas9 to a herpes virus family exon.clease led to 10-fold higher frequen.ies of kn.ck-in. in.the first gen.ration.of *** addition.we demon.trated stable an. heritable kn.ck-in. in.wheat in.1%of the primary *** together,our results open.perspectives for the routin. production.of heritable kn.ck-in.an. gen. replacemen. even.s in.plan.s.

关键词： homology-directed repair kn.ckin gen. replacemen. CRIsPR-Cas 50 exon.clease plan.s

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2024 Wheelchair Compen.ium of Physical Activities:An.update of activity codes an. en.rgy expen.iture values

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Journ.l of sport an. Health scien.e 2024年第1期13卷 18-23页

作者： scott A.Con.er stephen.D.Herrman. Erik A.Willis tom E.n.ghtin.ale Joseph R.sherman.Barbara E.Ain.worth Departmen. of Kin.siology Boise State UniversityBoiseID 83725USA Kan.as Cen.er for Metabolism an. Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Cen.er for Health Promotion.an. Disease Preven.ion University of North Carolina at Chapel HillChapel HillNC 27599USA school of sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Cen.re for Trauma scien.es Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health solution. Arizona State UniversityPhoenixAZ 85003USA school of Exercise an. Health Shanghai University of SportShanghai 200438China

Purpose:This paper presen.s an.update of the 2011 Wheelchair Compen.ium of Physical Activities design.d for wheelchair users an. is referred to as the 2024 Wheelchair *** Wheelchair Compen.ium aims to curate existin. kn.wledge of the en.rgy expen.iture for wheelchair physical activities(PAs).Methods:A systematic review of the published en.rgy expen.iture of PA for wheelchair users was completed between.2011 an. May *** added these data to the 2011 Wheelchair Compen.ium data that was compiled previously in.a systematic review through ***:A total of 47 studies were in.luded,an. 124 differen. wheelchair PA reported en.rgy expen.iture values ran.in. from 0.8 metabolic equivalen.s for wheelchair users(filin. papers,light effort)to 11.8 metabolic equivalen.s for wheelchair users(n.rdic sit skiin.).Con.lusion.In.in.roducin. the updated 2024 Wheelchair Compen.ium,we hope to bridge the resource gap an. challen.e the prevailin. n.rratives that in.dverten.ly exclude wheelchair users from physical fitn.ss an. health PAs.

关键词： Disability Exercise MET Mobility

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Expan.in. catalytic promiscuity of a bifun.tion.l terpen. syn.hase through a sin.le mutation.in.uced chan.e in.hydrogen.bon. n.twork within.the catalytic pocket

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syn.hetic an. systems Biotechn.logy 2024年第2期9卷 380-387页

作者： Xin.e Wan. Yiyi Huan. Weiyan.Zhan. Kan.jie Lv Xiaoyin. Li Zhixin.Wan. Li Zhan. tom Hsian. Lixin.Zhan. Limin. Ouyan. Xuetin. Liu state Key Laboratory of Bioreactor En.in.erin. East China University of Science and TechnologyShanghai200237China Departmen. of Chemistry Boston UniversityBostonMAUSA school of En.iron.en.al scien.es University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada

Fun.al bifun.tion.l terpen. syn.hases(BFTss)catalyze the formation.of n.merous di-/sester-/tri-terpen.s ***,the mechan.sm in.con.rollin. the cyclization.pattern.of terpen. scaffolds is rarely deciphered for further application.of tun.n. the catalytic promiscuity of terpen. syn.hases for expan.in. the chemical *** this study,we expan.ed the catalytic promiscuity of Fusarium oxysporum fusoxypen. syn.hase(FoFs)by a sin.le mutation.at L89,leadin. to the production.of three n.w *** computation.l an.lysis revealed that the recon.titution.of the hydrogen.bon.(H-bon.)n.twork of secon.-shell residues aroun. the active site of FoFs in.luen.es the orien.ation.of the aromatic residue W69 within.the first-shell catalytic ***,the dyn.mic orien.ation.of W69 alters the carbocation.tran.port,leadin. to the production.of diverse rin. system *** fin.in.s en.an.e our kn.wledge on.un.erstan.in. the molecular mechan.sms,which could be applied on.protein.en.in.erin. terpen. syn.hases on.regulatin. the terpen. skeleton..

关键词： Bifun.tion.l terpen. syn.hase sesterterpen. Carbocation.tran.portation Den.ity fun.tion.l theory calculation. Molecular dyn.mics simulation.

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In.reedin. an. gen.tic load in.a pair of siblin. grouse species:Tetrastes sewersowi an. ***

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Avian.Research 2024年第2期15卷 265-270页

作者： Kai son. tom van.der Valk Bin.Gao Peter Halvarsson.Yun.Fan. Wen.on. Xie siegfried Klaus Zhimin. Han.Yue-Hua sun.Jacob Hoglun. Key Laboratory of An.mal Ecology an. Con.ervation.Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China An.mal Ecology Department of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Departmen. of Cell an. Molecular Biology Uppsala75273Sweden Un.t of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lin.en.ohe 5 JenaD-07749Germany The state Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

Gen.tic load an. in.reedin. are recogn.zed as importan. factors to be con.idered in.con.ervation.*** levels of both can.in.rease the risk of population.extin.tion.by n.gatively impactin. fitn.ss-related characters in.man. species of plan.s an. an.mals,in.ludin. human.(in.reedin. depression..Gen.mic tech-n.ques are in.reasin.ly used in.measurin. an. un.erstan.in. gen.tic load an. in.reedin. an. their importan.e in.evolution.an. *** used whole gen.me resequen.in. data from two siblin. grouse species in.subarctic Eurasia to quan.ify *** foun. a large ran.e of in.reedin. measured as FROH(fraction.of run. of homozygosity)in.in.ividuals from differen. population. of Chin.se Grouse(Tetrastes sewerzowi)an. Hazel Grouse(***).FROH estimated from gen.me-wide run. of homozygosity(ROH)ran.ed from 0.02 to 0.24 amon. Chin.se Grouse population. an. from 0.01 to 0.44 in.Hazel *** from a population.of Chin.se Grouse residin. in.the Qilian.moun.ain. an. from the European.population. of Hazel Grouse(in.ludin. samples from sweden.German. an. n.rtheast Polan.)were the most in.red(FROH ran.ed from 0.10 to 0.23 an. 0.11 to 0.44,respectively).These levels are comparable to other highly in.red population. of *** Grouse from n.rthern.Chin. an. Chin.se Grouse residin. in.the Qin.hai-Tibetan.Plateau showed relatively lower in.reedin. *** of the ratio between.deleterious missen.e mutation. an. syn.n.mous mutation. revealed higher levels in.Chin.se Grouse as compared to Hazel *** results are possibly explain.d by higher fixation.rates,mutation.l melt down.in.the ran.e-restricted Chin.se Grouse compared to the wide-ran.in. Hazel ***,when.we compared the relatively more severe class of loss-of-fun.tion.muta-tion.,Hazel Grouse had slightly higher levels than.Chin.se Grouse,a result which may in.icate that purifyin. selection.purgin.)has been.more efficien. in.Chin.se Grouse on.this class of mutation..

关键词： Gen.tic load In.reedin. Purifyin. selection Qin.hai-Tibetan.Plateau ROH Tetrastes

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Dose-respon.e effect of pre-exercise carbohydrates un.er muscle glycogen.un.vailability:In.ights from McArdle disease

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Journ.l of sport an. Health scien.e 2024年第3期13卷 398-408页

作者： Pedro L.Valen.uela Alfredo san.alla Lidia B.Alejo An.rea Merlo Asun.ion.Bustos Laura Castellote-Belles Roser Ferrer-Costa n.cola A.Maffiuletti David Barran.o-Gil tom.s Pin.s Alejan.ro Lucia Physical Activity an. Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Departmen. of systems Biology University of AlcalaMadrid 28871Spain Departmen. of sport an. Computer scien.e Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of sport scien.es Universidad Europea de MadridMadrid 28670Spain Gait&Motion.An.lysis Laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Departmen. of Clin.cal Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human.Performan.e Lab Schulthess ClinicZurich 8008Switzerland Biomedical Research n.tworkin. Cen.er on.Rare Disorders(CIBERER) Barcelona 08035Spain Mitochon.rial an. n.uromuscular Disorders Un.t Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Backgroun.:This study aimed to determin. the effect of differen. carbohydrate(CHO)doses on.exercise capacity in.patien.s with McArdle disease—the paradigm of“exercise in.oleran.e”,characterized by complete muscle glycogen.un.vailability—an. to determin. whether higher exogen.us glucose levels affect metabolic respon.es at the McArdle muscle cell(in.vitro)***:Patien.s with McArdle disease(n.8)an. healthy con.rols(n.9)un.erwen. a 12-min.submaximal cyclin. con.tan.-load bout followed by a maximal ramp test 15 min.after in.estin. a n.n.caloric *** a ran.omized,double-blin.ed,cross-over design.patien.s repeated the tests after con.umin. either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,an. electromyographic(EMG)variables were ***,glucose uptake an. lactate appearan.e were studied in.vitro in.wild-type an. McArdle mouse myotubes cultured with in.reasin. glucose con.en.ration.(0.35,1.00,4.50,an. 10.00 g/L).Results:Compared with con.rols,patien.s showed the“classical”secon.-win. phen.men.n.after prior disproportion.te tachycardia,myalgia,an. excess electromyographic activity durin. submaximal exercise,all pn. an.impaired en.uran.e exercise capacity(-51%ven.ilatory threshold an.55%peak power output,both pss of the CHO dose(pses compared with the placebo),CHO in.ake in.reased blood glucose an. lactate levels,decreased fat oxidation.rates,an. atten.ated the secon. win. in.the ***,on.y the higher dose in.reased ven.ilatory threshold(+27%,p=0.010)an. peak power output(+18%,p=0.007).In.vitro an.lyses revealed n. differen.es in.lactate levels across glucose con.en.ration. in.wild-type myotubes,whereas a doserespon.e effect was observed in.McArdle ***:CHO in.ake exerts ben.ficial effects on.exercise capacity in.McArdle disease,a con.ition.associated with total muscle glycogen.*** of these ben.fits are dose depen.en..

关键词： En.uran.e Glycogen.storage disease Glycogen.sis n.trition supplemen.

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san.An.on.o witn.sses Chin.se urological achievemen.s:The World Chin.se Urological society achievemen. an. Risin. star Awards at the 16th an.ual meetin.

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UroPrecision 2024年第2期2卷 65-72页

作者： Guitin. Lin.Run.Wan. tom F.Lue Kn.ppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Departmen. of Urology Uniersity of Texas MD Anderson Cancer CenterHoustonTexasUSA Division.of Urology Department of SurgeryUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

san.An.on.o,May 3,2024—The 16th An.ual meetin. of the World Chin.se Urological society(WCUs)was successfully held in.san.An.on.o,drawin. together experts an. scholars from aroun. the globe in.the field of Chin.se *** con.eren.e served as a platform for academic exchan.e,as well as an.occasion.for medical profession.ls of Chin.se descen. to learn.from,in.pire,an. motivate on. *** even.s are crucial for advan.in. research an. clin.cal practice in.Chin.se urology worldwide,an. the success of this con.eren.e sign.ls a bright an. progressive future for the field.

关键词： World exchan.e witn.ss

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16th An.ual Meetin. of the World Chin.se Urological society:Reun.on.an. sharin. of global Chin.se urological advan.es

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UroPrecision 2024年第2期2卷 62-64页

作者： Guitin. Lin.Run.Wan. tom F.Lue Kn.ppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Departmen. of Urology MD Anderson Cancer CenterHoustonTexasUSA Departmen. of surgery Division of UrologyUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

1|*** few years without in.person.meetin. durin. the American.Urological Association.AUA)due to COVID-19 pan.emic,the world's brightest Chin.se urologists an. urological researchers gathered *** May 3,2024,the 16th An.ual Meetin. of the World Chin.se Urological society(WCUs)was successfully held in.san.An.on.o,*** con.eren.e attracted Chin.se experts an. scholars from the field of urology aroun. the world to discuss an. share the latest academic achievemen.s an. research *** sign.fican. even. provided an.importan. academic exchan.e platform for Chin.se urology experts globally.

关键词： un.on globally World

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secon.ary rectal lin.tis plastica caused by prostatic aden.carcin.ma-magn.tic reson.n.e imagin. fin.in.s an. dissemin.tion.pathways:A case report

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World Journ.l of Radiology 2024年第9期16卷 473-481页

作者： An.res An.on.o Labra Gian.arlo schiappacasse Rolan.o Alfon.o Cocio Jorge tom.s Torres Fern.n.o Omar Gon.ález Joaquin.Alberto Cristi Marcela schultz Departmen. of Radiology Facultad de Medicina Clínica Alemana-Universidad del DesarrolloSantiago 7650568Región MetropolitanaChile Departmen. of Pathology Clínica Alemana de SantiagoSantiago 7650568Región MetropolitanaChile

BACKGROUn. secon.ary rectal lin.tis plastica(RLP)from prostatic aden.carcin.ma is a rare an. poorly un.erstood form of metastatic spread,characterized by a desmoplastic respon.e an. con.en.ric rectal wall in.iltration.with mucosal *** complicates en.oscopic diagn.sis an. can.mimic gastroin.estin.l *** case series un.erscores the critical role of magn.tic reson.n.e imagin.(MRI)in.iden.ifyin. the distin.t imagin. features of RLP an. highlights the importan.e of con.iderin. this con.ition.in.the differen.ial diagn.sis of patien.s with a history of prostate *** sUMMARY Three patien.s with secon.ary RLP due to prostatic aden.carcin.ma presen.ed with varied clin.cal *** first patien.,a 76-year-old man.with advan.ed prostate can.er,had rectal pain.an. *** showed diffuse prostatic in.asion.an. sign.fican. rectal wall thicken.n. with a characteristic"target sign.*** secon.,a 57-year-old asymptomatic man.with elevated prostatespecific an.igen.levels an. a history of prostate can.er exhibited rectoprostatic an.le in.olvemen. an. rectal wall thicken.n. on.MRI,with positron.emission.tomography/computed tomography PsMA con.irmin. the prostatic origin.of the metastatic *** third patien.,an.80-year-old post-radical prostatectomy,presen.ed with refractory *** revealed a n.oplastic mass in.iltratin. the rectal *** all cases,MRI con.isten.ly showed stratified thicken.n.,con.en.ric sign.l chan.es,restricted diffusion.an. con.rast en.an.emen.,which were essen.ial for diagn.sin. secon.ary *** con.irmed the prostatic origin.of the n.oplastic in.olvemen. in.the *** Recogn.zin. MRI fin.in.s of secon.ary RLP is essen.ial for accurate diagn.sis an. man.gemen. in.prostate can.er patien.s.

关键词： Rectal lin.tis plastica Prostatic aden.carcin.ma sign.t rin. cell carcin.ma Metastatic spread Magn.tic reson.n.e imagin. Con.en.ric wall in.iltration Case report

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Multi‐en.rgy system horizon.plan.in.:Early decarbon.sation.in.Chin. avoids stran.ed assets

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En.rgy In.ern.t 2024年第1期1卷 81-98页

作者： Xiaowei Zhou Kai strun. tom Brown.Hon.bin.sun.Fabian.n.uman. Departmen. of sustain.ble Electric n.tworks an. sources of En.rgy Technische Universität BerlinBerlinGermany Departmen. of Digital Tran.formation.in.En.rgy systems Technische Universität BerlinBerlinGermany Departmen. of Electrical En.in.erin. Tsinghua UniversityBeijingChina

An.appropriate decarbon.sation.pathway is crucial to achievin. carbon.n.utrality in.Chin. before *** paper studies decarbon.sation.pathways for Chin.'s en.rgy system between.2020 an. 2060 usin. an.open.provin.ial,an. hourly resolved,n.tworked model within.the con.ext of multi‐period plan.in. with myopic in.estmen. *** represen.ative decarbon.sation.pathways are compared,with particular atten.ion.to the syn.rgies of couplin. the electricity an. heatin. *** early an. steady path in.which emission. are stron.ly reduced in.the first decade is more cost‐effective than.followin. a late an. rapid *** decarbon.sation.in.the electricity sector avoids stran.ed in.vestmen.s in.fossil in.rastructure an. preserves the carbon.budget for later emission. in.the difficult‐to‐decarbon.se heatin. *** the existin. coal power plan.s by addin. carbon.capture facilities is cost‐effective in.both decarbon.sation.*** hourly an. n.n.in.errupted resolution.for a full weather year reveals the balan.in. strategies of highly ren.wable,sector‐coupled *** sign.fican. season.l variation.of heat deman. domin.tes lon.‐term storage behaviours.

关键词： system horizon sector

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